Detailed information for compound 35885

Basic information

Technical information
  • TDR Targets ID: 35885
  • Name: 4-(4-chlorophenyl)pyrrolidin-2-one
  • MW: 195.645 | Formula: C10H10ClNO
  • H donors: 1 H acceptors: 1 LogP: 1.62 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NCC(C1)c1ccc(cc1)Cl
  • InChi: 1S/C10H10ClNO/c11-9-3-1-7(2-4-9)8-5-10(13)12-6-8/h1-4,8H,5-6H2,(H,12,13)
  • InChiKey: OVRPDYOZYMCTAK-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-(4-chlorophenyl)-2-pyrrolidinone
  • 4-(4-chlorophenyl)-2-pyrrolidone
  • 22518-27-0

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Echinococcus granulosus chromobox protein 1 0.0072 0.0425 0.0418
Schistosoma mansoni hypothetical protein 0.0498 0.3548 0.3544
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.002 0.0042 0.0035
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0193 0.0512
Echinococcus granulosus voltage gated potassium channel 0.0021 0.005 0.0043
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0397 0.281 0.7292
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0106 0.0671 0.0664
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0307 0.03
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0307 0.03
Echinococcus multilocularis 0.0028 0.0103 0.0096
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0106 0.0671 0.0664
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0307 0.03
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0397 0.281 0.2897
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0106 0.0671 0.1824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.014 0.0366
Echinococcus multilocularis mitogen activated protein kinase 0.0102 0.0644 0.0637
Echinococcus multilocularis transient receptor potential cation channel 0.002 0.0042 0.0035
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0157 0.0155
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0106 0.0671 0.174
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0085 0.0078
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.002 0.0042 0.0034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.02
Loa Loa (eye worm) oxidoreductase 0.002 0.0042 0.0091
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0106 0.0671 0.1824
Schistosoma mansoni netrin receptor unc5 0.0028 0.0105 0.0098
Trypanosoma brucei oxidoreductase-like protein 0.002 0.0042 0.0036
Echinococcus granulosus single minded 2 0.0076 0.0452 0.0446
Leishmania major 3-keto-dihydrosphingosine reductase 0.002 0.0042 0.0036
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0106 0.0671 0.1824
Brugia malayi Carboxylesterase family protein 0.0059 0.033 0.0857
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0142 0.0135
Echinococcus granulosus neuropeptide receptor 0.0056 0.0307 0.03
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0875 0.6309 0.6306
Loa Loa (eye worm) dehydrogenase 0.002 0.0042 0.0091
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0006
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0084 0.0077
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0026 0.0019
Schistosoma mansoni lamin 0.0053 0.0286 0.028
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0125 0.0118
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Echinococcus granulosus phd:f box containing protein 0.0026 0.0085 0.0078
Loa Loa (eye worm) oxidoreductase 0.002 0.0042 0.0091
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0084 0.0077
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0352 0.0345
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0307 0.03
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0085 0.0203
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0042 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.3646 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0059 0.033 0.0323
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0019 0.0011
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0307 0.078
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.031
Schistosoma mansoni gliotactin 0.0059 0.033 0.0323
Echinococcus granulosus lipoxygenase domain containing protein 0.0121 0.0783 0.0777
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.072 0.196
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0307 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0116 0.03
Brugia malayi TAR-binding protein 0.0062 0.0352 0.0912
Echinococcus granulosus hyperpolarization activated cyclic 0.0018 0.0026 0.0019
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Echinococcus granulosus glutamate synthase 0.0106 0.0671 0.0664
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0307 0.0796
Onchocerca volvulus 0.0056 0.0307 0.0786
Mycobacterium leprae putative cytochrome p450 0.0028 0.0103 0.0144
Loa Loa (eye worm) hypothetical protein 0.0059 0.033 0.0841
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0084 0.0077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0307 0.03
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0091 0.0087
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0042 0.0069
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0364 0.2567 0.6669
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0307 0.03
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0084 0.0212
Toxoplasma gondii thioredoxin reductase 0.0539 0.3849 1
Onchocerca volvulus 0.0025 0.0084 0.0125
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0125 0.0323
Brugia malayi Uncoordinated protein 44 0.0028 0.0105 0.0272
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0144 0.037
Mycobacterium tuberculosis Probable oxidoreductase 0.0601 0.4301 1
Onchocerca volvulus 0.0072 0.0426 0.1142
Echinococcus granulosus carbonyl reductase 1 0.002 0.0042 0.0035
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0084 0.0077
Brugia malayi Serotonin receptor 0.0056 0.0307 0.0796
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0144 0.0355
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Brugia malayi Carboxylesterase family protein 0.0059 0.033 0.0857
Toxoplasma gondii carbonyl reductase 1, putative 0.002 0.0042 0.0109
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0103 0.0096
Schistosoma mansoni hypothetical protein 0.0031 0.0125 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.2357 0.6458
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0033 0.0026
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0006
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0307 0.03
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0042 0.0069
Loa Loa (eye worm) hypothetical protein 0.0059 0.033 0.0841
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0693 0.0709
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.072 0.196
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0013 0.0006
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0397 0.281 0.6522
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0051 0.0131
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0443 0.1151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0307 0.03
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0042 0.0034
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0392 0.0397
Brugia malayi Dehydrogenases, short chain protein 2 0.002 0.0042 0.0108
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0106 0.0671 0.0686
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0307 0.03
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0013 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.3646 1
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0085 0.0078
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.02
Onchocerca volvulus 0.0056 0.0307 0.0786
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0789 0.0783
Onchocerca volvulus 0.015 0.0993 0.2825
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.002 0.0042 0.0035
Leishmania major hypothetical protein, conserved 0.002 0.0042 0.0036
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0601 0.4301 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0042 0.0034
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0144 0.0341
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0102 0.0644 0.0658
Mycobacterium ulcerans glutamate synthase subunit beta 0.0106 0.0671 0.2298
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0102 0.0644 0.0658
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0166 0.0413
Echinococcus multilocularis hyperpolarization activated cyclic 0.0018 0.0026 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0028 0.0103 0.0212
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0397 0.281 0.2805
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0615 0.1596
Echinococcus multilocularis Polycystic kidney disease protein 0.0121 0.0783 0.0777
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0307 0.03
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0307 0.078
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0042 0.0034
Plasmodium vivax thioredoxin reductase, putative 0.0539 0.3849 1
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.002 0.0042 0.0034
Echinococcus multilocularis conserved hypothetical protein 0.0683 0.4899 0.4896
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.012 0.0315
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0397 0.281 0.2805
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Schistosoma mansoni opsin-like receptor 0.0056 0.0307 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.014 0.0366
Brugia malayi hypothetical protein 0.0121 0.0783 0.2034
Leishmania major trypanothione reductase 0.0539 0.3849 0.3971
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.023 0.0223
Brugia malayi sulfakinin receptor protein 0.0056 0.0307 0.0796
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.002 0.0042 0.0138
Brugia malayi Cytochrome P450 family protein 0.0028 0.0103 0.0268
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0307 0.03
Loa Loa (eye worm) carboxylesterase 0.0059 0.033 0.0841
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0042 0.0069
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0307 0.03
Leishmania major hypothetical protein, conserved 0.0026 0.0085 0.008
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0145 0.0378
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0307 0.03
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0397 0.281 0.2805
Schistosoma mansoni glutamate synthase 0.0106 0.0671 0.0664
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0106 0.0671 0.174
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0309 0.2162 0.5012
Leishmania major protein kinase, putative 0.0026 0.0091 0.0087
Loa Loa (eye worm) oxidoreductase 0.002 0.0042 0.0091
Toxoplasma gondii exonuclease III APE 0.0018 0.0033 0.0085
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0397 0.281 1
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0033 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0183
Mycobacterium ulcerans ketoacyl reductase 0.002 0.0042 0.0034
Schistosoma mansoni ap endonuclease 0.0018 0.0033 0.0025
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0183 0.1235 0.1229
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.012 0.0133
Trypanosoma cruzi short chain dehydrogenase, putative 0.002 0.0042 0.0036
Schistosoma mansoni disulfide oxidoreductase 0.0106 0.0671 0.0664
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0018 0.0026 0.0052
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0106 0.0671 0.2298
Schistosoma mansoni intermediate filament proteins 0.0053 0.0286 0.028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.02
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.02
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.002 0.0042 0.0035
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.034 0.0333
