Detailed information for compound 367966

Basic information

Technical information
  • TDR Targets ID: 367966
  • Name: 3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2 ,3-benzoxazin-6-yl)-2-[(1-propan-2-yl-3,4-dih ydro-2H-naphthalen-1-yl)methyl]propanamide
  • MW: 488.499 | Formula: C26H27F3N2O4
  • H donors: 2 H acceptors: 3 LogP: 5.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C(F)(F)F)(CC1(CCCc2c1cccc2)C(C)C)O)Nc1ccc2c(c1)c(C)noc2=O
  • InChi: 1S/C26H27F3N2O4/c1-15(2)24(12-6-8-17-7-4-5-9-21(17)24)14-25(34,26(27,28)29)23(33)30-18-10-11-19-20(13-18)16(3)31-35-22(19)32/h4-5,7,9-11,13,15,34H,6,8,12,14H2,1-3H3,(H,30,33)
  • InChiKey: FBPWULIEFJXVSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,3,3-trifluoro-2-hydroxy-2-[(1-isopropyltetralin-1-yl)methyl]-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
  • 3,3,3-trifluoro-2-hydroxy-2-[(1-isopropyl-1-tetralinyl)methyl]-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
  • 3,3,3-trifluoro-2-hydroxy-2-[(1-isopropyltetralin-1-yl)methyl]-N-(1-keto-4-methyl-2,3-benzoxazin-6-yl)propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus metabotropic glutamate receptor 5 0.0041 0.0209 0.0187
Schistosoma mansoni hypothetical protein 0.0413 0.3324 0.3324
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0023 0.0023
Schistosoma mansoni ran 0.0021 0.0038 0.0038
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0112 0.0214
Echinococcus multilocularis serotonin receptor 0.1208 1 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.003 0.0118 0.0118
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0082 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0038
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0299 0.0757
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0883 0.7273 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1208 1 1
Schistosoma mansoni metabotropic glutamate receptor 0.0028 0.0099 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0605 0.4935 0.4935
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0605 0.4935 0.4924
Giardia lamblia GTOR 0.009 0.0618 0.1683
Onchocerca volvulus 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0112 0.0214
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0618 0.0597
Brugia malayi Serotonin receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.1933 0.1914
Echinococcus granulosus tissue type plasminogen activator 0.0029 0.0102 0.0079
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0112 0.0089
Echinococcus granulosus peptide allatostatin:somatostatin 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1208 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1208 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0159 0.1193 0.1173
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0293 0.0293
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0144 0.0121
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0023 0.0023
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0129 0.0106
Schistosoma mansoni hypothetical protein 0.0051 0.0293 0.0293
Echinococcus granulosus tm gpcr rhodopsin 0.1208 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1208 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0549 0.1483
Echinococcus multilocularis orexin receptor type 2 0.1208 1 1
Echinococcus multilocularis histone deacetylase 8 0.0159 0.1193 0.1173
Plasmodium vivax histone deacetylase, putative 0.0274 0.2161 0.6161
Loa Loa (eye worm) hypothetical protein 0.0182 0.1394 0.1374
Schistosoma mansoni hypothetical protein 0.0051 0.0293 0.0293
Entamoeba histolytica hypothetical protein 0.0057 0.0345 0.089
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1208 1 1
Echinococcus multilocularis alkaline phosphatase 0.0179 0.1367 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0429 0.3464 0.9938
Echinococcus granulosus serine protein kinase ATM 0.0057 0.0345 0.0323
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0089
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0179 0.1367 0.1347
Schistosoma mansoni neuropeptide receptor 0.1208 1 1
Schistosoma mansoni opsin-like receptor 0.1208 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0399 0.3214 0.9215
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Onchocerca volvulus 0.003 0.0112 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0112 0.0089
Brugia malayi hypothetical protein 0.1208 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0618 0.0618
Loa Loa (eye worm) histone deacetylase 1 0.0432 0.3485 0.347
Echinococcus multilocularis tissue type plasminogen activator 0.0029 0.0102 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.1208 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.3324 0.3309
Echinococcus multilocularis neuropeptide receptor 0.1208 1 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0159 0.1193 0.1193
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0846 0.0825
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Brugia malayi ecdysteroid receptor 0.0019 0.0023 0.0023
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0432 0.3485 1
Echinococcus granulosus allatostatin A receptor 0.1208 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.1208 1 1
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0023 0.0023
Echinococcus multilocularis neuropeptide Y receptor 0.1208 1 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.1088 0.8991 0.8988
