Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | membrane metallo-endopeptidase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4828 | 0.4828 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5172 | 0.5172 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4828 | 0.4828 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5172 | 0.5172 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.4408 | 0.4408 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4408 | 0.4408 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4408 | 0.4408 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.4408 | 0.4304 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4828 | 0.4828 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.4408 | 0.4408 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 377 nM | Inhibition of dog NEP | ChEMBL. | 16821800 |
IC50 (binding) | = 377 nM | Inhibition of dog NEP | ChEMBL. | 16821800 |
IC50 (binding) | > 3 uM | Inhibition of dog ACE | ChEMBL. | 16821800 |
IC50 (binding) | > 3 uM | Inhibition of dog ACE | ChEMBL. | 16821800 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.