Detailed information for compound 368299

Basic information

Technical information
  • TDR Targets ID: 368299
  • Name: 2-[(1-ethyl-3,4-dihydro-2H-naphthalen-1-yl)me thyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1 -oxo-2,3-benzoxazin-6-yl)propanamide
  • MW: 474.472 | Formula: C25H25F3N2O4
  • H donors: 2 H acceptors: 3 LogP: 5.4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1(CCCc2c1cccc2)CC(C(F)(F)F)(C(=O)Nc1ccc2c(c1)c(C)noc2=O)O
  • InChi: 1S/C25H25F3N2O4/c1-3-23(12-6-8-16-7-4-5-9-20(16)23)14-24(33,25(26,27)28)22(32)29-17-10-11-18-19(13-17)15(2)30-34-21(18)31/h4-5,7,9-11,13,33H,3,6,8,12,14H2,1-2H3,(H,29,32)
  • InChiKey: QNVMARIKSCEIAR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(1-ethyltetralin-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
  • 2-[(1-ethyl-1-tetralinyl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)propanamide
  • 2-[(1-ethyltetralin-1-yl)methyl]-3,3,3-trifluoro-2-hydroxy-N-(1-keto-4-methyl-2,3-benzoxazin-6-yl)propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0182 0.1394 0.1374
Plasmodium vivax histone deacetylase, putative 0.0274 0.2161 0.6161
Schistosoma mansoni hypothetical protein 0.0051 0.0293 0.0293
Echinococcus multilocularis histone deacetylase 8 0.0159 0.1193 0.1173
Echinococcus multilocularis orexin receptor type 2 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0051 0.0293 0.0293
Echinococcus granulosus tm gpcr rhodopsin 0.1208 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1208 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0549 0.1483
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0144 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0023 0.0023
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0129 0.0106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0293 0.0293
Onchocerca volvulus Histone deacetylase 10 homolog 0.0159 0.1193 0.1173
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1208 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.1208 1 1
Echinococcus granulosus tissue type plasminogen activator 0.0029 0.0102 0.0079
Loa Loa (eye worm) hypothetical protein 0.0247 0.1933 0.1914
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0112 0.0089
Brugia malayi Serotonin receptor 0.1208 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0618 0.0597
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0112 0.0214
Onchocerca volvulus 0.1208 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0605 0.4935 0.4924
Giardia lamblia GTOR 0.009 0.0618 0.1683
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0605 0.4935 0.4935
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1208 1 1
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0883 0.7273 1
Schistosoma mansoni metabotropic glutamate receptor 0.0028 0.0099 0.0099
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0038
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0299 0.0757
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.003 0.0118 0.0118
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0082 0.0549 0.0549
Echinococcus multilocularis serotonin receptor 0.1208 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0112 0.0214
Schistosoma mansoni ran 0.0021 0.0038 0.0038
Brugia malayi nuclear receptor NHR-88 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0413 0.3324 0.3324
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0023 0.0023
Echinococcus granulosus metabotropic glutamate receptor 5 0.0041 0.0209 0.0187
Echinococcus multilocularis dro:myosuppressin receptor 0.1208 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.1208 1 1
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0023 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Brugia malayi ecdysteroid receptor 0.0019 0.0023 0.0023
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0432 0.3485 1
Echinococcus granulosus allatostatin A receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0023 0.0023
Schistosoma mansoni histone deacetylase 1 2 3 0.0159 0.1193 0.1193
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0846 0.0825
Echinococcus multilocularis neuropeptide receptor 0.1208 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.3324 0.3309
Onchocerca volvulus Neuropeptide F receptor homolog 0.1208 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Echinococcus multilocularis tissue type plasminogen activator 0.0029 0.0102 0.0079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0618 0.0618
Loa Loa (eye worm) histone deacetylase 1 0.0432 0.3485 0.347
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Onchocerca volvulus 0.003 0.0112 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0112 0.0089
Brugia malayi hypothetical protein 0.1208 1 1
Schistosoma mansoni opsin-like receptor 0.1208 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0023 0.0023
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0399 0.3214 0.9215
Schistosoma mansoni neuropeptide receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0089
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0179 0.1367 0.1347
Echinococcus granulosus serine protein kinase ATM 0.0057 0.0345 0.0323
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0429 0.3464 0.9938
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus multilocularis alkaline phosphatase 0.0179 0.1367 0.1347
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Entamoeba histolytica hypothetical protein 0.0057 0.0345 0.089
Onchocerca volvulus 0.0029 0.0106 0.0083
Schistosoma mansoni hypothetical protein 0.1208 1 1
Echinococcus granulosus neuropeptide receptor 0.1208 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0147 0.1095 0.3068
Echinococcus multilocularis fmrfamide receptor 0.1208 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0059 0.0035
