Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0407 | 0.2888 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Brugia malayi | MTAP | 0.0514 | 0.3987 | 0.3987 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0407 | 0.2888 | 1 |
Mycobacterium tuberculosis | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) | 0.0225 | 0.1022 | 0.1022 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0514 | 0.3987 | 0.3987 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0407 | 0.2888 | 1 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.0288 | 0.1668 | 0.1668 |
Toxoplasma gondii | phosphorylase family protein | 0.0288 | 0.1668 | 0.5776 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0514 | 0.3987 | 0.5669 |
Schistosoma mansoni | uridine phosphorylase | 0.0288 | 0.1668 | 0.1668 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0288 | 0.1668 | 0.4184 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0407 | 0.2888 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0514 | 0.3987 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.1098 | 1 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0288 | 0.1668 | 0.1668 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0514 | 0.3987 | 0.3987 |
Loa Loa (eye worm) | uridine phosphorylase | 0.0288 | 0.1668 | 0.2372 |
Trypanosoma brucei | uridine phosphorylase | 0.0288 | 0.1668 | 0.4184 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0407 | 0.2888 | 1 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0514 | 0.3987 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0288 | 0.1668 | 0.4184 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.1098 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0288 | 0.1668 | 0.1668 |
Toxoplasma gondii | phosphorylase family protein | 0.0288 | 0.1668 | 0.5776 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0288 | 0.1668 | 0.1668 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.081 | 0.7034 | 0.7034 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.0288 | 0.1668 | 0.1668 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.081 | 0.7034 | 0.7034 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.1098 | 1 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0514 | 0.3987 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0514 | 0.3987 | 0.2783 |
Schistosoma mansoni | uridine phosphorylase | 0.0288 | 0.1668 | 0.1668 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0288 | 0.1668 | 0.1668 |
Brugia malayi | uridine phosphorylase family protein | 0.0288 | 0.1668 | 0.1668 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0288 | 0.1668 | 0.4184 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0514 | 0.3987 | 0.3987 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0407 | 0.2888 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0407 | 0.2888 | 0.1465 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0514 | 0.3987 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.1098 | 1 | 1 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0514 | 0.3987 | 0.3987 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.081 | 0.7034 | 0.7034 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 0.7034 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0288 | 0.1668 | 0.4184 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0407 | 0.2888 | 1 |
Chlamydia trachomatis | AMP nucleosidase | 0.0288 | 0.1668 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.1098 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0407 | 0.2888 | 0.1465 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1098 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 40 | Reduction in paw swelling at 100 mg/kg po dose in rat using adjuvant arthritis test. | ChEMBL. | 6620297 |
Relative potency (functional) | = 0.6 | Potency relative to [2-(2,4-Dichloro-phenoxy)-phenyl]-acetic acid in rat adjuvant arthritis test | ChEMBL. | 6620297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.