Detailed information for compound 36454

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 302.799 | Formula: C17H19ClN2O
  • H donors: 1 H acceptors: 3 LogP: 3.83 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(c1cncnc1)(C1CCCCC1)O
  • InChi: 1S/C17H19ClN2O/c18-16-8-6-14(7-9-16)17(21,13-4-2-1-3-5-13)15-10-19-12-20-11-15/h6-13,21H,1-5H2
  • InChiKey: DICQABMOHPLUNO-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cytochrome P450 19A1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster Cytochrome P450-4d1 Cytochrome P450 19A1   508 aa 464 aa 24.6 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 19A1   508 aa 465 aa 21.5 %
Loa Loa (eye worm) cytochrome P450 family protein Cytochrome P450 19A1   508 aa 450 aa 21.1 %
Brugia malayi Cytochrome P450 family protein Cytochrome P450 19A1   508 aa 448 aa 20.8 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 19A1   508 aa 473 aa 18.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.006 0.0847 0.0734
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.006 0.0847 0.0731
Loa Loa (eye worm) hypothetical protein 0.0035 0.0448 0.0475
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.006 0.0847 0.0847
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0448 0.0303
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0448 0.047
Onchocerca volvulus 0.0035 0.0448 0.1621
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0448 0.0448
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.006 0.0847 0.0847
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.006 0.0847 0.0734
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0448 0.047
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0028 0.0335 0.0356
Brugia malayi MH2 domain containing protein 0.0109 0.1649 0.1649
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0448 0.047
Echinococcus granulosus proteasome prosome macropain 0.0589 0.9425 0.9425
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0022 0.0022
Plasmodium vivax proteasome subunit alpha type-7, putative 0.006 0.0847 0.0731
Brugia malayi Muscleblind-like protein 0.0137 0.2094 0.2094
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0056 0.078 0.0662
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0023
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0167 0.0172
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.006 0.0847 0.0847
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0448 0.047
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.017 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0448 0.047
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3509 0.372
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.006 0.0847 0.0734
Schistosoma mansoni ferritin 0.0008 0.0005 0.0005
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0145 0.2233 0.2229
Echinococcus granulosus 20S proteasome subunit alpha 6 0.006 0.0847 0.0847
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.006 0.0847 0.0893
Mycobacterium tuberculosis Conserved protein 0.0035 0.0448 0.047
Loa Loa (eye worm) hypothetical protein 0.0008 0.0017 0.0018
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.006 0.0847 0.0734
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0448 0.0448
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0145 0.2233 0.2231
Trypanosoma cruzi 20S proteasome subunit 0.006 0.0847 0.0734
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.006 0.0847 0.0734
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0022 0.0022
Brugia malayi hypothetical protein 0.0008 0.0017 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0448 0.047
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.006 0.0847 0.0731
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.006 0.0847 0.0893
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0302 0.0321
Schistosoma mansoni ferritin light chain 0.0008 0.0005 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0022 0.0022
Plasmodium falciparum proteasome subunit beta type-5 0.0589 0.9425 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0448 0.0448
Toxoplasma gondii proteasome subunit alpha type, putative 0.006 0.0847 0.0882
Schistosoma mansoni apoferritin-2 0.0008 0.0005 0.0005
Brugia malayi Cytochrome P450 family protein 0.0026 0.0302 0.0302
Schistosoma mansoni cytochrome P450 0.0018 0.0167 0.0167
Giardia lamblia Proteasome subunit beta type 1 0.006 0.0847 0.0731
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.006 0.0847 0.0882
Brugia malayi Proteasome subunit alpha type 1 0.006 0.0847 0.0847
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.006 0.0847 0.0731
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.006 0.0847 0.0893
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.006 0.0847 0.0734
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0008 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0022 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0167 0.0172
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.006 0.0847 0.0734
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0167 0.0172
Plasmodium falciparum proteasome subunit beta type-6, putative 0.006 0.0847 0.0731