Leishmania major histone deacetylase, putative 0.0432 0.3485 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.003 0.0112 0.0214
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.003 0.0112 0.0214
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.003 0.0112 0.0214
Echinococcus granulosus G protein coupled receptor 139 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.051 0.4141 0.4127
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus multilocularis neuropeptide FF receptor 2 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Entamoeba histolytica histone deacetylase, putative 0.0432 0.3485 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus g protein coupled receptor 0.1208 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0147 0.1095 0.3068
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0432 0.3485 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0293 0.0271
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.205 0.2031
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0147 0.1095 0.1095
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0062 0.0385 0.1007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0293 0.0271
Echinococcus multilocularis GPCR, family 2 0.0051 0.0293 0.0271
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0388 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Echinococcus multilocularis Zinc finger, PHD finger 0.0082 0.0549 0.0528
Echinococcus granulosus intermediate filament protein 0.003 0.0112 0.0089
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0147 0.1095 0.3068
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1208 1 1
Brugia malayi putative neuropeptide receptor 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.003 0.0112 0.0112
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0059 0.0035
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0147 0.1095 0.3068
Echinococcus multilocularis fmrfamide receptor 0.1208 1 1
Echinococcus granulosus neuropeptide receptor 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.1208 1 1
Onchocerca volvulus 0.0029 0.0106 0.0083
Mycobacterium tuberculosis Conserved protein 0.0038 0.0178 0.0092
Schistosoma mansoni biogenic amine (5HT) receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0102 0.0079
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1208 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1208 1 1
Echinococcus multilocularis g protein coupled receptor 0.1208 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0015
Trypanosoma cruzi histone deacetylase, putative 0.0159 0.1193 0.3352
Schistosoma mansoni hypothetical protein 0.1208 1 1
Echinococcus granulosus neuropeptides capa receptor 0.1208 1 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0618 0.1683
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0082 0.0549 0.0549
Trypanosoma brucei histone deacetylase 1 0.0432 0.3485 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0326 0.2599 0.2582
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.0073
Echinococcus granulosus S formylglutathione hydrolase 0.0038 0.0178 0.0155
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Loa Loa (eye worm) intermediate filament protein 0.003 0.0112 0.0089
Echinococcus granulosus muscleblind protein 0.0147 0.1097 0.1077
Loa Loa (eye worm) phosphatidylinositol 3 0.054 0.4389 0.4376
Onchocerca volvulus 0.1208 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0147 0.1095 0.3068
Echinococcus multilocularis neuropeptide s receptor 0.1208 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0144 0.0307
Schistosoma mansoni hypothetical protein 0.0303 0.2407 0.2407
Toxoplasma gondii histone deacetylase HDAC2 0.0432 0.3485 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.003 0.0112 0.0214
Brugia malayi hypothetical protein 0.1208 1 1
Brugia malayi AKH receptor 0.1208 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0429 0.3464 0.3464
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0112 0.0112
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1208 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0023 0.0023
Toxoplasma gondii histone deacetylase HDAC4 0.0159 0.1193 0.3352
Onchocerca volvulus 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0618 0.0618
Onchocerca volvulus 0.1208 1 1
Echinococcus multilocularis lamin 0.003 0.0112 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0385 0.1007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0038 0.0015
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0023 0.0023
Leishmania major histone deacetylase, putative 0.0432 0.3485 1
Brugia malayi hypothetical protein 0.0034 0.0144 0.0144
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0247 0.1933 0.1914
Schistosoma mansoni amine GPCR 0.1208 1 1
Brugia malayi sulfakinin receptor protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0057 0.0345 0.089
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0329 0.2626 0.7509
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1208 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.1208 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.009 0.0618 0.1683
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0429 0.3464 0.9938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Schistosoma mansoni histone deacetylase 4 5 0.0274 0.2161 0.2161
