TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.511 | Formula: C22H28N8O
H donors: 1 H acceptors: 4 LogP: 2.21 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCC(CC1)NC(=O)c1cn2ccnc2c(n1)N1CCN(CC1)c1ccccn1
InChi: 1S/C22H28N8O/c1-27-9-5-17(6-10-27)25-22(31)18-16-30-11-8-24-20(30)21(26-18)29-14-12-28(13-15-29)19-4-2-3-7-23-19/h2-4,7-8,11,16-17H,5-6,9-10,12-15H2,1H3,(H,25,31)
InChiKey: CHOGQBQCWOMWDD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0094	0.2278	0.2107
Schistosoma mansoni	diacylglycerol kinase theta	0.0023	0.0223	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2262	0.2262
Echinococcus multilocularis	rac serine:threonine kinase	0.0131	0.337	0.4474
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0266	0.7294	1
Giardia lamblia	Kinase, CMGC CDK	0.0114	0.2875	0.6223
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0094	0.2278	0.3485
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.003	0.041	0.0306
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0123	0.313	0.4137
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0094	0.2278	0.2278
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0031	0.0454	0.0367
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0077	0.179	0.179
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2186	0.2186
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0065	0.145	0.177
Echinococcus granulosus	cyclins	0.0031	0.0454	0.0367
Echinococcus granulosus	Protein kinase C brain isozyme	0.0216	0.5833	0.7942
Schistosoma mansoni	protein kinase C	0.0025	0.0285	0.013
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0114	0.2875	0.5232
Trypanosoma cruzi	cdc2-related kinase 3	0.0114	0.2875	0.5232
Schistosoma mansoni	protein kinase C mu	0.0031	0.0442	0.0351
Entamoeba histolytica	cell division protein kinase 2, putative	0.0114	0.2875	0.4099
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.313	0.4137
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0124	0.3166	0.6084
Schistosoma mansoni	vav2	0.0037	0.0614	0.0594
Schistosoma mansoni	atypical protein kinase C	0.0146	0.3807	0.509
Giardia lamblia	Kinase, AGC PKA	0.0124	0.3166	0.6898
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0305	0.0158
Toxoplasma gondii	hypothetical protein	0.0024	0.0235	0.0066
Echinococcus multilocularis	cyclins	0.0031	0.0454	0.0367
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.017	0.4503	0.6069
Trypanosoma brucei	cdc2-related kinase 1	0.0114	0.2875	0.3163
Plasmodium vivax	glycogen synthase kinase 3, putative	0.017	0.4503	1
Schistosoma mansoni	protein kinase	0.0057	0.1196	0.1413
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.1196	0.1257
Echinococcus granulosus	nervana 2	0.0117	0.2947	0.3878
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0053	0.1089	0.1616
Echinococcus granulosus	cyclin dependent kinase 1	0.0114	0.2875	0.3777
Echinococcus multilocularis	mitogen activated protein kinase	0.0094	0.2278	0.2937
Schistosoma mansoni	cyclins	0.0031	0.0454	0.0367
Echinococcus granulosus	Glutaredoxin protein 5	0.0117	0.2947	0.3878
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0123	0.313	0.4137
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0123	0.313	0.4137
Brugia malayi	RhoGAP domain containing protein	0.003	0.041	0.0609
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0065	0.145	0.177
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.2875	0.3777
Trichomonas vaginalis	AGC family protein kinase	0.013	0.3335	0.4632
Brugia malayi	serine/threonine kinase 12	0.0057	0.1196	0.1776
Trichomonas vaginalis	AGC family protein kinase	0.0247	0.6735	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0065	0.145	0.177
Entamoeba histolytica	protein kinase, putative	0.017	0.4503	0.6587
Trichomonas vaginalis	cyclin D, putative	0.0031	0.0454	0.0085
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0247	0.6735	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0454	0.0085
Schistosoma mansoni	tyrosine kinase	0.0065	0.145	0.177
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0124	0.3166	0.4187
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0065	0.145	0.177