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.006 0.0847 0.0734
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0335 0.0335
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0167 0.0172
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0448 0.0448
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.006 0.0847 0.0731
Brugia malayi latrophilin 2 splice variant baaae 0.0061 0.0865 0.0865
Trypanosoma brucei proteasome beta 7 subunit 0.006 0.0847 0.0734
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0167 0.0172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0627 0.0627
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0302 0.0146
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.006 0.0847 0.0731
Mycobacterium leprae putative cytochrome p450 0.0018 0.0167 0.0172
Schistosoma mansoni apoferritin-2 0.0008 0.0005 0.0005
Mycobacterium ulcerans lipase LipD 0.0035 0.0448 0.047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0022 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.017 0.0003
Loa Loa (eye worm) cytochrome P450 0.0018 0.0167 0.0177
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0022 0.0022
Plasmodium vivax proteasome subunit alpha type-1, putative 0.006 0.0847 0.0731
Brugia malayi proteasome subunit beta type 2 0.006 0.0847 0.0847
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.006 0.0847 0.0731
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0167 0.0172
Giardia lamblia Proteasome subunit beta type 2 0.006 0.0847 0.0731
Schistosoma mansoni ferritin 0.0008 0.0005 0.0005
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.006 0.0847 0.0847
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.006 0.0847 0.0893
Brugia malayi nuclear receptor NHR-88 0.0009 0.0022 0.0022
Brugia malayi proteasome subunit beta type 1 0.006 0.0847 0.0847
Schistosoma mansoni ferritin light chain 0.0008 0.0005 0.0005
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.006 0.0847 0.0731
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0167 0.0172
Loa Loa (eye worm) proteasome subunit beta type 1 0.006 0.0847 0.0898
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0017 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0448 0.047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0022 0.0022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.017 0.0003
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0167 0.0172
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0017 0.0017
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0022 0.0018
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.006 0.0847 0.0898
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.006 0.0847 0.0734
Giardia lamblia Proteasome subunit beta type 4 precursor 0.006 0.0847 0.0731
Loa Loa (eye worm) proteasome subunit beta type 2 0.006 0.0847 0.0898
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0448 0.047
Toxoplasma gondii exonuclease III APE 0.0018 0.017 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0448 0.047
Plasmodium vivax proteasome subunit beta type-2, putative 0.006 0.0847 0.0731
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0022 0.0022
Echinococcus multilocularis proteasome subunit beta type 7 0.0624 1 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.006 0.0847 0.0734
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.006 0.0847 0.0898
Brugia malayi regulator of G-protein signaling egl-10 0.0008 0.0017 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0627 0.0627
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.078 0.0822
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0017 0.0018
Loa Loa (eye worm) transcription factor SMAD2 0.0109 0.1649 0.175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0627 0.0627
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.006 0.0847 0.0734
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0089 0.1321 0.1321
Brugia malayi steroid hormone receptor 0.0009 0.0022 0.0022
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0167 0.0167
Echinococcus granulosus Pleckstrin G protein interacting region 0.0008 0.0017 0.0017
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0167 0.0172
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0167 0.0172
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.006 0.0847 0.0893
Toxoplasma gondii ABC1 family protein 0.0035 0.0448 0.0458
Toxoplasma gondii proteasome subunit 0.006 0.0847 0.0882
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.006 0.0847 0.0882
Echinococcus multilocularis proteasome (prosome, macropain) 0.0589 0.9425 0.9425
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.006 0.0847 0.0847
Schistosoma mansoni dep domain containing protein 0.0008 0.0017 0.0017
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.006 0.0847 0.0731
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0022 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0022 0.0023
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.006 0.0847 0.0731
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.006 0.0847 0.0731
Plasmodium vivax proteasome subunit alpha type-3, putative 0.006 0.0847 0.0731
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0022 0.0022
