Detailed information for compound 369271

Basic information

Technical information
  • TDR Targets ID: 369271
  • Name: 1-(4-fluorophenyl)-8-[1-(4-fluorophenyl)cyclo heptyl]-3,8-diazaspiro[4.5]decan-4-one
  • MW: 438.553 | Formula: C27H32F2N2O
  • H donors: 1 H acceptors: 1 LogP: 5.22 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1CNC(=O)C21CCN(CC2)C1(CCCCCC1)c1ccc(cc1)F
  • InChi: 1S/C27H32F2N2O/c28-22-9-5-20(6-10-22)24-19-30-25(32)26(24)15-17-31(18-16-26)27(13-3-1-2-4-14-27)21-7-11-23(29)12-8-21/h5-12,24H,1-4,13-19H2,(H,30,32)
  • InChiKey: RDRVJQLAEXTGRZ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.006 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0063 0.0142
Echinococcus multilocularis hexokinase 0.0078 0.0342 0.032
Echinococcus granulosus cpg binding protein 0.0037 0.0041 0.0019
Brugia malayi Thioredoxin reductase 0.0148 0.0839 0.271
Plasmodium vivax multidomain scavenger receptor, putative 0.0085 0.0386 0.1298
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0048 0.0124 0.0403
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0061 0.0213 0.0655
Loa Loa (eye worm) phosphofructokinase 0.0224 0.1388 0.4485
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0096 0.0466 0.0445
Brugia malayi hypothetical protein 0.0309 0.2 0.6461
Schistosoma mansoni cpg binding protein 0.0037 0.0041 0.0041
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0096 0.0466 0.1506
Trichomonas vaginalis phosphofructokinase, putative 0.0224 0.1388 0.4687
Entamoeba histolytica phosphomannose isomerase, putative 0.0096 0.0466 0.2368
Loa Loa (eye worm) jmjC domain-containing protein 0.0237 0.1482 0.4788
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0118
Treponema pallidum hexokinase (hxk) 0.0078 0.0342 0.0828
Echinococcus multilocularis hexokinase 0.0078 0.0342 0.032
Trichomonas vaginalis pyruvate kinase, putative 0.0069 0.0272 0.0858
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0118
Plasmodium falciparum phosphomannomutase, putative 0.0042 0.0082 0.026
Trypanosoma brucei hexokinase, putative 0.0078 0.0342 0.1153
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0096 0.0466 0.1506
Echinococcus multilocularis lysine specific demethylase 6a 0.0062 0.0221 0.02
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0069 0.0272 0.1008
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0211 0.065
Trichomonas vaginalis chromobox protein, putative 0.022 0.1357 0.4582
Echinococcus multilocularis chromobox protein 1 0.022 0.1357 0.1338
Schistosoma mansoni chromobox protein 0.0036 0.0036 0.0036
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0087 0.0222
Echinococcus granulosus hexokinase 0.0078 0.0342 0.032
Brugia malayi chromobox protein homolog 3 0.0123 0.0663 0.2143
Echinococcus granulosus tar DNA binding protein 0.0062 0.0226 0.0205
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0337 0.2198 0.8894
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0036 0.0049
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0127 0.0689 0.234
Brugia malayi glutathione reductase 0.0148 0.0839 0.271
Brugia malayi acetyltransferase, GNAT family protein 0.0462 0.3095 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0129 0.0422
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0141 0.0466
Echinococcus multilocularis cpg binding protein 0.0037 0.0041 0.0019
Schistosoma mansoni chromobox protein 0.022 0.1357 0.1357
Trypanosoma cruzi polo-like protein kinase, putative 0.0295 0.1897 0.6472
Echinococcus multilocularis Polycystic kidney disease protein 0.0085 0.0386 0.0365
Loa Loa (eye worm) pyruvate kinase-PB 0.0048 0.0122 0.0396
Loa Loa (eye worm) hypothetical protein 0.0085 0.0386 0.1246
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0042 0.0077 0.0055
Onchocerca volvulus 0.0085 0.0386 0.1929
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0036 0.0106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0087 0.0222
Toxoplasma gondii phosphomannomutase 0.0042 0.0082 0.0204
Plasmodium falciparum pyruvate kinase 2 0.0035 0.0031 0.009
Onchocerca volvulus 0.0078 0.0342 0.1709
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0035 0.0013
Schistosoma mansoni zinc finger protein 0.0032 0.0004 0.0004
Loa Loa (eye worm) pyruvate kinase 0.0069 0.0272 0.0879
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1897 0.6434
Echinococcus granulosus 6 phosphofructokinase 0.0224 0.1388 0.1369
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0044 0.0093 0.0379
Mycobacterium leprae Probable pyruvate kinase PykA 0.0069 0.0272 0.063
Schistosoma mansoni hypothetical protein 0.006 0.0211 0.0211
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0414 0.275 0.2734
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0127 0.0689 0.0668
Onchocerca volvulus Pyruvate kinase homolog 0.0069 0.0272 0.136
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0295 0.1897 0.6472
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.0105
Brugia malayi F/Y-rich N-terminus family protein 0.0043 0.0088 0.0284
Entamoeba histolytica acetyltransferase, GNAT family 0.0123 0.0659 0.3396
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0048 0.0124 0.0351
Schistosoma mansoni lipoxygenase 0.0152 0.0871 0.0871
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.0077
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0051 0.0146 0.0479
Trichomonas vaginalis CAMK family protein kinase 0.0146 0.0827 0.2762
Echinococcus granulosus RUN 0.0085 0.0386 0.0365
Trypanosoma cruzi pyruvate kinase 2, putative 0.0069 0.0272 0.0915
Trichomonas vaginalis Heterochromatin protein, putative 0.0036 0.0036 0.0049
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0414 0.275 0.9388