Echinococcus granulosus	mitogen activated protein kinase	0.0094	0.2278	0.2937
Trichomonas vaginalis	AGC family protein kinase	0.0247	0.6735	1
Schistosoma mansoni	serine/threonine protein kinase	0.0216	0.5833	0.7942
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0057	0.1196	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0236	0.6415	0.6415
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0094	0.2278	0.3485
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.024	0.6531	0.6531
Onchocerca volvulus		0.003	0.0427	0.0376
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0056	0.1185	0.1396
Schistosoma mansoni	serine/threonine protein kinase	0.0266	0.7294	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1089	0.1089
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0117	0.2947	0.3878
Loa Loa (eye worm)	SRC-1	0.0065	0.145	0.145
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0057	0.1196	0.1533
Brugia malayi	Pleckstrin Homology Domain	0.003	0.0427	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.2875	0.3777
Trichomonas vaginalis	cyclins, putative	0.0053	0.1089	0.1087
Brugia malayi	Protein kinase domain containing protein	0.0031	0.0442	0.0656
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0065	0.145	0.177
Echinococcus granulosus	ephrin type A receptor 4 A	0.0118	0.2992	0.3942
Trichomonas vaginalis	cyclin D, putative	0.0031	0.0454	0.0085
Giardia lamblia	Kinase, CMGC CDK	0.0114	0.2875	0.6223
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0031	0.0442	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0285	0.0285
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0031	0.0454	0.0367
Loa Loa (eye worm)	AUR protein kinase	0.0057	0.1196	0.1196
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0057	0.1196	0.2328
Echinococcus multilocularis	cyclins	0.0031	0.0454	0.0367
Entamoeba histolytica	protein kinase, putative	0.024	0.6531	0.9688
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0065	0.145	0.177
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0118	0.2992	0.3942
Brugia malayi	Protein kinase domain containing protein	0.0114	0.2875	0.4268
Echinococcus granulosus	protein kinase C gamma type	0.0192	0.5156	0.6989
Brugia malayi	cell division control protein 2 homolog	0.0114	0.2875	0.4268
Echinococcus multilocularis	protein kinase c iota type	0.0146	0.3807	0.509
Entamoeba histolytica	hypothetical protein	0.0023	0.0223	0.0046
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0442	0.0351
Schistosoma mansoni	serine/threonine-protein kinase	0.0131	0.337	0.4474
Trypanosoma cruzi	cdc2-related kinase 1	0.0114	0.2875	0.5232
Trichomonas vaginalis	cyclin B3, putative	0.0031	0.0454	0.0085
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0094	0.2278	0.329
Echinococcus granulosus	nervana 2	0.0117	0.2947	0.3878
Echinococcus granulosus	tyrosine protein kinase HCK	0.0053	0.108	0.1249
Trypanosoma brucei	protein kinase, putative	0.0094	0.2278	0.2107
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.017	0.4503	0.4503
Echinococcus multilocularis	Glutaredoxin protein 5	0.0117	0.2947	0.3878
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0073	0.1669	0.2079
Schistosoma mansoni	serine/threonine protein kinase	0.0216	0.5833	0.7942
Echinococcus granulosus	cyclin B	0.0053	0.1089	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0193	0.0193
Schistosoma mansoni	tyrosine kinase	0.0065	0.145	0.177
Trichomonas vaginalis	cyclins, putative	0.0031	0.0454	0.0085
Trichomonas vaginalis	cyclins, putative	0.0053	0.1089	0.1087
Brugia malayi	serine/threonine-protein kinase 6	0.0057	0.1196	0.1776
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0067	0.1509	0.1853
Brugia malayi	Protein kinase domain containing protein	0.0247	0.6735	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0124	0.3166	0.4187
Echinococcus granulosus	protein kinase c epsilon type	0.0148	0.387	0.5178
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0059	0.1267	0.1513
Giardia lamblia	Kinase, CMGC MAPK	0.0094	0.2278	0.4839
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0123	0.313	0.313