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0028 0.0103 0.0255
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0106 0.0671 0.1742
Echinococcus granulosus steroid dehydrogenase 0.002 0.0042 0.0035
Schistosoma mansoni acetylcholinesterase 0.0059 0.033 0.0323
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Loa Loa (eye worm) hypothetical protein 0.0067 0.0388 0.0991
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0512 0.3646 0.9473
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0324 0.0317
Schistosoma mansoni chromobox protein 0.0072 0.0425 0.0418
Echinococcus granulosus acetylcholinesterase 0.0349 0.2457 0.2451
Echinococcus granulosus bloom syndrome protein 0.0021 0.0051 0.0044
Plasmodium falciparum ferrodoxin reductase-like protein 0.0106 0.0671 0.1716
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Mycobacterium ulcerans ketoacyl reductase 0.002 0.0042 0.0034
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0109
Echinococcus granulosus orexin receptor type 2 0.0056 0.0307 0.03
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0106 0.0671 0.0686
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0157 0.0155
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0144 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0107 0.0275
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0251 0.1736 0.173
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.023 0.0581
Onchocerca volvulus 0.0056 0.0307 0.0786
Leishmania major hypothetical protein, conserved 0.0074 0.0443 0.0451
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0426 0.042
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.012 0.0312
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0267
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0467 0.3321 0.3316
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0105 0.0098
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0033
Giardia lamblia Glutamate synthase 0.0106 0.0671 0.2298
Schistosoma mansoni hypothetical protein 0.0056 0.0307 0.03
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0042 0.0036
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0144 0.0373
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.005 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0335 0.0854
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Entamoeba histolytica hypothetical protein 0.0071 0.0417 0.5588
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0307 0.03
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0085 0.0078
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0084 0.0217
Mycobacterium leprae Conserved hypothetical protein 0.0028 0.0103 0.0144
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0292 0.2037 0.5292
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Loa Loa (eye worm) RecQ helicase 0.0021 0.0051 0.0113
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0042 0.0036
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0144 0.0137
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0106 0.0671 0.1743
Echinococcus granulosus Ankyrin 0.0029 0.0107 0.01
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0084 0.0077
Loa Loa (eye worm) carboxylesterase 0.0349 0.2457 0.6376
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0307 0.03
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0042 0.0036
Onchocerca volvulus 0.0056 0.0307 0.0786
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Onchocerca volvulus 0.0121 0.0783 0.2201
Echinococcus granulosus fmrfamide receptor 0.0056 0.0307 0.03
Brugia malayi jmjC domain containing protein 0.0026 0.0085 0.022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0307 0.03
Loa Loa (eye worm) hypoxia-induced factor 1 0.0303 0.2116 0.5488
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.002 0.0042 0.0036
Echinococcus granulosus geminin 0.0498 0.3548 0.3544
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0307 0.03
Echinococcus granulosus serotonin receptor 0.0056 0.0307 0.03
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0033 0.0046
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Brugia malayi G protein-coupled receptor 0.0056 0.0307 0.0796
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0307 0.03
Schistosoma mansoni inositol monophosphatase 0.0109 0.0693 0.0686
Leishmania major oxidoreductase-like protein 0.002 0.0042 0.0036
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0425 0.1088
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0013 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0307 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0084 0.0212
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0051 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.014 0.0366
Brugia malayi putative neuropeptide receptor 0.0056 0.0307 0.0796
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0105 0.0098
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0018 0.0026 0.0019
Brugia malayi hypothetical protein 0.002 0.0042 0.0108
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0042 0.0096
Onchocerca volvulus 0.0479 0.3409 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0105 0.0098
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.023 0.0597
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0307 0.03
Leishmania major C-8 sterol isomerase-like protein 0.0364 0.2567 0.2646
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.002 0.0042 0.0138
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.0042 0.0203 0.051
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Brugia malayi Carboxylesterase family protein 0.0349 0.2457 0.6383
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0307 0.03
Onchocerca volvulus 0.0059 0.033 0.0856
Chlamydia trachomatis thioredoxin reductase 0.0106 0.0671 0.2153
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0352 0.0897
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0183 0.1235 0.3208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1129 0.817 0.8437
Loa Loa (eye worm) glutathione reductase 0.0539 0.3849 1
Schistosoma mansoni hypothetical protein 0.0028 0.0105 0.0098
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0397 0.281 1
Schistosoma mansoni hypothetical protein 0.0498 0.3548 0.3544
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.002 0.0042 0.0096
Echinococcus multilocularis lysine specific demethylase 5A 0.0096 0.0599 0.0593
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0106 0.0671 0.9278
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Brugia malayi neuropeptide F receptor 0.0056 0.0307 0.0796
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0183 0.1235 0.4329
Onchocerca volvulus 0.0056 0.0307 0.0786
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Loa Loa (eye worm) phosphofructokinase 0.0112 0.072 0.1857
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Loa Loa (eye worm) oxidoreductase 0.002 0.0042 0.0091
Toxoplasma gondii hypothetical protein 0.0025 0.0084 0.0218
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0307 0.03
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0033 0.0066
Echinococcus multilocularis RUN 0.0121 0.0783 0.0777
Schistosoma mansoni hypothetical protein 0.0204 0.1392 0.1385
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0106 0.0671 0.1535
Echinococcus multilocularis thioredoxin glutathione reductase 0.0539 0.3849 0.3844
Plasmodium falciparum LCCL domain-containing protein 0.0121 0.0783 0.2009
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Onchocerca volvulus 0.0197 0.1341 0.3858
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.3646 1
Echinococcus multilocularis Ankyrin 0.0029 0.0107 0.01
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.002 0.0042 0.0034
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0042 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.2357 0.6458
Schistosoma mansoni lipoxygenase 0.0467 0.3321 0.3316
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0106 0.0671 0.1742
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.0343 0.0923
Onchocerca volvulus 0.0056 0.0307 0.0786
Loa Loa (eye worm) hypothetical protein 0.0031 0.0125 0.0306
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.002 0.0042 0.0034
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0028 0.0103 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0193 0.0512
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0539 0.3849 0.8945
Brugia malayi Augmenter of liver regeneration 0.0034 0.0144 0.0372
Mycobacterium ulcerans hypothetical protein 0.0106 0.0671 0.2298
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0307 0.078
Loa Loa (eye worm) hypothetical protein 0.0106 0.0671 0.1728
Echinococcus multilocularis carboxylesterase 5A 0.0349 0.2457 0.2451
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0046 0.0238 0.0601
Brugia malayi G-protein coupled receptor 0.0056 0.0307 0.0796
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0028 0.0103 0.0255
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0106 0.0671 0.1476
Echinococcus granulosus WW domain containing oxidoreductase 0.002 0.0042 0.0035
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0084 0.0077
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0106 0.0671 0.1716
Brugia malayi jmjC domain containing protein 0.0026 0.0085 0.022
Brugia malayi G-protein coupled receptor 0.0056 0.0307 0.0796
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.023 0.0223
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0397 0.281 0.73
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0085 0.0078
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0183 0.1235 0.285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0412
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.002 0.0042 0.0091
Giardia lamblia Kinase, CMGC MAPK 0.0102 0.0644 0.2201
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.3646 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.002 0.0042 0.0035
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.0107 0.01
Brugia malayi PAS domain containing protein 0.0098 0.0614 0.1595
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0085 0.0078
Brugia malayi Cytochrome P450 family protein 0.0037 0.0166 0.043
Leishmania major hypothetical protein, conserved 0.002 0.0042 0.0036
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0102 0.0644 0.1657
Loa Loa (eye worm) hypothetical protein 0.0074 0.0443 0.1135
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0042 0.0069
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0166 0.0164
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0183 0.1235 0.1269
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0244 0.1685 0.4369
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0042 0.0069
Schistosoma mansoni lamin 0.0053 0.0286 0.028
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0307 0.03
Plasmodium falciparum amino acid transporter, putative 0.0025 0.0084 0.0185
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.3646 1
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.0343 0.0874
Brugia malayi oxidoreductase 0.002 0.0042 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.249 0.6822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0183
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0106 0.0671 0.1535
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0991 0.7158 0.7392
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.0103 0.0269
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0443 0.1148
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.005 0.0043
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0106 0.0671 0.1476
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0018 0.0026 0.0019
Entamoeba histolytica thioredoxin reductase, putative 0.0106 0.0671 0.9278
Echinococcus granulosus BC026374 protein S09 family 0.0059 0.033 0.0323