Echinococcus multilocularis jumonji domain containing protein 0.0127 0.0688 0.0668
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.0049
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0127 0.0689 0.2393
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0036 0.0049
Loa Loa (eye worm) hypothetical protein 0.0188 0.1132 0.3657
Brugia malayi jmjC domain containing protein 0.0237 0.1482 0.4788
Entamoeba histolytica hypothetical protein 0.0074 0.0307 0.1519
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0221 0.0221
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0042 0.0077 0.0077
Plasmodium falciparum pyruvate kinase 0.0069 0.0272 0.091
Schistosoma mansoni cpg binding protein 0.0037 0.0041 0.0041
Toxoplasma gondii phosphofructokinase PFKII 0.0061 0.0213 0.0655
Toxoplasma gondii PHD-finger domain-containing protein 0.0091 0.0432 0.1407
Brugia malayi PHD-finger family protein 0.0035 0.0033 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0213 0.0655
Toxoplasma gondii 6-phosphofructokinase 0.0061 0.0213 0.0655
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1897 0.6434
Entamoeba histolytica pyruvate kinase, putative 0.0048 0.0122 0.0536
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0051 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0049 0.0129 0.0417
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0096 0.0466 0.1572
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0096 0.0466 0.1506
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1847 0.626
Schistosoma mansoni jumonji/arid domain-containing protein 0.0237 0.1482 0.1482
Giardia lamblia Pyruvate kinase 0.0069 0.0272 0.0828
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0337 0.2198 0.8894
Loa Loa (eye worm) hypothetical protein 0.0103 0.0516 0.1668
Mycobacterium tuberculosis Probable reductase 0.0337 0.2198 0.8894
Echinococcus granulosus Chromobox protein 3 0.0036 0.0036 0.0014
Schistosoma mansoni hypothetical protein 0.0085 0.0386 0.0386
Brugia malayi hypothetical protein 0.0085 0.0386 0.1246
Brugia malayi Hexokinase family protein 0.0049 0.0132 0.0425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0146 0.0482
Trypanosoma cruzi hexokinase, putative 0.0078 0.0342 0.1153
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0124 0.041
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.044 0.2936 1
Trichomonas vaginalis pyruvate kinase, putative 0.0069 0.0272 0.0858
Trichomonas vaginalis glutaminase, putative 0.0269 0.1713 0.5801
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0118
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0307 0.0285
Plasmodium falciparum glutathione reductase 0.0148 0.0839 0.2844
Plasmodium vivax thioredoxin reductase, putative 0.0148 0.0839 0.2844
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0171 0.1009 0.3262
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0213 0.0655
Plasmodium falciparum hexokinase 0.0078 0.0342 0.1148
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0138 0.0769 0.0748
Toxoplasma gondii phosphomannose isomerase type I protein 0.0096 0.0466 0.1524
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.005 0.0141 0.0371
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0419 0.2792 0.2776
Echinococcus granulosus lysine specific demethylase 6a 0.0062 0.0221 0.02
Brugia malayi Pyruvate kinase, M2 isozyme 0.0069 0.0272 0.0879
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0677 0.0657
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0307 0.0307
Schistosoma mansoni loxhd1 0.0085 0.0386 0.0386
Echinococcus multilocularis thioredoxin glutathione reductase 0.0148 0.0839 0.0819
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0091 0.0432 0.0432
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0213 0.0655
Loa Loa (eye worm) heterochromatin protein 1 0.022 0.1357 0.4386
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.044 0.2936 1
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0077
Brugia malayi CHD4 protein 0.0042 0.0077 0.025
Loa Loa (eye worm) helicase 0.0036 0.0036 0.0118
Echinococcus granulosus hexokinase type 2 0.0078 0.0342 0.032
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0051 0.0146 0.0124
Plasmodium falciparum thioredoxin reductase 0.0051 0.0146 0.0479
Loa Loa (eye worm) 6-phosphofructokinase 0.0224 0.1388 0.4485
Brugia malayi Hexokinase family protein 0.0078 0.0342 0.1104
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.004 0.0059
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0374 0.2468 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0146 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.003 0.0009
Schistosoma mansoni hypothetical protein 0.0074 0.0307 0.0307
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0036 0.0036 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0146 0.0482
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0249 0.0249
Onchocerca volvulus Putative phosphomannomutase 0.0042 0.0082 0.0408
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.06 0.1938
Giardia lamblia Kinase, PLK 0.0295 0.1897 0.6423
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0062 0.0221 0.0741
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.005 0.0141 0.047
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0677 0.0677
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0171 0.1009 0.1009
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0133 0.073 0.3653
Echinococcus multilocularis pyruvate kinase 0.0035 0.0031 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0087 0.0222
Toxoplasma gondii hexokinase 0.0078 0.0342 0.1097
Echinococcus granulosus mannose 6 phosphate isomerase 0.0096 0.0466 0.0445
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.004 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0146 0.0482