Schistosoma mansoni hypothetical protein 0.003 0.0112 0.0112
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1208 1 1
Brugia malayi putative neuropeptide receptor 0.1208 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0147 0.1095 0.3068
Echinococcus granulosus intermediate filament protein 0.003 0.0112 0.0089
Echinococcus multilocularis Zinc finger, PHD finger 0.0082 0.0549 0.0528
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0388 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0293 0.0271
Echinococcus multilocularis GPCR, family 2 0.0051 0.0293 0.0271
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0062 0.0385 0.1007
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.205 0.2031
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0147 0.1095 0.1095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0293 0.0271
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0432 0.3485 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0147 0.1095 0.3068
Echinococcus granulosus g protein coupled receptor 0.1208 1 1
Entamoeba histolytica histone deacetylase, putative 0.0432 0.3485 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Echinococcus multilocularis neuropeptide FF receptor 2 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.051 0.4141 0.4127
Echinococcus granulosus G protein coupled receptor 139 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.1208 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0023 0.0023
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.003 0.0112 0.0214
Entamoeba histolytica hypothetical protein 0.003 0.0112 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0023 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.003 0.0112 0.0214
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.1088 0.8991 0.8988
Leishmania major histone deacetylase, putative 0.0432 0.3485 1
Brugia malayi hypothetical protein 0.0034 0.0144 0.0144
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Leishmania major histone deacetylase, putative 0.0432 0.3485 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0023 0.0023
Echinococcus multilocularis lamin 0.003 0.0112 0.0089
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0038 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0385 0.1007
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Onchocerca volvulus 0.1208 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0618 0.0618
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0023 0.0023
Toxoplasma gondii histone deacetylase HDAC4 0.0159 0.1193 0.3352
Onchocerca volvulus 0.1208 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0112 0.0112
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1208 1 1
Brugia malayi hypothetical protein 0.1208 1 1
Brugia malayi AKH receptor 0.1208 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0429 0.3464 0.3464
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.003 0.0112 0.0214
Toxoplasma gondii histone deacetylase HDAC2 0.0432 0.3485 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0144 0.0307
Schistosoma mansoni hypothetical protein 0.0303 0.2407 0.2407
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0147 0.1095 0.3068
Echinococcus multilocularis neuropeptide s receptor 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.054 0.4389 0.4376
Loa Loa (eye worm) intermediate filament protein 0.003 0.0112 0.0089
Echinococcus granulosus muscleblind protein 0.0147 0.1097 0.1077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1208 1 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0326 0.2599 0.2582
Echinococcus granulosus S formylglutathione hydrolase 0.0038 0.0178 0.0155
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.0073
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0082 0.0549 0.0549
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0618 0.1683
Trypanosoma brucei histone deacetylase 1 0.0432 0.3485 1
Echinococcus granulosus neuropeptides capa receptor 0.1208 1 1
Echinococcus multilocularis g protein coupled receptor 0.1208 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0038 0.0015
Trypanosoma cruzi histone deacetylase, putative 0.0159 0.1193 0.3352
Schistosoma mansoni hypothetical protein 0.1208 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1208 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0102 0.0079
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.1208 1 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0178 0.0092
Onchocerca volvulus 0.1208 1 1
Echinococcus multilocularis somatostatin receptor 0.1208 1 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0028 0.0099 0.0076
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0247 0.1933 0.1914
Schistosoma mansoni neuropeptide receptor 0.1208 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1208 1 1
Schistosoma mansoni opsin-like receptor 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.016 0.0354
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0095 0.0658 0.1799
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0333 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0112 0.0214
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0147 0.1095 0.1095
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1208 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1208 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0096 0.0167
Loa Loa (eye worm) hypothetical protein 0.0052 0.0299 0.0277
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0326 0.2599 0.2582
Echinococcus multilocularis g protein coupled receptor 0.1208 1 1
Schistosoma mansoni histamine h1 receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi Histone deacetylase 1 0.0432 0.3485 0.3485
Echinococcus granulosus histone deacetylase 6 0.0274 0.2161 0.2143
