Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase A2, group IVB (cytosolic) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | Get druggable targets OG5_134171 | All targets in OG5_134171 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4358 | 0.636 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.6742 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4358 | 0.636 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.6742 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.6742 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4358 | 0.636 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4358 | 0.636 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1241 | 0.1599 | 0.1058 |
Brugia malayi | Dihydrofolate reductase | 0.6742 | 1 | 1 |
Onchocerca volvulus | 0.1241 | 0.1599 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.059 | 0.0605 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.6742 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.6742 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.6742 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.6742 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4358 | 0.636 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4358 | 0.636 | 1 |
Brugia malayi | thymidylate synthase | 0.1241 | 0.1599 | 0.1058 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.6742 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 7.2 | Calculated partition coefficient (clogP) | ChEMBL. | 11882004 |
IC50 (binding) | = 0.017 uM | Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by bilayer assay | ChEMBL. | 11882004 |
IC50 (binding) | = 0.017 uM | Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by bilayer assay | ChEMBL. | 11882004 |
IC50 (binding) | = 0.15 uM | Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay | ChEMBL. | 11882004 |
IC50 (binding) | = 0.15 uM | Inhibitory activity against cytosolic Phospholipase A2 (PLA2) by soluble assay | ChEMBL. | 11882004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.