Brugia malayi jmjC domain containing protein 0.0062 0.0221 0.0715
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0051 0.0146 0.0388
Echinococcus multilocularis JmjC domain containing protein 4 0.0062 0.0221 0.02
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0127 0.0689 0.0668
Leishmania major hypothetical protein, conserved 0.0438 0.2929 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.0077
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0036 0.0036 0.0049
Echinococcus granulosus citrate lyase subunit beta protein 0.005 0.0141 0.0119
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0048 0.0124 0.031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0087 0.0222
Trichomonas vaginalis chromobox protein, putative 0.022 0.1357 0.4582
Loa Loa (eye worm) doublecortin family protein 0.0085 0.0386 0.1246
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0123 0.0663 0.3317
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0141 0.0466
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0051 0.0146 0.0388
Mycobacterium ulcerans 6-phosphofructokinase 0.0224 0.1388 0.4973
Brugia malayi Heterochromatin protein 1 0.022 0.1357 0.4386
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0051 0.0146 0.0482
Trypanosoma brucei hypothetical protein, conserved 0.0438 0.2929 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0034 0.0022 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0036 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0087 0.0222
Giardia lamblia PHD finger protein 15 0.0091 0.0432 0.1379
Loa Loa (eye worm) hypothetical protein 0.0062 0.0221 0.0715
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0051 0.0146 0.0388
Trichomonas vaginalis chromobox protein, putative 0.0133 0.073 0.2431
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0129 0.0426
Echinococcus multilocularis hexokinase type 2 0.0078 0.0342 0.032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0146 0.0482
Trypanosoma brucei hexokinase 0.0078 0.0342 0.1153
Schistosoma mansoni bromodomain containing protein 0.0145 0.0822 0.0822
Mycobacterium ulcerans hypothetical protein 0.0049 0.0129 0.0328
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0052 0.0151 0.0512
Schistosoma mansoni hypothetical protein 0.0091 0.0432 0.0432
Entamoeba histolytica serine/threonine protein kinase, putative 0.0295 0.1897 1
Entamoeba histolytica hexokinase 2 0.0078 0.0342 0.1705
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.003 0.0009
Leishmania major eukaryotic translation initiation factor-like 0.0034 0.0022 0.006
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0124 0.0103
Loa Loa (eye worm) bromodomain containing protein 0.0049 0.0133 0.0431
Trypanosoma brucei pyruvate kinase 1, putative 0.0069 0.0272 0.0915
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1847 0.626
Echinococcus multilocularis pyruvate kinase 0.0069 0.0272 0.0251
Loa Loa (eye worm) hypothetical protein 0.0085 0.0386 0.1246
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0414 0.275 0.8887
Leishmania major ATP-dependent phosphofructokinase 0.0224 0.1388 0.4731
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0374 0.2468 1
Leishmania major phosphomannose isomerase 0.0096 0.0466 0.1578
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0224 0.1388 0.4731
Leishmania major hexokinase, putative 0.0078 0.0342 0.1153
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0414 0.275 1
Loa Loa (eye worm) pyruvate kinase 0.0069 0.0272 0.0879
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0036 0.0036 0.0118
Echinococcus granulosus phosphomannomutase 0.0042 0.0082 0.006
Brugia malayi 6-phosphofructokinase 0.0224 0.1388 0.4485
Echinococcus granulosus chromobox protein 1 0.022 0.1357 0.1338
Echinococcus multilocularis lipoxygenase domain containing protein 0.0085 0.0386 0.0365
Loa Loa (eye worm) glutathione reductase 0.0148 0.0839 0.271
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0788 0.2761
Trichomonas vaginalis chromobox protein, putative 0.0133 0.073 0.2431
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0221 0.0715
Trypanosoma brucei polo-like protein kinase 0.0295 0.1897 0.6472
Trichomonas vaginalis bromodomain-containing protein, putative 0.0141 0.0788 0.2627
Echinococcus granulosus chromobox protein 1 0.022 0.1357 0.1338
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0051 0.0146 0.049
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0034 0.0022 0.006
Loa Loa (eye worm) hypothetical protein 0.0054 0.0162 0.0525
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0127 0.0689 0.2715
Trichomonas vaginalis hypothetical protein 0.0036 0.0036 0.0049
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.013
Brugia malayi glucose-6-phosphate dehydrogenase 0.0414 0.275 0.8887
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0213 0.0655
Loa Loa (eye worm) hypothetical protein 0.0097 0.0472 0.1525
Schistosoma mansoni phosphatidylserine receptor 0.0062 0.0221 0.0221
Echinococcus granulosus L aminoadipate semialdehyde 0.0171 0.1009 0.099
Echinococcus granulosus peregrin 0.0109 0.0561 0.054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0677 0.2351
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.013
Echinococcus multilocularis hexokinase 0.0078 0.0342 0.032
Trypanosoma cruzi hexokinase, putative 0.0078 0.0342 0.1153
Plasmodium vivax JmjC domain containing protein 0.0062 0.0221 0.0737
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0036 0.0036
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0051 0.0146 0.0482
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0211 0.0683
Echinococcus multilocularis lipoxygenase domain containing protein 0.0085 0.0386 0.0365