Loa Loa (eye worm) esterase D 0.0038 0.0178 0.0155
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Brugia malayi G protein-coupled receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Schistosoma mansoni histone deacetylase 4 5 0.0274 0.2161 0.2161
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0147 0.1095 0.3068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0429 0.3464 0.9938
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.009 0.0618 0.1683
Brugia malayi hypothetical protein 0.1208 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.1208 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1208 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0329 0.2626 0.7509
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0057 0.0345 0.089
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0247 0.1933 0.1914
Schistosoma mansoni amine GPCR 0.1208 1 1
Brugia malayi sulfakinin receptor protein 0.1208 1 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0057 0.0345 0.089
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0112 0.0089
Echinococcus granulosus lamin dm0 0.003 0.0112 0.0089
Schistosoma mansoni biogenic amine (5HT) receptor 0.1208 1 1
Toxoplasma gondii histone deacetylase HDAC3 0.0432 0.3485 1
Brugia malayi G-protein coupled receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus histone deacetylase 8 0.0159 0.1193 0.1173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0385 0.1007
Schistosoma mansoni survival motor neuron protein 0.0053 0.0309 0.0309
Echinococcus granulosus GPCR family 2 0.0051 0.0293 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0102 0.0186
Schistosoma mansoni coup transcription factor 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus neuropeptide receptor 0.1208 1 1
Brugia malayi Dopamine receptor 0.1208 1 1
Echinococcus granulosus dnaJ subfamily B 0.0413 0.3324 0.3309
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1208 1 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0082 0.0549 0.1483
Brugia malayi ORL1-like opioid receptor 0.1208 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0023 0.0023
Echinococcus granulosus hypothetical protein 0.1208 1 1
Trypanosoma brucei histone deacetylase, putative 0.0274 0.2161 0.6161
Schistosoma mansoni neuropeptide F-like receptor 0.1208 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.205 0.2031
Schistosoma mansoni growth hormone secretagogue receptor 0.1208 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.1208 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.009 0.0618 0.1683
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0793 0.0793
Echinococcus granulosus neuropeptide FF receptor 2 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1088 0.8991 0.8988
Schistosoma mansoni histone deacetylase 0.0432 0.3485 0.3485
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0112 0.0214
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.003 0.0112 0.0214
Plasmodium falciparum histone deacetylase, putative 0.0274 0.2161 0.6161
Plasmodium falciparum phosphatidylinositol 4-kinase 0.003 0.0112 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus histone deacetylase 3 0.0432 0.3485 0.347
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Loa Loa (eye worm) hypothetical protein 0.0034 0.0144 0.0121
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.016 0.0137
Onchocerca volvulus 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Giardia lamblia Hypothetical protein 0.003 0.0112 0.0214
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0274 0.2161 0.6161
Brugia malayi Dopamine receptor protein 2 0.1208 1 1
Brugia malayi neuropeptide F receptor 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.1208 1 1
Plasmodium vivax histone deacetylase 2, putative 0.0274 0.2161 0.6161
Loa Loa (eye worm) TK/ROR protein kinase 0.0029 0.0102 0.0079
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1208 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0057 0.0345 0.0345
Echinococcus multilocularis 0.003 0.0112 0.0089
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0101 0.0183
Brugia malayi Histone deacetylase family protein 0.0274 0.2161 0.2161
Echinococcus multilocularis muscleblind protein 0.0147 0.1097 0.1077
Brugia malayi hypothetical protein 0.1208 1 1
Echinococcus multilocularis histone deacetylase 7 0.0274 0.2161 0.2143
Echinococcus granulosus histone deacetylase 0.0274 0.2161 0.2143
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0023 0.0023
Echinococcus multilocularis neuropeptide Y receptor 0.1208 1 1
Loa Loa (eye worm) histone deacetylase 11 0.0159 0.1193 0.1173
Echinococcus multilocularis neuropeptides capa receptor 0.1208 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0293 0.0271
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1208 1 1
Schistosoma mansoni amine GPCR 0.1208 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1208 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Entamoeba histolytica protein kinase rad3, putative 0.0057 0.0345 0.089
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.003 0.0112 0.0089
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0082 0.0549 0.1483
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus g protein coupled receptor 0.1208 1 1
Loa Loa (eye worm) histone deacetylase 3 0.0432 0.3485 0.347
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0182 0.1387 0.3913
Echinococcus granulosus orexin receptor type 2 0.1208 1 1
Brugia malayi neuropeptide F receptor 0.1208 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1208 1 1
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1097 0.1077
Onchocerca volvulus 0.1208 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.1208 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0136 0.0136
