Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | thymidine kinase, putative | 0.011006 | 1 | 1 |
Loa Loa (eye worm) | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0100335 | 0 | 0.5 |
Trypanosoma brucei | thymidine kinase | 0.011006 | 1 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.011006 | 1 | 1 |
Plasmodium vivax | thymidylate kinase, putative | 0.0100335 | 0 | 0.5 |
Chlamydia trachomatis | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0100335 | 0 | 0.5 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0100335 | 0 | 0.5 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0100335 | 0 | 0.5 |
Toxoplasma gondii | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Entamoeba histolytica | thymidine kinase, putative | 0.011006 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.011006 | 1 | 1 |
Brugia malayi | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.011006 | 1 | 1 |
Giardia lamblia | Thymidine kinase | 0.011006 | 1 | 1 |
Leishmania major | thymidine kinase, putative | 0.011006 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0100335 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.011006 | 1 | 1 |
Echinococcus granulosus | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Plasmodium falciparum | thymidylate kinase | 0.0100335 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 150 nM | In vitro for inhibition of parasite development of Plasmodium falciparum (W-2 strain) cultured in human erythrocytes in an antiparasitic assay | ChEMBL. | 11992775 |
IC50 (functional) | = 150 nM | In vitro for inhibition of parasite development of Plasmodium falciparum (W-2 strain) cultured in human erythrocytes in an antiparasitic assay | ChEMBL. | 11992775 |
IC50 (functional) | = 620 nM | In vitro for antimalarial activity against Plasmodium falciparum (W-2 strain) cultured in human erythrocytes by the inhibition of [3H]-hypoxanthine uptake | ChEMBL. | 11992775 |
IC50 (functional) | = 620 nM | In vitro for antimalarial activity against Plasmodium falciparum (W-2 strain) cultured in human erythrocytes by the inhibition of [3H]-hypoxanthine uptake | ChEMBL. | 11992775 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11992775 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.