Loa Loa (eye worm) glutaminase 2 0.0269 0.1713 0.5534
Schistosoma mansoni 6-phosphofructokinase 0.0224 0.1388 0.1388
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0307 0.0285
Plasmodium vivax hypothetical protein, conserved 0.0091 0.0432 0.1456
Echinococcus multilocularis geminin 0.0167 0.0977 0.0957
Loa Loa (eye worm) hypothetical protein 0.0171 0.1009 0.3262
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0035 0.0013
Mycobacterium tuberculosis Conserved protein 0.005 0.0141 0.047
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0141 0.0788 0.2627
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0143 0.0809 0.3206
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0051 0.0146 0.0479
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0051 0.0146 0.0388
Echinococcus multilocularis Chromobox protein 3 0.0036 0.0036 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0226 0.0226
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0148 0.0839 0.3329
Trichomonas vaginalis glutathione reductase, putative 0.0051 0.0146 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0036 0.0049
Plasmodium falciparum phd finger protein, putative 0.0091 0.0432 0.1456
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0414 0.275 0.275
Schistosoma mansoni jumonji domain containing protein 0.0358 0.2351 0.2351
Echinococcus granulosus PHD finger protein rhinoceros 0.0091 0.0432 0.0411
Echinococcus multilocularis L aminoadipate semialdehyde 0.0171 0.1009 0.099
Loa Loa (eye worm) hypothetical protein 0.0062 0.0221 0.0715
Loa Loa (eye worm) hypothetical protein 0.0091 0.0432 0.1396
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0061 0.0213 0.0624
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0146 0.0482
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0061 0.0213 0.0708
Echinococcus multilocularis lysine specific demethylase 5A 0.0231 0.1441 0.1422
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0129 0.0571
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0074 0.0307 0.1519
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0129 0.0328
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.004 0.012
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0462 0.3095 0.3095
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0221 0.0715
Onchocerca volvulus 0.0049 0.0132 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0036 0.0049
Plasmodium falciparum LCCL domain-containing protein 0.0085 0.0386 0.1298
Onchocerca volvulus 0.0309 0.2 1
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0034 0.0022 0.006
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0146 0.0482
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0414 0.275 1
Schistosoma mansoni phd/f-box containing protein 0.0062 0.0221 0.0221
Onchocerca volvulus 0.0049 0.0129 0.0645
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0118
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0036 0.0049
Onchocerca volvulus Pyruvate kinase homolog 0.0069 0.0272 0.136
Schistosoma mansoni polycystin 1-related 0.0085 0.0386 0.0386
Echinococcus granulosus pyruvate kinase 0.0035 0.0031 0.001
Leishmania major trypanothione reductase 0.0148 0.0839 0.2853
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0129 0.0021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0129 0.0021
Trypanosoma brucei pyruvate kinase 1 0.0069 0.0272 0.0915
Entamoeba histolytica phosphomannomutase, putative 0.0042 0.0082 0.0318
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0304 0.1965 0.1947
Loa Loa (eye worm) hypothetical protein 0.0069 0.0272 0.0879
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0041 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0226 0.0226
Echinococcus multilocularis citrate lyase subunit beta protein 0.005 0.0141 0.0119
Loa Loa (eye worm) CBP-B 0.0092 0.0437 0.1414
Leishmania major eukaryotic translation initiation factor-like protein 0.0034 0.0022 0.006
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.044 0.2936 1
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1897 0.6434
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0213 0.0655
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0051 0.0146 0.0424
Trypanosoma cruzi hypothetical protein, conserved 0.0438 0.2929 1
Echinococcus granulosus JmjC domain containing protein 4 0.0062 0.0221 0.02
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0048 0.0124 0.031
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0146 0.0482
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0129 0.0328
Schistosoma mansoni hypothetical protein 0.0043 0.0083 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1897 0.6434
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0146 0.0482
Schistosoma mansoni pyruvate kinase 0.0069 0.0272 0.0272
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0138 0.0769 0.0748
Brugia malayi M-phase phosphoprotein, mpp8 0.0036 0.0036 0.0118
Brugia malayi Protein cec-1. 0.0036 0.0036 0.0118
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0077
Echinococcus granulosus pyruvate kinase 0.0035 0.0031 0.001
Schistosoma mansoni hypothetical protein 0.0167 0.0977 0.0977
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0096 0.0466 0.1506
Loa Loa (eye worm) RNA binding protein 0.0062 0.0226 0.0731
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0129 0.0328
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0124 0.0406
Loa Loa (eye worm) CHromoDomain protein family member 0.0042 0.0077 0.025
Loa Loa (eye worm) thioredoxin reductase 0.0148 0.0839 0.271
Echinococcus multilocularis phd:f box containing protein 0.0062 0.0221 0.02
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0038 0.0048 0.0155
