Detailed information for compound 368246

Basic information

Technical information
  • TDR Targets ID: 368246
  • Name: (3-hydroxy-3-sulfanylidene-2-oxa-3$l^{5}-phos phacyclopent-1-yl)methyl hexadecanoate
  • MW: 406.56 | Formula: C20H39O4PS
  • H donors: 1 H acceptors: 2 LogP: 8.08 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCCC(=O)OCC1CCP(=S)(O1)O
  • InChi: 1S/C20H39O4PS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(21)23-18-19-16-17-25(22,26)24-19/h19H,2-18H2,1H3,(H,22,26)
  • InChiKey: HGTUZBIEGDZLRZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3-hydroxy-3-thioxo-2-oxa-3$l^{5}-phosphacyclopent-1-yl)methyl hexadecanoate
  • hexadecanoic acid (3-hydroxy-3-thioxo-2-oxa-3$l^{5}-phosphacyclopent-1-yl)methyl ester
  • palmitic acid (3-hydroxy-3-thioxo-2-oxa-3$l^{5}-phosphacyclopent-1-yl)methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysophosphatidic acid receptor 1 Starlite/ChEMBL References
Homo sapiens lysophosphatidic acid receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0021 0.0053
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0914 0.3396
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0195 0.0192
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0178 0.0525
Entamoeba histolytica hypothetical protein 0.0035 0.0195 0.0778
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0163 0.0401
Schistosoma mansoni jumonji domain containing protein 0.0209 0.2801 0.28
Leishmania major pyruvate kinase 0.0033 0.0163 0.0527
Plasmodium falciparum LCCL domain-containing protein 0.0079 0.0841 0.3124
Schistosoma mansoni rab6-interacting 0.0079 0.0841 0.0838
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0112 0.1348 0.4674
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0531 0.0528
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0151 0.0484
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0163 0.0649
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0214 0.2873 0.8887
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0834 0.3099
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0018 0.0015
Echinococcus granulosus lysine specific demethylase 5A 0.0132 0.1647 0.1645
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0103 0.037
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0151 0.0484
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0231 0.0229
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0573 0.057
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0188 0.2474 0.6082
Brugia malayi Thioredoxin reductase 0.0094 0.107 0.2631
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0151 0.0566
Loa Loa (eye worm) hypothetical protein 0.0033 0.0163 0.0401
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0178 0.0176
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0248 0.3385 0.3384
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0914 0.3396
Leishmania major hypothetical protein, conserved 0.0034 0.0178 0.0581
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0103 0.0375
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.2474 0.8666
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.1002 0.3727
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0163 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0486 0.1802
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0185 0.2438 0.8547
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0112 0.1348 0.4674
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0163 0.0464
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0188 0.2474 0.8674
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0036 0.0124
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0151 0.0484
Plasmodium falciparum pyruvate kinase 0.0033 0.0163 0.0598
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.01 0.0363
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0573 0.1972
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0045
Schistosoma mansoni hypothetical protein 0.0409 0.579 0.5789
Mycobacterium tuberculosis Probable oxidoreductase 0.0238 0.3231 1
Brugia malayi Bromodomain containing protein 0.0085 0.0944 0.2321
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2474 0.9213
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0825 0.3067
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0283 0.39 0.3898
Schistosoma mansoni bromodomain containing protein 0.0074 0.0769 0.0766
Entamoeba histolytica hypothetical protein 0.0023 0.0014 0.0044
Mycobacterium ulcerans hypothetical protein 0.0024 0.003 0.0069
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.107 0.3284
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.1292 0.3175
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0178 0.0525
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0185 0.2438 0.8547
Brugia malayi hypothetical protein 0.0079 0.0841 0.2067
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.1292 0.1289
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.107 0.1068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0151 0.0428
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0151 0.0553
Loa Loa (eye worm) hypothetical protein 0.0058 0.0531 0.1305
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0094 0.023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0715 0.0713
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0185 0.2438 0.5994
Leishmania major trypanothione reductase 0.0094 0.107 0.3725
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0531 0.1969
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.003 0.0028
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1292 0.4805
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.01 0.0363
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0045