Echinococcus multilocularis lamin 0.0053 0.0286 0.028
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0042 0.0036
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0042 0.0036
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0028 0.0103 0.0212
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0084 0.0218
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0084 0.0077
Plasmodium falciparum steroid dehydrogenase, putative 0.002 0.0042 0.0077
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0349 0.2457 0.2451
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Plasmodium falciparum transporter, putative 0.0025 0.0084 0.0185
Brugia malayi isocitrate dehydrogenase 0.0016 0.0013 0.0032
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1129 0.817 0.8437
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Echinococcus granulosus RUN 0.0121 0.0783 0.0777
Leishmania major pteridine reductase 1 0.002 0.0042 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.014 0.0366
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.002 0.0042 0.0036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0028 0.0103 0.0255
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0224 0.0217
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0042 0.0034
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0106 0.0671 0.1743
Plasmodium vivax glutathione reductase, putative 0.0539 0.3849 1
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0085 0.0078
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.002 0.0042 0.0035
Schistosoma mansoni hypothetical protein 0.0031 0.0125 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0991 0.7158 0.7392
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.034 0.0333
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0183 0.1235 0.4329
Schistosoma mansoni biogenic amine receptor 0.0056 0.0307 0.03
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.012 0.028
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.033 0.074
Schistosoma mansoni opsin-like receptor 0.0056 0.0307 0.03
Brugia malayi Pre-SET motif family protein 0.006 0.034 0.0883
Echinococcus granulosus mitogen activated protein kinase 3 0.0102 0.0644 0.0637
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0103 0.01
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0042 0.0036
Trichomonas vaginalis apoptosis inducing factor, putative 0.0106 0.0671 0.1824
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.072 0.1593
Brugia malayi hypothetical protein 0.0071 0.0417 0.1082
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.0343 0.0336
Toxoplasma gondii hypothetical protein 0.0025 0.0084 0.0218
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Echinococcus multilocularis transfer RNA-Lys 0.0072 0.0428 0.0421
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0251 0.1736 0.173
Schistosoma mansoni amine GPCR 0.0056 0.0307 0.03
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0013 0.0006
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0106 0.0671 0.1535
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.023 0.0223
Giardia lamblia GTOR 0.0044 0.0224 0.0688
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0671 0.0686
Schistosoma mansoni opsin-like receptor 0.0056 0.0307 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0084 0.0212
Brugia malayi Carboxylesterase family protein 0.0059 0.033 0.0857
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0102 0.0644 0.0658
Plasmodium falciparum phd finger protein, putative 0.0029 0.011 0.0253
Leishmania major protein kinase, putative 0.0031 0.0126 0.0123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0042 0.0034
Echinococcus granulosus carbonyl reductase 1 0.002 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0042 0.0036
Schistosoma mansoni aryl hydrocarbon receptor 0.0098 0.0614 0.0608
Schistosoma mansoni lipoxygenase 0.025 0.1727 0.1721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0182
Brugia malayi jmjC domain containing protein 0.0026 0.0085 0.022
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0018 0.0026 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.02
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0106 0.0671 0.0686
Echinococcus granulosus serotonin transporter 0.015 0.0993 0.0987
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0193 0.045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1335 0.9681 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0042 0.0034
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0042 0.0069
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.031
Onchocerca volvulus 0.0056 0.0307 0.0786
Loa Loa (eye worm) hypothetical protein 0.0053 0.0286 0.0727
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0084 0.02
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0307 0.0796
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Onchocerca volvulus 0.0056 0.0307 0.0786
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0397 0.281 0.7292
Echinococcus multilocularis inositol monophosphatase 1 0.0109 0.0693 0.0686
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.002 0.0042 0.0109
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0103 0.01
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Echinococcus multilocularis steroid dehydrogenase 0.002 0.0042 0.0035
Loa Loa (eye worm) RNA binding protein 0.0062 0.0352 0.0897
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0042 0.0096
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0307 0.03
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.002 0.0042 0.0069
Echinococcus multilocularis serotonin transporter 0.015 0.0993 0.0987
Echinococcus granulosus survival motor neuron protein 1 0.0473 0.336 0.3355
Echinococcus granulosus hypothetical protein 0.0739 0.5308 0.5305
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.3646 1
Echinococcus granulosus neuropeptide receptor 0.0056 0.0307 0.03
Trichomonas vaginalis spcc417.12 protein, putative 0.0059 0.033 0.0888
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.072 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0307 0.03
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0106 0.0671 0.0686
Schistosoma mansoni carbonyl reductase 0.002 0.0042 0.0035
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0307 0.0796
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0216 0.0574
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0425 0.1149
Brugia malayi jmjC domain containing protein 0.0026 0.0085 0.022
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0644 0.0637
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0042 0.0036
Schistosoma mansoni carbonyl reductase 0.002 0.0042 0.0035
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0042 0.0069
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0106 0.0258
Treponema pallidum sodium- and chloride- dependent transporter 0.015 0.0993 0.3459
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0106 0.0671 0.1743
Brugia malayi Retinol dehydrogenase 12 0.002 0.0042 0.0108
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Trichomonas vaginalis mercuric reductase, putative 0.0397 0.281 0.7701
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.002 0.0042 0.0069
Mycobacterium ulcerans oxidoreductase 0.002 0.0042 0.0034
Loa Loa (eye worm) hypothetical protein 0.0059 0.033 0.0841
Schistosoma mansoni hypothetical protein 0.0067 0.0388 0.0381
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0183 0.1235 0.1229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0307 0.03
Leishmania major hypothetical protein, conserved 0.0106 0.0671 0.0686
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0307 0.03
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0397 0.281 0.7301
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0185
Onchocerca volvulus 0.0106 0.0671 0.1867
Echinococcus multilocularis lipoxygenase domain containing protein 0.0121 0.0783 0.0777
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0789 0.2051
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.072 0.0737
Leishmania major cytochrome p450-like protein 0.0028 0.0103 0.01
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0085 0.0078
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0352 0.0897
Loa Loa (eye worm) hypothetical protein 0.006 0.034 0.0867
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1335 0.9681 1
Schistosoma mansoni neuropeptide receptor 0.0056 0.0307 0.03
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.005 0.0043
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0144 0.0141
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.034 0.0884
Schistosoma mansoni biogenic amine receptor 0.0056 0.0307 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0107 0.0275
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.02
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0166 0.0164
Schistosoma mansoni jumonji domain containing protein 0.0136 0.0894 0.0888
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0084 0.0212
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.002 0.0042 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0604 0.1568
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0084 0.0077
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0125 0.0323
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0106 0.0671 0.1535
Leishmania major cytochrome p450-like protein 0.0037 0.0166 0.0164
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0059 0.033 0.0323
Echinococcus multilocularis retinol dehydrogenase 11 0.002 0.0042 0.0035
Brugia malayi Cyclic-nucleotide gated cation channel 0.0018 0.0026 0.0067
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0091 0.0087
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0392 0.0397
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0106 0.0671 0.2298
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0644 0.175
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0106 0.0671 0.2298
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0042 0.0096
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0307 0.03
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0125 0.0118
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Loa Loa (eye worm) solute carrier family 6 member 4 0.015 0.0993 0.2567
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0042 0.0069
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0105 0.0098
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0307 0.03
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0085 0.008
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0106 0.0671 0.1535
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0109 0.0693 0.2377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0307 0.03
Onchocerca volvulus 0.0056 0.0307 0.0786
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Schistosoma mansoni cytochrome P450 0.0028 0.0103 0.0096
Schistosoma mansoni microtubule-associated protein tau 0.1379 1 1
Loa Loa (eye worm) hypothetical protein 0.0349 0.2457 0.6376
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0013 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.023 0.0223
Loa Loa (eye worm) dehydrogenase 0.002 0.0042 0.0091
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0307 0.03
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0106 0.0671 0.2298
Loa Loa (eye worm) carboxylesterase 0.0059 0.033 0.0841
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0059 0.033 0.0323
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0307 0.03
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0084 0.0077
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0042 0.0035
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0106 0.0671 0.1535
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0307 0.078