Loa Loa (eye worm) hypothetical protein 0.0097 0.0475 0.1535
Mycobacterium tuberculosis Probable oxidoreductase 0.0374 0.2468 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0788 0.3122
Trichomonas vaginalis Citrate lyase beta chain, putative 0.005 0.0141 0.0408
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0051 0.0146 0.047
Plasmodium vivax heterochromatin protein 1, putative 0.0036 0.0036 0.0106
Schistosoma mansoni hexokinase 0.0078 0.0342 0.0342
Brugia malayi Pyruvate kinase, muscle isozyme 0.0069 0.0272 0.0879
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0226 0.0226
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0087 0.0222
Trichomonas vaginalis phosphofructokinase, putative 0.0224 0.1388 0.4687
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.005 0.0141 0.0371
Schistosoma mansoni pyruvate kinase 0.0069 0.0272 0.0272
Mycobacterium ulcerans pyruvate kinase 0.0069 0.0272 0.0855
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0374 0.2468 1
Loa Loa (eye worm) hexokinase 0.0078 0.0342 0.1104
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0129 0.0328
Echinococcus multilocularis pyruvate kinase 0.0069 0.0272 0.0251
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0285 0.1825 0.6225
Onchocerca volvulus Serine\/threonine kinase homolog 0.0295 0.1897 0.9489
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0129 0.0571
Entamoeba histolytica hexokinase 1 0.0078 0.0342 0.1705
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0146 1
Brugia malayi translation initiation factor 4E 0.0034 0.0022 0.0071
Echinococcus granulosus pyruvate kinase 0.0069 0.0272 0.0251
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0127 0.0689 0.2393
Schistosoma mansoni hypothetical protein 0.0167 0.0977 0.0977
Trichomonas vaginalis phosphofructokinase, putative 0.0224 0.1388 0.4687
Loa Loa (eye worm) hypothetical protein 0.0049 0.0129 0.0417
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0118
Echinococcus granulosus CREB binding protein 0.0125 0.0677 0.0656
Trypanosoma brucei phosphomannomutase 0.0042 0.0082 0.0264
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1897 0.6434
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0048 0.0124 0.031
Trypanosoma brucei phosphomannose isomerase 0.0096 0.0466 0.1578
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0226 0.0731
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0146 0.0482
Echinococcus granulosus pyruvate kinase 0.0069 0.0272 0.0251
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0211 0.019
Echinococcus multilocularis dnaJ subfamily B 0.044 0.2942 0.2926
Loa Loa (eye worm) hypothetical protein 0.0048 0.0122 0.0396
Trypanosoma cruzi hypothetical protein, conserved 0.0438 0.2929 1
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0677 0.2249
Loa Loa (eye worm) hypothetical protein 0.0051 0.0146 0.0472
Brugia malayi Bromodomain containing protein 0.0169 0.0995 0.3216
Brugia malayi Valyl-tRNA synthetase 0.0036 0.0036 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0036 0.0106
Loa Loa (eye worm) hypothetical protein 0.0146 0.0825 0.2667
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.044 0.2936 1
Loa Loa (eye worm) phosphomannomutase 2 0.0042 0.0082 0.0264
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0221 0.0715
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0337 0.2198 0.8894
Trypanosoma cruzi phosphomannose isomerase, putative 0.0096 0.0466 0.1578
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0035 0.0035
Plasmodium falciparum thioredoxin reductase 0.0148 0.0839 0.2844
Brugia malayi serine/threonine-protein kinase plk-2 0.0295 0.1897 0.6131
Echinococcus multilocularis Chromo domain 0.0036 0.0036 0.0014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0129 0.0328
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.013
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0061 0.0213 0.1018
Entamoeba histolytica phosphofructokinase, putative 0.0224 0.1388 0.7284
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.031 0.0289
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0096 0.0466 0.1572
Echinococcus multilocularis pyruvate kinase 0.0035 0.0031 0.001
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.0036 0.0118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0118
Brugia malayi jmjC domain containing protein 0.0062 0.0221 0.0715
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0285 0.1825 0.6225
Onchocerca volvulus Alhambra homolog 0.0091 0.0432 0.2161
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0034 0.0022 0.006
Loa Loa (eye worm) pyruvate kinase 0.0069 0.0272 0.0879
Onchocerca volvulus 0.0078 0.0342 0.1709
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0087 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0405 0.1313
Echinococcus multilocularis PHD finger protein rhinoceros 0.0091 0.0432 0.0411
Schistosoma mansoni hypothetical protein 0.0032 0.0004 0.0004
Leishmania major pyruvate kinase 0.0069 0.0272 0.0915
Plasmodium vivax phosphomannomutase, putative 0.0042 0.0082 0.026
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0129 0.0417
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0038 0.0048 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0663 0.22
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0036 0.0036 0.0014
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0224 0.1388 0.5577
Trichomonas vaginalis phosphomannomutase, putative 0.0042 0.0082 0.0204
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0224 0.1388 0.4813
Plasmodium falciparum histone acetyltransferase GCN5 0.0123 0.0659 0.223
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0061 0.0213 0.0708