Brugia malayi histone deacetylase 11 0.0159 0.1193 0.1193
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0144 0.0144
Echinococcus multilocularis serotonin receptor 0.1208 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0549 0.1483
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0023 0.0023
Trypanosoma cruzi histone deacetylase 1, putative 0.0432 0.3485 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.1208 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.1223 0.1223
Leishmania major hypothetical protein, conserved 0.0029 0.0102 0.0186
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0056 0.0052
Schistosoma mansoni hypothetical protein 0.0035 0.016 0.016
Brugia malayi G-protein coupled receptor 0.1208 1 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0112 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0247 0.1933 0.1933
Brugia malayi Histone deacetylase family protein 0.0274 0.2161 0.2161
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0112 0.0214
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0023 0.0023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.1223 0.1203
Loa Loa (eye worm) hypothetical protein 0.0051 0.0293 0.0271
Echinococcus multilocularis sex peptide receptor 0.1208 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.0364 0.2917 0.8354
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Schistosoma mansoni fkbp-rapamycin associated protein 0.0057 0.0345 0.0345
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0147 0.1095 0.3068
Schistosoma mansoni amine GPCR 0.1208 1 1
Schistosoma mansoni histone deacetylase hda2 0.0159 0.1193 0.1193
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0429 0.3464 0.9938
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.003 0.0112 0.0112
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0023 0.0023
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0429 0.3464 0.9938
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Leishmania major phosphatidylinositol kinase, putative 0.003 0.0112 0.0214
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0112 0.0089
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0618 0.0597
Loa Loa (eye worm) neuropeptide F receptor 0.1208 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0429 0.3464 0.9938
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni ran 0.0021 0.0038 0.0038
Brugia malayi Serotonin receptor 0.1208 1 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0057 0.0345 0.089
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0033 0.0136 0.0113
Brugia malayi Pre-SET motif family protein 0.023 0.1793 0.1793
Echinococcus granulosus histone deacetylase 6 0.0274 0.2161 0.2143
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0883 0.7273 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0618 0.1683
Toxoplasma gondii histone deacetylase HDAC1 0.0274 0.2161 0.6161
Mycobacterium tuberculosis Probable conserved exported protein 0.0038 0.0178 0.0092
Onchocerca volvulus 0.0034 0.0144 0.0121
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0299 0.0757
Leishmania major phosphatidylinositol 3-related kinase, putative 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.0122 0.0884 0.0863
Schistosoma mansoni amine GPCR 0.1208 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0056 0.0052
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0549 0.1483
Echinococcus granulosus importin subunit beta 1 0.0028 0.0101 0.0078
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0082 0.0549 0.0549
Trypanosoma cruzi histone deacetylase, putative 0.0274 0.2161 0.6161
Brugia malayi intermediate filament protein 0.003 0.0112 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0023 0.0023
Loa Loa (eye worm) histone deacetylase 0.0274 0.2161 0.2143
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0028 0.0099 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0112 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0023 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0299 0.0757
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.009 0.0618 0.1683
Echinococcus granulosus histone deacetylase 1 0.0432 0.3485 0.347
Echinococcus multilocularis G protein coupled receptor 139 0.1208 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0112 0.0089
Brugia malayi RNA, U transporter 1 0.0081 0.054 0.054
Onchocerca volvulus 0.003 0.0112 0.0089
Loa Loa (eye worm) histone deacetylase 7A 0.0274 0.2161 0.2143
Leishmania major hypothetical protein, conserved 0.0405 0.326 0.9347
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1208 1 1
Brugia malayi Esterase D 0.0038 0.0178 0.0178
Brugia malayi Kringle domain containing protein 0.0029 0.0102 0.0102
Brugia malayi histone deacetylase 1 (HD1) 0.0432 0.3485 0.3485
Onchocerca volvulus 0.0053 0.0309 0.0286
Echinococcus multilocularis cpg binding protein 0.0031 0.012 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0144 0.0144
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0106 0.0083
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0038 0.0178 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Leishmania major phosphatidylinositol 3-kinase, putative 0.0082 0.0549 0.1483
Brugia malayi Melatonin receptor type 1A 0.1208 1 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0432 0.3485 1
Brugia malayi putative neuropeptide receptor NPR1 0.1208 1 1
Schistosoma mansoni histone deacetylase hda2 0.028 0.2215 0.2215
Echinococcus multilocularis neuropeptide receptor A26 0.1208 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.1208 1 1
Loa Loa (eye worm) glutamate receptor 0.0034 0.0144 0.0121
Leishmania major hypothetical protein, conserved 0.0052 0.0299 0.0757
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1208 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.1097 0.1077
