Detailed information for compound 360700

Basic information

Technical information
  • TDR Targets ID: 360700
  • Name: 1-[N'-[3-[7-[3-[[amino-[[N'-(3,3-diphenylprop yl)carbamimidoyl]amino]methylidene]amino]prop ylamino]heptylamino]propyl]carbamimidoyl]-2-( 3,3-diphenylpropyl)guanidine
  • MW: 801.123 | Formula: C47H68N12
  • H donors: 8 H acceptors: 0 LogP: 7.45 Rotable bonds: 34
    Rule of 5 violations (Lipinski): 3
  • SMILES: N=C(NC(=N)NCCC(c1ccccc1)c1ccccc1)NCCCNCCCCCCCNCCCNC(=N)NC(=N)NCCC(c1ccccc1)c1ccccc1
  • InChi: 1S/C47H68N12/c48-44(58-46(50)56-36-28-42(38-20-8-4-9-21-38)39-22-10-5-11-23-39)54-34-18-32-52-30-16-2-1-3-17-31-53-33-19-35-55-45(49)59-47(51)57-37-29-43(40-24-12-6-13-25-40)41-26-14-7-15-27-41/h4-15,20-27,42-43,52-53H,1-3,16-19,28-37H2,(H5,48,50,54,56,58)(H5,49,51,55,57,59)
  • InChiKey: VEHIZKIENTWGCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[N'-[3-[7-[3-[[amino-[[N'-(3,3-diphenylpropyl)carbamimidoyl]amino]methylene]amino]propylamino]heptylamino]propyl]carbamimidoyl]-2-(3,3-diphenylpropyl)guanidine
  • 1-[amino-[3-[7-[3-[[amino-[[amino(3,3-diphenylpropylimino)methyl]amino]methylene]amino]propylamino]heptylamino]propylimino]methyl]-2-(3,3-diphenylpropyl)guanidine
  • 1-[N'-[3-[7-[3-[[azanyl-[[N'-(3,3-diphenylpropyl)carbamimidoyl]amino]methylidene]amino]propylamino]heptylamino]propyl]carbamimidoyl]-2-(3,3-diphenylpropyl)guanidine
  • 1-[N'-[3-[7-[3-[[amino-[[N'-(3,3-diphenylpropyl)amidino]amino]methylene]amino]propylamino]heptylamino]propyl]amidino]-2-(3,3-diphenylpropyl)guanidine
  • 1-[N'-[3-[7-[3-[[amino-[[N'-[3,3-di(phenyl)propyl]carbamimidoyl]amino]methylidene]amino]propylamino]heptylamino]propyl]carbamimidoyl]-2-[3,3-di(phenyl)propyl]guanidine
  • 1-[N'-[3-[7-[3-[[amino-[[N'-[3,3-di(phenyl)propyl]carbamimidoyl]amino]methylene]amino]propylamino]heptylamino]propyl]carbamimidoyl]-2-[3,3-di(phenyl)propyl]guanidine
  • 1-[amino-[3-[7-[3-[[amino-[[amino-[3,3-di(phenyl)propylimino]methyl]amino]methylene]amino]propylamino]heptylamino]propylimino]methyl]-2-[3,3-di(phenyl)propyl]guanidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 1A Starlite/ChEMBL References
Trypanosoma cruzi trypanothione reductase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Lysine-specific histone demethylase 1 Get druggable targets OG5_130448 All targets in OG5_130448
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130448 All targets in OG5_130448
Onchocerca volvulus Get druggable targets OG5_130448 All targets in OG5_130448
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lysine specific histone demethylase 1A Get druggable targets OG5_130448 All targets in OG5_130448
Echinococcus multilocularis lysine specific histone demethylase 1A Get druggable targets OG5_130448 All targets in OG5_130448
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00540 amine oxidase (flavin containing) domain 2 [EC:1.-.-.-], putative Get druggable targets OG5_130448 All targets in OG5_130448
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Lysine-specific histone demethylase 1, putative Get druggable targets OG5_130448 All targets in OG5_130448
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130448 All targets in OG5_130448
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi SWIRM domain containing protein Get druggable targets OG5_130448 All targets in OG5_130448
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130448 All targets in OG5_130448
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 492 aa 548 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.00399563 0.0479866 0.0876641
Brugia malayi Nuclear hormone receptor family member nhr-49 0.00399563 0.0479866 0.0479866
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.00399563 0.0479866 0.0876641
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0104877 0.213273 0.389617
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0196155 0.445663 0.814159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.00399563 0.0479866 0.0504053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.00399563 0.0479866 0.0479866
