Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0802 | 1 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0802 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0369 | 0 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0802 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | = 1.5 mg kg-1 | Evaluated for ouabain-induced arrhythmia in anesthetized adult male mongrel dogs. Administered intravenously. | ChEMBL. | 6384519 |
Inhibition (functional) | = 49 % | Parasympatholytic activity was assessed from the ability to inhibit electrically stimulated contraction of isolated guinea pig ileum at 4 mg/L of base | ChEMBL. | 6384519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.