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0106 0.0671 0.0664
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0224 0.0564
Echinococcus granulosus biogenic amine 5HT receptor 0.0176 0.1189 0.1183
Plasmodium vivax multidomain scavenger receptor, putative 0.0121 0.0783 0.2033
Treponema pallidum thioredoxin reductase (trxB) 0.0106 0.0671 0.2298
Echinococcus multilocularis GPCR, family 2 0.0031 0.0125 0.0118
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0033 0.0026
Leishmania major NADH dehydrogenase, putative 0.0106 0.0671 0.0686
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0018 0.0026 0.0049
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0028 0.0103 0.0255
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.002 0.0042 0.0069
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0028 0.0103 0.0255
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0109
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0084 0.0212
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0238 0.0231
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0109 0.0693 0.1884
Brugia malayi hypoxia-induced factor 1 0.0303 0.2116 0.5496
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0042 0.0096
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.002 0.0042 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0412
Leishmania major hypothetical protein, conserved 0.002 0.0042 0.0036
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0309 0.2162 0.5012
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0309 0.2162 0.5012
Loa Loa (eye worm) hypothetical protein 0.0059 0.033 0.0841
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.02
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0028 0.0103 0.0255
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0028 0.0103 0.0255
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0052 0.0046
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0042 0.0077
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Schistosoma mansoni hypothetical protein 0.0031 0.0125 0.0118
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0307 0.03
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0042 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0307 0.03
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0042 0.0138
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0028 0.0103 0.0212
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0106 0.0671 0.0664
Echinococcus granulosus oxidoreductase 0.002 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0098 0.0615 0.1582
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0307 0.03
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.0026 0.0019
Onchocerca volvulus 0.0059 0.033 0.0856
Brugia malayi 6-phosphofructokinase 0.0112 0.0721 0.1872
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.002 0.0042 0.0036
Mycobacterium ulcerans putative regulatory protein 0.0072 0.0428 0.1425
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.002 0.0042 0.0035
Schistosoma mansoni neuropeptide receptor 0.0056 0.0307 0.03
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.034 0.0333
Brugia malayi Carboxylesterase family protein 0.0059 0.033 0.0857
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0106 0.0671 0.1824
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0352 0.0345
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.002 0.0042 0.0036
Trypanosoma brucei protein kinase, putative 0.0102 0.0644 0.0658
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0085 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.249 0.6822
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0307 0.03
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0106 0.0671 0.0664
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.002 0.0042 0.0109
Echinococcus granulosus inositol monophosphatase 1 0.0109 0.0693 0.0686
Mycobacterium ulcerans ketoacyl reductase 0.002 0.0042 0.0034
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0599 0.0593
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Brugia malayi RNA binding protein 0.0062 0.0352 0.0912
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1335 0.9681 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0203
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.015 0.0993 0.0987
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0042 0.0096
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0106 0.0274
Onchocerca volvulus 0.0053 0.0286 0.0726
Entamoeba histolytica hypothetical protein 0.0071 0.0417 0.5588
Brugia malayi dehydrogenases, short chain protein 9 0.002 0.0042 0.0108
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0028 0.0103 0.0255
Trypanosoma brucei NADH dehydrogenase 0.0106 0.0671 0.0686
Loa Loa (eye worm) hypothetical protein 0.015 0.0993 0.2567
Brugia malayi Cytochrome P450 family protein 0.0047 0.0239 0.062
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0109 0.0693 0.2377
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Brugia malayi RE15519p 0.0056 0.0307 0.0796
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0028 0.0103 0.0212
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0307 0.078
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0084 0.0077
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0144 0.0141
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0106 0.0671 0.1824
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0307 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0412
Schistosoma mansoni amine GPCR 0.0547 0.3908 0.3903
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.02
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0443 0.0451
Onchocerca volvulus 0.0056 0.0307 0.0786
Brugia malayi Melatonin receptor type 1A 0.0056 0.0307 0.0796
Brugia malayi glutamate synthase 0.0106 0.0671 0.1742
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0042 0.0138
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0042 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0789 0.2725
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.0328 0.2299 0.5965
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.002 0.0042 0.0034
Schistosoma mansoni ap endonuclease 0.0018 0.0033 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0644 0.0658
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Mycobacterium tuberculosis Probable dehydrogenase 0.0309 0.2162 0.5012
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.002 0.0042 0.0108
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0176 0.1189 0.3077
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0307 0.03
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.012 0.0309
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0307 0.03
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Brugia malayi jmjC domain containing protein 0.0096 0.0599 0.1556
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0106 0.0671 0.2298
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0184 0.0177
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0307 0.0786
Schistosoma mansoni glutamate synthase 0.0106 0.0671 0.0664
Schistosoma mansoni hypothetical protein 0.0029 0.011 0.0103
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0084 0.0212
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0105 0.0255
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.031
Trichomonas vaginalis inositol monophosphatase, putative 0.0109 0.0693 0.1884
Entamoeba histolytica hypothetical protein 0.0071 0.0417 0.5588
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.002 0.0042 0.0069
Mycobacterium ulcerans dehydrogenase/reductase 0.002 0.0042 0.0034
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.072 0.0714
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.011 0.0285
Brugia malayi Dopamine receptor protein 2 0.0056 0.0307 0.0796
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0028 0.0103 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0224 0.0595
Loa Loa (eye worm) hypothetical protein 0.0059 0.033 0.0841
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0307 0.03
Toxoplasma gondii 6-phosphofructokinase 0.003 0.012 0.0312
Brugia malayi Dehydrogenases, short chain protein 30 0.002 0.0042 0.0108
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0307 0.03
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0693 0.0709
Schistosoma mansoni biogenic amine receptor 0.0056 0.0307 0.03
Leishmania major short chain dehydrogenase, putative 0.002 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0307 0.03
Schistosoma mansoni sulfide quinone reductase 0.0106 0.0671 0.0664
Onchocerca volvulus 0.0053 0.0286 0.0726
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0307 0.03
Mycobacterium ulcerans ferredoxin reductase 0.0106 0.0671 0.2298
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0042 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0412
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0352 0.0345
Schistosoma mansoni hypothetical protein 0.0028 0.0103 0.0096
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0307 0.03
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0042 0.0036
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0085 0.008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Loa Loa (eye worm) oxidoreductase 0.002 0.0042 0.0091
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0042 0.0069
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0106 0.0671 0.1824
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.2357 0.6458
Onchocerca volvulus 0.0056 0.0307 0.0786
Echinococcus granulosus tm gpcr rhodopsin 0.0875 0.6309 0.6306
Entamoeba histolytica short chain dehydrogenase family protein 0.002 0.0042 0.0138
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0307 0.078
Mycobacterium ulcerans carboxylesterase, LipT 0.0059 0.033 0.1072
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0018 0.0026 0.0019
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0109 0.0693 0.1884
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0106 0.0671 0.1824
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Brugia malayi Dopamine receptor protein 1 0.0056 0.0307 0.0796
Schistosoma mansoni adenoreceptor 0.0056 0.0307 0.03
Brugia malayi Sodium:neurotransmitter symporter family protein 0.015 0.0993 0.258
Schistosoma mansoni hypothetical protein 0.0106 0.0671 0.0664
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0144 0.0137
Treponema pallidum oxidoreductase 0.0106 0.0671 0.2298
Brugia malayi chromobox protein homolog 3 0.004 0.0193 0.0501
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0105 0.0098
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0238 0.0231
Schistosoma mansoni single-minded 0.0098 0.0614 0.0608
Echinococcus multilocularis chromobox protein 1 0.0072 0.0425 0.0418
Echinococcus granulosus tar DNA binding protein 0.0062 0.0352 0.0345
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0028 0.0103 0.0255
Onchocerca volvulus 0.0056 0.0307 0.0786
Trypanosoma cruzi trypanothione reductase, putative 0.0397 0.281 0.2897
Onchocerca volvulus 0.0059 0.033 0.0856
Echinococcus granulosus sodium channel protein 0.0117 0.0754 0.0748
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0013 0.0032
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0028 0.0103 0.0255
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0106 0.0671 0.0686
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0397 0.281 0.2897
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0279 0.1943 0.5039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0203
Brugia malayi hypothetical protein 0.0074 0.0443 0.115
Brugia malayi cytochrome P450 0.0028 0.0103 0.0268
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0084 0.02
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0307 0.03
