TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 335.393 | Formula: C17H18FNO3S
H donors: 1 H acceptors: 2 LogP: 1.41 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CN(CC(=O)O)CCOc1ccccc1Sc1ccc(cc1)F
InChi: 1S/C17H18FNO3S/c1-19(12-17(20)21)10-11-22-15-4-2-3-5-16(15)23-14-8-6-13(18)7-9-14/h2-9H,10-12H2,1H3,(H,20,21)
InChiKey: KFSZSFFYZIJTHW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Sodium- and chloride-dependent glycine transporter 1, putative	Get druggable targets OG5_128673	All targets in OG5_128673
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128673	All targets in OG5_128673
Echinococcus multilocularis	sodium and chloride dependent glycine	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma japonicum	Sodium- and chloride-dependent glycine transporter 1, putative	Get druggable targets OG5_128673	All targets in OG5_128673
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128673	All targets in OG5_128673
Echinococcus granulosus	sodium and chloride dependent glycine	Get druggable targets OG5_128673	All targets in OG5_128673
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Get druggable targets OG5_128673	All targets in OG5_128673
Echinococcus granulosus	sodium and chloride dependent glycine	Get druggable targets OG5_128673	All targets in OG5_128673
Echinococcus multilocularis	sodium and chloride dependent glycine	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma japonicum	Sodium-dependent proline transporter, putative	Get druggable targets OG5_128673	All targets in OG5_128673
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128673	All targets in OG5_128673

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	serotonin transporter	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	633 aa	616 aa	38.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	biogenic amine 5HT receptor	0.011	0.0083	0.0237
Schistosoma mansoni	amine GPCR	0.011	0.0083	0.0237
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.011	0.0083	0.0237
Echinococcus granulosus	g protein coupled receptor	0.011	0.0083	0.0237
Echinococcus granulosus	orexin receptor type 2	0.011	0.0083	0.0237
Echinococcus granulosus	dihydrofolate reductase	0.0857	0.1373	0.39
Loa Loa (eye worm)	TYRA-2 protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0857	0.1373	0.39
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.011	0.0083	0.0237
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.011	0.0083	0.0237
Echinococcus multilocularis	thymidylate synthase	0.2102	0.3521	1
Brugia malayi	neuropeptide F receptor	0.011	0.0083	0.0025
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.011	0.0083	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Brugia malayi	sulfakinin receptor protein	0.5857	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.011	0.0083	0.0237
Echinococcus granulosus	tm gpcr rhodopsin	0.011	0.0083	0.0237
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.011	0.0083	0.0237
Onchocerca volvulus		0.2102	0.3521	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Loa Loa (eye worm)	neuropeptide F receptor	0.011	0.0083	0.0025
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.011	0.0083	0.0237
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.011	0.0083	0.0025
Brugia malayi	G-protein coupled receptor	0.011	0.0083	0.0025
Echinococcus multilocularis	g protein coupled receptor	0.011	0.0083	0.0237
Schistosoma mansoni	neuropeptide receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	neuropeptide Y receptor	0.011	0.0083	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.011	0.0083	0.0237
Echinococcus multilocularis	neuropeptide FF receptor 2	0.011	0.0083	0.0237
Echinococcus granulosus	g protein coupled receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.011	0.0083	0.0025
Brugia malayi	Melatonin receptor type 1A	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	sodium/chloride dependent transporter	0.0096	0.0059	0.0167
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	thymidylate synthase	0.2102	0.3521	0.3483
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus granulosus	somatostatin receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0083	0.0237
Echinococcus granulosus	neuropeptide Y receptor	0.011	0.0083	0.0237
Brugia malayi	hypothetical protein	0.011	0.0083	0.0025
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.011	0.0083	0.0025
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.011	0.0083	0.0237
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.296	0.5001	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Brugia malayi	Serotonin receptor	0.011	0.0083	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0083	0.0237
Brugia malayi	hypothetical protein	0.011	0.0083	0.0025
Echinococcus granulosus	G protein coupled receptor 139	0.011	0.0083	0.0237
Echinococcus granulosus	sodium and chloride dependent glycine	0.0096	0.0059	0.0167
Echinococcus multilocularis	allatostatin A receptor	0.011	0.0083	0.0237
Schistosoma mansoni	neuropeptide receptor	0.011	0.0083	0.0237
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.011	0.0083	0.0237
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.2102	0.3521	1
Brugia malayi	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.296	0.5001	1
Mycobacterium tuberculosis	Hypothetical protein	0.1	0.162	0.46
Schistosoma mansoni	neuropeptide receptor	0.011	0.0083	0.0237
Echinococcus granulosus	7TM GPCR rhodopsin	0.011	0.0083	0.0237