Leishmania major proteasome beta 7 subunit, putative 0.006 0.0847 0.0734
Toxoplasma gondii proteasome subunit alpha1, putative 0.006 0.0847 0.0882
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0589 0.9425 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.006 0.0847 0.0734
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0023
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0448 0.047
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0627 0.0665
Toxoplasma gondii proteasome subunit beta type 2, putative 0.006 0.0847 0.0882
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.006 0.0847 0.0731
Schistosoma mansoni coup transcription factor 0.0009 0.0022 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0448 0.047
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.006 0.0856 0.0742
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0335 0.0335
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.006 0.0847 0.0734
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.006 0.0847 0.0847
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0167 0.0172
Echinococcus multilocularis proteasome subunit alpha type 2 0.006 0.0847 0.0847
Brugia malayi Cytochrome P450 family protein 0.0018 0.0167 0.0167
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.006 0.0847 0.0731
Loa Loa (eye worm) proteasome subunit alpha type 2 0.006 0.0847 0.0898
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.006 0.0847 0.0847
Trypanosoma brucei proteasome subunit beta type-2, putative 0.006 0.0847 0.0734
Echinococcus multilocularis muscleblind protein 1 0.0137 0.2094 0.2094
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0022 0.0022
Echinococcus multilocularis muscleblind protein 0.0137 0.2094 0.2094
Mycobacterium ulcerans proteasome PrcA 0.006 0.0847 0.0893
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0167 0.016
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0167 0.0172
Brugia malayi cytochrome P450 0.0018 0.0167 0.0167
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.017 0.017
Trichomonas vaginalis esterase, putative 0.0035 0.0448 0.047
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.006 0.0847 0.0734
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.006 0.0847 0.0734
Brugia malayi beta-lactamase 0.0035 0.0448 0.0448
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.006 0.0847 0.0734
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0008 0.0017 0.0017
Brugia malayi proteasome subunit alpha type 1 0.006 0.0847 0.0847
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.006 0.0847 0.0847
Brugia malayi Proteasome A-type and B-type family protein 0.0589 0.9425 0.9425
Leishmania major proteasome alpha 3 subunit, putative 0.006 0.0847 0.0734
Onchocerca volvulus 0.0035 0.0448 0.1621
Brugia malayi N-terminal motif family protein 0.0172 0.2674 0.2674
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0167 0.0172
Brugia malayi Proteasome A-type and B-type family protein 0.006 0.0847 0.0847
Plasmodium vivax proteasome subunit alpha type-6, putative 0.006 0.0847 0.0731
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0335 0.0335
Echinococcus granulosus proteasome subunit alpha type 2 0.006 0.0847 0.0847
Trypanosoma brucei proteasome beta 6 subunit 0.006 0.0847 0.0734
Echinococcus granulosus expressed protein 0.0008 0.0005 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0022 0.0022
Leishmania major proteasome alpha 7 subunit, putative 0.006 0.0847 0.0734
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0589 0.9425 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0167 0.0172
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0335 0.0335
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.006 0.0847 0.0893
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0167 0.0172
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0448 0.047
Loa Loa (eye worm) proteasome subunit alpha type 6 0.006 0.0847 0.0898
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0167 0.0172
Mycobacterium leprae Probable lipase LipE 0.0035 0.0448 0.047
Brugia malayi nuclear hormone receptor 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0137 0.2094 0.2222
Echinococcus granulosus proteasome subunit beta t family 0.006 0.0847 0.0847
Leishmania major proteasome alpha 7 subunit, putative 0.006 0.0847 0.0734
Echinococcus granulosus ferritin 0.0008 0.0005 0.0005
Plasmodium vivax proteasome subunit beta type-3, putative 0.006 0.0847 0.0731
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0167 0.0172
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.017 0.1956
Schistosoma mansoni hypothetical protein 0.0028 0.0335 0.0335
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0167 0.0172
Giardia lamblia 20S proteasome alpha subunit 1 0.006 0.0847 0.0731
Echinococcus granulosus proteasome prosome macropain subunit beta 0.006 0.0847 0.0847
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0022 0.0022
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.006 0.0847 0.0847
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0022 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0448 0.047
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.006 0.0847 0.0731