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.002 0.0042 0.0069
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0216 0.0516
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0307 0.03
Giardia lamblia Reductase, putative 0.002 0.0042 0.0034
Brugia malayi MAP kinase sur-1 0.0102 0.0644 0.1672
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0042 0.0096
Echinococcus multilocularis microtubule associated protein 2 0.1379 1 1
Echinococcus multilocularis glutamate synthase 0.0106 0.0671 0.0664
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0028 0.0103 0.0212
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.033 0.074
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0307 0.03
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0307 0.03
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0106 0.0671 0.1476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.023 0.0223
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0033 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0417 0.041
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.002 0.0042 0.0077
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0166 0.0413
Loa Loa (eye worm) hypothetical protein 0.0066 0.038 0.097
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0028 0.0103 0.0255
Echinococcus multilocularis musashi 0.0053 0.0286 0.028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0307 0.03
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0033 0.0025
Onchocerca volvulus 0.0121 0.0783 0.2201
Onchocerca volvulus 0.0025 0.0084 0.0124
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0084 0.0077
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0028 0.0103 0.0212
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0028 0.0103 0.0212
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0042 0.0069
Mycobacterium tuberculosis Probable reductase 0.0309 0.2162 0.5012
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.031
Echinococcus granulosus lamin dm0 0.0053 0.0286 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0157 0.0412
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Echinococcus granulosus allatostatin A receptor 0.0056 0.0307 0.03
Brugia malayi hypothetical protein 0.0059 0.033 0.0857
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.011 0.0103
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0109 0.0693 0.9599
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0084 0.0077
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0042 0.0036
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0084 0.0077
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.002 0.0042 0.0108
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.011 0.0285
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0106 0.0671 0.0686
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0106 0.0671 0.2298
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0084 0.0217
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0084 0.0077
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0789 0.0783
Trichomonas vaginalis steroid dehydrogenase, putative 0.002 0.0042 0.0096
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0307 0.03
Toxoplasma gondii oxidoreductase, putative 0.002 0.0042 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0671 0.0686
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0103 0.01
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0084 0.0077
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.014 0.0364
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0166 0.048
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0085 0.0203
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.002 0.0042 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0307 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.014 0.0366
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.012 0.0133
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0307 0.03
Onchocerca volvulus Glucosylceramidase homolog 0.0336 0.2357 0.6877
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0109 0.0693 0.18
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0028 0.0103 0.0255
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0163 0.1091 0.2821
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.072 0.196
Plasmodium vivax SET domain protein, putative 0.006 0.034 0.0881
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.034 0.0333
Brugia malayi glutathione reductase 0.0539 0.3849 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.011 0.0267
Loa Loa (eye worm) doublecortin family protein 0.0121 0.0783 0.202
Schistosoma mansoni histamine h1 receptor 0.0056 0.0307 0.03
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.2357 0.6458
Plasmodium vivax hypothetical protein, conserved 0.0029 0.011 0.0282
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0392 0.1001
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0184 0.0177
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0013 0.0033
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0042 0.0035
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0106 0.0671 0.0686
Mycobacterium ulcerans oxidoreductase 0.002 0.0042 0.0034
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.005 0.0043
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.0026 0.0019
Brugia malayi Serotonin receptor 0.0511 0.3641 0.946
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0155 0.1037 0.103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0789 0.2725
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0106 0.0671 0.1716
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0051 0.012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0693 0.0709
Echinococcus granulosus g protein coupled receptor 0.0056 0.0307 0.03
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0028 0.0103 0.0212
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0018 0.0026 0.0019
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.002 0.0042 0.0036
Trichomonas vaginalis set domain proteins, putative 0.0479 0.3407 0.9343
Echinococcus multilocularis serotonin receptor 0.0176 0.1189 0.1183
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0307 0.03
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0084 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0644 0.175
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0033 0.0026
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0028 0.0103 0.0212
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0106 0.0671 0.0686
Echinococcus granulosus thioredoxin glutathione reductase 0.0539 0.3849 0.3844
Loa Loa (eye worm) norepinephrine transporter 0.015 0.0993 0.2567
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0084 0.02
Loa Loa (eye worm) hypothetical protein 0.0465 0.3308 0.8591
Mycobacterium tuberculosis Possible ketoacyl reductase 0.002 0.0042 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Schistosoma mansoni rab6-interacting 0.0121 0.0783 0.0777
Plasmodium vivax JmjC domain containing protein 0.0026 0.0085 0.0218
Leishmania major hypothetical protein, conserved 0.0034 0.0144 0.0141
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.002 0.0042 0.0138
Brugia malayi AKH receptor 0.0056 0.0307 0.0796
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Entamoeba histolytica short chain dehydrogenase family protein 0.002 0.0042 0.0138
Loa Loa (eye worm) hypothetical protein 0.0052 0.0279 0.0709
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0018 0.0026 0.0052
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0307 0.078
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.023 0.0223
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0042 0.0036
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0084 0.0212
Echinococcus multilocularis acetylcholinesterase 0.0349 0.2457 0.2451
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0352 0.0345
Loa Loa (eye worm) oxidoreductase 0.002 0.0042 0.0091
Brugia malayi PHD-finger family protein 0.0029 0.011 0.0284
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0117 0.0754 0.0748
Echinococcus multilocularis hyperpolarization activated cyclic 0.0018 0.0026 0.0019
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0085 0.0188
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0084 0.0077
Plasmodium falciparum thioredoxin reductase 0.0397 0.281 0.7292
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0032 0.0051
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0397 0.281 0.73
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0033 0.0026
Schistosoma mansoni BC026374 protein (S09 family) 0.0059 0.033 0.0323
Brugia malayi Carboxylesterase family protein 0.0349 0.2457 0.6383
Loa Loa (eye worm) acetylcholinesterase 1 0.0349 0.2457 0.6376
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0033 0.007
Schistosoma mansoni amine GPCR 0.0056 0.0307 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0091 0.0229
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0106 0.0671 0.0664
Loa Loa (eye worm) programmed cell death 8 0.0106 0.0671 0.1728
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0106 0.0671 0.0664
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Leishmania major short chain dehydrogenase/reductase, putative 0.002 0.0042 0.0036
Brugia malayi neuropeptide F receptor 0.0056 0.0307 0.0796
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0307 0.03
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0307 0.03
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0013 0.0006
Brugia malayi Inositol-1 0.0109 0.0693 0.1799
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0085 0.0078
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.072 0.0737
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0033 0.0025
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0006
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Echinococcus granulosus lamin 0.0053 0.0286 0.028
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0392 0.0385
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.002 0.0042 0.0036
Plasmodium vivax hypothetical protein, conserved 0.002 0.0042 0.0106
Schistosoma mansoni biogenic amine (5HT) receptor 0.0176 0.1189 0.1183
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0392 0.5218
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0085 0.008
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0046 0.0238 0.0617
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0307 0.03
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Echinococcus multilocularis geminin 0.0498 0.3548 0.3544
Echinococcus multilocularis serotonin receptor 0.0176 0.1189 0.1183
Trichomonas vaginalis glutamate synthase, putative 0.0106 0.0671 0.1824
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0307 0.03
Brugia malayi hypothetical protein 0.0126 0.0819 0.2127
Leishmania major hypothetical protein, conserved 0.0106 0.0671 0.0686
Schistosoma mansoni jun-related protein 0.0204 0.1392 0.1385
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0028 0.0103 0.0212
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0033 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0224 0.0595
Echinococcus multilocularis steroid dehydrogenase 0.002 0.0042 0.0035
Mycobacterium ulcerans monoxygenase 0.0106 0.0671 0.2298
Echinococcus multilocularis conserved hypothetical protein 0.002 0.0042 0.0035
Entamoeba histolytica hypothetical protein 0.0071 0.0417 0.5588
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0106 0.0671 0.1728
Loa Loa (eye worm) hypothetical protein 0.0473 0.336 0.8727
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0085 0.0221
Echinococcus multilocularis peregrin 0.0029 0.011 0.0103
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0307 0.03