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0118 0.1428 0.4987
Brugia malayi PHD-finger family protein 0.0058 0.0531 0.1305
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0178 0.0581
Treponema pallidum NADH oxidase 0.0033 0.0151 0.0566
Loa Loa (eye worm) hypothetical protein 0.0149 0.1896 0.4661
Schistosoma mansoni pyruvate kinase 0.0033 0.0163 0.016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0132 0.1647 0.1645
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0163 0.0401
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0151 0.0553
Mycobacterium ulcerans hypothetical protein 0.0024 0.0018 0.002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0151 0.0566
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0055 0.0195
Plasmodium falciparum thioredoxin reductase 0.0033 0.0151 0.0553
Brugia malayi 6-phosphofructokinase 0.0109 0.1292 0.3175
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.01 0.0363
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2474 0.9213
Onchocerca volvulus Alhambra homolog 0.0058 0.0531 0.2137
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.1292 0.1289
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0531 0.0528
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0151 0.0553
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0163 0.0649
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0202 0.2685 1
Brugia malayi phosphofructokinase 0.0109 0.1292 0.3175
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0163 0.0598
Onchocerca volvulus 0.0061 0.0574 0.2313
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0163 0.0401
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.1002 0.3727
Schistosoma mansoni hypothetical protein 0.0079 0.0841 0.0838
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0202 0.2685 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0014 0.0041
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0163 0.0527
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0438
Brugia malayi CHD4 protein 0.0026 0.0056 0.0137
Brugia malayi serine/threonine-protein kinase plk-2 0.0188 0.2474 0.6082
Brugia malayi CXXC zinc finger family protein 0.0029 0.0094 0.023
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0185 0.2438 1
Echinococcus granulosus Polycystic kidney disease protein 0.0079 0.0841 0.0838
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.107 0.3688
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0834 0.283
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0003 0.0006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0151 0.0148
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0151 0.0553
Trichomonas vaginalis chromobox protein, putative 0.0138 0.1736 0.6464
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0531 0.0528
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0238 0.3231 1
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0151 0.0553
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0036 0.0019
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.003 0.0059
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0151 0.0553
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.003 0.0069
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.003 0.0069
Echinococcus multilocularis cpg binding protein 0.0032 0.0147 0.0144
Schistosoma mansoni cpg binding protein 0.0029 0.0094 0.0091
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0121 0.1475 0.5491
Echinococcus granulosus CREB binding protein 0.0072 0.0742 0.0739
Loa Loa (eye worm) hypothetical protein 0.0023 0.0012 0.0029
Schistosoma mansoni microtubule-associated protein tau 0.069 1 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0188 0.2474 0.2472
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0573 0.2307
Loa Loa (eye worm) hypothetical protein 0.0078 0.0825 0.2029
Echinococcus granulosus histone acetyltransferase KAT2B 0.0282 0.3884 0.3882
Schistosoma mansoni kinase 0.0095 0.1092 0.1089
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0036 0.0124
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0006
Mycobacterium tuberculosis Probable dehydrogenase 0.0214 0.2873 0.8887
Brugia malayi 6-phosphofructokinase 0.0109 0.1292 0.3175
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0178 0.0176
Brugia malayi TAZ zinc finger family protein 0.0111 0.1323 0.3254
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0151 0.0428
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0056 0.0053
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0151 0.0566
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.002
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0202 0.2685 1
Brugia malayi hypothetical protein 0.0149 0.1896 0.4661
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0151 0.0148
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0163 0.0598
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0531 0.1305
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0214 0.2873 0.8887
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.01 0.0363
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0151 0.0427
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0103 0.0375
Brugia malayi Bromodomain containing protein 0.0069 0.0699 0.1719
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0151 0.0428
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.1002 0.3727
Loa Loa (eye worm) bromodomain containing protein 0.0027 0.0061 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0178 0.0438
Entamoeba histolytica hypothetical protein 0.0035 0.0195 0.0778
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0573 0.1738
Plasmodium falciparum glutathione reductase 0.0033 0.0151 0.0553
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0103 0.0375