Onchocerca volvulus		0.0053	0.1089	0.144
Echinococcus granulosus	raf serine:threonine protein kinase	0.0026	0.0305	0.0158
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0115	0.2911	0.3964
Trichomonas vaginalis	CMGC family protein kinase	0.017	0.4503	0.6476
Trichomonas vaginalis	cyclin B, putative	0.0053	0.1089	0.1087
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0025	0.0285	0.013
Loa Loa (eye worm)	TK protein kinase	0.0059	0.1267	0.1267
Plasmodium falciparum	glycogen synthase kinase 3	0.017	0.4503	1
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.1196	0.1257
Onchocerca volvulus		0.0023	0.0223	0.0048
Echinococcus granulosus	protein kinase c eta type	0.0023	0.0223	0.0042
Schistosoma mansoni	cyclin B3	0.0031	0.0454	0.0367
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0216	0.5833	0.7942
Schistosoma mansoni	unc-13 (munc13)	0.0025	0.0285	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0094	0.2278	0.2965
Echinococcus granulosus	cyclin b3	0.0031	0.0454	0.0367
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0123	0.313	0.4137
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0059	0.1267	0.1513
Trichomonas vaginalis	CMGC family protein kinase	0.0094	0.2278	0.2965
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1509	0.1509
Trichomonas vaginalis	AGC family protein kinase	0.0247	0.6735	1
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0123	0.313	0.4137
Echinococcus multilocularis	cyclin dependent kinase 1	0.0114	0.2875	0.3777
Echinococcus granulosus	cyclin dependent kinase	0.0114	0.2875	0.3777
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Echinococcus multilocularis	protein kinase c eta type	0.0023	0.0223	0.0042
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.1196	0.1413
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0114	0.2875	0.3777
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.017	0.4503	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0031	0.0454	0.0674
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.2278	0.2937
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0026	0.0305	0.0158
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0059	0.1267	0.1513
Entamoeba histolytica	protein kinase, putative	0.0247	0.6735	1
Toxoplasma gondii	AGC kinase	0.024	0.6531	1
Brugia malayi	GCC2 and GCC3 family protein	0.0022	0.0193	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0928	0.0928
Giardia lamblia	Kinase, AGC AKT	0.015	0.3928	0.8668
Loa Loa (eye worm)	TK protein kinase	0.0053	0.108	0.108
Brugia malayi	SRC-1	0.0065	0.145	0.2153
Loa Loa (eye worm)	hypothetical protein	0.0107	0.2656	0.2656
Trichomonas vaginalis	AGC family protein kinase	0.0123	0.313	0.431
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.313	0.4137
Echinococcus multilocularis	myotubularin protein 13	0.003	0.0427	0.033
Trichomonas vaginalis	AGC family protein kinase	0.0123	0.313	0.431
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0442	0.0351
Trypanosoma brucei	aurora B kinase	0.0057	0.1196	0.019
Brugia malayi	intracellular kinase	0.017	0.4503	0.6685
Echinococcus multilocularis	cyclin dependent kinase 5	0.0114	0.2875	0.3777
Echinococcus multilocularis	cyclin B	0.0053	0.1089	0.1261
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.017	0.4503	0.6069
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Echinococcus granulosus	protein kinase c iota type	0.0146	0.3807	0.509
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.003	0.041	0.0306
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0094	0.2278	0.3485
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0193	0.0193
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0031	0.0442	0.0351
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0094	0.2278	0.3485
Trichomonas vaginalis	cyclins, putative	0.0053	0.1089	0.1087
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0114	0.2875	0.2875
Brugia malayi	GCC2 and GCC3 family protein	0.0022	0.0193	0.0286
Entamoeba histolytica	protein kinase 2, putative	0.0124	0.3166	0.4544
Onchocerca volvulus		0.0093	0.2262	0.3325