Loa Loa (eye worm) PAS-3 protein 0.006 0.0847 0.0898
Giardia lamblia Proteasome subunit beta type 9 precursor 0.006 0.0847 0.0731
Echinococcus multilocularis Proteasome subunit alpha type 7 0.006 0.0847 0.0847
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0023
Toxoplasma gondii proteasome subunit beta type 1, putative 0.006 0.0847 0.0882
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.006 0.0847 0.0893
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.006 0.0847 1
Brugia malayi ecdysteroid receptor 0.0009 0.0022 0.0022
Mycobacterium ulcerans beta-lactamase 0.0035 0.0448 0.047
Leishmania major proteasome beta 5 subunit, putative 0.0589 0.9425 1
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.006 0.0847 0.0734
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0056 0.078 0.078
Schistosoma mansoni regulator of G protein signaling 0.0008 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0061 0.0865 0.0917
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0016
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.006 0.0847 0.0847
Brugia malayi Proteasome A-type and B-type family protein 0.006 0.0847 0.0847
Toxoplasma gondii aldehyde dehydrogenase 0.0056 0.078 0.0811
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.017 0.0175
Echinococcus granulosus proteasome subunit beta type 7 0.0624 1 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.006 0.0847 0.0734
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0448 0.0303
Brugia malayi Proteasome subunit alpha type 7-1 0.006 0.0847 0.0847
Brugia malayi Calcitonin receptor-like protein seb-1 0.0089 0.1321 0.1321
Schistosoma mansoni hypothetical protein 0.0028 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0172 0.2674 0.2837
Loa Loa (eye worm) MH2 domain-containing protein 0.0109 0.1649 0.175
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0022 0.0022
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0172 0.2674 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.006 0.0847 0.0734
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.006 0.0847 0.0734
Loa Loa (eye worm) hypothetical protein 0.0035 0.0448 0.0475
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0448 0.0303
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0627 0.0627
Entamoeba histolytica proteasome subunit beta type 3, putative 0.006 0.0847 0.0731
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0302 0.0316
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0335 0.0335
Schistosoma mansoni ferritin 0.0008 0.0005 0.0005
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.006 0.0847 0.0882
Brugia malayi beta-lactamase family protein 0.0035 0.0448 0.0448
Brugia malayi proteasome subunit alpha type 3 0.006 0.0847 0.0847
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0022 0.0018
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0167 0.0172
Toxoplasma gondii peptidase, T1 family protein 0.006 0.0847 0.0882
Schistosoma mansoni ap endonuclease 0.0018 0.017 0.017
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.006 0.0847 0.0734
Loa Loa (eye worm) hypothetical protein 0.0035 0.0448 0.0475
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0448 0.0475
Loa Loa (eye worm) hypothetical protein 0.0008 0.0017 0.0018
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0589 0.9425 1
Trypanosoma brucei proteasome alpha 7 subunit 0.006 0.0847 0.0734
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0302 0.0321
Brugia malayi Cytochrome P450 family protein 0.0054 0.0756 0.0756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0022 0.0023
Schistosoma mansoni hypothetical protein 0.0028 0.0335 0.0335
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0145 0.2233 0.2365
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0302 0.0321
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.006 0.0847 0.0731
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0022 0.0022
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0589 0.9425 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0167 0.0172
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.006 0.0847 0.0734
Giardia lamblia 20S proteasome alpha subunit 6 0.006 0.0847 0.0731
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0756 0.0802
Schistosoma mansoni dishevelled 0.0008 0.0017 0.0017
Echinococcus multilocularis 0.0018 0.0167 0.0167
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0167 0.0172
Loa Loa (eye worm) hypothetical protein 0.0137 0.2094 0.2222
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0335 0.0335
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.006 0.0847 0.0847
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0017 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0302 0.0146
Plasmodium vivax proteasome subunit beta type-5, putative 0.0589 0.9425 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0022 0.0022
Plasmodium vivax proteasome subunit beta type-1, putative 0.006 0.0847 0.0731
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.006 0.0847 0.0734
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0167 0.0172
