Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0516 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2015 | 1 |
Echinococcus granulosus | thymidylate kinase | 0.007 | 0.0516 | 0.0516 |
Chlamydia trachomatis | thymidylate kinase | 0.007 | 0.0516 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0484 | 0.6019 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.1208 | 0.1208 |
Onchocerca volvulus | 0.0182 | 0.2015 | 1 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.1338 | 0.1338 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.1338 | 0.1338 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0783 | 1 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0484 | 0.6019 | 1 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0069 | 0.051 | 0.051 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.007 | 0.0516 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 0.2015 | 0.2015 |
Echinococcus multilocularis | thymidylate kinase | 0.007 | 0.0516 | 0.0516 |
Loa Loa (eye worm) | thymidylate kinase | 0.007 | 0.0516 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2015 | 1 |
Plasmodium vivax | thymidylate kinase, putative | 0.007 | 0.0516 | 1 |
Loa Loa (eye worm) | deoxynucleoside kinase | 0.0069 | 0.051 | 0.253 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.007 | 0.0516 | 0.0012 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0.2015 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.1208 | 0.1208 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 0.2015 | 0.2015 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2015 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 0.2015 | 0.2015 |
Echinococcus granulosus | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0069 | 0.051 | 0.051 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 0.2015 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 0.2015 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.007 | 0.0516 | 0.0516 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 0.2015 | 0.2015 |
Echinococcus multilocularis | thymidine kinase | 0.0783 | 1 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0484 | 0.6019 | 1 |
Echinococcus multilocularis | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0069 | 0.051 | 0.051 |
Brugia malayi | thymidylate kinase | 0.007 | 0.0516 | 0.2562 |
Plasmodium falciparum | thymidylate kinase | 0.007 | 0.0516 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.1208 | 0.1208 |
Giardia lamblia | Thymidine kinase | 0.0484 | 0.6019 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.007 | 0.0516 | 0.5 |
Schistosoma mansoni | thymidylate kinase | 0.007 | 0.0516 | 0.0516 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.1338 | 0.1338 |
Giardia lamblia | Deoxynucleoside kinase | 0.0434 | 0.5354 | 0.8794 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0182 | 0.2015 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0484 | 0.6019 | 1 |
Leishmania major | thymidine kinase, putative | 0.0484 | 0.6019 | 1 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.007 | 0.0516 | 0.0012 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0484 | 0.6019 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0484 | 0.6019 | 1 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0783 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0484 | 0.6019 | 1 |
Onchocerca volvulus | Putative thymidylate kinase | 0.007 | 0.0516 | 0.2562 |
Echinococcus granulosus | thymidine kinase | 0.0783 | 1 | 1 |
Giardia lamblia | CDC8 | 0.007 | 0.0516 | 0.0012 |
Brugia malayi | Deoxynucleoside kinase family protein | 0.0069 | 0.051 | 0.253 |
Toxoplasma gondii | thymidylate kinase | 0.007 | 0.0516 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0254 | 0.0254 |
Schistosoma mansoni | thymidine kinase | 0.0783 | 1 | 1 |
Echinococcus multilocularis | thymidine kinase | 0.0783 | 1 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.007 | 0.0516 | 0.5 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.007 | 0.0516 | 0.0012 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 0.2015 | 1 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.007 | 0.0516 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of [3H]DA reuptake at DA transporter in HEK293 cells | ChEMBL. | 16750363 | |
IC50 (binding) | 0 | Inhibition of [3H]DA reuptake at DA transporter in HEK293 cells | ChEMBL. | 16750363 |
IC50 (binding) | = 17 nM | Inhibition of [3H]5HT reuptake at 5HT transporter in HEK293 cells | ChEMBL. | 16750363 |
IC50 (binding) | = 17 nM | Inhibition of [3H]5HT reuptake at 5HT transporter in HEK293 cells | ChEMBL. | 16750363 |
IC50 (binding) | = 28 nM | Inhibition of [3H]NA reuptake at NA transporter in HEK293 cells | ChEMBL. | 16750363 |
IC50 (binding) | = 28 nM | Inhibition of [3H]NA reuptake at NA transporter in HEK293 cells | ChEMBL. | 16750363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.