Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0149 | 0.1728 | 0.1717 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0079 | 0.0797 | 0.0812 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0101 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0699 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1728 | 0.1728 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Brugia malayi | ecdysone receptor | 0.007 | 0.0685 | 0.0672 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.007 | 0.0685 | 0.0685 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0077 | 0.0774 | 0.0788 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0149 | 0.1728 | 0.1778 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0149 | 0.1728 | 0.2719 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0013 | 0.0013 |
Echinococcus granulosus | jun protein | 0.0088 | 0.0917 | 0.0937 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.007 | 0.0685 | 0.1242 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.007 | 0.0685 | 0.0672 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.007 | 0.0685 | 0.0696 |
Echinococcus granulosus | tumor protein p63 | 0.0745 | 0.9655 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1728 | 0.1728 |
Onchocerca volvulus | 0.0053 | 0.046 | 0.0674 | |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0721 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0149 | 0.1728 | 0.1778 |
Brugia malayi | nuclear receptor NHR-67 | 0.007 | 0.0685 | 0.0672 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0149 | 0.1728 | 0.1717 |
Onchocerca volvulus | 0.0109 | 0.1203 | 0.1871 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0149 | 0.1728 | 0.1778 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.0042 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0101 | 0.0101 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0257 | 0.3173 | 0.3276 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0022 | 0.0042 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.007 | 0.0685 | 0.0696 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0022 | 0.0042 | 0.0029 |
Brugia malayi | hypothetical protein | 0.0261 | 0.3218 | 0.3209 |
Brugia malayi | steroid hormone receptor | 0.0149 | 0.1728 | 0.1717 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0042 | 0.0052 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.007 | 0.0685 | 0.0696 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.1247 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0014 | 0.0371 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0088 | 0.0917 | 0.0937 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0014 | 0.0014 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0022 | 0.0042 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0149 | 0.1728 | 0.2719 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0797 | 0.0784 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0112 | 0.1247 | 0.1278 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0061 | 0.0562 | 0.0569 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0014 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0042 | 0.0042 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0149 | 0.1728 | 0.3173 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0643 | 0.1164 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.007 | 0.0685 | 0.0696 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0721 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0426 | 0.5418 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.007 | 0.0685 | 0.1242 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0149 | 0.1728 | 0.3173 |
Schistosoma mansoni | rab6-interacting | 0.0022 | 0.0042 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0042 | 0.0042 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.007 | 0.0685 | 0.1037 |
Echinococcus multilocularis | jun protein | 0.0088 | 0.0917 | 0.0937 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.007 | 0.0685 | 0.0672 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0101 | 0.0704 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0149 | 0.1728 | 0.1778 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1728 | 0.1728 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0209 | 0.0195 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0101 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.007 | 0.0685 | 0.0696 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0149 | 0.1728 | 0.1717 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0079 | 0.0797 | 0.0797 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0101 | 0.1227 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0149 | 0.1728 | 0.1728 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0149 | 0.1728 | 0.1717 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0149 | 0.1728 | 0.1717 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.0643 | 0.0652 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0149 | 0.1728 | 0.1717 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0014 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.01 | 0.0086 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0149 | 0.1728 | 0.1717 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0149 | 0.1728 | 0.1717 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Echinococcus granulosus | FTZ F1 alpha | 0.0149 | 0.1728 | 0.1778 |
Brugia malayi | nuclear receptor RXR | 0.007 | 0.0685 | 0.0672 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.01 | 0.01 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.042 | 0.0407 |
Loa Loa (eye worm) | runx1 | 0.0061 | 0.0568 | 0.0568 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0278 | 0.3443 | 0.3556 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.046 | 0.0825 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0013 | 0.5 |
Onchocerca volvulus | 0.0488 | 0.6243 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0797 | 0.0797 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0149 | 0.1728 | 0.1728 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0149 | 0.1728 | 0.1728 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.01 | 0.1208 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0077 | 0.0774 | 0.0788 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0149 | 0.1728 | 0.1717 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0261 | 0.3218 | 0.3323 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0278 | 0.3443 | 0.3556 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0013 | 0.0013 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0014 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0261 | 0.3218 | 0.3323 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0426 | 0.5418 | 0.5605 |