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0589 0.9425 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0022 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0302 0.0146
Schistosoma mansoni ap endonuclease 0.0018 0.017 0.017
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0167 0.0172
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.006 0.0847 0.0731
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0022 0.0022
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.006 0.0847 0.0734
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0448 0.047
Entamoeba histolytica proteasome subunit beta type 1, putative 0.006 0.0847 0.0731
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.006 0.0847 0.0847
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.006 0.0847 0.0734
Leishmania major proteasome beta 2 subunit, putative 0.006 0.0847 0.0734
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0056 0.078 0.078
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.006 0.0847 0.0734
Plasmodium vivax proteasome subunit beta type-4, putative 0.006 0.0847 0.0731
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0167 0.0172
Echinococcus multilocularis GPCR, family 2 0.0028 0.0335 0.0335
Leishmania major hypothetical protein, conserved 0.0035 0.0448 0.0303
Schistosoma mansoni z-protein (S1r protein) 0.0008 0.0017 0.0017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0022 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.078 0.078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0022 0.0022
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.006 0.0847 0.0734
Plasmodium vivax proteasome subunit alpha type-5, putative 0.006 0.0847 0.0731
Echinococcus multilocularis expressed protein 0.0008 0.0005 0.0005
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0624 1 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0167 0.0172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.078 0.0822
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0627 0.0627
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.006 0.0847 0.0734
Giardia lamblia 20S proteasome alpha subunit 2 0.006 0.0847 0.0731
Echinococcus multilocularis Proteasome subunit alpha type 7 0.006 0.0847 0.0847
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.006 0.0847 0.0734
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0145 0.2233 0.2355
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0023
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.006 0.0847 0.0731
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0022 0.0022
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.006 0.0847 0.0734
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.017 0.0175
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0589 0.9425 1
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0008 0.0017 0.0017
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.006 0.0847 0.0893
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.006 0.0847 0.0731
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.006 0.0847 0.0734
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0022 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0022 0.0022
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0145 0.2233 0.2229
Leishmania major cytochrome p450-like protein 0.0026 0.0302 0.0146
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.017 0.017
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.006 0.0847 0.0882
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0627 0.0627
Loa Loa (eye worm) proteasome subunit beta type 3 0.006 0.0847 0.0898
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0448 0.047
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0167 0.0172
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0056 0.078 0.0822
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.006 0.0847 0.0847
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0448 0.0475
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0022 0.0018
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.006 0.0847 0.0847
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.006 0.0847 0.0893
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.006 0.0847 0.0734
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.017 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0167 0.0172
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0022 0.0022
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.006 0.0847 0.0847
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0022 0.0022
Echinococcus multilocularis ferritin 0.0008 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0022 0.0022
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.006 0.0847 0.0734
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0589 0.9425 0.9425
Echinococcus granulosus Proteasome subunit alpha beta 0.006 0.0847 0.0847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0022 0.0023
Echinococcus multilocularis Proteasome, subunit alpha beta 0.006 0.0847 0.0847
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0167 0.0172
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0145 0.2233 0.2231
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.006 0.0847 0.0893