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0147 0.1095 0.3068
Brugia malayi G protein-coupled receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Echinococcus granulosus histone deacetylase 6 0.0274 0.2161 0.2143
Loa Loa (eye worm) esterase D 0.0038 0.0178 0.0155
Brugia malayi Histone deacetylase 1 0.0432 0.3485 0.3485
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Schistosoma mansoni histamine h1 receptor 0.1208 1 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0326 0.2599 0.2582
Echinococcus multilocularis g protein coupled receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0299 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0096 0.0167
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1208 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0147 0.1095 0.1095
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0112 0.0214
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0333 0.0856
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0095 0.0658 0.1799
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.016 0.0354
Schistosoma mansoni opsin-like receptor 0.1208 1 1
Schistosoma mansoni neuropeptide receptor 0.1208 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0247 0.1933 0.1914
Echinococcus granulosus metabotropic glutamate receptor 2 0.0028 0.0099 0.0076
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Echinococcus multilocularis somatostatin receptor 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Echinococcus granulosus histone deacetylase 3 0.0432 0.3485 0.347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.003 0.0112 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0112 0.0214
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1088 0.8991 0.8988
Schistosoma mansoni histone deacetylase 0.0432 0.3485 0.3485
Plasmodium falciparum histone deacetylase, putative 0.0274 0.2161 0.6161
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.003 0.0112 0.0214
Echinococcus granulosus neuropeptide FF receptor 2 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Leishmania major phosphatidylinositol 3-kinase, putative 0.009 0.0618 0.1683
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0793 0.0793
Echinococcus multilocularis neuropeptides capa receptor 0.1208 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.1208 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.205 0.2031
Trypanosoma brucei histone deacetylase, putative 0.0274 0.2161 0.6161
Echinococcus granulosus hypothetical protein 0.1208 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.1208 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0023 0.0023
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0082 0.0549 0.1483
Brugia malayi ORL1-like opioid receptor 0.1208 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1208 1 1
Brugia malayi Dopamine receptor 0.1208 1 1
Echinococcus granulosus dnaJ subfamily B 0.0413 0.3324 0.3309
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus neuropeptide receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0089
Schistosoma mansoni coup transcription factor 0.0019 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0102 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus GPCR family 2 0.0051 0.0293 0.0271
Schistosoma mansoni survival motor neuron protein 0.0053 0.0309 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0385 0.1007
Echinococcus granulosus histone deacetylase 8 0.0159 0.1193 0.1173
Toxoplasma gondii histone deacetylase HDAC3 0.0432 0.3485 1
Brugia malayi G-protein coupled receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0112 0.0089
Schistosoma mansoni biogenic amine (5HT) receptor 0.1208 1 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0057 0.0345 0.089
Echinococcus granulosus lamin dm0 0.003 0.0112 0.0089
Brugia malayi neuropeptide F receptor 0.1208 1 1
Echinococcus granulosus orexin receptor type 2 0.1208 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0182 0.1387 0.3913
Loa Loa (eye worm) histone deacetylase 3 0.0432 0.3485 0.347
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus g protein coupled receptor 0.1208 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0082 0.0549 0.1483
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.003 0.0112 0.0089
Entamoeba histolytica protein kinase rad3, putative 0.0057 0.0345 0.089
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1208 1 1
Schistosoma mansoni amine GPCR 0.1208 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1208 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0293 0.0271
Echinococcus multilocularis neuropeptides capa receptor 0.1208 1 1
Loa Loa (eye worm) histone deacetylase 11 0.0159 0.1193 0.1173
Echinococcus multilocularis neuropeptide Y receptor 0.1208 1 1
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0023 0.0023
Echinococcus granulosus histone deacetylase 0.0274 0.2161 0.2143
Brugia malayi hypothetical protein 0.1208 1 1
Echinococcus multilocularis histone deacetylase 7 0.0274 0.2161 0.2143
Echinococcus multilocularis muscleblind protein 0.0147 0.1097 0.1077
Echinococcus multilocularis 0.003 0.0112 0.0089
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0101 0.0183
Brugia malayi Histone deacetylase family protein 0.0274 0.2161 0.2161
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0057 0.0345 0.0345
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1208 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0029 0.0102 0.0079