Echinococcus multilocularis | tumor protein p63 | 0.0745 | 0.9655 | 1 |
Onchocerca volvulus | 0.0149 | 0.1728 | 0.2719 | |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1728 | 0.1728 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0149 | 0.1728 | 0.2719 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0101 | 0.1227 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.01 | 0.1208 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | doublecortin family protein | 0.0022 | 0.0042 | 0.0042 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.2236 | 0.4112 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0149 | 0.1728 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0209 | 0.0361 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0149 | 0.1728 | 0.1717 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0149 | 0.1728 | 0.1728 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.007 | 0.0685 | 0.1037 |
Schistosoma mansoni | jun-related protein | 0.0071 | 0.0699 | 0.1268 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0179 | 0.213 | 0.2194 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0149 | 0.1728 | 0.1778 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0643 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0885 | 0.0885 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.01 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0079 | 0.0797 | 0.0812 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0149 | 0.1728 | 0.1717 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0101 | 0.1227 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0721 | 0.1308 |
Schistosoma mansoni | nuclear receptor | 0.007 | 0.0685 | 0.1242 |
Echinococcus multilocularis | geminin | 0.0187 | 0.2236 | 0.2305 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0101 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 0.6243 | 0.6243 |
Schistosoma mansoni | thyroid hormone receptor | 0.0426 | 0.5418 | 1 |
Onchocerca volvulus | 0.0069 | 0.0667 | 0.1008 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0643 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0112 | 0.1247 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0101 | 0.0101 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0149 | 0.1728 | 0.1778 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1203 | 0.1203 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0149 | 0.1728 | 0.1717 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0101 | 0.1394 |
Schistosoma mansoni | hypothetical protein | 0.0278 | 0.3443 | 0.6345 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.007 | 0.0685 | 0.0696 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.0042 | 0.0029 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0149 | 0.1728 | 0.1728 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0149 | 0.1728 | 0.1778 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0101 | 0.1394 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0149 | 0.1728 | 0.3173 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0643 | 0.1164 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.1247 | 0.2281 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.007 | 0.0685 | 0.0696 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.3218 | 0.3218 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0014 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0101 | 0.0704 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0061 | 0.0562 | 0.0569 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0721 | 0.0733 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0079 | 0.0797 | 0.1449 |
Brugia malayi | hypothetical protein | 0.0069 | 0.0667 | 0.0654 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0073 | 0.0721 | 0.5732 |
Brugia malayi | nuclear receptor NHR-88 | 0.0149 | 0.1728 | 0.1717 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0149 | 0.1728 | 0.3173 |
Schistosoma mansoni | zinc finger protein | 0.007 | 0.0685 | 0.1242 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0149 | 0.1728 | 0.1728 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0101 | 0.0087 |
Onchocerca volvulus | 0.0026 | 0.0101 | 0.0094 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0149 | 0.1728 | 0.1717 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0101 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.0313 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.2236 | 0.4112 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.007 | 0.0685 | 0.0696 |
Echinococcus multilocularis | Protein lozenge | 0.0061 | 0.0568 | 0.0574 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0042 | 0.0028 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.01 | 0.1372 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.007 | 0.0685 | 0.1242 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.1247 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0149 | 0.1728 | 0.1728 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0088 | 0.0917 | 0.0937 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.0313 | 0.031 |
Brugia malayi | Doublecortin family protein | 0.0022 | 0.0042 | 0.0028 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0014 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1728 | 0.1728 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0073 | 0.0721 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0013 | 0.0013 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0109 | 0.1203 | 0.22 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0149 | 0.1728 | 0.1778 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0149 | 0.1728 | 0.1717 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0149 | 0.1728 | 0.1778 |
Schistosoma mansoni | nuclear hormone receptor | 0.007 | 0.0685 | 0.1242 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0149 | 0.1728 | 0.1778 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.007 | 0.0685 | 0.0672 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0721 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0771 | 1 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0721 | 0.0733 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0101 | 0.1394 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0149 | 0.1728 | 0.1778 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0149 | 0.1728 | 0.3173 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.007 | 0.0685 | 0.0696 |