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0825 0.3329
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0151 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.002
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0118 0.1428 0.3511
Loa Loa (eye worm) acetyltransferase 0.0294 0.4067 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0151 0.0484
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.1002 0.1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1055 0.3922
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0151 0.0484
Loa Loa (eye worm) glutathione reductase 0.0094 0.107 0.2631
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0178 0.0438
Echinococcus multilocularis RUN 0.0079 0.0841 0.0838
Schistosoma mansoni polycystin 1-related 0.0079 0.0841 0.0838
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0151 1
Leishmania major hypothetical protein, conserved 0.0025 0.0036 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0045
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0178 0.0176
Loa Loa (eye worm) hypothetical protein 0.0053 0.046 0.113
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.006 0.0556 0.1865
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0103 0.0375
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.1428 0.1426
Schistosoma mansoni chromobox protein 0.0138 0.1736 0.1734
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0573 0.2307
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2474 0.9213
Brugia malayi glucose-6-phosphate dehydrogenase 0.0185 0.2438 0.5994
Echinococcus granulosus pyruvate kinase 0.0033 0.0163 0.016
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0151 0.0371
Schistosoma mansoni lipoxygenase 0.0283 0.39 0.3898
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2474 0.9213
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0056 0.0053
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0178 0.0176
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0178 0.0655
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.1292 0.4473
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0036 0.0124
Brugia malayi jmjC domain containing protein 0.0034 0.0178 0.0438
Brugia malayi Heterochromatin protein 1 0.0138 0.1736 0.4269
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0018 0.0015
Giardia lamblia Kinase, PLK 0.0188 0.2474 0.9183
Trypanosoma brucei polo-like protein kinase 0.0188 0.2474 0.8674
Echinococcus multilocularis Polycystic kidney disease protein 0.0079 0.0841 0.0838
Brugia malayi hypothetical protein 0.0025 0.0036 0.0088
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0014 0.0041
Plasmodium vivax glutathione reductase, putative 0.0094 0.107 0.398
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0151 0.0566
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0061 0.0583 0.1959
Loa Loa (eye worm) hypothetical protein 0.0115 0.1385 0.3406
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.1292 0.3175
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0647 0.2401
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0112 0.1348 0.4705
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0103 0.0375
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0026 0.0023
Brugia malayi jmjC domain containing protein 0.0034 0.0178 0.0438
Brugia malayi jmjC domain containing protein 0.0132 0.1647 0.405
Leishmania major pyruvate kinase 0.0033 0.0163 0.0527
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1292 0.5215
Loa Loa (eye worm) hypothetical protein 0.0038 0.0238 0.0585
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0088
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0026 0.0023
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0026 0.0023
Echinococcus granulosus phd:f box containing protein 0.0034 0.0178 0.0176
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0018 0.0015
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0118 0.1428 0.4397
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.1454 0.3576
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1292 0.5215
Schistosoma mansoni pyruvate kinase 0.0033 0.0163 0.016
Brugia malayi glutathione reductase 0.0094 0.107 0.2631
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0018 0.002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0914 0.3686
Schistosoma mansoni hypothetical protein 0.0035 0.0195 0.0192
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0909 0.2234
Brugia malayi hypothetical protein 0.0079 0.0841 0.2067
Echinococcus granulosus chromobox protein 1 0.0138 0.1736 0.1734
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.285 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0283 0.39 0.3898
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0018 0.002
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0573 0.2126
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.1002 0.3727
Mycobacterium tuberculosis Probable reductase 0.0214 0.2873 0.8887
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0006
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0036 0.0078
Loa Loa (eye worm) helicase 0.0023 0.0003 0.0006
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0103 0.0375
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0294 0.4067 0.4066
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0573 0.2307
Schistosoma mansoni lipoxygenase 0.0141 0.178 0.1778
Plasmodium vivax multidomain scavenger receptor, putative 0.0079 0.0841 0.3124
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.107 0.398
Entamoeba histolytica serine/threonine protein kinase, putative 0.0188 0.2474 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0834 0.3364
Chlamydia trachomatis pyruvate kinase 0.0033 0.0163 0.0616
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0248 0.3385 0.3384