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.011	0.0083	0.0025
Echinococcus multilocularis	orexin receptor type 2	0.011	0.0083	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0083	0.0237
Brugia malayi	putative neuropeptide receptor NPR1	0.011	0.0083	0.0025
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	alpha-1 adrenergic receptor	0.011	0.0083	0.0237
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.2102	0.3521	1
Schistosoma mansoni	opsin-like receptor	0.011	0.0083	0.0237
Schistosoma mansoni	biogenic amine receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	g protein coupled receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus granulosus	neuropeptide receptor	0.011	0.0083	0.0237
Chlamydia trachomatis	dihydrofolate reductase	0.0857	0.1373	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.011	0.0083	0.0025
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.011	0.0083	0.0237
Echinococcus granulosus	sex peptide receptor	0.011	0.0083	0.0237
Brugia malayi	hypothetical protein	0.011	0.0083	0.0025
Brugia malayi	G-protein coupled receptor	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus granulosus	g-protein coupled receptor	0.011	0.0083	0.0237
Schistosoma mansoni	neuropeptide f receptor 76f	0.011	0.0083	0.0237
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0096	0.0059	0.0167
Echinococcus granulosus	sodium and chloride dependent glycine	0.0096	0.0059	0.0167
Echinococcus granulosus	allatostatin A receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Brugia malayi	neuropeptide F receptor	0.011	0.0083	0.0025
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.011	0.0083	0.0237
Loa Loa (eye worm)	G-protein coupled receptor	0.011	0.0083	0.0025
Echinococcus granulosus	biogenic amine 5HT receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus granulosus	dro:myosuppressin receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	G-protein coupled receptor, putative	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus granulosus	peptide allatostatin:somatostatin	0.011	0.0083	0.0237
Echinococcus multilocularis	neuropeptide receptor A26	0.011	0.0083	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0083	0.0237
Echinococcus multilocularis	somatostatin receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.011	0.0083	0.0237
Echinococcus granulosus	tachykinin peptides receptor 99D	0.011	0.0083	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Echinococcus granulosus	tm gpcr rhodopsin	0.011	0.0083	0.0237
Brugia malayi	Dopamine receptor	0.011	0.0083	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0083	0.0237
Loa Loa (eye worm)	neuropeptide F receptor	0.011	0.0083	0.0025
Echinococcus granulosus	neuropeptide s receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.011	0.0083	0.0025
Schistosoma mansoni	opsin-like receptor	0.011	0.0083	0.0237
Echinococcus granulosus	tm gpcr rhodopsin	0.011	0.0083	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0083	0.0237
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0857	0.1373	0.39
Echinococcus granulosus	alpha 1A adrenergic receptor	0.011	0.0083	0.0237
Echinococcus granulosus	fmrfamide receptor	0.011	0.0083	0.0237
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.011	0.0083	0.0025
Echinococcus granulosus	thymidylate synthase	0.2102	0.3521	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	biogenic amine (5HT) receptor	0.011	0.0083	0.0237
Brugia malayi	Serotonin receptor	0.011	0.0083	0.0025
Echinococcus granulosus	serotonin receptor	0.011	0.0083	0.0237
Schistosoma mansoni	growth hormone secretagogue receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	neuropeptide F-like receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0096	0.0059	0.0167
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.296	0.5001	0.5
Brugia malayi	dihydrofolate reductase family protein	0.0857	0.1373	0.1322
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.011	0.0083	0.0237
Schistosoma mansoni	myosin xvIII	0.011	0.0083	0.0237
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.011	0.0083	0.0237
Schistosoma mansoni	neuropeptide receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	neuropeptide receptor	0.011	0.0083	0.0237
Brugia malayi	thymidylate synthase	0.2102	0.3521	0.3483
Brugia malayi	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	fmrfamide receptor	0.011	0.0083	0.0237
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.011	0.0083	0.0237
Echinococcus granulosus	neuropeptides capa receptor	0.011	0.0083	0.0237
Echinococcus granulosus	neuropeptide receptor A26	0.011	0.0083	0.0237
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.011	0.0083	0.0237
Brugia malayi	G protein-coupled receptor F59B2.13	0.011	0.0083	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0083	0.0237
Loa Loa (eye worm)	melatonin receptor type 1A	0.011	0.0083	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0083	0.0237
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.011	0.0083	0.0237
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Schistosoma mansoni	biogenic amine (5HT) receptor	0.011	0.0083	0.0237
Brugia malayi	Dopamine receptor protein 2	0.011	0.0083	0.0025
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	G-protein coupled receptor	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Echinococcus granulosus	neuropeptides capa receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.296	0.5001	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.011	0.0083	0.0237
