TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 543.315 | Formula: C21H25Br2N3O2S
H donors: 2 H acceptors: 2 LogP: 4.78 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: Brc1sc(c(c1)C(=O)Nc1cc(CN2CCCC2)c(c(c1)CN1CCCC1)O)Br
InChi: 1S/C21H25Br2N3O2S/c22-18-11-17(20(23)29-18)21(28)24-16-9-14(12-25-5-1-2-6-25)19(27)15(10-16)13-26-7-3-4-8-26/h9-11,27H,1-8,12-13H2,(H,24,28)
InChiKey: QEFXGWYLORXXQC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0134	0.128	0.1204
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Plasmodium falciparum	serine repeat antigen 9	0.0134	0.128	0.1689
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0866	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0627	0.7155	1
Onchocerca volvulus	Cathepsin L homolog	0.0627	0.7155	1
Echinococcus granulosus	geminin	0.0173	0.1738	0.1667
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0134	0.128	0.1204
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0034	0.0085	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0134	0.128	0.1204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Toxoplasma gondii	cathepsin CPC2	0.0134	0.128	0.1689
Plasmodium vivax	vivapain-2	0.0627	0.7155	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.128	0.1204
Giardia lamblia	Hypothetical protein	0.0134	0.128	0.3069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0134	0.128	0.1689
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0334	0.3661	0.3607
Plasmodium falciparum	serine repeat antigen 7	0.0134	0.128	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0134	0.128	0.1204
Echinococcus granulosus	microtubule associated protein 2	0.0703	0.8059	0.8042
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.3661	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0134	0.128	0.1689
Onchocerca volvulus		0.0427	0.4773	0.6631
Onchocerca volvulus		0.0627	0.7155	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0134	0.128	0.3069
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0627	0.7155	0.713
Giardia lamblia	Cathepsin L precursor	0.0134	0.128	0.3069
Trypanosoma cruzi	major cysteine proteinase, putative	0.0134	0.128	0.1204
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Onchocerca volvulus	Cathepsin L homolog	0.0627	0.7155	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0627	0.7155	1
Plasmodium falciparum	serine repeat antigen 4	0.0134	0.128	0.1689
Leishmania major	cathepsin L-like protease	0.0627	0.7155	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0866	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Plasmodium falciparum	serine repeat antigen 8	0.0134	0.128	0.1689
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0134	0.128	0.1689
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0134	0.128	0.1689
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0627	0.7155	0.7155
Loa Loa (eye worm)	hypothetical protein	0.0866	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.3661	0.5059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.3661	0.5059
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.3661	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0134	0.128	0.1204
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0134	0.128	0.1204
Loa Loa (eye worm)	hypothetical protein	0.02	0.2062	0.1994
Giardia lamblia	Cathepsin L precursor	0.0134	0.128	0.3069
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.3661	0.4054
Onchocerca volvulus		0.0134	0.128	0.1689
Onchocerca volvulus	Cathepsin F homolog	0.0627	0.7155	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0427	0.4773	0.4728
Plasmodium vivax	serine-repeat antigen (SERA)	0.0134	0.128	0.1689
Leishmania major	cathepsin L-like protease	0.0627	0.7155	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0134	0.128	0.1204
Trypanosoma cruzi	cysteine peptidase, putative	0.0627	0.7155	0.713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.4773	0.6631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0134	0.128	0.1689
Giardia lamblia	Cathepsin B precursor	0.0361	0.3977	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0134	0.128	0.1689
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0627	0.7155	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0627	0.7155	0.713
Echinococcus granulosus	cathepsin l1	0.0627	0.7155	0.713
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0334	0.3661	0.3607
Brugia malayi	Papain family cysteine protease containing protein	0.0134	0.128	0.1204
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0134	0.128	0.1689
Brugia malayi	Cathepsin L-like precursor	0.0627	0.7155	0.713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0134	0.128	0.1689