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0307 0.03
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0007 0.0017
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0307 0.0786
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.0671 0.0686
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0397 0.281 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.002 0.0042 0.0036
Echinococcus granulosus chromobox protein 1 0.0072 0.0425 0.0418
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.0599 0.1542
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0443 0.1122
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0042 0.0034
Plasmodium vivax steroid dehydrogenase, putative 0.002 0.0042 0.0106
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0193 0.0186
Echinococcus granulosus Polycystic kidney disease protein 0.0121 0.0783 0.0777
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.072 0.2477
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0042 0.0035
Trypanosoma cruzi oxidoreductase-like protein, putative 0.002 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0084 0.0077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0615 0.1596
Mycobacterium ulcerans short-chain dehydrogenase 0.002 0.0042 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0307 0.03
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0018 0.0026 0.0019
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Mycobacterium tuberculosis Probable dehydrogenase 0.002 0.0042 0.0069
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0307 0.0796
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0224 0.2777
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.072 1
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.072 0.196
Echinococcus granulosus hypothetical protein 0.002 0.0042 0.0035
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0085 0.0078
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0307 0.03
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.002 0.0042 0.0138
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Trichomonas vaginalis glutathione reductase, putative 0.0397 0.281 0.7701
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Loa Loa (eye worm) inositol-1 0.0109 0.0693 0.1785
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0644 0.175
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0028 0.0103 0.0255
Plasmodium falciparum glutathione reductase 0.0397 0.281 0.7292
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0789 0.0783
Echinococcus multilocularis survival motor neuron protein 1 0.0473 0.336 0.3355
Giardia lamblia Hypothetical protein 0.002 0.0042 0.0034
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.002 0.0042 0.0035
Schistosoma mansoni hypothetical protein 0.0056 0.0307 0.03
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0018 0.0026 0.0049
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0397 0.281 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0084 0.0218
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0106 0.0671 0.0664
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0307 0.03
Echinococcus granulosus carbonyl reductase 1 0.002 0.0042 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0789 0.0783
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0085 0.0078
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.072 0.0714
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0319
Schistosoma mansoni hypothetical protein 0.0056 0.0307 0.03
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0059 0.033 0.0888
Brugia malayi bZIP transcription factor family protein 0.0251 0.1736 0.451
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0106 0.0671 0.0664
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0307 0.03
Echinococcus granulosus jun protein 0.0251 0.1736 0.173
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Loa Loa (eye worm) hypothetical protein 0.0364 0.2567 0.6663
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0166 0.0164
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0307 0.03
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Mycobacterium ulcerans NADH dehydrogenase 0.0106 0.0671 0.2298
Onchocerca volvulus 0.0072 0.0428 0.1147
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0397 0.281 0.2897
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0142 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0107 0.0259
Schistosoma mansoni myosin xvIII 0.0056 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.004 0.0193 0.0485
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0307 0.03
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0106 0.0671 0.0686
Loa Loa (eye worm) hypothetical protein 0.0328 0.2302 0.5973
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0125 0.0118
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0106 0.0671 0.9278
Echinococcus granulosus retinol dehydrogenase 11 0.002 0.0042 0.0035
Echinococcus multilocularis sex peptide receptor 0.0056 0.0307 0.03
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0085 0.0203
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Onchocerca volvulus 0.0059 0.033 0.0856
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0084 0.0077
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0307 0.0796
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0106 0.0671 0.0664
Brugia malayi GnHR receptor homolog 0.0056 0.0307 0.0796
Echinococcus multilocularis carbonyl reductase 1 0.002 0.0042 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0042 0.0036
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0417 0.041
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.012 0.028
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0106 0.0671 0.1743
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0028 0.0103 0.0212
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0425 0.1149
Echinococcus multilocularis neuroligin 0.0059 0.033 0.0323
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.002 0.0042 0.0036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0307 0.03
Brugia malayi hypothetical protein 0.0048 0.025 0.0648
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0085 0.0078
Leishmania major short chain dehydrogenase, putative 0.002 0.0042 0.0036
Trypanosoma cruzi short chain dehydrogenase, putative 0.002 0.0042 0.0036
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0397 0.281 0.73
Echinococcus granulosus mitogen activated protein kinase 0.0102 0.0644 0.0637
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0103 0.01
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0262 0.0255
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0467 0.3321 0.3316
Brugia malayi hypothetical protein 0.0197 0.1341 0.3484
Mycobacterium ulcerans carveol-like dehydrogenase 0.002 0.0042 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Brugia malayi Pre-SET motif family protein 0.0421 0.2981 0.7746
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0018 0.0026 0.0019
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.072 0.0737
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.033 0.0323
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0417 0.041
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0084 0.0077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0006
Echinococcus multilocularis BC026374 protein (S09 family) 0.0059 0.033 0.0323
Schistosoma mansoni hypothetical protein 0.0096 0.0604 0.0597
Trypanosoma cruzi NADH dehydrogenase, putative 0.0106 0.0671 0.0686
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0307 0.03
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.034 0.0333
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.012 0.0312
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0644 0.175
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0392 0.0385
Onchocerca volvulus 0.0056 0.0307 0.0786
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0307 0.03
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0097 0.061 0.1392
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0307 0.03
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0085 0.0221
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0106 0.0671 0.2298
Echinococcus granulosus retinol dehydrogenase 11 0.002 0.0042 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0145 0.0378
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.0026 0.0019
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.011 0.0103
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0644 0.0658
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0262 0.0255
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0307 0.03
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0397 0.281 1
Treponema pallidum NADH oxidase 0.0397 0.281 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Brugia malayi Death domain containing protein 0.0028 0.0105 0.0272
Leishmania major hypothetical protein, conserved 0.002 0.0042 0.0036
Brugia malayi dehydrogenases, short chain protein 2 0.002 0.0042 0.0108
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0307 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0176 0.0464
Echinococcus multilocularis acetylcholinesterase 0.0349 0.2457 0.2451
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0185
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0106 0.0671 0.9278
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0028 0.0103 0.0255
Echinococcus multilocularis retinol dehydrogenase 13 0.002 0.0042 0.0035
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0105 0.0187
Brugia malayi ORL1-like opioid receptor 0.0056 0.0307 0.0796
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0307 0.0796
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0307 0.03
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1129 0.817 0.8437
Trypanosoma brucei trypanothione reductase 0.0539 0.3849 0.3971
Mycobacterium ulcerans dehydrogenase 0.0106 0.0671 0.2298
Schistosoma mansoni hypothetical protein 0.0106 0.0676 0.0669
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0102 0.0644 0.0658
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0307 0.03
Echinococcus multilocularis lamin dm0 0.0053 0.0286 0.028
Brugia malayi hypothetical protein 0.002 0.0042 0.0108
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0084 0.0077
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.072 0.2477
Leishmania major cytochrome p450-like protein 0.0028 0.0103 0.01
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.002 0.0042 0.0035
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0224 0.0217
Schistosoma mansoni amine GPCR 0.0056 0.0307 0.03
Echinococcus granulosus lipoxygenase domain containing protein 0.0121 0.0783 0.0777
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0307 0.03
Leishmania major dihydrolipoamide dehydrogenase, putative 0.1335 0.9681 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0106 0.0671 0.9278
Entamoeba histolytica disulphide oxidoreductase, putative 0.0106 0.0671 0.9278
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0789 0.1811
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0013 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0182
Loa Loa (eye worm) hypothetical protein 0.0059 0.033 0.0841
Echinococcus multilocularis jun protein 0.0251 0.1736 0.173
Plasmodium falciparum thioredoxin reductase 0.0539 0.3849 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0093 0.0235
Onchocerca volvulus 0.0059 0.033 0.0856
Plasmodium vivax amine transporter, putative 0.0025 0.0084 0.0215
Mycobacterium tuberculosis Carboxylesterase LipT 0.0059 0.033 0.074
Schistosoma mansoni hypothetical protein 0.0061 0.0343 0.0336
Brugia malayi Bromodomain containing protein 0.0029 0.011 0.0284
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0307 0.078