Loa Loa (eye worm) hypothetical protein 0.0111 0.0793 0.0771
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0023 0.0023
Echinococcus granulosus 7tm_1 domain containing protein 0.1208 1 1
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0038 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0147 0.1097 0.1077
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0618 0.1683
Trypanosoma cruzi histone deacetylase 1, putative 0.0432 0.3485 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0299 0.0757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0096 0.0167
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.051 0.4141 0.4141
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.009 0.0618 0.0597
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0147 0.1095 0.3068
Echinococcus multilocularis serine protein kinase ATM 0.0057 0.0345 0.0323
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1208 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Trichomonas vaginalis set domain proteins, putative 0.0262 0.2059 0.5862
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.016 0.0137
Trypanosoma brucei histone deacetylase 3 0.0274 0.2161 0.6161
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0023 0.0023
Echinococcus granulosus somatostatin receptor 0.1208 1 1
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0038 0.0178 0.0404
Giardia lamblia Histone deacetylase 0.0432 0.3485 1
Trypanosoma cruzi histone deacetylase, putative 0.0159 0.1193 0.3352
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1208 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Echinococcus multilocularis musashi 0.003 0.0112 0.0089
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.1793 0.1774
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0179 0.1367 0.1347
Schistosoma mansoni neuropeptide f receptor 76f 0.1208 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0112 0.0214
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0299 0.0757
Loa Loa (eye worm) hypothetical protein 0.0261 0.205 0.2031
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Leishmania major histone deacetylase, putative 0.0274 0.2161 0.6161
Trypanosoma brucei histone deacetylase 2 0.0159 0.1193 0.3352
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0082 0.0549 0.1483
Brugia malayi CXXC zinc finger family protein 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0034 0.0144 0.0144
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1208 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0399 0.3211 0.3195
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1208 1 1
Toxoplasma gondii histone deacetylase HDAC5 0.0159 0.1193 0.3352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0209 0.0187
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0101 0.0183
Brugia malayi hypothetical protein 0.1208 1 1
Leishmania major hypothetical protein, unknown function 0.003 0.0112 0.0214
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0385 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0144 0.0144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0144 0.0121
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1208 1 1
Echinococcus granulosus alkaline phosphatase 0.0179 0.1367 0.1347
Onchocerca volvulus 0.1208 1 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0326 0.2599 0.2582
Echinococcus granulosus intestinal type alkaline phosphatase 0.0179 0.1367 0.1347
Schistosoma mansoni phosphatidylinositol 4-kinase 0.003 0.0112 0.0112
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0117 0.0846 0.2344
Brugia malayi follicle stimulating hormone receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi hypothetical protein 0.0052 0.0299 0.0299
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0033 0.0136 0.0113
Schistosoma mansoni myosin xvIII 0.1208 1 1
Brugia malayi hypothetical protein 0.1208 1 1
Schistosoma mansoni adenoreceptor 0.1208 1 1
Echinococcus multilocularis neuropeptide receptor 0.1208 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0082 0.0549 0.1483
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus neuropeptide Y receptor 0.1208 1 1
Toxoplasma gondii kringle domain-containing protein 0.0029 0.0102 0.0186
Schistosoma mansoni hypothetical protein 0.0053 0.0309 0.0309
Plasmodium falciparum importin beta, putative 0.0028 0.0101 0.0183
Schistosoma mansoni amine GPCR 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0023 0.0059 0.0059
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0023 0.0023
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0326 0.2599 0.2582
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0023 0.0023
Brugia malayi RE15519p 0.1208 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1208 1 1
Schistosoma mansoni intermediate filament proteins 0.003 0.0112 0.0112
Echinococcus granulosus neuropeptide s receptor 0.1208 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0364 0.2917 0.8354
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1208 1 1
Echinococcus granulosus neuropeptides capa receptor 0.1208 1 1
Brugia malayi hypothetical protein 0.1208 1 1
Echinococcus granulosus neuropeptide receptor A26 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1193 0.1173
Echinococcus granulosus sex peptide receptor 0.1208 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0429 0.3464 0.9938
Echinococcus multilocularis histone deacetylase 0.0274 0.2161 0.2143
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0038 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Plasmodium vivax histone deacetylase 1, putative 0.0432 0.3485 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0549 0.1483
Loa Loa (eye worm) hypothetical protein 0.0028 0.0101 0.0078