Echinococcus multilocularis lipoxygenase domain containing protein 0.0079 0.0841 0.0838
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0151 0.0428
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0103 0.0375
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0178 0.0176
Loa Loa (eye worm) hypothetical protein 0.0083 0.0909 0.2234
Echinococcus granulosus lipoxygenase domain containing protein 0.0079 0.0841 0.0838
Onchocerca volvulus 0.0079 0.0841 0.3391
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0103 0.037
Echinococcus granulosus lipoxygenase domain containing protein 0.0079 0.0841 0.0838
Onchocerca volvulus 0.0079 0.0841 0.3391
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0185 0.2438 0.2436
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0006
Echinococcus granulosus cpg binding protein 0.0032 0.0147 0.0144
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0871 0.0868
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0003 0.0006
Giardia lamblia Pyruvate kinase 0.0033 0.0163 0.0232
Brugia malayi Protein cec-1. 0.0023 0.0003 0.0006
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.579 0.5789
Loa Loa (eye worm) hypothetical protein 0.0079 0.0841 0.2067
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1292 0.4805
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.01 0.0363
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.1428 0.5835
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.003 0.0052
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0151 0.0553
Echinococcus multilocularis chromobox protein 1 0.0138 0.1736 0.1734
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0178 0.0176
Echinococcus granulosus pyruvate kinase 0.0033 0.0163 0.016
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0202 0.2685 1
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0202 0.2685 1
Loa Loa (eye worm) phosphofructokinase 0.0109 0.1292 0.3175
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0111 0.1323 0.1321
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0576 0.0573
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0054 0.0051
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0531 0.1969
Echinococcus multilocularis pyruvate kinase 0.0033 0.0163 0.016
Leishmania major hypothetical protein, conserved 0.0213 0.285 1
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0163 0.0616
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.1292 0.5271
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1292 0.4805
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0178 0.0176
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.1292 0.4506
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0438
Loa Loa (eye worm) heterochromatin protein 1 0.0138 0.1736 0.4269
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0185 0.2438 1
Echinococcus multilocularis chromobox protein 1 0.0138 0.1736 0.1734
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0018 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.0017
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0871 0.0868
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0151 0.0553
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1292 0.5215
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0202 0.0199
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.0017
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0178 0.0176
Schistosoma mansoni cpg binding protein 0.0032 0.0147 0.0144
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0185 0.2438 0.8539
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0103 0.0375
Onchocerca volvulus 0.0149 0.1896 0.7661
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0106 0.1255 0.3086
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0045
Echinococcus granulosus RUN 0.0079 0.0841 0.0838
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0006
Brugia malayi PHD-finger family protein 0.0035 0.0194 0.0477
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0103 0.0375
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0214 0.2873 0.8887
Loa Loa (eye worm) hypothetical protein 0.0079 0.0841 0.2067
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0151 0.0428
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0573 0.057
Brugia malayi jmjC domain containing protein 0.0034 0.0178 0.0438
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0021 0.0053
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0202 0.2685 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0079 0.0841 0.0838
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.1292 0.3972
Plasmodium falciparum thioredoxin reductase 0.0094 0.107 0.398
Brugia malayi hypothetical protein 0.0023 0.0003 0.0006
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0178 0.0176
Loa Loa (eye worm) hypothetical protein 0.005 0.0407 0.0999
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0018 0.0015
Schistosoma mansoni CREB-binding protein 2 0.0111 0.1323 0.1321
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0151 0.0428
Schistosoma mansoni rab6-interacting 0.0079 0.0841 0.0838
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1292 0.4805
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.003 0.0069
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0178 0.0655
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0238 0.3231 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0163 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0486 0.1802
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0151 0.0185
Schistosoma mansoni hypothetical protein 0.0058 0.0531 0.0528
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0231 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0825 0.3067
