Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5355 | 0.5355 |
Echinococcus granulosus | carboxylesterase 5A | 0.0149 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0092 | 0.5355 | 0.5355 |
Echinococcus granulosus | acetylcholinesterase | 0.0149 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0092 | 0.5355 | 0.5355 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5355 | 0.5355 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.01494 | 0.5 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01494 | 0.5 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0025 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0149 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.01494 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.01494 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0149 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0149 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0092 | 0.5355 | 0.5355 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0149 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4845 | 0.4845 |
Echinococcus multilocularis | acetylcholinesterase | 0.0149 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01494 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0092 | 0.5355 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.01494 | 0.5 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0149 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.01494 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0092 | 0.5355 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0149 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.01494 | 0.5 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0092 | 0.5355 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0149 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.01494 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.01494 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.01494 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.01494 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.01494 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 500 nM | Inhibition of scarpie prion formation in mouse ScN2a cell line | ChEMBL. | 16913719 |
Activity (functional) | = 500 nM | Inhibition of scarpie prion formation in mouse ScN2a cell line | ChEMBL. | 16913719 |
Activity (ADMET) | = 5000 nM | Toxicity against ScN2a cell line | ChEMBL. | 16913719 |
Activity (ADMET) | = 5000 nM | Toxicity against ScN2a cell line | ChEMBL. | 16913719 |
CC50 (ADMET) | = 22000 nM | Toxicity against MRC5 cell line | ChEMBL. | 16913719 |
CC50 (ADMET) | = 22000 nM | Toxicity against MRC5 cell line | ChEMBL. | 16913719 |
EC50 (functional) | = 300 nM | Inhibition of scarpie prion formation in mouse ScN2a cell line relative to control | ChEMBL. | 16913719 |
EC50 (functional) | = 300 nM | Inhibition of scarpie prion formation in mouse ScN2a cell line relative to control | ChEMBL. | 16913719 |
IC50 (functional) | = 27.7 nM | Antimalaraial activity against CQ-resistant Plasmodium falciparum FcB1 | ChEMBL. | 16913719 |
IC50 (functional) | = 27.7 nM | Antimalaraial activity against CQ-resistant Plasmodium falciparum FcB1 | ChEMBL. | 16913719 |
Selectivity index (functional) | = 16.7 | Selectivity index, toxicity against ScN2a cell line/EC50 for scarpie prion formation in mouse ScN2a cell line | ChEMBL. | 16913719 |
Selectivity index (functional) | = 73.3 | Selectivity index, toxicity against MRC5 cell line/EC50 for scarpie prion formation in mouse ScN2a cell line | ChEMBL. | 16913719 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 16913719 | |
Mus musculus | ChEMBL23 | 16913719 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.