Echinococcus multilocularis g protein coupled receptor 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0093 0.0644 0.0644
Brugia malayi Protein kinase domain containing protein 0.0326 0.2599 0.2599
Echinococcus multilocularis lamin dm0 0.003 0.0112 0.0089
Onchocerca volvulus 0.1208 1 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0029 0.0102 0.0186
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.003 0.0112 0.0089
Echinococcus multilocularis histone deacetylase 1 0.0432 0.3485 0.347
Brugia malayi FAT domain containing protein 0.0033 0.0136 0.0136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0144 0.0121
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0309 0.0309
Echinococcus multilocularis S formylglutathione hydrolase 0.0038 0.0178 0.0155
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.003 0.0112 0.0214
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0082 0.0549 0.0528
Trypanosoma cruzi hypothetical protein, conserved 0.0375 0.301 0.8623
Schistosoma mansoni hypothetical protein 0.0051 0.0293 0.0293
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0062 0.0385 0.1007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0038 0.0178 0.0092
Plasmodium vivax histone deacetylase, putative 0.0159 0.1193 0.3352
Trypanosoma brucei histone deacetylase 4 0.0274 0.2161 0.6161
Echinococcus multilocularis histone deacetylase 6 0.0274 0.2161 0.2143
Echinococcus granulosus lamin 0.003 0.0112 0.0089
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0329 0.2626 0.7509
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Onchocerca volvulus 0.1208 1 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0029 0.0102 0.0186
Toxoplasma gondii FATC domain-containing protein 0.0057 0.0345 0.089
Brugia malayi hypothetical protein 0.0261 0.205 0.205
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0057 0.0345 0.0323
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0112 0.0112
Brugia malayi hypothetical protein 0.1208 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.1208 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.009 0.0618 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Schistosoma mansoni lamin 0.003 0.0112 0.0112
Loa Loa (eye worm) G-protein coupled receptor 0.1208 1 1
Schistosoma mansoni opsin-like receptor 0.1208 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1208 1 1
Mycobacterium tuberculosis Possible conserved membrane protein 0.0038 0.0178 0.0092
Echinococcus granulosus tm gpcr rhodopsin 0.1208 1 1
Brugia malayi Muscleblind-like protein 0.0147 0.1097 0.1097
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0023 0.0023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0618 0.0618
Trypanosoma brucei target of rapamycin kinase 3, putative 0.009 0.0618 0.1683
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0618 0.1683
Brugia malayi steroid hormone receptor 0.0019 0.0023 0.0023
Loa Loa (eye worm) melatonin receptor type 1A 0.1208 1 1
Echinococcus granulosus histone deacetylase 6 0.028 0.2215 0.2196
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0082 0.0549 0.1483
Schistosoma mansoni cpg binding protein 0.0029 0.0106 0.0106
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0057 0.0345 0.0323
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0326 0.2599 0.2599
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0082 0.0549 0.1483
Echinococcus multilocularis histone deacetylase 6 0.0274 0.2161 0.2143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0112 0.0112
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.009 0.0618 0.1683
Echinococcus granulosus g protein coupled receptor 0.1208 1 1
Schistosoma mansoni hypothetical protein 0.0051 0.0293 0.0293
Echinococcus granulosus serotonin receptor 0.1208 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Schistosoma mansoni histone deacetylase 4 5 0.0274 0.2161 0.2161
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1208 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.009 0.0618 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0136 0.0284
Brugia malayi histone deacetylase 3 (HD3) 0.0432 0.3485 0.3485
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.003 0.0112 0.0214
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0299 0.0757
Brugia malayi Importin beta-1 subunit 0.0028 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0029 0.0102 0.0102
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0082 0.0549 0.1483
Schistosoma mansoni histone deacetylase 0.0432 0.3485 0.3485
Echinococcus granulosus tachykinin peptides receptor 99D 0.1208 1 1
Schistosoma mansoni neuropeptide receptor 0.1208 1 1
Onchocerca volvulus 0.1208 1 1
Onchocerca volvulus 0.0262 0.2059 0.204
Trypanosoma cruzi histone deacetylase, putative 0.0274 0.2161 0.6161
Brugia malayi nuclear hormone receptor 0.0019 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.003 0.0112 0.0214
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.003 0.0112 0.0112
Echinococcus granulosus alpha 1A adrenergic receptor 0.1208 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0618 0.1683
Echinococcus granulosus histone deacetylase 7 0.0274 0.2161 0.2143
Schistosoma mansoni biogenic amine receptor 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.003 0.0112 0.0214
Schistosoma mansoni neuropeptide receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Entamoeba histolytica hypothetical protein 0.0035 0.016 0.0354
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0112 0.0112
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1208 1 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0175 0.1335 0.1335
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0038 0.0178 0.0092
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0057 0.0345 0.089
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0059 0.0035