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.006 0.0847 0.0847
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.006 0.0847 0.0893
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0167 0.0172
Echinococcus granulosus proteasome subunit beta type 6 0.006 0.0847 0.0847
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.006 0.0847 0.0731
Brugia malayi proteasome subunit alpha type 6 0.006 0.0847 0.0847
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.017 0.0003
Giardia lamblia Proteasome subunit beta type 3 0.006 0.0847 0.0731
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.006 0.0847 0.0734
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0145 0.2233 0.2229
Schistosoma mansoni ferritin 0.0008 0.0005 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.078 0.078
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.006 0.0847 0.0847
Brugia malayi proteasome subunit alpha type 2 0.006 0.0847 0.0847
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.006 0.0847 0.0734
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0589 0.9425 1
Echinococcus multilocularis subfamily T1A non peptidase ue 0.006 0.0847 0.0847
Schistosoma mansoni hypothetical protein 0.0061 0.0865 0.0865
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.078 0.0822
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.006 0.0847 0.0847
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0448 0.03
Brugia malayi beta-lactamase family protein 0.0035 0.0448 0.0448
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0627 0.0627
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0017 0.0017
Onchocerca volvulus 0.0035 0.0448 0.1621
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.017 0.017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0022 0.0022
Leishmania major proteasome alpha 2 subunit, putative 0.006 0.0847 0.0734
Echinococcus granulosus proteasome prosome macropain subunit beta 0.006 0.0847 0.0847
Toxoplasma gondii proteasome beta subunit 0.006 0.0847 0.0882
Onchocerca volvulus 0.0009 0.0022 0.0018
Leishmania major proteasome beta 3 subunit, putative 0.006 0.0847 0.0734
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.006 0.0847 0.0893
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0167 0.0172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0022 0.0022
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.006 0.0847 0.0731
Brugia malayi hypothetical protein 0.0008 0.0017 0.0017
Brugia malayi Cytochrome P450 family protein 0.0026 0.0302 0.0302
Giardia lamblia 20S proteasome alpha subunit 4 0.006 0.0847 0.0731
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.006 0.0847 0.0847
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0627 0.0627
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0167 0.0172
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.017 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0022 0.0023
Echinococcus multilocularis Proteasome subunit alpha type 7 0.006 0.0847 0.0847
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0589 0.9425 1
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0589 0.9425 1
Trypanosoma brucei proteasome beta-1 subunit, putative 0.006 0.0847 0.0734
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.006 0.0847 0.0847
Trypanosoma brucei proteasome beta 3 subunit, putative 0.006 0.0847 0.0734
Giardia lamblia 20S proteasome alpha subunit 3 0.006 0.0847 0.0731
Schistosoma mansoni dishevelled 0.0008 0.0017 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0167 0.0172
Plasmodium vivax proteasome subunit alpha type-4, putative 0.006 0.0847 0.0731
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0022 0.0022
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0022 0.0022
Trypanosoma brucei ATP-dependent protease subunit HslV 0.006 0.0847 0.0734
Schistosoma mansoni hypothetical protein 0.0018 0.0167 0.0167
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.006 0.0847 0.0893
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0022 0.0023
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.006 0.0847 0.0893
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.017 0.018
Echinococcus granulosus muscleblind protein 0.0137 0.2094 0.2094
Toxoplasma gondii proteasome subunit beta type, putative 0.0589 0.9425 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0022 0.0022
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.006 0.0847 0.0731
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0022 0.0022
Leishmania major proteasome beta 2 subunit, putative 0.0145 0.2233 0.2231
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0017 0.0017
Brugia malayi proteasome subunit alpha type 4 0.006 0.0847 0.0847
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0167 0.0172
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0017 0.0017
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0448 0.0448
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.006 0.0847 0.0731
Mycobacterium tuberculosis Conserved protein 0.0035 0.0448 0.047
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0089 0.1321 0.1401
Echinococcus multilocularis proteasome subunit beta type 6 0.006 0.0847 0.0847