Plasmodium vivax histone deacetylase 2, putative 0.0274 0.2161 0.6161
Schistosoma mansoni hypothetical protein 0.1208 1 1
Brugia malayi neuropeptide F receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0274 0.2161 0.6161
Brugia malayi Dopamine receptor protein 2 0.1208 1 1
Giardia lamblia Hypothetical protein 0.003 0.0112 0.0214
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.016 0.0137
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0144 0.0121
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.003 0.0112 0.0112
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0429 0.3464 0.9938
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0023 0.0023
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0429 0.3464 0.9938
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0147 0.1095 0.3068
Schistosoma mansoni histone deacetylase hda2 0.0159 0.1193 0.1193
Schistosoma mansoni amine GPCR 0.1208 1 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0057 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.0364 0.2917 0.8354
Loa Loa (eye worm) hypothetical protein 0.0051 0.0293 0.0271
Echinococcus multilocularis sex peptide receptor 0.1208 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0023 0.0023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.1223 0.1203
Brugia malayi Histone deacetylase family protein 0.0274 0.2161 0.2161
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0112 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0247 0.1933 0.1933
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Plasmodium vivax hypothetical protein, conserved 0.003 0.0112 0.0214
Brugia malayi G-protein coupled receptor 0.1208 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0056 0.0052
Schistosoma mansoni hypothetical protein 0.0035 0.016 0.016
Leishmania major hypothetical protein, conserved 0.0029 0.0102 0.0186
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0432 0.3485 1
Loa Loa (eye worm) G-protein coupled receptor 0.1208 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.1223 0.1223
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0023 0.0023
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0549 0.1483
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0144 0.0144
Brugia malayi histone deacetylase 11 0.0159 0.1193 0.1193
Echinococcus multilocularis serotonin receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0136 0.0136
Loa Loa (eye worm) neuropeptide F receptor 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1097 0.1077
Echinococcus multilocularis G-protein coupled receptor, putative 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1208 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Echinococcus granulosus histone deacetylase 1 0.0432 0.3485 0.347
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.009 0.0618 0.1683
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0023 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0299 0.0757
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0112 0.0214
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0618 0.1683
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) histone deacetylase 0.0274 0.2161 0.2143
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0028 0.0099 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0023 0.0023
Brugia malayi intermediate filament protein 0.003 0.0112 0.0112
Trypanosoma cruzi histone deacetylase, putative 0.0274 0.2161 0.6161
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0082 0.0549 0.0549
Echinococcus granulosus importin subunit beta 1 0.0028 0.0101 0.0078
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0549 0.1483
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0056 0.0052
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.009 0.0618 0.1683
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0299 0.0757
Loa Loa (eye worm) hypothetical protein 0.0122 0.0884 0.0863
Schistosoma mansoni amine GPCR 0.1208 1 1
Onchocerca volvulus 0.0034 0.0144 0.0121
Mycobacterium tuberculosis Probable conserved exported protein 0.0038 0.0178 0.0092
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0883 0.7273 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0618 0.1683
Toxoplasma gondii histone deacetylase HDAC1 0.0274 0.2161 0.6161
Echinococcus granulosus histone deacetylase 6 0.0274 0.2161 0.2143
Brugia malayi Pre-SET motif family protein 0.023 0.1793 0.1793
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0033 0.0136 0.0113
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0057 0.0345 0.089
Brugia malayi Serotonin receptor 0.1208 1 1
Schistosoma mansoni ran 0.0021 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0429 0.3464 0.9938
Loa Loa (eye worm) neuropeptide F receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0112 0.0089
Leishmania major phosphatidylinositol kinase, putative 0.003 0.0112 0.0214
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0618 0.0597
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Echinococcus multilocularis serine protein kinase ATM 0.0057 0.0345 0.0323
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0147 0.1095 0.3068
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.009 0.0618 0.0597
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.051 0.4141 0.4141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0096 0.0167