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.00399563 0.0479866 0.0504053
Brugia malayi steroid hormone receptor 0.00399563 0.0479866 0.0479866
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.00399563 0.0479866 0.0876641
Trypanosoma brucei trypanothione reductase 0.00761339 0.140094 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.00263827 0.0134283 0.0301311
Schistosoma mansoni retinoic acid receptor RXR 0.00399563 0.0479866 0.0876641
Loa Loa (eye worm) hypothetical protein 0.00399563 0.0479866 0.0504053
Brugia malayi Steroid receptor seven-up type 2 0.00399563 0.0479866 0.0479866
Trichomonas vaginalis mercuric reductase, putative 0.00263827 0.0134283 0.5
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0196155 0.445663 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00399563 0.0479866 0.0479866
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.00761339 0.140094 1
Brugia malayi nuclear receptor NHR-88 0.00399563 0.0479866 0.0479866
Echinococcus granulosus thioredoxin glutathione reductase 0.00761339 0.140094 0.314349
Brugia malayi Nuclear hormone receptor family member nhr-3 0.00399563 0.0479866 0.0479866
Loa Loa (eye worm) hypothetical protein 0.00399563 0.0479866 0.0504053
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.00263827 0.0134283 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00399563 0.0479866 0.0479866
Schistosoma mansoni thyroid hormone receptor 0.0236111 0.547391 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00399563 0.0479866 0.0479866
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.00399563 0.0479866 0.0504053
Brugia malayi Nuclear hormone receptor-like 1 0.0395037 0.952013 0.952013
Loa Loa (eye worm) hypothetical protein 0.0104877 0.213273 0.224023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00399563 0.0479866 0.0479866
Brugia malayi Nuclear hormone receptor family member nhr-41 0.00399563 0.0479866 0.0479866
Schistosoma mansoni RAR-like nuclear receptor 0.00399563 0.0479866 0.0876641
Trypanosoma cruzi trypanothione reductase, putative 0.00761339 0.140094 1
Loa Loa (eye worm) hypothetical protein 0.0114817 0.238581 0.250607
Loa Loa (eye worm) hypothetical protein 0.00399563 0.0479866 0.0504053
Loa Loa (eye worm) steroid hormone receptor 0.00399563 0.0479866 0.0504053
Brugia malayi photoreceptor-specific nuclear receptor 0.00399563 0.0479866 0.0479866
Trichomonas vaginalis glutathione reductase, putative 0.00263827 0.0134283 0.5
Loa Loa (eye worm) hypothetical protein 0.00399563 0.0479866 0.0504053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00399563 0.0479866 0.0876641
Echinococcus multilocularis FTZ F1 alpha 0.00399563 0.0479866 0.0876641
Loa Loa (eye worm) hypothetical protein 0.00267753 0.014428 0.0151553
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00399563 0.0479866 0.0479866
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00263827 0.0134283 0.5
Onchocerca volvulus 0.0114817 0.238581 1
Toxoplasma gondii thioredoxin reductase 0.00761339 0.140094 1
Echinococcus multilocularis ecdysone induced protein 78C 0.00399563 0.0479866 0.0876641
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.00399563 0.0479866 0.0876641
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.00399563 0.0479866 0.107675
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.00263827 0.0134283 0.0245315
Giardia lamblia NADH oxidase lateral transfer candidate 0.00263827 0.0134283 0.5
Leishmania major trypanothione reductase 0.00761339 0.140094 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.00399563 0.0479866 0.0479866
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00399563 0.0479866 0.0479866
Loa Loa (eye worm) hypothetical protein 0.00399563 0.0479866 0.0504053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00399563 0.0479866 0.0876641
Loa Loa (eye worm) hypothetical protein 0.00399563 0.0479866 0.0504053
Loa Loa (eye worm) hypothetical protein 0.0392777 0.946259 0.993955
Plasmodium falciparum glutathione reductase 0.00761339 0.140094 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.00399563 0.0479866 0.0876641
