Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.0143 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0143 | 0.5 | 0.5 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0143 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0143 | 0.5 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0143 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0143 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0143 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.2 | Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
IC50 (binding) | = 8.43 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
IC50 (binding) | = 0.0037 uM | Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees. | ChEMBL. | 11814774 |
IC50 (binding) | = 0.0037 uM | In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 9135032 |
IC50 (binding) | = 0.0037 uM | Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees. | ChEMBL. | 11814774 |
IC50 (binding) | = 0.0037 uM | In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 9135032 |
IC50 (binding) | = 6.33 uM | In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 9135032 |
IC50 (binding) | = 6.33 uM | In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 9135032 |
Ki (binding) | = 1.23 | Inhibitory constant against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
Ki (binding) | = 2.36 | Inhibitory constant against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
Ki (binding) | = 1.23 | Inhibitory constant against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
Ki (binding) | = 2.36 | Inhibitory constant against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
Log IC50 (binding) | = 5.2 | Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
Log IC50 (binding) | = 8.43 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
Selectivity (binding) | = 3.23 | Selectivity as log (IC50[COX-1]/IC50[COX-2]). | ChEMBL. | 12383007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.