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0299 0.0757
Trypanosoma cruzi histone deacetylase 1, putative 0.0432 0.3485 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.0147 0.1097 0.1077
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0023 0.0023
Echinococcus granulosus 7tm_1 domain containing protein 0.1208 1 1
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0038 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0111 0.0793 0.0771
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.0147 0.1097 0.1077
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1208 1 1
Loa Loa (eye worm) glutamate receptor 0.0034 0.0144 0.0121
Brugia malayi Tachykinin-like peptides receptor 99D 0.1208 1 1
Leishmania major hypothetical protein, conserved 0.0052 0.0299 0.0757
Schistosoma mansoni histone deacetylase hda2 0.028 0.2215 0.2215
Echinococcus multilocularis neuropeptide receptor A26 0.1208 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.1208 1 1
Brugia malayi Melatonin receptor type 1A 0.1208 1 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0432 0.3485 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Leishmania major phosphatidylinositol 3-kinase, putative 0.0082 0.0549 0.1483
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0038 0.0178 0.0092
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0106 0.0083
Echinococcus multilocularis cpg binding protein 0.0031 0.012 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0144 0.0144
Onchocerca volvulus 0.0053 0.0309 0.0286
Brugia malayi histone deacetylase 1 (HD1) 0.0432 0.3485 0.3485
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1208 1 1
Brugia malayi Esterase D 0.0038 0.0178 0.0178
Brugia malayi Kringle domain containing protein 0.0029 0.0102 0.0102
Leishmania major hypothetical protein, conserved 0.0405 0.326 0.9347
Loa Loa (eye worm) histone deacetylase 7A 0.0274 0.2161 0.2143
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0112 0.0089
Onchocerca volvulus 0.003 0.0112 0.0089
Brugia malayi RNA, U transporter 1 0.0081 0.054 0.054
Echinococcus multilocularis G protein coupled receptor 139 0.1208 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.003 0.0112 0.0112
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0326 0.2599 0.2582
Echinococcus granulosus intestinal type alkaline phosphatase 0.0179 0.1367 0.1347
Onchocerca volvulus 0.1208 1 1
Echinococcus granulosus alkaline phosphatase 0.0179 0.1367 0.1347
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0144 0.0121
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0385 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Leishmania major hypothetical protein, unknown function 0.003 0.0112 0.0214
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0209 0.0187
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0101 0.0183
Brugia malayi hypothetical protein 0.1208 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Toxoplasma gondii histone deacetylase HDAC5 0.0159 0.1193 0.3352
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1208 1 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0034 0.0144 0.0144
Onchocerca volvulus 0.1208 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1208 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0399 0.3211 0.3195
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0106 0.0106
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0082 0.0549 0.1483
Trypanosoma brucei histone deacetylase 2 0.0159 0.1193 0.3352
Leishmania major histone deacetylase, putative 0.0274 0.2161 0.6161
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0112 0.0214
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0299 0.0757
Loa Loa (eye worm) hypothetical protein 0.0261 0.205 0.2031
Schistosoma mansoni neuropeptide f receptor 76f 0.1208 1 1
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0179 0.1367 0.1347
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1208 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0159 0.1193 0.3352
Echinococcus multilocularis musashi 0.003 0.0112 0.0089
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.1793 0.1774
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0038 0.0178 0.0404
Echinococcus granulosus somatostatin receptor 0.1208 1 1
Giardia lamblia Histone deacetylase 0.0432 0.3485 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0023 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.016 0.0137
Trypanosoma brucei histone deacetylase 3 0.0274 0.2161 0.6161
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1208 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Trichomonas vaginalis set domain proteins, putative 0.0262 0.2059 0.5862
Brugia malayi FAT domain containing protein 0.0033 0.0136 0.0136
Echinococcus multilocularis histone deacetylase 1 0.0432 0.3485 0.347
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0112 0.0089
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0029 0.0102 0.0186
Onchocerca volvulus 0.1208 1 1
Echinococcus multilocularis lamin dm0 0.003 0.0112 0.0089
Brugia malayi Protein kinase domain containing protein 0.0326 0.2599 0.2599
Schistosoma mansoni hypothetical protein 0.0093 0.0644 0.0644
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0549 0.1483
Echinococcus multilocularis g protein coupled receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0038 0.0015