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.00263827 0.0134283 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.00399563 0.0479866 0.0504053
Loa Loa (eye worm) hypothetical protein 0.00399563 0.0479866 0.0504053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.00399563 0.0479866 0.107675
Brugia malayi ecdysteroid receptor 0.00399563 0.0479866 0.0479866
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00399563 0.0479866 0.107675
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.00263827 0.0134283 0.5
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0104877 0.213273 0.389617
Schistosoma mansoni hypothetical protein 0.0196155 0.445663 0.814159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.00399563 0.0479866 0.0876641
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.00399563 0.0479866 0.0876641
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.00399563 0.0479866 0.107675
Mycobacterium ulcerans flavoprotein disulfide reductase 0.00263827 0.0134283 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00399563 0.0479866 0.107675
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.00399563 0.0479866 0.0876641
Echinococcus granulosus FTZ F1 alpha 0.00399563 0.0479866 0.107675
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0395037 0.952013 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00399563 0.0479866 0.0876641
Brugia malayi Nuclear hormone receptor-like 1 0.0413885 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.00399563 0.0479866 0.0876641
Schistosoma mansoni thyroid hormone receptor 0.0236111 0.547391 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.00399563 0.0479866 0.0479866
Brugia malayi amine oxidase, flavin-containing family protein 0.00267753 0.014428 0.014428
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.00263827 0.0134283 0.0245315
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00263827 0.0134283 0.5
Brugia malayi Thioredoxin reductase 0.00761339 0.140094 0.140094
Loa Loa (eye worm) glutathione reductase 0.00761339 0.140094 0.147155
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.00399563 0.0479866 0.0876641
Plasmodium vivax thioredoxin reductase, putative 0.00761339 0.140094 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0236111 0.547391 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.00399563 0.0479866 0.0504053
Echinococcus granulosus ecdysone induced protein 78C 0.00399563 0.0479866 0.107675
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.00399563 0.0479866 0.107675
Plasmodium falciparum thioredoxin reductase 0.00761339 0.140094 1
Brugia malayi Nuclear hormone receptor-like 1 0.0395037 0.952013 0.952013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.00399563 0.0479866 0.107675
Brugia malayi Nuclear hormone receptor family member nhr-14 0.00399563 0.0479866 0.0479866
Loa Loa (eye worm) thioredoxin reductase 0.00761339 0.140094 0.147155
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.00263827 0.0134283 0.0134283
Schistosoma mansoni coup transcription factor 0.00399563 0.0479866 0.0876641
Loa Loa (eye worm) hypothetical protein 0.0104877 0.213273 0.224023
Echinococcus multilocularis thioredoxin glutathione reductase 0.00761339 0.140094 0.25593
Plasmodium vivax glutathione reductase, putative 0.00761339 0.140094 1
Brugia malayi glutathione reductase 0.00761339 0.140094 0.140094
Treponema pallidum NADH oxidase 0.00263827 0.0134283 0.5
Brugia malayi SWIRM domain containing protein 0.0114817 0.238581 0.238581
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.00399563 0.0479866 0.0504053
Schistosoma mansoni steroid hormone receptor ad4bp 0.00399563 0.0479866 0.0876641
Loa Loa (eye worm) hypothetical protein 0.00399563 0.0479866 0.0504053
Brugia malayi nuclear hormone receptor 0.00399563 0.0479866 0.0479866
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.00263827 0.0134283 0.5
Echinococcus granulosus lysine specific histone demethylase 1A 0.0104877 0.213273 0.478552
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.00399563 0.0479866 0.0504053

