Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 0.022 | 0.0225 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.022 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.022 | 0.0225 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0031 | 0.022 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.022 | 0.0225 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.022 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 0.022 | 0.0225 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.022 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0663 | 0.9754 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 0.022 | 0.0225 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 0.022 | 1 |
Brugia malayi | steroid hormone receptor | 0.0031 | 0.022 | 0.0225 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.022 | 0.0225 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 0.022 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.022 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.022 | 0.0225 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 0.022 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0031 | 0.022 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 0.022 | 0.0225 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.022 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.022 | 0.0225 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 0.022 | 0.0225 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.022 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 0.022 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 0.022 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.022 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 0.022 | 0.0225 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0031 | 0.022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.022 | 0.0225 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 0.022 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.022 | 0.0225 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.022 | 0.0225 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 0.022 | 0.0225 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0031 | 0.022 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0031 | 0.022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0649 | 0.9534 | 0.9775 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.022 | 0.0225 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 0.022 | 0.0225 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 0.022 | 0.0225 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 0.022 | 0.0225 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.022 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.022 | 0.0225 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 0.022 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0031 | 0.022 | 0.0225 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 0.022 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 0.022 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0663 | 0.9754 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 0.022 | 0.0225 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 0.022 | 0.0225 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.022 | 0.0225 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 0.022 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.022 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity against human MCHR1 expressed in CHO cells assessed by inhibition of MCH-stimulated G protein-GTPgamma35S binding | ChEMBL. | 16814542 | |
Activity (functional) | 0 | Antagonist activity against human MCHR1 expressed in CHO cells assessed by inhibition of MCH-stimulated G protein-GTPgamma35S binding | ChEMBL. | 16814542 |
Ki (binding) | = -7.79 | Displacement of [125I-Tyr13]MCH from human MCHR1 expressed in HEK293 cells | ChEMBL. | 16814542 |
Ki (binding) | = 16 nM | Displacement of [125I-Tyr13]MCH from human MCHR1 expressed in HEK293 cells | ChEMBL. | 16814542 |
Ki (binding) | = 16 nM | Displacement of [125I-Tyr13]MCH from human MCHR1 expressed in HEK293 cells | ChEMBL. | 16814542 |
Log Ki (binding) | = 7.79 | Displacement of [125I-Tyr13]MCH from human MCHR1 expressed in HEK293 cells | ChEMBL. | 16814542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.