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0038 0.0178 0.0092
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.009 0.0618 0.1683
Echinococcus granulosus neuropeptide Y receptor 0.1208 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0056 0.0052
Onchocerca volvulus 0.003 0.0112 0.0089
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1208 1 1
Echinococcus multilocularis fmrfamide receptor 0.1208 1 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0605 0.4935 0.4924
Leishmania major importin beta-1 subunit, putative 0.0023 0.0056 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Echinococcus granulosus biogenic amine 5HT receptor 0.1208 1 1
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0038 0.0178 0.0092
Plasmodium vivax hypothetical protein 0.003 0.0112 0.0214
Brugia malayi Pre-SET motif family protein 0.0034 0.0144 0.0144
Onchocerca volvulus 0.1208 1 1
Loa Loa (eye worm) TYRA-2 protein 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0056 0.0052
Echinococcus multilocularis allatostatin A receptor 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0345 0.089
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1208 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0023 0.0023
Leishmania major histone deacetylase, putative 0.0274 0.2161 0.6161
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0085
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0345 0.0345
Brugia malayi Protein kinase domain containing protein 0.0029 0.0102 0.0102
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0618 0.0597
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.003 0.0112 0.0214
Brugia malayi hypothetical protein 0.1208 1 1
Schistosoma mansoni alkaline phosphatase 0.0179 0.1367 0.1367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0179 0.1367 0.1347
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0082 0.0549 0.1483
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1208 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0144 0.0307
Brugia malayi larval opioid receptor 0.1208 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.009 0.0618 0.1683
Echinococcus multilocularis histone deacetylase 6 0.028 0.2215 0.2196
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0144 0.0144
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0082 0.0549 0.0528
Schistosoma mansoni serine/threonine protein kinase 0.0326 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0432 0.3485 0.347
Schistosoma mansoni biogenic amine receptor 0.1208 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.003 0.0112 0.0214
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0101 0.0183
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0112 0.0089
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0618 0.1683
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0023 0.0023
Brugia malayi GnHR receptor homolog 0.1208 1 1
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0179 0.1367 0.1347
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0326 0.2599 0.2582
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0082 0.0549 0.0528
Brugia malayi G protein-coupled receptor F59B2.13 0.1208 1 1
Onchocerca volvulus 0.003 0.0112 0.0089
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0299 0.0757
Echinococcus granulosus cpg binding protein 0.0031 0.012 0.0097
Onchocerca volvulus 0.0029 0.0102 0.0079
Echinococcus multilocularis g-protein coupled receptor 0.1208 1 1
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0038 0.0178 0.0092
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0293 0.0293
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0136 0.0113
Schistosoma mansoni alkaline phosphatase 0.0179 0.1367 0.1367
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1208 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.016 0.016
Plasmodium falciparum histone deacetylase 1 0.0432 0.3485 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.003 0.0112 0.0089
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Schistosoma mansoni cpg binding protein 0.0031 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1208 1 1
Entamoeba histolytica hypothetical protein 0.003 0.0112 0.0214
Echinococcus granulosus biogenic amine 5HT receptor 0.1208 1 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0056 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1208 1 1
Brugia malayi hypothetical protein 0.0035 0.016 0.016
Giardia lamblia Phosphatidylinositol 4-kinase 0.003 0.0112 0.0214
Entamoeba histolytica hypothetical protein 0.0035 0.016 0.0354
Schistosoma mansoni importin beta-1 0.0028 0.0101 0.0101
Echinococcus granulosus g-protein coupled receptor 0.1208 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0432 0.3485 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0618 0.1683
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0096 0.0167
Schistosoma mansoni cpg binding protein 0.0031 0.012 0.012
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1208 1 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0264 0.208 0.5925
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0179 0.1367 0.1347
Echinococcus granulosus rhodopsin orphan GPCR 0.1208 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0345 0.0323
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0082 0.0549 0.1483
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0399 0.3211 0.3195
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1208 1 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0041 0.0209 0.0187
Entamoeba histolytica hypothetical protein 0.0035 0.016 0.0354
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.2407 0.2389
Plasmodium falciparum histone deacetylase 2 0.0274 0.2161 0.6161
Schistosoma mansoni hypothetical protein 0.0111 0.0793 0.0793