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Giardia lamblia PHD finger protein 15 0.0029 0.011 0.0278
Echinococcus granulosus nuclear factor of activated T cells 5 0.0145 0.0959 0.0953
Schistosoma mansoni hypothetical protein 0.0121 0.0783 0.0777
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0106 0.0671 0.2298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0109 0.0281
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0084 0.0077
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0307 0.03
Echinococcus granulosus carboxylesterase 5A 0.0349 0.2457 0.2451
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.002 0.0042 0.0069
Echinococcus granulosus somatostatin receptor 0.0056 0.0307 0.03
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Onchocerca volvulus 0.0025 0.0084 0.0124
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0106 0.0671 0.0664
Schistosoma mansoni short chain dehydrogenase 0.002 0.0042 0.0035
Loa Loa (eye worm) cytochrome P450 0.0028 0.0103 0.0251
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0224 0.0224
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0117 0.0754 0.0772
Brugia malayi Doublecortin family protein 0.0121 0.0783 0.2034
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.0599 0.0593
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0085 0.0078
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0106 0.0671 0.1742
Echinococcus granulosus intermediate filament protein 0.0053 0.0286 0.028
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0042 0.0034
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0307 0.03
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Loa Loa (eye worm) hypothetical protein 0.015 0.0993 0.2567
Schistosoma mansoni sulfide quinone reductase 0.0106 0.0671 0.0664
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0352 0.0345
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0085 0.0078
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0307 0.03
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0789 0.0809
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.002 0.0042 0.0096
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Plasmodium falciparum glutathione reductase 0.0539 0.3849 1
Brugia malayi Dopamine receptor 0.0056 0.0307 0.0796
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0106 0.0671 0.2298
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.002 0.0042 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.2357 0.6458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0183
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0028 0.0103 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0093 0.0235
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Schistosoma mansoni hypothetical protein 0.0056 0.0307 0.03
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0307 0.03
Brugia malayi hypothetical protein 0.0056 0.0307 0.0796
Brugia malayi intermediate filament protein 0.0053 0.0286 0.0743
Schistosoma mansoni polycystin 1-related 0.0121 0.0783 0.0777
Schistosoma mansoni survival motor neuron protein 0.0096 0.0604 0.0597
Trypanosoma brucei C-8 sterol isomerase, putative 0.0364 0.2567 0.2646
Loa Loa (eye worm) oxidoreductase 0.002 0.0042 0.0091
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0286 0.0727
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0307 0.03
Brugia malayi Cytochrome P450 family protein 0.0037 0.0166 0.043
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0084 0.0077
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0103 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0042 0.0036
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.002 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.002 0.0042 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0216 0.0574
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0028 0.0103 0.0255
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.012 0.031
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0397 0.281 0.2897
Echinococcus granulosus hyperpolarization activated cyclic 0.0018 0.0026 0.0019
Loa Loa (eye worm) oxidoreductase 0.002 0.0042 0.0091
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.011 0.0103
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0091 0.0084
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0091 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0443 0.0451
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.012 0.0309
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0157 0.0155
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0144 0.0141
Mycobacterium ulcerans short-chain type oxidoreductase 0.002 0.0042 0.0034
Brugia malayi Protein kinase domain containing protein 0.0029 0.0112 0.0289
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.072 0.1857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0224 0.0595
Schistosoma mansoni steroid dehydrogenase 0.002 0.0042 0.0035
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0286 0.0727
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.072 0.0714
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0042 0.0069
Schistosoma mansoni hypothetical protein 0.0031 0.0125 0.0118
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0085 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.2357 0.6458
Brugia malayi larval opioid receptor 0.0056 0.0307 0.0796
Schistosoma mansoni neuroligin 3 (S09 family) 0.0059 0.033 0.0323
Trypanosoma brucei short-chain dehydrogenase, putative 0.002 0.0042 0.0036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0307 0.03
Onchocerca volvulus 0.0056 0.0307 0.0786
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Leishmania major hypothetical protein, conserved 0.002 0.0042 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0307 0.03
Loa Loa (eye worm) serotonin transporter b 0.015 0.0993 0.2567
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0028 0.0103 0.0255
Echinococcus multilocularis lipoxygenase domain containing protein 0.0121 0.0783 0.0777
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.002 0.0042 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0084 0.008
Brugia malayi Heterochromatin protein 1 0.0072 0.0425 0.1104
Echinococcus granulosus g protein coupled receptor 0.0056 0.0307 0.03
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.002 0.0042 0.0069
Brugia malayi 6-phosphofructokinase 0.0112 0.072 0.1871
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0084 0.0217
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.014 0.0366
Mycobacterium leprae Possible regulatory protein 0.0025 0.0084 0.0099
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0352 0.0912
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0106 0.0671 0.1824
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0991 0.7158 0.7392
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0084 0.0218
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0106 0.0671 0.1743
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0013 0.0006
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0145 0.0959 0.0953
Brugia malayi hypothetical protein 0.0025 0.0084 0.0217
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0601 0.4301 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.014 0.0366
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0292 0.2037 0.5292
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0307 0.03
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0392 0.0397
Schistosoma mansoni rab6-interacting 0.0121 0.0783 0.0777
Schistosoma mansoni hypothetical protein 0.0033 0.0142 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0091 0.0229
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0106 0.0671 0.0686
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0224 0.058
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0106 0.0671 0.2298
Echinococcus multilocularis oxidoreductase 0.002 0.0042 0.0035
Brugia malayi hypothetical protein 0.0121 0.0783 0.2034
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0084 0.0212
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0239 0.0604
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.002 0.0042 0.0036
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0106 0.0671 0.1824
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0084 0.0212
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0125 0.0306
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.005 0.013
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0033 0.0082
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0397 0.281 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0042 0.0034
Brugia malayi DnaJ domain containing protein 0.0061 0.0343 0.089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.023 0.0223
Echinococcus granulosus peregrin 0.0029 0.011 0.0103
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.072 0.0714
Trichomonas vaginalis short-chain dehydrogenase, putative 0.002 0.0042 0.0096
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0307 0.03
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0028 0.0103 0.0255
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0183 0.1235 0.1229
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Schistosoma mansoni amine GPCR 0.0056 0.0307 0.03
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0307 0.03
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0006
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0084 0.008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0224 0.0224
Echinococcus multilocularis somatostatin receptor 0.0056 0.0307 0.03
Onchocerca volvulus Alhambra homolog 0.0029 0.011 0.0201
Schistosoma mansoni neuropeptide receptor 0.0056 0.0307 0.03
Loa Loa (eye worm) oxidoreductase 0.002 0.0042 0.0091
Entamoeba histolytica hypothetical protein 0.002 0.0042 0.0138
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0084 0.0217
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.2981 0.7742
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0028 0.0103 0.0212
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.012 0.031
Leishmania major dehydrogenase-like protein 0.002 0.0042 0.0036
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0097 0.061 0.1332
Echinococcus multilocularis chromobox protein 1 0.0072 0.0425 0.0418
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0392 0.0397
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.2357 0.6458
Echinococcus granulosus sex peptide receptor 0.0056 0.0307 0.03
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0028 0.0103 0.0212
Loa Loa (eye worm) hypothetical protein 0.0059 0.033 0.0841
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0018 0.0026 0.0019
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.012 0.0315
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0084 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.034 0.0333
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0084 0.0212
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.012 0.1273
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0224 0.0217
Schistosoma mansoni retinal dehydrogenase 0.002 0.0042 0.0035
Leishmania major hypothetical protein, conserved 0.0106 0.0671 0.0686
Trichomonas vaginalis glutamate synthase, putative 0.0106 0.0671 0.1824
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0392 0.1016
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0042 0.0036
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.072 0.1857
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0109
Leishmania major short chain dehydrogenase/reductase, putative 0.002 0.0042 0.0036
Onchocerca volvulus 0.0056 0.0307 0.0786
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0224 0.2777
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0033 0.0083
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0307 0.03