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 15.8 % Inhibition of recombinant LSD1/CoREST (unknown origin) assessed as residual activity at 10 uM incubated for 30 mins to 4 hrs by fluorescence based assay relative to control ChEMBL. 25580204
Activity (functional) = 20 % Induction of SFRP4 expression in human RKO cells at 1 uM ChEMBL. 19534534
Activity (functional) = 20 % Induction of SFRP5 expression in human RKO cells at 1 uM ChEMBL. 19534534
Activity (functional) = 20 % Induction of H3K4me2 expression in human RKO cells at 1 uM ChEMBL. 19534534
GI (functional) = 85 % Cytotoxicity against human PC3 cells assessed as growth inhibition at 8 uM incubated for 48 to 72 hrs by MTS method ChEMBL. 25580204
IC50 (functional) = 224 nM Antiplasmodial activity against asexual intraerythrocytic ring stage of antifolate-resistant Plasmodium falciparum HB3 infected in human O+ erythrocytes assessed as inhibition of parasitic proliferation after 96 hrs by SYBR Green-1 based fluorescence assay ChEMBL. 25684422
IC50 (binding) = 0.5 uM Inhibition of full length N-terminal 6x His-tagged human LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate by luminol dependent chemiluminescence assay ChEMBL. 22975593
IC50 (functional) = 0.62 uM Antitrypanosomal activity against Trypanosoma brucei brucei ChEMBL. 16616495
IC50 (functional) = 0.62 uM Antitrypanosomal activity against Trypanosoma brucei brucei ChEMBL. 16616495
IC50 (binding) = 0.95 uM Inhibition of Trypanosoma cruzi TR ChEMBL. 16616495
IC50 (binding) = 0.95 uM Inhibition of Trypanosoma cruzi TR ChEMBL. 16616495
IC50 (binding) = 1 uM Inhibition of LSD1 ChEMBL. 21955276
IC50 (functional) = 5.9 uM Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by MTS assay ChEMBL. 24883177
IC50 (binding) > 100 uM Inhibition of human glutathione reductase ChEMBL. 16616495
IC50 (binding) > 100 uM Inhibition of human glutathione reductase ChEMBL. 16616495
Inhibition (binding) > 50 % Inhibition of N-terminal His-6-tagged full length human LSD-1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate at 1 uM by Western blotting analysis relative to control ChEMBL. No reference
Inhibition (binding) = 82.9 % Inhibition of human recombinant N-terminal histidine tagged LSD1 expressed in Escherichia coli BL21 (DE3) assessed as production of H2O2 using H3K4me2 (1 to 21 amino acid residues) as substrate at 10 uM by chemiluminescence assay ChEMBL. 22876979
Inhibition (binding) = 90.9 % Inhibition of LSD1 at 1 uM ChEMBL. 19534534
Inhibition (binding) = 90.9 % Inhibition of N-terminal His6-tagged full length human LSD1 expressed in Escherichia coli BL21 (DE3) using H3K4me2 (1 to 21 amino acids) as substrate assessed as production of H2O2 at 1 uM by luminol-dependent chemiluminescence assay relative to control ChEMBL. 23293738
Inhibition (binding) = 95 % Inhibition of recombinant LSD1 (unknown origin) using di-methylated H3-K4 peptide as substrate at 10 uM after 25 mins by fluorescence assay relative to control ChEMBL. 24883177

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 24883177
Trypanosoma brucei gambiense 16616495
Plasmodium falciparum ChEMBL23 25684422

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

8 literature references were collected for this gene.

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