Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0273 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0273 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0273 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0273 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0273 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0273 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0273 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0273 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0273 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0273 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against gram positive methicillin-resistant Staphylococcus aureus OC 2878 | ChEMBL. | 16806921 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against gram positive vancomycin-resistant Enterococcus faecium OC 3312 | ChEMBL. | 16806921 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against gram positive methicillin-susceptible Staphylococcus aureus Smith OC 4172 by broth microdilution assay | ChEMBL. | 16806921 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against gram positive vancomycin-susceptible Enterococcus faecalis ATCC 29212 | ChEMBL. | 16806921 |
MIC (functional) | = 64 ug ml-1 | Antibacterial activity against gram positive Staphylococcus aureus Smith OC 4172 in presence of 50% mouse serum | ChEMBL. | 16806921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.