Echinococcus multilocularis microtubule associated protein 2 0.069 1 1
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.1292 0.1289
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0103 0.0375
Echinococcus multilocularis zinc finger protein 0.003 0.0114 0.0111
Mycobacterium ulcerans hypothetical protein 0.0024 0.003 0.0069
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0056 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0012 0.0009
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0103 0.037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0151 0.0428
Brugia malayi Doublecortin family protein 0.0079 0.0841 0.2067
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0238 0.3231 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.1292 0.3972
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0003 0.0006
Echinococcus granulosus CREB binding protein 0.0111 0.1323 0.1321
Trypanosoma cruzi hypothetical protein, conserved 0.0213 0.285 1
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.1292 0.1289
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0014 0.0041
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.003 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0178 0.0438
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0151 0.0484
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0531 0.1969
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0064 0.0626 0.1903
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.1428 0.1426
Brugia malayi jmjC domain containing protein 0.0248 0.3385 0.8323
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.003 0.0103
Schistosoma mansoni loxhd1 0.0079 0.0841 0.0838
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.107 0.2631
Brugia malayi SET domain containing protein 0.0023 0.0012 0.003
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.107 0.1068
Schistosoma mansoni zinc finger protein 0.003 0.0114 0.0111
Plasmodium falciparum phd finger protein, putative 0.0058 0.0531 0.1969
Echinococcus granulosus zinc finger protein 0.003 0.0114 0.0111
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0056 0.0137
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0121 0.1475 0.603
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0018 0.0064
Brugia malayi jmjC domain containing protein 0.0034 0.0178 0.0438
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0103 0.0407
Echinococcus multilocularis peregrin 0.0069 0.0699 0.0697
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0909 0.0906
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0214 0.2873 0.8887
Brugia malayi acetyltransferase, GNAT family protein 0.0294 0.4067 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0006
Mycobacterium tuberculosis Conserved protein 0.0024 0.003 0.0052
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0103 0.0375
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0178 0.0655
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0003 0.0006
Onchocerca volvulus Serine\/threonine kinase homolog 0.0188 0.2474 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0014 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2474 0.9213
Trypanosoma brucei trypanothione reductase 0.0094 0.107 0.3725
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0909 0.0906
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0178 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0151 0.0428
Loa Loa (eye worm) hypothetical protein 0.0071 0.0723 0.1777
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.01 0.0363
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0012 0.0037
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.1002 0.3727
Trichomonas vaginalis chromobox protein, putative 0.0138 0.1736 0.6464
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0163 0.0598
Loa Loa (eye worm) hypothetical protein 0.0048 0.0376 0.0925
Echinococcus multilocularis CREB binding protein 0.0079 0.0846 0.0844
Schistosoma mansoni chromobox protein 0.0138 0.1736 0.1734
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0294 0.4067 0.4066
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0185 0.2438 0.2436
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0103 0.0375
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0036 0.0124
Echinococcus granulosus peregrin 0.0069 0.0699 0.0697
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0214 0.2873 0.8887
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0178 0.0176
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0163 0.0598
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0151 0.0484
Onchocerca volvulus 0.0083 0.0909 0.3666
Echinococcus multilocularis pyruvate kinase 0.0033 0.0163 0.016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0195 0.0192
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.1292 0.5271
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2474 0.9213
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0715 0.0713
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0018 0.002
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0188 0.2474 0.2472
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0573 0.057
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0163 0.0527
Onchocerca volvulus 0.0029 0.0094 0.0368
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0178 0.0176
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.2474 0.9213
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0163 0.0471
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0151 0.0148
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0163 0.0401
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.1292 0.4506
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.01 0.0363