Echinococcus granulosus	7tm_1 domain containing protein	0.011	0.0083	0.0237
Echinococcus multilocularis	serotonin receptor	0.011	0.0083	0.0237
Schistosoma mansoni	amine GPCR	0.011	0.0083	0.0237
Schistosoma mansoni	adenoreceptor	0.011	0.0083	0.0237
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Echinococcus granulosus	hypothetical protein	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	histamine h1 receptor	0.011	0.0083	0.0237
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.0295	0.0839
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.011	0.0083	0.0237
Echinococcus granulosus	g protein coupled receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus granulosus	neuropeptide Y receptor	0.011	0.0083	0.0237
Schistosoma mansoni	dihydrofolate reductase	0.0857	0.1373	0.39
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.011	0.0083	0.0025
Echinococcus multilocularis	neuropeptides capa receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	amine GPCR	0.011	0.0083	0.0237
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	g protein coupled receptor	0.011	0.0083	0.0237
Schistosoma mansoni	hypothetical protein	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Brugia malayi	follicle stimulating hormone receptor	0.011	0.0083	0.0025
Brugia malayi	hypothetical protein	0.011	0.0083	0.0025
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.296	0.5001	1
Echinococcus multilocularis	neuropeptide receptor	0.011	0.0083	0.0237
Brugia malayi	ORL1-like opioid receptor	0.011	0.0083	0.0025
Brugia malayi	RE15519p	0.011	0.0083	0.0025
Schistosoma mansoni	biogenic amine receptor	0.011	0.0083	0.0237
Brugia malayi	hypothetical protein	0.011	0.0083	0.0025
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.2102	0.3521	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.011	0.0083	0.0025
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.011	0.0083	0.0237
Brugia malayi	G protein-coupled receptor	0.011	0.0083	0.0025
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.296	0.5001	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Brugia malayi	larval opioid receptor	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	dihydrofolate reductase	0.0857	0.1373	0.39
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Brugia malayi	GnHR receptor homolog	0.011	0.0083	0.0025
Schistosoma mansoni	hypothetical protein	0.011	0.0083	0.0237
Mycobacterium ulcerans	thymidylate synthase	0.2102	0.3521	1
Loa Loa (eye worm)	dihydrofolate reductase	0.0857	0.1373	0.1322
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.011	0.0083	0.0237
Schistosoma mansoni	biogenic amine receptor	0.011	0.0083	0.0237
Schistosoma mansoni	neuropeptide F-like receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	G protein coupled receptor 139	0.011	0.0083	0.0237
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.011	0.0083	0.0237
Echinococcus multilocularis	neuropeptides capa receptor	0.011	0.0083	0.0237
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.011	0.0083	0.0237
Schistosoma mansoni	opsin-like receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	rhodopsin orphan GPCR	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	dro:myosuppressin receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Brugia malayi	hypothetical protein	0.1	0.162	0.157
Brugia malayi	Dopamine receptor protein 1	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.5857	1	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.011	0.0083	0.0237
Brugia malayi	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	hypothetical protein	0.011	0.0083	0.0237
Trichomonas vaginalis	conserved hypothetical protein	0.1	0.162	0.5
Schistosoma mansoni	amine GPCR	0.011	0.0083	0.0237
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.011	0.0083	0.0025
Echinococcus multilocularis	sex peptide receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	neuropeptide Y receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	serotonin receptor	0.011	0.0083	0.0237
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.011	0.0083	0.0237
Echinococcus multilocularis	fmrfamide receptor	0.011	0.0083	0.0237
Brugia malayi	AKH receptor	0.011	0.0083	0.0025
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	sodium/chloride dependent transporter	0.0096	0.0059	0.0167
Echinococcus granulosus	neuropeptide receptor	0.011	0.0083	0.0237
Brugia malayi	putative neuropeptide receptor	0.011	0.0083	0.0025
Brugia malayi	hypothetical protein	0.011	0.0083	0.0025
Schistosoma mansoni	hypothetical protein	0.011	0.0083	0.0237
Brugia malayi	Dihydrofolate reductase	0.0857	0.1373	0.1322
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.011	0.0083	0.0237
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.011	0.0083	0.0237
Loa Loa (eye worm)	hypothetical protein	0.011	0.0083	0.0025
Echinococcus multilocularis	g-protein coupled receptor	0.011	0.0083	0.0237
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.011	0.0083	0.0237
Schistosoma mansoni	amine GPCR	0.011	0.0083	0.0237

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 15 uM	Inhibition of [3H]glycine uptake at human GlyT1b transporter	ChEMBL.	16725323
IC50 (binding)	= 15 uM	Inhibition of [3H]glycine uptake at human GlyT1b transporter	ChEMBL.	16725323

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 369013