Plasmodium vivax histone deacetylase 1, putative 0.0432 0.3485 1
Echinococcus multilocularis histone deacetylase 0.0274 0.2161 0.2143
Echinococcus granulosus neuropeptide receptor A26 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1193 0.1173
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0429 0.3464 0.9938
Echinococcus granulosus sex peptide receptor 0.1208 1 1
Brugia malayi hypothetical protein 0.1208 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1208 1 1
Echinococcus granulosus neuropeptides capa receptor 0.1208 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0023 0.0023
Brugia malayi RE15519p 0.1208 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1208 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0364 0.2917 0.8354
Schistosoma mansoni intermediate filament proteins 0.003 0.0112 0.0112
Echinococcus granulosus neuropeptide s receptor 0.1208 1 1
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0023 0.0023
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0326 0.2599 0.2582
Schistosoma mansoni amine GPCR 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0023 0.0059 0.0059
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus neuropeptide Y receptor 0.1208 1 1
Toxoplasma gondii kringle domain-containing protein 0.0029 0.0102 0.0186
Schistosoma mansoni hypothetical protein 0.0053 0.0309 0.0309
Plasmodium falciparum importin beta, putative 0.0028 0.0101 0.0183
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni adenoreceptor 0.1208 1 1
Echinococcus multilocularis neuropeptide receptor 0.1208 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0082 0.0549 0.1483
Schistosoma mansoni myosin xvIII 0.1208 1 1
Brugia malayi hypothetical protein 0.1208 1 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0033 0.0136 0.0113
Brugia malayi hypothetical protein 0.0052 0.0299 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi follicle stimulating hormone receptor 0.1208 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0117 0.0846 0.2344
Brugia malayi histone deacetylase 3 (HD3) 0.0432 0.3485 0.3485
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.003 0.0112 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0136 0.0284
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0299 0.0757
Echinococcus granulosus tm gpcr rhodopsin 0.1208 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.009 0.0618 0.0597
Onchocerca volvulus 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni histone deacetylase 4 5 0.0274 0.2161 0.2161
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0051 0.0293 0.0293
Echinococcus granulosus g protein coupled receptor 0.1208 1 1
Echinococcus granulosus serotonin receptor 0.1208 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.009 0.0618 0.1683
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0112 0.0112
Echinococcus multilocularis histone deacetylase 6 0.0274 0.2161 0.2143
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0549 0.1483
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0326 0.2599 0.2599
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0082 0.0549 0.1483
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0057 0.0345 0.0323
Schistosoma mansoni cpg binding protein 0.0029 0.0106 0.0106
Echinococcus granulosus histone deacetylase 6 0.028 0.2215 0.2196
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0618 0.1683
Brugia malayi steroid hormone receptor 0.0019 0.0023 0.0023
Loa Loa (eye worm) melatonin receptor type 1A 0.1208 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.009 0.0618 0.1683
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0618 0.0618
Mycobacterium tuberculosis Possible conserved membrane protein 0.0038 0.0178 0.0092
Echinococcus granulosus tm gpcr rhodopsin 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1208 1 1
Brugia malayi Muscleblind-like protein 0.0147 0.1097 0.1097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) G-protein coupled receptor 0.1208 1 1
Schistosoma mansoni opsin-like receptor 0.1208 1 1
Schistosoma mansoni lamin 0.003 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus dro:myosuppressin receptor 0.1208 1 1
Brugia malayi hypothetical protein 0.1208 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.009 0.0618 0.0618
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0112 0.0112
Toxoplasma gondii FATC domain-containing protein 0.0057 0.0345 0.089
Plasmodium falciparum cysteine repeat modular protein 1 0.0029 0.0102 0.0186
Brugia malayi hypothetical protein 0.0261 0.205 0.205
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0057 0.0345 0.0323
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0329 0.2626 0.7509
Onchocerca volvulus 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus multilocularis histone deacetylase 6 0.0274 0.2161 0.2143
Echinococcus granulosus lamin 0.003 0.0112 0.0089
Plasmodium vivax histone deacetylase, putative 0.0159 0.1193 0.3352
Trypanosoma brucei histone deacetylase 4 0.0274 0.2161 0.6161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0038 0.0178 0.0092
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0062 0.0385 0.1007
Schistosoma mansoni hypothetical protein 0.0051 0.0293 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.0375 0.301 0.8623
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0082 0.0549 0.0528
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.003 0.0112 0.0214