Leishmania major	cathepsin L-like protease	0.0627	0.7155	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0134	0.128	0.1204
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0627	0.7155	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.3661	0.5059
Trypanosoma cruzi	cysteine proteinase, putative	0.0334	0.3661	0.3607
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0134	0.128	0.1689
Giardia lamblia	Cathepsin L-like protease	0.0134	0.128	0.3069
Trichomonas vaginalis	conserved hypothetical protein	0.0134	0.128	0.1689
Echinococcus multilocularis	cathepsin L cysteine protease	0.0627	0.7155	0.7155
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0134	0.128	0.1689
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0134	0.128	0.1689
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0034	0.0085	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0134	0.128	0.1689
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0866	1	1
Echinococcus multilocularis	cysteine protease	0.0627	0.7155	0.7155
Brugia malayi	Papain family cysteine protease containing protein	0.0334	0.3661	0.3607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.128	0.1204
Echinococcus multilocularis	microtubule associated protein 2	0.0703	0.8059	0.8059
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0134	0.128	0.1204
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0361	0.3977	0.3925
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Giardia lamblia	Cathepsin L precursor	0.0134	0.128	0.3069
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0627	0.7155	0.713
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0134	0.128	0.1689
Echinococcus multilocularis	cysteine protease	0.0627	0.7155	0.7155
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0134	0.128	0.1689
Echinococcus granulosus	cathepsin L cysteine protease	0.0334	0.3661	0.3607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0334	0.3661	0.3607
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0134	0.128	0.1689
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0134	0.128	0.1689
Leishmania major	cathepsin L-like protease	0.0627	0.7155	1
Leishmania major	cathepsin L-like protease	0.0627	0.7155	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0627	0.7155	1
Brugia malayi	Cathepsin L-like precursor	0.0627	0.7155	0.713
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0134	0.128	0.1204
Giardia lamblia	Hypothetical protein	0.0134	0.128	0.3069
Trypanosoma cruzi	cysteine peptidase, putative	0.0627	0.7155	0.713
Trypanosoma cruzi	cysteine peptidase, putative	0.0627	0.7155	0.713
Chlamydia trachomatis	pyruvate kinase	0.0034	0.0085	0.5
Brugia malayi	cathepsin L precursor	0.0134	0.128	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0427	0.4773	0.4728
Entamoeba histolytica	cysteine proteinase 1, putative	0.0334	0.3661	0.4054
Toxoplasma gondii	cathepsin CPC1	0.0134	0.128	0.1689
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0134	0.128	0.1204
Entamoeba histolytica	cysteine proteinase, putative	0.0627	0.7155	1
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Brugia malayi	fibroinase precursor	0.0134	0.128	0.1204
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Plasmodium falciparum	serine repeat antigen 6	0.0134	0.128	0.1689
Plasmodium vivax	vivapain-3	0.0334	0.3661	0.5059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0627	0.7155	1
Trypanosoma cruzi	cruzipain precursor, putative	0.02	0.2062	0.1994
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0134	0.128	0.3069
Brugia malayi	Cathepsin L-like precursor	0.0427	0.4773	0.4728
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Brugia malayi	Papain family cysteine protease containing protein	0.0134	0.128	0.1204
Brugia malayi	Cathepsin L-like precursor	0.0427	0.4773	0.4728
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0134	0.128	0.1689
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Loa Loa (eye worm)	cathepsin B	0.0361	0.3977	0.3925
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Echinococcus multilocularis	cathepsin b	0.0866	1	1
Giardia lamblia	Cathepsin L precursor	0.0134	0.128	0.3069
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0627	0.7155	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0134	0.128	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0134	0.128	0.1204
Brugia malayi	Cathepsin L-like precursor	0.0627	0.7155	0.713
Loa Loa (eye worm)	hypothetical protein	0.02	0.2062	0.1994
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0627	0.7155	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0334	0.3661	0.5059
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0134	0.128	0.1204
