TDR Targets

Basic information

Technical information

TDR Targets ID: 35984
Name: 5-bromo-6-methoxyisoquinoline
MW: 238.081 | Formula: C10H8BrNO
H donors: 0 H acceptors: 1 LogP: 2.76 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1Br)ccnc2
InChi: 1S/C10H8BrNO/c1-13-9-3-2-7-6-12-5-4-8(7)10(9)11/h2-6H,1H3
InChiKey: UHAJOUKNSQWSDL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-bromo-6-methoxy-isoquinoline

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IMP (inosine 5'-monophosphate) dehydrogenase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma japonicum	ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Neospora caninum	hypothetical protein	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania braziliensis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Loa Loa (eye worm)	IMP dehydrogenase 1	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium hominis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium parvum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania infantum	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium berghei	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium knowlesi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Theileria parva	Inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania braziliensis	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium yoelii	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma congolense	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Babesia bovis	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Toxoplasma gondii	IMP dehydrogenas	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania infantum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania donovani	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin l1	0.0428	0.4691	0.4649
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Echinococcus multilocularis	cysteine protease	0.0428	0.4691	0.4649
Brugia malayi	Cathepsin L-like precursor	0.0294	0.2833	0.2777
Echinococcus granulosus	cathepsin L	0.0231	0.1966	0.1903
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0097	0.0108	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0811	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0428	0.4691	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0108	0.0031
Plasmodium falciparum	serine repeat antigen 1	0.0097	0.0108	0.0231
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0097	0.0108	0.0066
Toxoplasma gondii	cathepsin B	0.0318	0.3168	0.6698
Leishmania major	cathepsin L-like protease	0.0428	0.4691	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0097	0.0108	0.0031
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0294	0.2833	0.2777
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0428	0.4691	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Leishmania major	cathepsin L-like protease	0.0428	0.4691	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0428	0.4691	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0428	0.4691	0.4649
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0294	0.2833	0.2777
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0231	0.1966	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0108	0.0031
Echinococcus multilocularis	cysteine protease	0.0428	0.4691	0.4649
Echinococcus granulosus	cathepsin L cysteine protease	0.0231	0.1966	0.1903
Brugia malayi	Cathepsin L-like precursor	0.0134	0.0623	0.0549
Brugia malayi	cathepsin F-like cysteine proteinase	0.0134	0.0623	0.0549
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Giardia lamblia	Cathepsin B precursor	0.0318	0.3168	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0097	0.0108	0.0231
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0134	0.0623	0.0549
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0428	0.4691	0.4649
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0231	0.1966	0.1903
Trypanosoma cruzi	cysteine peptidase, putative	0.0134	0.0623	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0623	0.0549
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0811	1	1
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Loa Loa (eye worm)	cysteine protease	0.0428	0.4691	0.4649
Trypanosoma cruzi	cysteine proteinase, putative	0.0231	0.1966	0.1903
Entamoeba histolytica	cysteine protease, putative	0.0428	0.4691	1
Plasmodium falciparum	serine repeat antigen 8	0.0097	0.0108	0.0231
Brugia malayi	Cathepsin L-like precursor	0.0428	0.4691	0.4649
Brugia malayi	cathepsin L-like cysteine proteinase	0.0097	0.0108	0.0031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Echinococcus multilocularis	cathepsin L	0.0097	0.0108	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0318	0.3168	0.6676
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0097	0.0108	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Plasmodium vivax	vivapain-2	0.0428	0.4691	1
Echinococcus granulosus	cysteine protease	0.0231	0.1966	0.1903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0428	0.4691	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0108	0.0031
Plasmodium vivax	serine-repeat antigen (SERA)	0.0097	0.0108	0.0231
Trypanosoma cruzi	cysteine peptidase, putative	0.0231	0.1966	0.1903
Echinococcus multilocularis	cathepsin b	0.0811	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0428	0.4691	0.4649
Leishmania major	cathepsin L-like protease	0.0428	0.4691	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0097	0.0108	0.0231