Brugia malayi Doublecortin family protein 0.0085 0.0386 0.1246
Toxoplasma gondii pyruvate kinase PyKII 0.0035 0.0031 0.0033
Leishmania major hypothetical protein, conserved 0.0285 0.1825 0.6225
Loa Loa (eye worm) 6-phosphofructokinase 0.0224 0.1388 0.4485
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0034 0.0022 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0129 0.0328
Entamoeba histolytica phosphofructokinase, putative 0.0224 0.1388 0.7284
Schistosoma mansoni zinc finger protein 0.0055 0.0174 0.0174
Echinococcus multilocularis RUN 0.0085 0.0386 0.0365
Loa Loa (eye worm) hypothetical protein 0.0049 0.0129 0.0417
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1847 0.626
Schistosoma mansoni lipoxygenase 0.0304 0.1965 0.1965
Brugia malayi hypothetical protein 0.0036 0.0036 0.0118
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0141 0.0788 0.2627
Brugia malayi jmjC domain containing protein 0.0062 0.0221 0.0715
Brugia malayi phosphomannomutase 2 0.0042 0.0082 0.0264
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0067 0.0262 0.0241
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0295 0.1897 0.6131
Schistosoma mansoni hypothetical protein 0.044 0.2942 0.2942
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0124 0.0124
Echinococcus granulosus phd:f box containing protein 0.0062 0.0221 0.02
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0677 0.2667
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0051 0.0146 0.0479
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0118
Echinococcus granulosus lipoxygenase domain containing protein 0.0085 0.0386 0.0365
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0127 0.0689 0.2226
Echinococcus granulosus zinc finger protein 0.0055 0.0174 0.0153
Schistosoma mansoni chromobox protein 0.0036 0.0036 0.0036
Trypanosoma brucei hexokinase 0.0078 0.0342 0.1153
Plasmodium vivax pyruvate kinase, putative 0.0069 0.0272 0.091
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0129 0.0417
Schistosoma mansoni phosphomannomutase 0.0042 0.0082 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0226 0.0226
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0087 0.0222
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0047 0.0047
Loa Loa (eye worm) hexokinase type II 0.0078 0.0342 0.1104
Onchocerca volvulus 0.0097 0.0472 0.236
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0062 0.0221 0.0741
Brugia malayi jmjC domain containing protein 0.0062 0.0221 0.0715
Echinococcus multilocularis chromobox protein 2 0.0036 0.0036 0.0014
Onchocerca volvulus Hexokinase homolog 0.0049 0.0132 0.0658
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0677 0.0677
Echinococcus multilocularis pyruvate kinase 0.0035 0.0031 0.001
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0224 0.1388 0.5392
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0419 0.2792 0.2776
Echinococcus granulosus pyruvate kinase 0.0035 0.0031 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0129 0.0426
Echinococcus granulosus hexokinase 0.0078 0.0342 0.032
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0061 0.0213 0.0655
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0295 0.1897 0.1879
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0061 0.0213 0.0337
Plasmodium vivax 6-phosphofructokinase, putative 0.0061 0.0213 0.0708
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0129 0.0417
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0067 0.0262 0.0241
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0051 0.0146 0.0479
Leishmania major phosphopantetheinyl transferase-like protein 0.0048 0.0124 0.041
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.013
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0226 0.0205
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0146 0.0482
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0125 0.0677 0.0677
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.027 0.1719 0.6195
Echinococcus multilocularis microtubule associated protein 2 0.1422 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.0114
Leishmania major phosphomannomutase, putative 0.0042 0.0082 0.0264
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0062 0.0221 0.0741
Schistosoma mansoni serine/threonine protein kinase 0.0295 0.1897 0.1897
Mycobacterium tuberculosis Probable dehydrogenase 0.0337 0.2198 0.8894
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1847 0.9729
Echinococcus granulosus Chromo domain 0.0036 0.0036 0.0014
Toxoplasma gondii pyruvate kinase PyK1 0.0069 0.0272 0.0858
Brugia malayi PHD-finger family protein 0.0066 0.0253 0.0819
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.044 0.2936 1
Loa Loa (eye worm) hexokinase 0.0078 0.0342 0.1104
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0036 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0036 0.0049
Brugia malayi 6-phosphofructokinase 0.0224 0.1388 0.4485
Schistosoma mansoni 6-phosphofructokinase 0.0224 0.1388 0.1388
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0146 0.0482
Brugia malayi DnaJ domain containing protein 0.006 0.0211 0.0683
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0414 0.275 0.9388
Leishmania major pyruvate kinase 0.0069 0.0272 0.0915
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0036 0.0106
Trypanosoma cruzi phosphomannose isomerase, putative 0.0096 0.0466 0.1578
Onchocerca volvulus 0.0171 0.1009 0.5048
Brugia malayi Bromodomain containing protein 0.0092 0.0439 0.1418
Echinococcus granulosus hexokinase 0.0078 0.0342 0.032
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0133 0.0734 0.2495
Leishmania major hexokinase, putative 0.0078 0.0342 0.1153
Loa Loa (eye worm) hypothetical protein 0.0079 0.0346 0.1119
