Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.1127 | 0.1845 | 0.1844 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0536 | 0.0858 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.0001 | 0.0004 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3969 | 0.6593 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0023 | 0.0001 | 0.0004 |
Onchocerca volvulus | 0.0023 | 0.0001 | 0.0004 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.6008 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3969 | 0.6593 | 1 |
Onchocerca volvulus | 0.0023 | 0.0001 | 0.0004 | |
Brugia malayi | hypothetical protein | 0.0536 | 0.0858 | 0.0858 |
Echinococcus granulosus | thymidylate synthase | 0.1127 | 0.1845 | 0.1844 |
Echinococcus multilocularis | thymidylate synthase | 0.1127 | 0.1845 | 0.1844 |
Mycobacterium ulcerans | thymidylate synthase | 0.1127 | 0.1845 | 0.1845 |
Onchocerca volvulus | 0.0023 | 0.0001 | 0.0004 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1127 | 0.1845 | 0.1844 |
Trypanosoma brucei | pteridine reductase 1 | 0.0394 | 0.062 | 0.0941 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0536 | 0.0858 | 0.0858 |
Loa Loa (eye worm) | thymidylate synthase | 0.1127 | 0.1845 | 0.1844 |
Schistosoma mansoni | dihydrofolate reductase | 0.6008 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0399 | 0.0629 | 0.0954 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3969 | 0.6593 | 0.5 |
Onchocerca volvulus | 0.0023 | 0.0001 | 0.0004 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3969 | 0.6593 | 1 |
Onchocerca volvulus | 0.0023 | 0.0001 | 0.0004 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1127 | 0.1845 | 0.1845 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0536 | 0.0858 | 0.1302 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3969 | 0.6593 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3969 | 0.6593 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.6008 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.6008 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.6008 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.6008 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.6008 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.6008 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.6008 | 1 | 1 |
Onchocerca volvulus | 0.1127 | 0.1845 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | ~ 3 uM | In vitro inhibitory activity of the compound against the growth of WISH cell derived from human cervical carcinoma was determined | ChEMBL. | 14684314 |
IC50 (functional) | ~ 3 uM | In vitro inhibitory activity of the compound against the growth of WISH cell derived from human cervical carcinoma was determined | ChEMBL. | 14684314 |
Inhibition (functional) | ~ 70 % | In vitro inhibitory activity of the compound against the growth of WISH cell derived from human cervical carcinoma was determined | ChEMBL. | 14684314 |
Inhibition (functional) | ~ 70 % | In vitro inhibitory activity of the compound against the growth of WISH cell derived from human cervical carcinoma was determined | ChEMBL. | 14684314 |
Ki (binding) | > 10 uM | Displacement of [3H]-flunitrazepine binding from GABA-A central benzodiazepine receptor of rat cerebral cortical membrane | ChEMBL. | No reference |
Ki (binding) | > 10 uM | Displacement of [3H]-flunitrazepine binding from GABA-A central benzodiazepine receptor of rat cerebral cortical membrane | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 14684314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.