Detailed information for compound 367934

Basic information

Technical information
  • TDR Targets ID: 367934
  • Name: 2-hydroxy-4-[5-(6-sulfanylidene-3H-purin-9-yl )pentanoylamino]benzoic acid
  • MW: 387.413 | Formula: C17H17N5O4S
  • H donors: 3 H acceptors: 7 LogP: 1.71 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(c(c1)O)C(=O)O)CCCCn1cnc2c1ncnc2S
  • InChi: 1S/C17H17N5O4S/c23-12-7-10(4-5-11(12)17(25)26)21-13(24)3-1-2-6-22-9-20-14-15(22)18-8-19-16(14)27/h4-5,7-9,23H,1-3,6H2,(H,21,24)(H,25,26)(H,18,19,27)
  • InChiKey: VBWYJYHALYDELZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-hydroxy-4-[5-(6-thioxo-3H-purin-9-yl)pentanoylamino]benzoic acid
  • 2-hydroxy-4-[[1-oxo-5-(6-thioxo-3H-purin-9-yl)pentyl]amino]benzoic acid
  • 3275-78-3
  • NCIOpen2_009766
  • NSC89820

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0004 0.0004
Leishmania major DNA polymerase eta, putative 0.0038 0.0013 0.0013
Mycobacterium ulcerans phosphoribosylaminoimidazole synthetase 0.0035 0.001 0.0006
Brugia malayi dihydrofolate reductase family protein 0.052 0.0514 0.0524
Echinococcus multilocularis snurportin 1 0.0372 0.036 0.0367
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT 0.016 0.014 0.0132
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0018 0.0018
Mycobacterium ulcerans phosphoribosylamine--glycine ligase 0.016 0.014 0.0138
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.052 0.0514 0.052
Leishmania major DNA polymerase eta, putative 0.0054 0.003 0.003
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0004 0.0004
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.9645 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.024 0.024
Brugia malayi Bromodomain containing protein 0.0035 0.001 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.003 0.003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0093 0.0095
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.024 0.024
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0004 0.0009
Echinococcus multilocularis thymidylate synthase 0.9447 0.9793 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.9645 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0049 0.005
Brugia malayi RNA, U transporter 1 0.0099 0.0076 0.0078
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.052 0.0514 0.052
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0013 0.0013
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.001 0.001
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0069 0.007
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.001 0.001
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0004 0.0004
Echinococcus multilocularis peregrin 0.0035 0.001 0.001
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.001 0.001
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0018 0.0018
Mycobacterium tuberculosis Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) 0.0035 0.001 0.0006
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0013 0.0013
Echinococcus multilocularis dna polymerase eta 0.0054 0.003 0.003
Echinococcus granulosus snurportin 1 0.0372 0.036 0.0367
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.9447 0.9793 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0036 0.0037
Schistosoma mansoni hypothetical protein 0.0372 0.036 0.0367
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0018 0.0018
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Echinococcus granulosus dna polymerase eta 0.0054 0.003 0.003
Brugia malayi jmjC domain containing protein 0.0043 0.0018 0.0018
Echinococcus granulosus dihydrofolate reductase 0.052 0.0514 0.0524
Schistosoma mansoni dihydrofolate reductase 0.052 0.0514 0.0524
Plasmodium falciparum phd finger protein, putative 0.0035 0.001 0.001
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.9645 1 1
Brugia malayi hypothetical protein 0.4494 0.4645 0.4743
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.024 0.024
Brugia malayi jmjC domain containing protein 0.0115 0.0093 0.0095
Leishmania major hypothetical protein, conserved 0.0257 0.024 0.024
Loa Loa (eye worm) thymidylate synthase 0.9447 0.9793 1
Onchocerca volvulus 0.0035 0.001 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0035 0.001 0.001
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.9447 0.9793 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.9645 1 1
Echinococcus granulosus peregrin 0.0035 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.001 0.001
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0024 0.0025
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase 0.016 0.014 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0018 0.0018
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.4494 0.4645 0.4645
Brugia malayi thymidylate synthase 0.9447 0.9793 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0093 0.0095
Loa Loa (eye worm) dihydrofolate reductase 0.052 0.0514 0.0524
Brugia malayi PHD-finger family protein 0.0035 0.001 0.001
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.003 0.003
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.003 0.003
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0054 0.003 0.003
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0004 0.0004
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.9447 0.9793 1
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0004 0.0004
Mycobacterium ulcerans thymidylate synthase 0.9447 0.9793 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0018 0.0018
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.9645 1 1
Brugia malayi Dihydrofolate reductase 0.052 0.0514 0.0524
Onchocerca volvulus 0.9447 0.9793 1
Chlamydia trachomatis dihydrofolate reductase 0.052 0.0514 0.5
Echinococcus granulosus thymidylate synthase 0.9447 0.9793 1
Onchocerca volvulus Alhambra homolog 0.0035 0.001 0.0008
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0024 0.0025
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.052 0.0514 0.0515
Echinococcus multilocularis dihydrofolate reductase 0.052 0.0514 0.0524
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.036 0.0367
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.001 0.001
Entamoeba histolytica Ran family GTPase 0.0026 0 0.5
Mycobacterium tuberculosis Hypothetical protein 0.4494 0.4645 0.4741
Trichomonas vaginalis conserved hypothetical protein 0.4494 0.4645 1
Schistosoma mansoni DNA polymerase eta 0.0054 0.003 0.003
Giardia lamblia PHD finger protein 15 0.0035 0.001 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % Cytotoxicity against human HEY cell line at 20 uM by MTT assay ChEMBL. 16854058
Inhibition (functional) = 0 % Cytotoxicity against human HEY cell line at 20 uM by MTT assay ChEMBL. 16854058
Inhibition (functional) = 1 % Cytotoxicity against human MCF7 cell line at 20 uM by MTT assay ChEMBL. 16854058
Inhibition (functional) = 1 % Cytotoxicity against human MDA-MB-435 cell line at 20 uM by MTT assay ChEMBL. 16854058
Inhibition (functional) = 1 % Cytotoxicity against human MCF7 cell line at 20 uM by MTT assay ChEMBL. 16854058
Inhibition (functional) = 1 % Cytotoxicity against human MDA-MB-435 cell line at 20 uM by MTT assay ChEMBL. 16854058
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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