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0627	0.7155	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0134	0.128	0.1204
Plasmodium vivax	unspecified product	0.0334	0.3661	0.5059
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0134	0.128	0.1204
Loa Loa (eye worm)	ctsf protein	0.0627	0.7155	0.713
Giardia lamblia	Cathepsin B precursor	0.0134	0.128	0.3069
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Giardia lamblia	Cysteine protease	0.0134	0.128	0.3069
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0627	0.7155	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0427	0.4773	0.4728
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0134	0.128	0.1204
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0627	0.7155	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0134	0.128	0.1204
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0334	0.3661	0.3607
Leishmania major	cathepsin L-like protease	0.0627	0.7155	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0134	0.128	0.1689
Plasmodium vivax	unspecified product	0.02	0.2062	0.2796
Trypanosoma cruzi	cruzipain precursor, putative	0.0627	0.7155	0.713
Echinococcus multilocularis	cathepsin b	0.0866	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0627	0.7155	0.713
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0134	0.128	0.1689
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Giardia lamblia	Cathepsin B precursor	0.0134	0.128	0.3069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Onchocerca volvulus		0.0627	0.7155	1
Giardia lamblia	Encystation-specific protease	0.0134	0.128	0.3069
Leishmania major	cathepsin L-like protease	0.0627	0.7155	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0134	0.128	0.1689
Echinococcus granulosus	cathepsin b	0.0866	1	1
Echinococcus multilocularis	cathepsin L	0.0134	0.128	0.128
Echinococcus multilocularis	cathepsin L cysteine protease	0.0627	0.7155	0.7155
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0134	0.128	0.1204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0361	0.3977	0.5504
Loa Loa (eye worm)	hypothetical protein	0.0627	0.7155	0.713
Giardia lamblia	Cysteine protease	0.0134	0.128	0.3069
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Leishmania major	cysteine peptidase A (CPA)	0.0627	0.7155	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.02	0.2062	0.1994
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0627	0.7155	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.3661	0.5059
Echinococcus granulosus	cathepsin L	0.0334	0.3661	0.3607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0134	0.128	0.1204
Giardia lamblia	Cathepsin L precursor	0.0134	0.128	0.3069
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0134	0.128	0.1689
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0627	0.7155	0.713
Plasmodium falciparum	serine repeat antigen 1	0.0134	0.128	0.1689
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0134	0.128	0.1689
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0627	0.7155	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.128	0.1204
Giardia lamblia	Cathepsin B precursor	0.0134	0.128	0.3069
Trypanosoma cruzi	cysteine proteinase, putative	0.0334	0.3661	0.3607
Brugia malayi	Cathepsin L-like precursor	0.0627	0.7155	0.713
Leishmania major	cathepsin L-like protease	0.0627	0.7155	1
Brugia malayi	Papain family cysteine protease containing protein	0.0334	0.3661	0.3607
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0134	0.128	0.1689
Onchocerca volvulus		0.0627	0.7155	1
Loa Loa (eye worm)	fibroinase	0.0627	0.7155	0.713
Schistosoma mansoni	microtubule-associated protein tau	0.0703	0.8059	0.8042
Plasmodium vivax	vivapain-1	0.0334	0.3661	0.5059
Loa Loa (eye worm)	cysteine protease	0.0627	0.7155	0.713
Plasmodium falciparum	serine repeat antigen 5	0.0134	0.128	0.1689
Plasmodium falciparum	serine repeat antigen 3	0.0134	0.128	0.1689
Onchocerca volvulus		0.0627	0.7155	1
Echinococcus granulosus	cathepsin b	0.0866	1	1
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Plasmodium vivax	serine-repeat antigen (SERA)	0.0134	0.128	0.1689
Entamoeba histolytica	cysteine proteinase, putative	0.0627	0.7155	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0134	0.128	0.1689
Brugia malayi	Cathepsin L-like precursor	0.0627	0.7155	0.713
Schistosoma mansoni	hypothetical protein	0.0173	0.1738	0.1667
Schistosoma mansoni	cathepsin C	0.0134	0.128	0.1204
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.4773	0.6631
Entamoeba histolytica	cysteine proteinase 2	0.0334	0.3661	0.4054
Echinococcus multilocularis	cathepsin L	0.0334	0.3661	0.3661
Giardia lamblia	Cysteine protease	0.0134	0.128	0.3069
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0134	0.128	0.1204
