Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosylhomocysteinase | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0809 | 1 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.016 | 0.174 | 0.1737 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0164 | 0.1785 | 0.1782 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0687 | 0.0687 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0809 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | adenosylhomocysteinase | 0.05 | 0.6073 | 0.6071 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0809 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0078 | 0.0687 | 0.0683 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0027 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0809 | 1 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0078 | 0.0687 | 0.0683 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0078 | 0.0687 | 0.0683 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0809 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0809 | 1 | 0.5 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0078 | 0.0687 | 0.0683 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0164 | 0.1782 | 0.1779 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus granulosus | ankyrin repeat protein | 0.016 | 0.174 | 0.1737 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0078 | 0.0687 | 0.0683 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0809 | 1 | 0.5 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0809 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0024 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | adenosylhomocysteinase | 0.05 | 0.6073 | 0.6071 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0809 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0027 | 0.0042 | 0.0042 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0809 | 1 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0809 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Echinococcus granulosus | voltage dependent calcium channel | 0.0027 | 0.0042 | 0.0038 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Echinococcus multilocularis | ankyrin repeat protein | 0.016 | 0.174 | 0.1737 |
Schistosoma mansoni | voltage-gated cation channel | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0078 | 0.0687 | 0.0683 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0024 | 0.0004 | 0.0004 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | adenosylhomocysteinase | 0.05 | 0.6073 | 0.6071 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0809 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0024 | 0.0004 | 0.0004 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0078 | 0.0687 | 0.0683 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Schistosoma mansoni | adenosylhomocysteinase | 0.05 | 0.6073 | 0.6071 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0024 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | calcium channel | 0.0078 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 4 | Inhibition of matrix metalloproteinase-1(HFC) | ChEMBL. | 9871766 |
Activity (binding) | = 7 | Inhibition of matrix metalloproteinase-7(Matrilysin) | ChEMBL. | 9871766 |
Activity (binding) | = 9 | Inhibition of matrix metalloproteinase-2(Gel.A) | ChEMBL. | 9871766 |
Activity (binding) | = 40 | Inhibition of matrix metalloproteinase-3(Strom-1) | ChEMBL. | 9871766 |
Activity (binding) | = 1500 | TNF-alpha convertase activity following phorbol 12-myristate 13-acetate (PMA) stimulation of U937 cells | ChEMBL. | 9871766 |
Activity (binding) | = 4 | Inhibition of matrix metalloproteinase-1(HFC) | ChEMBL. | 9871766 |
Activity (binding) | = 7 | Inhibition of matrix metalloproteinase-7(Matrilysin) | ChEMBL. | 9871766 |
Activity (binding) | = 9 | Inhibition of matrix metalloproteinase-2(Gel.A) | ChEMBL. | 9871766 |
Activity (binding) | = 40 | Inhibition of matrix metalloproteinase-3(Strom-1) | ChEMBL. | 9871766 |
Activity (binding) | = 1500 | TNF-alpha convertase activity following phorbol 12-myristate 13-acetate (PMA) stimulation of U937 cells | ChEMBL. | 9871766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.