Brugia malayi | bZIP transcription factor family protein | 0.0088 | 0.0917 | 0.0904 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.042 | 0.042 |
Onchocerca volvulus | 0.007 | 0.0685 | 0.1037 | |
Brugia malayi | conserved hypotetical protein | 0.007 | 0.0685 | 0.0672 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0079 | 0.0797 | 0.0784 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0101 | 0.1394 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.1247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0209 | 0.0209 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0014 | 0.5 |
Brugia malayi | hypothetical protein | 0.007 | 0.0685 | 0.0672 |
Schistosoma mansoni | lipoxygenase | 0.0061 | 0.0562 | 0.1015 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.007 | 0.0685 | 0.0672 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.007 | 0.0685 | 0.0696 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.042 | 0.042 |
Brugia malayi | Nuclear hormone receptor E75 | 0.007 | 0.0685 | 0.0672 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0797 | 0.0797 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0149 | 0.1728 | 0.1717 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0149 | 0.1728 | 0.1778 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0079 | 0.0797 | 0.1449 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0014 | 0.0017 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.046 | 0.0447 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.0643 | 0.0652 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.01 | 0.01 |
Brugia malayi | hypothetical protein | 0.0112 | 0.1247 | 0.1234 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0149 | 0.1728 | 0.3173 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1728 | 0.1728 |
Schistosoma mansoni | nuclear receptor | 0.007 | 0.0685 | 0.1242 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0257 | 0.3173 | 0.5846 |
Brugia malayi | ecdysteroid receptor | 0.0149 | 0.1728 | 0.1717 |
Brugia malayi | nuclear hormone receptor | 0.0149 | 0.1728 | 0.1717 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.007 | 0.0685 | 0.0696 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0101 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Brugia malayi | nuclear receptor NHR-88 | 0.007 | 0.0685 | 0.0672 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1728 | 0.1728 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0073 | 0.0721 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0112 | 0.1247 | 0.2281 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.01 | 0.1208 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0101 | 0.1394 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0101 | 0.1394 |
Brugia malayi | nuclear hormone receptor | 0.007 | 0.0685 | 0.0672 |
Brugia malayi | hypothetical protein | 0.007 | 0.0685 | 0.0672 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1728 | 0.1728 |
Schistosoma mansoni | polycystin 1-related | 0.0022 | 0.0042 | 0.0052 |
Schistosoma mansoni | nuclear hormone receptor | 0.0149 | 0.1728 | 0.3173 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0022 | 0.0042 | 0.0029 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.0042 | 0.0029 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0149 | 0.1728 | 0.1728 |
Schistosoma mansoni | rab6-interacting | 0.0022 | 0.0042 | 0.0052 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0149 | 0.1728 | 0.1778 |
Onchocerca volvulus | 0.007 | 0.0685 | 0.1037 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0101 | 0.1394 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.007 | 0.0685 | 0.0685 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0101 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0797 | 0.0797 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0797 | 0.0784 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0149 | 0.1728 | 0.3173 |
Schistosoma mansoni | coup transcription factor | 0.0149 | 0.1728 | 0.3173 |
Echinococcus granulosus | geminin | 0.0187 | 0.2236 | 0.2305 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.0042 | 0.0029 |
Echinococcus granulosus | RUN | 0.0022 | 0.0042 | 0.0029 |
Loa Loa (eye worm) | DR-78 | 0.007 | 0.0685 | 0.0685 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0685 | 0.0685 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0149 | 0.1728 | 0.1778 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0079 | 0.0797 | 0.0784 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0101 | 0.0704 |
Brugia malayi | nuclear receptor RXR | 0.0079 | 0.0797 | 0.0784 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0042 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0797 | 0.0797 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.0643 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.007 | 0.0685 | 0.0672 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0643 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.042 | 0.0407 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.0643 | 0.8903 |
Brugia malayi | tailless protein | 0.007 | 0.0685 | 0.0672 |
Schistosoma mansoni | lozenge | 0.0061 | 0.0568 | 0.1024 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.1247 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0022 | 0.0042 | 0.0052 |
Schistosoma mansoni | loxhd1 | 0.0022 | 0.0042 | 0.0052 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0797 | 0.0797 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.0643 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 0.6243 | 0.6243 |
Brugia malayi | hypothetical protein | 0.0488 | 0.6243 | 0.6238 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0101 | 0.1394 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.007 | 0.0685 | 0.0685 |
Schistosoma mansoni | nuclear hormone receptor | 0.007 | 0.0685 | 0.1242 |
Echinococcus multilocularis | RUN | 0.0022 | 0.0042 | 0.0029 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0149 | 0.1728 | 0.1717 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.01 | 0.1208 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.01 | 0.01 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.046 | 0.0825 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0149 | 0.1728 | 0.1778 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 21 | Reduction in paw swelling at 100 mg/kg po dose in rat using adjuvant arthritis test. | ChEMBL. | 6620297 |
Relative potency (functional) | ND 0 | Potency relative to [2-(2,4-Dichloro-phenoxy)-phenyl]-acetic acid in rat adjuvant arthritis test;ND means no data. | ChEMBL. | 6620297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.