Schistosoma mansoni	cathepsin F (C01 family)	0.0627	0.7155	0.713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Giardia lamblia	Cathepsin B precursor	0.0361	0.3977	1
Entamoeba histolytica	cysteine proteinase, putative	0.0427	0.4773	0.5946
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0134	0.128	0.1689
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0134	0.128	0.1204
Plasmodium vivax	vivapain-2	0.0627	0.7155	1
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0085	0.0085
Toxoplasma gondii	cathepsin B	0.0361	0.3977	0.5504
Brugia malayi	cathepsin L-like precursor	0.0427	0.4773	0.4728
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0361	0.3977	0.5504
Trichomonas vaginalis	conserved hypothetical protein	0.0134	0.128	0.1689
Entamoeba histolytica	cysteine protease, putative	0.0627	0.7155	1
Giardia lamblia	Cathepsin L precursor	0.0134	0.128	0.3069
Onchocerca volvulus		0.0627	0.7155	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0627	0.7155	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.2062	0.1994
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0134	0.128	0.1689
Echinococcus granulosus	cysteine protease	0.0334	0.3661	0.3607
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.02	0.2062	0.1994
Schistosoma mansoni	hypothetical protein	0.0173	0.1738	0.1667
Onchocerca volvulus		0.0627	0.7155	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.02	0.2062	0.1994
Trypanosoma cruzi	cysteine protease, putative	0.0334	0.3661	0.3607
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Giardia lamblia	Cathepsin B precursor	0.0361	0.3977	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0866	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0627	0.7155	1
Brugia malayi	Cathepsin L-like precursor	0.02	0.2062	0.1994
Schistosoma mansoni	cathepsin s	0.02	0.2062	0.1994
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0134	0.128	0.1689
Toxoplasma gondii	cathepsin CPL	0.0627	0.7155	1
Plasmodium falciparum	serine repeat antigen 2	0.0134	0.128	0.1689
Giardia lamblia	Cathepsin L-like protease	0.0134	0.128	0.3069
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0627	0.7155	0.7155
Trypanosoma cruzi	cysteine peptidase, putative	0.02	0.2062	0.1994
Loa Loa (eye worm)	hypothetical protein	0.0427	0.4773	0.4728
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0334	0.3661	0.3607
Mycobacterium ulcerans	pyruvate kinase	0.0034	0.0085	0.5
Echinococcus granulosus	cathepsin l1	0.0427	0.4773	0.4728
Giardia lamblia	Cathepsin B precursor	0.0134	0.128	0.3069
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0134	0.128	0.1204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0627	0.7155	1
Onchocerca volvulus		0.0627	0.7155	1
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.3661	0.4054
Giardia lamblia	Cysteine protease	0.0134	0.128	0.3069
Brugia malayi	Papain family cysteine protease containing protein	0.0627	0.7155	0.713
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0134	0.128	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0427	0.4773	0.4728
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.05	0.5634	0.5597
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0361	0.3977	0.5504
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0627	0.7155	0.713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0134	0.128	0.1689
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0134	0.128	0.1204
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0134	0.128	0.1689
Entamoeba histolytica	cysteine protease, putative	0.0334	0.3661	0.4054
Plasmodium vivax	unspecified product	0.0134	0.128	0.1689
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0134	0.128	0.3069
Brugia malayi	Protein kinase domain containing protein	0.05	0.5634	0.5597
Echinococcus multilocularis	geminin	0.0173	0.1738	0.1738
Echinococcus granulosus	cathepsin L	0.0134	0.128	0.1204
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0361	0.3977	0.3925
Brugia malayi	Cathepsin L-like precursor	0.0627	0.7155	0.713
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0134	0.128	0.3069
Brugia malayi	cathepsin F-like cysteine proteinase	0.0134	0.128	0.1204
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0427	0.4773	0.4728
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0134	0.128	0.1689
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0866	1	1
Giardia lamblia	Cathepsin B precursor	0.0134	0.128	0.3069

Activities

Activity type	Activity value	Assay description	Source	Reference
Dose (functional)	= 4.3 mg kg-1	Evaluated for ouabain-induced arrhythmia in anesthetized adult male mongrel dogs. Administered intravenously.	ChEMBL.	6384519

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 36002