Echinococcus multilocularis S formylglutathione hydrolase 0.0038 0.0178 0.0155
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0144 0.0121
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0309 0.0309
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0144 0.0307
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1208 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0082 0.0549 0.1483
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0179 0.1367 0.1347
Schistosoma mansoni alkaline phosphatase 0.0179 0.1367 0.1367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Brugia malayi hypothetical protein 0.1208 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0345 0.0345
Brugia malayi Protein kinase domain containing protein 0.0029 0.0102 0.0102
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0618 0.0597
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0085
Leishmania major histone deacetylase, putative 0.0274 0.2161 0.6161
Echinococcus multilocularis allatostatin A receptor 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0056 0.0052
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Loa Loa (eye worm) TYRA-2 protein 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Brugia malayi Pre-SET motif family protein 0.0034 0.0144 0.0144
Leishmania major importin beta-1 subunit, putative 0.0023 0.0056 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Plasmodium vivax hypothetical protein 0.003 0.0112 0.0214
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0038 0.0178 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.1208 1 1
Echinococcus multilocularis fmrfamide receptor 0.1208 1 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0605 0.4935 0.4924
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1208 1 1
Onchocerca volvulus 0.003 0.0112 0.0089
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.009 0.0618 0.1683
Echinococcus granulosus neuropeptide Y receptor 0.1208 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0056 0.0052
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0038 0.0178 0.0092
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0059 0.0035
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0057 0.0345 0.089
Entamoeba histolytica hypothetical protein 0.0035 0.016 0.0354
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0112 0.0112
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0038 0.0178 0.0092
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1208 1 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0175 0.1335 0.1335
Schistosoma mansoni neuropeptide receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0112 0.0214
Echinococcus granulosus histone deacetylase 7 0.0274 0.2161 0.2143
Schistosoma mansoni biogenic amine receptor 0.1208 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.1208 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0618 0.1683
Trypanosoma cruzi histone deacetylase, putative 0.0274 0.2161 0.6161
Brugia malayi nuclear hormone receptor 0.0019 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.003 0.0112 0.0214
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.003 0.0112 0.0112
Onchocerca volvulus 0.0262 0.2059 0.204
Onchocerca volvulus 0.1208 1 1
Schistosoma mansoni neuropeptide receptor 0.1208 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.1208 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0549 0.1483
Schistosoma mansoni histone deacetylase 0.0432 0.3485 0.3485
Schistosoma mansoni hypothetical protein 0.0029 0.0102 0.0102
Brugia malayi Importin beta-1 subunit 0.0028 0.0101 0.0101
Brugia malayi hypothetical protein 0.0035 0.016 0.016
Giardia lamblia Phosphatidylinositol 4-kinase 0.003 0.0112 0.0214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0056 0.0052
Echinococcus granulosus biogenic amine 5HT receptor 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.003 0.0112 0.0214
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1208 1 1
Schistosoma mansoni cpg binding protein 0.0031 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.003 0.0112 0.0089
Plasmodium falciparum histone deacetylase 1 0.0432 0.3485 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1208 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0136 0.0113
Schistosoma mansoni alkaline phosphatase 0.0179 0.1367 0.1367
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0038 0.0178 0.0092
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0023 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0293 0.0293
Onchocerca volvulus 0.0029 0.0102 0.0079
Echinococcus multilocularis g-protein coupled receptor 0.1208 1 1
Echinococcus granulosus cpg binding protein 0.0031 0.012 0.0097
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0299 0.0757
Onchocerca volvulus 0.003 0.0112 0.0089
Brugia malayi G protein-coupled receptor F59B2.13 0.1208 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0082 0.0549 0.0528
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0326 0.2599 0.2582
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0023 0.0023
Brugia malayi GnHR receptor homolog 0.1208 1 1
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0179 0.1367 0.1347
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Leishmania major phosphatidylinositol kinase related protein, putative 0.003 0.0112 0.0214