Plasmodium falciparum	serine repeat antigen 6	0.0097	0.0108	0.0231
Loa Loa (eye worm)	ctsf protein	0.0428	0.4691	0.4649
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0108	0.0031
Onchocerca volvulus	Cathepsin L homolog	0.0428	0.4691	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0318	0.3168	0.6698
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Brugia malayi	Cathepsin L-like precursor	0.0428	0.4691	0.4649
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0231	0.1966	0.1903
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0097	0.0108	0.0231
Brugia malayi	Papain family cysteine protease containing protein	0.0231	0.1966	0.1903
Plasmodium vivax	vivapain-1	0.0231	0.1966	0.4191
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0097	0.0108	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0428	0.4691	0.4649
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0318	0.3168	0.3114
Loa Loa (eye worm)	hypothetical protein	0.0294	0.2833	0.2777
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0108	0.0031
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0097	0.0108	0.0231
Echinococcus multilocularis	cathepsin L cysteine protease	0.0428	0.4691	0.4649
Schistosoma mansoni	cathepsin F (C01 family)	0.0428	0.4691	0.4649
Entamoeba histolytica	cysteine proteinase, putative	0.0231	0.1966	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0231	0.1966	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Toxoplasma gondii	cathepsin CPC1	0.0097	0.0108	0.0066
Schistosoma mansoni	cathepsin S (C01 family)	0.0097	0.0108	0.0031
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0097	0.0108	0.0031
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0097	0.0108	0.0231
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0097	0.0108	0.0031
Giardia lamblia	Cathepsin B precursor	0.0318	0.3168	1
Onchocerca volvulus		0.0428	0.4691	1
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0294	0.2833	0.5946
Trypanosoma cruzi	cysteine protease, putative	0.0231	0.1966	0.1903
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0095	0.0078	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0318	0.3168	0.3114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0294	0.2833	0.5946
Plasmodium falciparum	serine repeat antigen 5	0.0097	0.0108	0.0231
Onchocerca volvulus		0.0294	0.2833	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0811	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0097	0.0108	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0108	0.0031
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0095	0.0078	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0428	0.4691	1
Leishmania major	cathepsin L-like protease	0.0428	0.4691	1
Onchocerca volvulus		0.0428	0.4691	1
Echinococcus granulosus	cathepsin L	0.0097	0.0108	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0623	0.0549
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0097	0.0108	0.0231
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0097	0.0108	0.0031
Plasmodium vivax	vivapain-2	0.0428	0.4691	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0294	0.2833	0.2777
Schistosoma mansoni	cathepsin s	0.0134	0.0623	0.0549
Brugia malayi	Cathepsin L-like precursor	0.0428	0.4691	0.4649
Loa Loa (eye worm)	cathepsin B	0.0318	0.3168	0.3114
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0097	0.0108	0.0031
Plasmodium falciparum	serine repeat antigen 4	0.0097	0.0108	0.0231
Entamoeba histolytica	cysteine proteinase, putative	0.0231	0.1966	0.4054
Echinococcus granulosus	cathepsin l1	0.0294	0.2833	0.2777
Trypanosoma cruzi	cruzipain precursor, putative	0.0134	0.0623	0.0549
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Schistosoma mansoni	cathepsin C	0.0097	0.0108	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0097	0.0108	0.0031
Leishmania major	cysteine peptidase A (CPA)	0.0428	0.4691	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0428	0.4691	1
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0097	0.0108	0.0031
Toxoplasma gondii	cathepsin CPL	0.0428	0.4691	1
Brugia malayi	Papain family cysteine protease containing protein	0.0428	0.4691	0.4649
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0108	0.0031
Onchocerca volvulus		0.0428	0.4691	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0108	0.0031
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0231	0.1966	0.1903
Entamoeba histolytica	cysteine proteinase, putative	0.0294	0.2833	0.5946
Onchocerca volvulus		0.0428	0.4691	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0097	0.0108	0.0231
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0108	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0294	0.2833	0.2777
Brugia malayi	Cathepsin L-like precursor	0.0428	0.4691	0.4649
Entamoeba histolytica	cysteine proteinase, putative	0.0428	0.4691	1
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0095	0.0078	1
Giardia lamblia	Cathepsin B precursor	0.0318	0.3168	1
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Plasmodium falciparum	serine repeat antigen 7	0.0097	0.0108	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0231	0.1966	0.4093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0428	0.4691	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0108	0.0031
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0428	0.4691	0.4649
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0097	0.0108	0.0231
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0811	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Loa Loa (eye worm)	fibroinase	0.0428	0.4691	0.4649