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0112 0.0089
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1208 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0345 0.0345
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0618 0.0597
Schistosoma mansoni biogenic amine receptor 0.1208 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.003 0.0112 0.0214
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.009 0.0618 0.1683
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0883 0.7273 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0112 0.0214
Echinococcus granulosus snurportin 1 0.0303 0.2407 0.2389
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0023 0.0023
Onchocerca volvulus 0.1208 1 1
Brugia malayi Dopamine receptor protein 1 0.1208 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.1208 1 1
Schistosoma mansoni lamin 0.003 0.0112 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0023 0.0023
Echinococcus granulosus fmrfamide receptor 0.1208 1 1
Echinococcus multilocularis histone deacetylase 3 0.0432 0.3485 0.347
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Echinococcus multilocularis snurportin 1 0.0303 0.2407 0.2389
Echinococcus granulosus 7TM GPCR rhodopsin 0.1208 1 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0101 0.0183
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0112 0.0089
Loa Loa (eye worm) hypothetical protein 0.1208 1 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0831 0.081
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0101 0.0078
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0618 0.1683
Trypanosoma cruzi target of rapamycin kinase 3 0.009 0.0618 0.1683
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0082 0.0549 0.0528

Activities

Activity type Activity value Assay description Source Reference
%max (functional) = 31 % Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
%max (functional) = 31 % Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
%max (functional) = 73 % Agonist activity at GR assessed as NFkappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
%max (functional) = 73 % Agonist activity at GR assessed as NFkappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
Activity (functional) 0 Agonist activity at glucocorticoid receptor Q570A mutant in COS7 cells at 1 uM by NFkappaB-luciferase reporter gene assay ChEMBL. 18038970
Activity (functional) 0 Agonist activity at glucocorticoid receptor R611A mutant in COS7 cells at 1 uM by NFkappaB-luciferase reporter gene assay ChEMBL. 18038970
Activity (functional) = 31 % Agonist activity at glucocorticoid receptor in human A549 cells at 10 mM by MMTV transactivation assay relative to dexamethasone ChEMBL. 18038970
Activity (functional) = 31 % Agonist activity at glucocorticoid receptor in human A549 cells at 10 mM by MMTV transactivation assay relative to dexamethasone ChEMBL. 18038970
Activity (functional) = 73 % Agonist activity at glucocorticoid receptor in human A549 cells at 10 mM by NFkappaB transrepression assay relative to dexamethasone ChEMBL. 18038970
Activity (functional) = 73 % Agonist activity at glucocorticoid receptor in human A549 cells at 10 mM by NFkappaB transrepression assay relative to dexamethasone ChEMBL. 18038970
EC50 (functional) = 8.04 Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
EC50 (functional) = 8.04 Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay ChEMBL. 18038970
ED50 (functional) = 5 ug Anti-inflammatory activity against oxazolone-induced ear skin delayed types hypersensitivity model in topically dosed Balb/c mouse ChEMBL. 16821781
ED50 (functional) = 5 ug Anti-inflammatory activity against oxazolone-induced ear skin delayed types hypersensitivity model in topically dosed Balb/c mouse ChEMBL. 16821781
IC50 (functional) = 6.7 Activity at GR assessed as ability to antagonize dexamethasone-induced MMTV luciferase reporter gene transactivation in human A549 cells ChEMBL. 16821781
IC50 (functional) = 6.7 Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexamethasone-induced activation ChEMBL. 18038970
IC50 (binding) = 8.21 Inhibition of fluorescent-labeled dexamethasone binding to GR ChEMBL. 16821781
IC50 (binding) = 8.21 Displacement of fluorescent labeled dexamethasone from glucocorticoid receptor ChEMBL. 18038970
IC50 (functional) = 8.3 Agonist activity at GR assessed as NFkappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cells ChEMBL. 16821781
IC50 (functional) = 8.3 Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay ChEMBL. 18038970
Log EC50 (functional) = 8.04 Agonist activity at GR assessed as MMTV-mediated transactivation of renilla luciferase gene in human A549 cells relative to dexamethasone ChEMBL. 16821781
Log EC50 (functional) = 8.04 Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay ChEMBL. 18038970
Log IC50 (functional) = 6.7 Activity at GR assessed as ability to antagonize dexamethasone-induced MMTV luciferase reporter gene transactivation in human A549 cells ChEMBL. 16821781
Log IC50 (functional) = 6.7 Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexamethasone-induced activation ChEMBL. 18038970
Log IC50 (binding) = 8.21 Inhibition of fluorescent-labeled dexamethasone binding to GR ChEMBL. 16821781
Log IC50 (binding) = 8.21 Displacement of fluorescent labeled dexamethasone from glucocorticoid receptor ChEMBL. 18038970
Log IC50 (functional) = 8.3 Agonist activity at GR assessed as NFkappaB-mediated transrepression of secreted placental alkaline phosphatase gene in human A549 cells ChEMBL. 16821781
Log IC50 (functional) = 8.3 Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay ChEMBL. 18038970

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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