Echinococcus multilocularis phosphomannomutase 0.0042 0.0082 0.006
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0096 0.0466 0.1524
Onchocerca volvulus 0.0078 0.0342 0.1709
Schistosoma mansoni CREB-binding protein 2 0.0125 0.0677 0.0677
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0224 0.1388 0.4731
Schistosoma mansoni microtubule-associated protein tau 0.1422 1 1
Entamoeba histolytica hypothetical protein 0.0074 0.0307 0.1519
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0096 0.0466 0.1571
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0083 0.027
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0062 0.0221 0.0221
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0788 0.0767
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0062 0.0221 0.0684
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0414 0.275 0.9388
Echinococcus multilocularis CREB binding protein 0.0091 0.0431 0.041
Giardia lamblia NADH oxidase lateral transfer candidate 0.0051 0.0146 0.0393
Toxoplasma gondii NADPH-glutathione reductase 0.0051 0.0146 0.0424
Echinococcus granulosus lipoxygenase domain containing protein 0.0085 0.0386 0.0365
Echinococcus multilocularis peregrin 0.0109 0.0561 0.054
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0141 0.0788 0.2627
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0414 0.275 0.2734
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0146 0.0482
Echinococcus granulosus chromobox protein 2 0.0036 0.0036 0.0014
Entamoeba histolytica phosphofructokinase, putative 0.0224 0.1388 0.7284
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0124 0.0103
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0052 0.0151 0.0114
Brugia malayi phosphofructokinase 0.0224 0.1388 0.4485
Onchocerca volvulus 0.0037 0.0041 0.0206
Leishmania major hypothetical protein, conserved 0.0062 0.0221 0.0741
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1897 0.6434
Schistosoma mansoni protein phosphatase 2C 0.0062 0.0221 0.0221
Echinococcus multilocularis chromobox protein 1 0.022 0.1357 0.1338
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.0077
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.013
Entamoeba histolytica hypothetical protein 0.0048 0.0124 0.0545
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0061 0.0213 0.0637
Giardia lamblia Histone acetyltransferase GCN5 0.0123 0.0659 0.216
Schistosoma mansoni chromobox protein 0.022 0.1357 0.1357
Loa Loa (eye worm) translation initiation factor 4E 0.0034 0.0022 0.0071
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1847 0.9729
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.1847 0.6559
Trypanosoma cruzi polo-like protein kinase, putative 0.0295 0.1897 0.6472
Schistosoma mansoni rab6-interacting 0.0085 0.0386 0.0386
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0129 0.0426
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0141 0.0788 0.267
Echinococcus granulosus CREB binding protein 0.0083 0.0377 0.0355
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0226 0.0731
Trichomonas vaginalis CAMK family protein kinase 0.0146 0.0827 0.2762
Mycobacterium ulcerans hypothetical protein 0.005 0.0141 0.0371
Treponema pallidum NADH oxidase 0.0051 0.0146 0.0081
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0788 0.2834
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0462 0.3095 0.308
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.005 0.0141 0.0371
Entamoeba histolytica hypothetical protein 0.0074 0.0307 0.1519
Brugia malayi TAR-binding protein 0.0062 0.0226 0.0731
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi glutaminase DH11.1 0.0269 0.1713 0.5534
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1847 0.626
Toxoplasma gondii thioredoxin reductase 0.0148 0.0839 0.2803
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0051 0.0146 0.0482
Schistosoma mansoni pyruvate kinase 0.0035 0.0031 0.0031
Echinococcus granulosus dnaJ subfamily B 0.044 0.2942 0.2926
Trypanosoma cruzi trypanothione reductase, putative 0.0148 0.0839 0.2853
Brugia malayi jmjC domain containing protein 0.0419 0.2792 0.902
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0141 0.0466
Trichomonas vaginalis mercuric reductase, putative 0.0051 0.0146 0.0424
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0127 0.0689 0.0689
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1847 0.626
Loa Loa (eye worm) acetyltransferase 0.0462 0.3095 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0304 0.1965 0.1947
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.044 0.2936 1
Echinococcus granulosus jumonji domain containing protein 0.0127 0.0688 0.0668
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0061 0.0213 0.0637
Echinococcus granulosus lysine specific demethylase 5A 0.0237 0.1482 0.1463
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0036 0.0036 0.0106
Trypanosoma brucei trypanothione reductase 0.0148 0.0839 0.2853
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0146 0.0482
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0036 0.0036
Plasmodium falciparum heterochromatin protein 1 0.0036 0.0036 0.0106
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0048 0.0124 0.0351
Echinococcus granulosus jumonji domain containing 1A 0.0062 0.0221 0.02
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1847 0.626
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.1897 0.6434
Brugia malayi hypothetical protein 0.0074 0.0307 0.0991
Loa Loa (eye worm) hexokinase 0.0049 0.0132 0.0425
Schistosoma mansoni rab6-interacting 0.0085 0.0386 0.0386
Brugia malayi hexokinase 0.0078 0.0342 0.1104
Mycobacterium ulcerans hypothetical protein 0.005 0.0141 0.0371