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0811	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0428	0.4691	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Echinococcus multilocularis	cathepsin b	0.0811	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0097	0.0108	0.0031
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0097	0.0108	0.0231
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0231	0.1966	0.1903
Plasmodium falciparum	serine repeat antigen 9	0.0097	0.0108	0.0231
Trypanosoma cruzi	cysteine peptidase, putative	0.0428	0.4691	0.4649
Onchocerca volvulus	Cathepsin L homolog	0.0428	0.4691	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0231	0.1966	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Onchocerca volvulus		0.0428	0.4691	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0097	0.0108	0.0031
Echinococcus multilocularis	cathepsin L	0.0231	0.1966	0.1903
Plasmodium falciparum	serine repeat antigen 2	0.0097	0.0108	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0108	0.0031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0428	0.4691	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0428	0.4691	0.4649
Toxoplasma gondii	cathepsin CPC2	0.0097	0.0108	0.0066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0231	0.1966	0.4054
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0097	0.0108	0.0031
Entamoeba histolytica	cysteine proteinase 2	0.0231	0.1966	0.4054
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0097	0.0108	0.0031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0428	0.4691	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Leishmania major	cathepsin L-like protease	0.0428	0.4691	1
Loa Loa (eye worm)	hypothetical protein	0.0294	0.2833	0.2777
Plasmodium vivax	unspecified product	0.0134	0.0623	0.1328
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0428	0.4691	1
Brugia malayi	fibroinase precursor	0.0097	0.0108	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0231	0.1966	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0231	0.1966	0.1903
Trypanosoma cruzi	cysteine peptidase, putative	0.0428	0.4691	0.4649
Plasmodium vivax	unspecified product	0.0097	0.0108	0.0231
Brugia malayi	Cathepsin L-like precursor	0.0428	0.4691	0.4649
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0318	0.3168	0.6698
Trypanosoma cruzi	cysteine proteinase, putative	0.0231	0.1966	0.1903
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0428	0.4691	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0623	0.0549
Leishmania major	cathepsin L-like protease	0.0428	0.4691	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0231	0.1966	0.4191
Brugia malayi	cathepsin L-like precursor	0.0294	0.2833	0.2777
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0428	0.4691	0.4649
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0428	0.4691	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0097	0.0108	0.0031
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0428	0.4691	0.4649
Plasmodium vivax	vivapain-3	0.0231	0.1966	0.4191
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0428	0.4691	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Onchocerca volvulus	Cathepsin F homolog	0.0428	0.4691	1
Brugia malayi	cathepsin L precursor	0.0097	0.0108	0.0031
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0134	0.0623	0.0549
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0428	0.4691	1
Leishmania major	cathepsin L-like protease	0.0428	0.4691	1
Brugia malayi	Cathepsin L-like precursor	0.0428	0.4691	0.4649
Trypanosoma cruzi	cruzipain precursor, putative	0.0428	0.4691	0.4649
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0097	0.0108	0.0231
Echinococcus multilocularis	cathepsin L cysteine protease	0.0428	0.4691	0.4649
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0095	0.0078	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0428	0.4691	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0428	0.4691	0.4649
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0108	0.0031
Echinococcus granulosus	cathepsin b	0.0811	1	1
Onchocerca volvulus		0.0428	0.4691	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0097	0.0108	0.0031
Echinococcus granulosus	cathepsin b	0.0811	1	1
Leishmania major	cathepsin L-like protease	0.0428	0.4691	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0108	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0811	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0428	0.4691	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0428	0.4691	0.4649
Schistosoma mansoni	cathepsin F (C01 family)	0.0294	0.2833	0.2777
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0231	0.1966	0.4093
Plasmodium vivax	unspecified product	0.0231	0.1966	0.4191
Plasmodium falciparum	serine repeat antigen 3	0.0097	0.0108	0.0231
Onchocerca volvulus		0.0428	0.4691	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0097	0.0108	0.0031
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0108	0.0031
Entamoeba histolytica	cysteine proteinase, putative	0.0231	0.1966	0.4054

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 5 uM	Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II)	ChEMBL.	12657279
IC50 (binding)	> 5 uM	Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II)	ChEMBL.	12657279

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 22226545

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 35984