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0145 0.2233 0.2369
Loa Loa (eye worm) proteasome subunit alpha type 1 0.006 0.0847 0.0898
Loa Loa (eye worm) beta-lactamase 0.0035 0.0448 0.0475
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.006 0.0847 0.0847
Plasmodium vivax proteasome subunit beta type-7, putative 0.0145 0.2233 0.2229
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.006 0.0847 0.0731
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0167 0.0172
Echinococcus granulosus subfamily T1A non peptidase ue 0.006 0.0847 0.0847
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0035 0.0448 0.047
Plasmodium vivax proteasome subunit alpha type-2, putative 0.006 0.0847 0.0731
Loa Loa (eye worm) hypothetical protein 0.0089 0.1321 0.1401
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.006 0.0847 0.0731
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0017 0.0017
Loa Loa (eye worm) proteasome subunit alpha type 3 0.006 0.0847 0.0898
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0167 0.0172
Toxoplasma gondii heat shock protein hslv, putative 0.006 0.0847 0.0882
Loa Loa (eye worm) hypothetical protein 0.0035 0.0448 0.0475
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0017 0.0017
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.006 0.0847 0.0847
Loa Loa (eye worm) DIX domain-containing protein 0.0008 0.0017 0.0018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0022 0.0022
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0167 0.0172
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.006 0.0847 0.0734
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.006 0.0847 0.0847
Echinococcus granulosus GPCR family 2 0.0028 0.0335 0.0335
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.006 0.0847 0.0898
Giardia lamblia 20S proteasome alpha subunit 7 0.006 0.0847 0.0731
Echinococcus granulosus proteasome subunit alpha type 6 0.006 0.0847 0.0847
Leishmania major proteasome alpha 1 subunit, putative 0.006 0.0847 0.0734
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.006 0.0847 0.0893
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.006 0.0847 0.0847
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.006 0.0847 0.0898
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0022 0.0022
Brugia malayi proteasome subunit beta type 3 0.006 0.0847 0.0847
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0335 0.0356
Echinococcus granulosus Proteasome subunit alpha type 7 0.006 0.0847 0.0847
Plasmodium falciparum proteasome subunit beta type-1, putative 0.006 0.0847 0.0731
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.017 0.0175
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0022 0.0022
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.006 0.0847 0.0734
Leishmania major proteasome beta-1 subunit, putative 0.006 0.0847 0.0734
Leishmania major proteasome alpha 1 subunit, putative 0.006 0.0847 0.0734
Loa Loa (eye worm) hypothetical protein 0.0035 0.0448 0.0475
Plasmodium falciparum proteasome subunit beta type-3, putative 0.006 0.0847 0.0731
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0167 0.0172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0022 0.0022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0022 0.0022
Onchocerca volvulus Notchless protein homolog 0.006 0.0847 0.3123
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.006 0.0847 0.0847
Plasmodium falciparum proteasome subunit beta type-2, putative 0.006 0.0847 0.0731
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0448 0.047
Plasmodium vivax proteasome subunit beta type-6, putative 0.006 0.0847 0.0731
Brugia malayi DIX domain containing protein 0.0008 0.0017 0.0017
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0017 0.0017
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0022 0.0023
Brugia malayi 20S proteasome alpha5 subunit 0.006 0.0847 0.0847
Plasmodium falciparum proteasome subunit beta type-4 0.006 0.0847 0.0731
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0167 0.0172
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0022 0.0022
Mycobacterium ulcerans proteasome PrcB 0.0589 0.9425 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0022 0.0022
Giardia lamblia 20S proteasome alpha subunit 5 0.006 0.0847 0.0731
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0167 0.0172
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0167 0.0172
Schistosoma mansoni hypothetical protein 0.0028 0.0335 0.0335
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.006 0.0847 0.0734
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.006 0.0847 0.0893
Echinococcus multilocularis proteasome subunit alpha type 6 0.006 0.0847 0.0847
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0167 0.0172

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 4 uM In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]-androstenedione and NADPH-generating system. ChEMBL. 3612685
EC50 (binding) = 4 uM In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]-androstenedione and NADPH-generating system. ChEMBL. 3612685

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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