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0388 0.1007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0599 0.0593
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1129 0.817 0.8437
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.002 0.0042 0.0138
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0286 0.0743
Toxoplasma gondii oxidoreductase, putative 0.002 0.0042 0.0109
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0364 0.2567 0.2646
Schistosoma mansoni sodium/chloride dependent transporter 0.015 0.0993 0.0987
Toxoplasma gondii NADPH-glutathione reductase 0.0397 0.281 0.7301
Schistosoma mansoni chromobox protein 0.0072 0.0425 0.0418
Giardia lamblia Thioredoxin reductase 0.0106 0.0671 0.2298
Plasmodium vivax ferrodoxin reductase, putative 0.0106 0.0671 0.174
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0028 0.0103 0.0212
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0307 0.03
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0307 0.03
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0084 0.008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Echinococcus granulosus GPCR family 2 0.0031 0.0125 0.0118
Echinococcus granulosus death domain containing protein 0.0028 0.0105 0.0098
Schistosoma mansoni inositol monophosphatase 0.0109 0.0693 0.0686
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0106 0.0671 0.0686
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0084 0.0077
Echinococcus multilocularis retinol dehydrogenase 11 0.002 0.0042 0.0035
Echinococcus granulosus para nitrobenzyl esterase 0.0059 0.033 0.0323
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.033 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0084 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0352 0.0345
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0051 0.012
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.002 0.0042 0.0069
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.002 0.0042 0.0034
Trypanosoma cruzi trypanothione reductase, putative 0.0539 0.3849 0.3971
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0224 0.0224
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0102 0.0644 0.0658
Giardia lamblia Short-chain dehydrogenase, putative 0.002 0.0042 0.0034
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.002 0.0042 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0183
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0093 0.0235
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0106 0.0671 0.1824
Onchocerca volvulus 0.0056 0.0307 0.0786
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0105 0.0255
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.002 0.0042 0.0109
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0392 0.0385
Leishmania major short chain dehydrogenase-like protein 0.002 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0186 0.1262 0.3266
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0144 0.0141
Loa Loa (eye worm) thioredoxin reductase 0.0539 0.3849 1
Onchocerca volvulus 0.0096 0.0604 0.1669
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0443 0.1122
Schistosoma mansoni short-chain dehydrogenase/reductase 0.002 0.0042 0.0035
Schistosoma mansoni carbonyl reductase 0.002 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.015 0.0993 0.2567
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.002 0.0042 0.0036
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0106 0.0671 0.1476
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0224 0.0224
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.002 0.0042 0.0036
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0106 0.0671 0.2298
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.002 0.0042 0.0069
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0105 0.0272
Echinococcus multilocularis sodium channel protein 0.0117 0.0754 0.0748
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0028 0.0103 0.0212
Loa Loa (eye worm) hypothetical protein 0.0121 0.0783 0.202
Toxoplasma gondii selenide, water dikinase 0.0106 0.0671 0.1743
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0085 0.0078
Onchocerca volvulus 0.0056 0.0307 0.0786
Giardia lamblia NADH oxidase lateral transfer candidate 0.0397 0.281 1
Schistosoma mansoni hypothetical protein 0.0071 0.0417 0.041
Brugia malayi phosphofructokinase 0.0112 0.072 0.1871
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0102 0.0644 0.1673
Schistosoma mansoni loxhd1 0.0121 0.0783 0.0777
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0224 0.0224
Onchocerca volvulus 0.0025 0.0084 0.0124
Echinococcus granulosus g protein coupled receptor 0.0056 0.0307 0.03
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0042 0.0036
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0028 0.0103 0.0255
Loa Loa (eye worm) hypothetical protein 0.0121 0.0783 0.202
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.002 0.0042 0.0035
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0015 0.0008
Brugia malayi hypothetical protein 0.0328 0.2302 0.598
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0512 0.3646 0.9474
Echinococcus granulosus neuroligin 0.0059 0.033 0.0323
Mycobacterium ulcerans short chain dehydrogenase 0.002 0.0042 0.0034
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0028 0.0103 0.0255
Loa Loa (eye worm) hypothetical protein 0.0465 0.3308 0.8591
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.002 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0204
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0615 0.1582
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0125 0.0118
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0307 0.03
Mycobacterium ulcerans dehydrogenase 0.002 0.0042 0.0034
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.005 0.0043
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0307 0.03
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0106 0.0671 0.0664
Loa Loa (eye worm) hypothetical protein 0.0176 0.1189 0.3077
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0991 0.7158 0.7392
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0693 0.0709
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0166 0.0413
Echinococcus granulosus hypothetical protein 0.002 0.0042 0.0035
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.033 0.0323
Brugia malayi follicle stimulating hormone receptor 0.0279 0.1943 0.5048
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0091 0.0087
Schistosoma mansoni 60S ribosomal protein L21 0.0016 0.0015 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0028 0.0103 0.0212
Echinococcus multilocularis mitogen activated protein kinase 3 0.0102 0.0644 0.0637
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0307 0.03
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0018 0.0026 0.0019
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0307 0.078
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0309 0.2162 0.4978
Brugia malayi hypothetical protein 0.0473 0.336 0.8729
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0028 0.0103 0.0212
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0307 0.03
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0155 0.1037 0.103
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0108
Echinococcus granulosus acetylcholinesterase 0.0349 0.2457 0.2451
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0084 0.0001
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.078
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0309 0.2162 0.5012
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.072 0.165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0307 0.03
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0106 0.0671 0.9278
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0084 0.0077
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0307 0.03
Trypanosoma cruzi short-chain dehydrogenase, putative 0.002 0.0042 0.0036
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0042 0.0109
Loa Loa (eye worm) hypothetical protein 0.0349 0.2457 0.6376
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0028 0.0103 0.0212
Brugia malayi jmjC domain containing protein 0.0155 0.1037 0.2693
Onchocerca volvulus 0.0032 0.013 0.026
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.002 0.0042 0.0036
Trypanosoma cruzi short-chain dehydrogenase, putative 0.002 0.0042 0.0036
Brugia malayi bHLH-PAS transcription factor 0.0072 0.0428 0.1112
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0091
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0307 0.0796
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.072 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0224 0.0224
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0443 0.0451
Leishmania major quinonoid dihydropteridine reductase 0.002 0.0042 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0789 0.2725
Schistosoma mansoni glutamate synthase 0.0106 0.0671 0.0664
Brugia malayi Thioredoxin reductase 0.0539 0.3849 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0307 0.03
Echinococcus granulosus carbonyl reductase 1 0.002 0.0042 0.0035
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.0343 0.0336
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0307 0.0796
Schistosoma mansoni neuropeptide receptor 0.0056 0.0307 0.03
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0601 0.4301 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0106 0.0671 0.0686

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 2 Number of rats displaying convulsions by pretreatment with 55 mg/kg of compound (ip) in the presence of isoniazid after 49 mins out of 8 rats tested ChEMBL. 2724304
Activity (functional) = 0.28 ug ml-1 Amount of metabolite produced in brain of rat at a concentration of 12000 g of the compound ChEMBL. 2724304
Activity (functional) = 2.11 ug ml-1 Amount of metabolite produced in brain of rat at a concentration of 700 g of the compound ChEMBL. 2724304
Activity (functional) = 14.6 ug ml-1 Amount of metabolite produced in liver of rat at a concentration of 12000 g of the compound ChEMBL. 2724304
Activity (functional) = 26.4 ug ml-1 Amount of metabolite produced in liver of rat at a concentration of 700 g of the compound ChEMBL. 2724304
ED50 (functional) = 41 mg kg-1 Anticonvulsant activity of the compound was determined by using subcutaneous pentylenetetrazol (Metrazol) seizure threshold test in mice ChEMBL. 2724304
ED50 (functional) = 41 mg kg-1 Anticonvulsant activity of the compound was determined by using subcutaneous pentylenetetrazol (Metrazol) seizure threshold test in mice ChEMBL. 2724304
ED50 (functional) = 68 mg kg-1 Anticonvulsant activity of the compound was determined by using maximal electroshock seizure test in mice ChEMBL. 2724304
ED50 (functional) = 68 mg kg-1 Anticonvulsant activity of the compound was determined by using maximal electroshock seizure test in mice ChEMBL. 2724304
ED50 (functional) = 143 mg kg-1 Anticonvulsant activity of the compound was determined by using bicuculline test in mice ChEMBL. 2724304
ED50 (functional) = 143 mg kg-1 Anticonvulsant activity of the compound was determined by using bicuculline test in mice ChEMBL. 2724304
No. of rats died (ADMET) = 1 Number of rats died by pretreatment with 55 mg/kg of compound (ip) in the presence of isoniazid after 49 mins out of 8 rats tested ChEMBL. 2724304
TD50 (functional) = 117 mg kg-1 Anticonvulsant activity of the compound was determined by using rotorod toxicity test in mice ChEMBL. 2724304
TD50 (functional) = 117 mg kg-1 Anticonvulsant activity of the compound was determined by using rotorod toxicity test in mice ChEMBL. 2724304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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