Trypanosoma brucei hypothetical protein, conserved 0.0213 0.285 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0018 0.0064
Entamoeba histolytica hypothetical protein 0.0035 0.0195 0.0778
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.1428 0.5835
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0195 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.2474 0.2472
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0107 0.0263
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0185 0.2438 1
Entamoeba histolytica hypothetical protein 0.0035 0.0195 0.0778
Loa Loa (eye worm) jmjC domain-containing protein 0.0132 0.1647 0.405
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0573 0.057
Echinococcus granulosus dnaJ subfamily B 0.0409 0.579 0.5789
Giardia lamblia PHD finger protein 15 0.0058 0.0531 0.1656
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0163 0.0471
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0103 0.0375
Echinococcus multilocularis lysine specific demethylase 5A 0.0129 0.1594 0.1592
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0036 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0048 0.0168
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0151 0.0428
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0118 0.1428 0.1426
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0202 0.2685 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0055 0.0195
Loa Loa (eye worm) hypothetical protein 0.0061 0.0574 0.1412
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.2474 0.8666
Toxoplasma gondii thioredoxin reductase 0.0094 0.107 0.398
Brugia malayi Bromodomain containing protein 0.0047 0.037 0.091
Schistosoma mansoni cpg binding protein 0.0032 0.0147 0.0144
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0018 0.0064
Brugia malayi chromobox protein homolog 3 0.0078 0.0825 0.2029
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0202 0.0199
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1055 0.3922
Echinococcus multilocularis pyruvate kinase 0.0026 0.0058 0.0055
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0163 0.0464
Leishmania major hypothetical protein, conserved 0.0112 0.1348 0.4705
Schistosoma mansoni jumonji/arid domain-containing protein 0.0132 0.1647 0.1645
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0103 0.0375
Plasmodium falciparum glutathione reductase 0.0094 0.107 0.398
Echinococcus granulosus chromobox protein 1 0.0138 0.1736 0.1734
Loa Loa (eye worm) doublecortin family protein 0.0079 0.0841 0.2067
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0151 0.0484
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0185 0.2438 0.2436
Onchocerca volvulus 0.0023 0.0012 0.0038
Onchocerca volvulus 0.0024 0.0018 0.0064
Loa Loa (eye worm) CBP-B 0.008 0.086 0.2113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.01 0.0363
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0909 0.0906
Plasmodium vivax JmjC domain containing protein 0.0034 0.0178 0.0655
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0006
Brugia malayi hypothetical protein 0.0035 0.0195 0.0479

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) Activity at human LPA3 receptor in RH7777 cells at 30 uM by calcium mobilization assay ChEMBL. 16913720
EC50 (functional) Activity at human LPA1 receptor in RH7777 cells at 30 uM by calcium mobilization assay ChEMBL. 16913720
EC50 (functional) Activity at human LPA2 receptor in RH7777 cells at 30 uM by calcium mobilization assay ChEMBL. 16913720
EC50 (functional) 0 Activity at human LPA3 receptor in RH7777 cells at 30 uM by calcium mobilization assay ChEMBL. 16913720
EC50 (functional) 0 Activity at human LPA2 receptor in RH7777 cells at 30 uM by calcium mobilization assay ChEMBL. 16913720
EC50 (functional) 0 Activity at human LPA1 receptor in RH7777 cells at 30 uM by calcium mobilization assay ChEMBL. 16913720
Emax (functional) Activity at human LPA1 receptor expressed in RH7777 cells relative to LPA by calcium mobilization assay ChEMBL. 16913720
Emax (functional) Activity at human LPA3 receptor expressed in RH7777 cells relative to LPA by calcium mobilization assay ChEMBL. 16913720
Emax (functional) 0 Activity at human LPA1 receptor expressed in RH7777 cells relative to LPA by calcium mobilization assay ChEMBL. 16913720
Emax (functional) 0 Activity at human LPA3 receptor expressed in RH7777 cells relative to LPA by calcium mobilization assay ChEMBL. 16913720
IC50 (functional) Activity at human LPA2 receptor in RH7777 cells at 30 uM by calcium mobilization assay ChEMBL. 16913720
IC50 (functional) 0 Activity at human LPA2 receptor in RH7777 cells at 30 uM by calcium mobilization assay ChEMBL. 16913720
IC50 (functional) = 799 nM Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
IC50 (functional) = 799 nM Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
IC50 (functional) = 2340 nM Activity at human LPA3 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
IC50 (functional) = 2340 nM Activity at human LPA3 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
Ki (functional) Activity at human LPA2 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
Ki (functional) 0 Activity at human LPA2 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
Ki (functional) = 314 nM Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
Ki (functional) = 314 nM Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
Ki (functional) = 1150 nM Activity at human LPA3 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
Ki (functional) = 1150 nM Activity at human LPA3 receptor expressed in RH7777 cells by calcium mobilization assay ChEMBL. 16913720
pKa = 6.48 Dissociation constant, pKa of the compound ChEMBL. 16913720

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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