Schistosoma mansoni glutaminase 0.0269 0.1713 0.1713
Brugia malayi Bromodomain containing protein 0.0109 0.0561 0.1812
Brugia malayi RNA binding protein 0.0062 0.0226 0.0731
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0129 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0036 0.0049
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0677 0.2351
Schistosoma mansoni kinase 0.015 0.0855 0.0855
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0285 0.1825 0.6225
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0405 0.1313
Loa Loa (eye worm) glutaminase 0.0269 0.1713 0.5534
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0295 0.1897 0.1879
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0337 0.2198 0.8894
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0226 0.0731
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1847 0.626
Toxoplasma gondii PHD-finger domain-containing protein 0.0091 0.0432 0.1407
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0663 0.22
Plasmodium vivax hexokinase, putative 0.0078 0.0342 0.1148
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.027 0.1719 0.5823
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0036 0.0049
Schistosoma mansoni mannose-6-phosphate isomerase 0.0096 0.0466 0.0466
Trichomonas vaginalis phosphofructokinase, putative 0.0061 0.0213 0.0655
Plasmodium vivax 6-phosphofructokinase, putative 0.0061 0.0213 0.0708
Plasmodium falciparum JmjC domain-containing protein, putative 0.0062 0.0221 0.0737
Toxoplasma gondii histone lysine methyltransferase SET1 0.0076 0.0328 0.1049
Chlamydia trachomatis pyruvate kinase 0.0069 0.0272 0.0855
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.031 0.0289
Onchocerca volvulus 0.0036 0.0036 0.0182
Echinococcus multilocularis 6 phosphofructokinase 0.0224 0.1388 0.1369
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0036 0.0049
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0129 0.0571
Brugia malayi PHD-finger family protein 0.0091 0.0432 0.1396
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0063 0.0142
Echinococcus multilocularis zinc finger protein 0.0055 0.0174 0.0153
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0414 0.275 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0035 0.0035
Onchocerca volvulus Pyruvate kinase homolog 0.0069 0.0272 0.136
Plasmodium vivax pyruvate kinase 2, putative 0.0035 0.0031 0.009
Trichomonas vaginalis phosphofructokinase, putative 0.0224 0.1388 0.4687
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0337 0.2198 0.8848
Loa Loa (eye worm) PHD-finger family protein 0.0091 0.0432 0.1396
Plasmodium falciparum glutathione reductase 0.0051 0.0146 0.0479
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0677 0.2351
Trypanosoma cruzi phosphomannomutase, putative 0.0042 0.0082 0.0264
Loa Loa (eye worm) hypothetical protein 0.0123 0.0663 0.2143
Plasmodium vivax glutathione reductase, putative 0.0148 0.0839 0.2844
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0042 0.0077 0.0055
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0036 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1847 0.626
Trypanosoma cruzi pyruvate kinase 2, putative 0.0069 0.0272 0.0915
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0124 0.0406
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0137 0.0763 0.2593
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.1847 0.6248
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0129 0.0328
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0226 0.0226
Brugia malayi SET domain containing protein 0.0037 0.0041 0.0133
Brugia malayi TAZ zinc finger family protein 0.0125 0.0677 0.2188
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0211 0.019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0442 0.2954 0.2939
Echinococcus granulosus Polycystic kidney disease protein 0.0085 0.0386 0.0365
Onchocerca volvulus 0.0036 0.0036 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0036 0.0049
Echinococcus granulosus geminin 0.0167 0.0977 0.0957
Loa Loa (eye worm) hypothetical protein 0.0309 0.2 0.6461
Onchocerca volvulus 0.0085 0.0386 0.1929
Echinococcus granulosus thioredoxin glutathione reductase 0.0148 0.0839 0.0819
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0077
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0677 0.0657
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0051 0.0146 0.0482
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.044 0.2936 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0237 0.1482 0.1482
Loa Loa (eye worm) jmjC domain-containing protein 0.0188 0.1129 0.3647
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0036 0.0049
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0036 0.0049
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0062 0.0221 0.0684
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0051 0.0146 0.0124
Brugia malayi hypothetical protein 0.0085 0.0386 0.1246
Echinococcus multilocularis pyruvate kinase 0.0054 0.0168 0.0146
Echinococcus multilocularis jumonji domain containing 1A 0.0062 0.0221 0.02
Mycobacterium ulcerans glutaminase 0.0269 0.1713 0.6172
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0677 0.2301

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 245 nM Inhibition of [3H]glycine uptake at GlyT1 ChEMBL. 16762550
Activity (binding) = 245 nM Inhibition of [3H]glycine uptake at GlyT1 ChEMBL. 16762550
Activity (binding) > 30 uM Inhibition of [3H]glycine uptake at GlyT2 ChEMBL. 16762550
Activity (binding) > 30 uM Inhibition of [3H]glycine uptake at GlyT2 ChEMBL. 16762550

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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