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0101 0.0183
Schistosoma mansoni biogenic amine receptor 0.1208 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0112 0.0089
Loa Loa (eye worm) hypothetical protein 0.0432 0.3485 0.347
Schistosoma mansoni serine/threonine protein kinase 0.0326 0.2599 0.2599
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0082 0.0549 0.0528
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0144 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Brugia malayi larval opioid receptor 0.1208 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.009 0.0618 0.1683
Echinococcus multilocularis histone deacetylase 6 0.028 0.2215 0.2196
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0082 0.0549 0.0528
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0618 0.1683
Trypanosoma cruzi target of rapamycin kinase 3 0.009 0.0618 0.1683
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0101 0.0078
Loa Loa (eye worm) hypothetical protein 0.0115 0.0831 0.081
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0101 0.0183
Echinococcus granulosus 7TM GPCR rhodopsin 0.1208 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0112 0.0089
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus multilocularis snurportin 1 0.0303 0.2407 0.2389
Echinococcus multilocularis histone deacetylase 3 0.0432 0.3485 0.347
Echinococcus granulosus fmrfamide receptor 0.1208 1 1
Schistosoma mansoni lamin 0.003 0.0112 0.0112
Schistosoma mansoni neuropeptide F-like receptor 0.1208 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0023 0.0023
Onchocerca volvulus 0.1208 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0023 0.0023
Brugia malayi Dopamine receptor protein 1 0.1208 1 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0112 0.0214
Echinococcus granulosus snurportin 1 0.0303 0.2407 0.2389
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0883 0.7273 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni biogenic amine receptor 0.1208 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.003 0.0112 0.0214
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0345 0.0345
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0618 0.0597
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0111 0.0793 0.0793
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.2407 0.2389
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0112 0.0089
Plasmodium falciparum histone deacetylase 2 0.0274 0.2161 0.6161
Entamoeba histolytica hypothetical protein 0.0035 0.016 0.0354
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0082 0.0549 0.1483
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1208 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0399 0.3211 0.3195
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0041 0.0209 0.0187
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0345 0.0323
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0179 0.1367 0.1347
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1208 1 1
Schistosoma mansoni cpg binding protein 0.0031 0.012 0.012
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0264 0.208 0.5925
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0618 0.1683
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0096 0.0167
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Schistosoma mansoni importin beta-1 0.0028 0.0101 0.0101
Echinococcus granulosus g-protein coupled receptor 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.016 0.0354

Activities

Activity type Activity value Assay description Source Reference
%max (functional) = 43 % Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
%max (functional) = 43 % Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
%max (functional) = 77 % Agonist activity at GR assessed as NFkappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
%max (functional) = 77 % Agonist activity at GR assessed as NFkappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
EC50 (functional) = 7.73 Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
Efficacy (functional) = 34 % Selectivity for MMTV transactivation assay over NFkappaB transrepression assay for GR agonism in A549 cells ChEMBL. 16821781
Efficacy (functional) = 34 % Selectivity for MMTV transactivation assay over NFkappaB transrepression assay for GR agonism in A549 cells ChEMBL. 16821781
IC50 (functional) = 6.89 Activity at GR assessed as ability to antagonize dexamethasone-induced MMTV luciferase reporter gene transactivation in human A549 cells ChEMBL. 16821781
IC50 (binding) = 8.32 Inhibition of fluorescent-labeled dexamethasone binding to GR ChEMBL. 16821781
IC50 (functional) = 8.53 Agonist activity at GR assessed as NFkappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cells ChEMBL. 16821781
Log EC50 (functional) = 7.73 Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
Log IC50 (functional) = 6.89 Activity at GR assessed as ability to antagonize dexamethasone-induced MMTV luciferase reporter gene transactivation in human A549 cells ChEMBL. 16821781
Log IC50 (binding) = 8.32 Inhibition of fluorescent-labeled dexamethasone binding to GR ChEMBL. 16821781
Log IC50 (functional) = 8.53 Agonist activity at GR assessed as NFkappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cells ChEMBL. 16821781

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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