Giardia lamblia	G2/mitotic-specific cyclin B	0.0053	0.1089	0.2078
Brugia malayi	C1-like domain containing protein	0.0031	0.0442	0.0656
Echinococcus multilocularis	protein kinase shaggy	0.017	0.4503	0.6069
Echinococcus granulosus	N chimaerin	0.003	0.041	0.0306
Brugia malayi	Variant SH3 domain containing protein	0.003	0.041	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Echinococcus multilocularis	serine threonine protein kinase	0.0192	0.5156	0.6989
Trichomonas vaginalis	CMGC family protein kinase	0.0114	0.2875	0.3906
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0266	0.7294	0.7294
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.1196	0.1257
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0123	0.313	0.313
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0023	0.0223	0.0042
Entamoeba histolytica	cyclin family protein	0.0031	0.0454	0.0399
Loa Loa (eye worm)	AUR protein kinase	0.0057	0.1196	0.1196
Trichomonas vaginalis	cyclin B, putative	0.0053	0.1089	0.1087
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0123	0.313	0.313
Schistosoma mansoni	serine/threonine-protein kinase	0.0131	0.337	0.4474
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0023	0.0223	0.0042
Giardia lamblia	Kinase, CMGC GSK	0.017	0.4503	1
Trichomonas vaginalis	AGC family protein kinase	0.0123	0.313	0.431
Schistosoma mansoni	cyclin B	0.0053	0.1089	0.1261
Plasmodium falciparum	cyclin	0.0031	0.0454	0.0605
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0056	0.1185	0.1396
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0094	0.2278	0.3485
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0131	0.337	0.4856
Brugia malayi	RhoGAP domain containing protein	0.0023	0.0223	0.0331
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.015	0.3928	0.5832
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0123	0.313	0.4137
Echinococcus multilocularis	cyclin B3 1	0.0031	0.0454	0.0367
Echinococcus granulosus	cyclins	0.0031	0.0454	0.0367
Trichomonas vaginalis	CMGC family protein kinase	0.0094	0.2278	0.2965
Trichomonas vaginalis	AGC family protein kinase	0.0247	0.6735	1
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.017	0.4503	0.4503
Echinococcus granulosus	cyclin dependent kinase 5	0.0114	0.2875	0.3777
Trichomonas vaginalis	CMGC family protein kinase	0.0114	0.2875	0.3906
Echinococcus multilocularis	protein kinase c epsilon type	0.0148	0.387	0.5178
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0053	0.1089	0.1616
Echinococcus granulosus	Diacylglycerol kinase theta	0.0023	0.0223	0.0042
Giardia lamblia	Cyclin A	0.0031	0.0454	0.0605
Leishmania major	protein kinase, putative	0.0057	0.1196	0.0315
Brugia malayi	GCC2 and GCC3 family protein	0.0022	0.0193	0.0286
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0094	0.2278	0.2937
Entamoeba histolytica	protein kinase domain containing protein	0.017	0.4503	0.6587
Trichomonas vaginalis	AGC family protein kinase	0.0247	0.6735	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0065	0.145	0.177
Brugia malayi	p70 ribosomal S6 kinase beta	0.024	0.6531	0.9697
Loa Loa (eye worm)	hypothetical protein	0.0259	0.7092	0.7092
Echinococcus granulosus	tyrosine kinase	0.0059	0.1267	0.1513
Entamoeba histolytica	protein kinase domain containing protein	0.017	0.4503	0.6587
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.145	0.177
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0023	0.0223	0.0223
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0065	0.145	0.177
Echinococcus granulosus	mitogen activated protein kinase 3	0.0094	0.2278	0.2937
Trichomonas vaginalis	cyclin B, putative	0.0053	0.1089	0.1087
Trichomonas vaginalis	cyclin A, putative	0.0053	0.1089	0.1087
Entamoeba histolytica	protein kinase, putative	0.0053	0.108	0.1356
Echinococcus multilocularis	unc 13 (munc13)	0.0025	0.0285	0.013
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0053	0.108	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.313	0.4137
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0157	0.4133	0.8916
Entamoeba histolytica	protein kinase, putative	0.0057	0.1196	0.1533
Loa Loa (eye worm)	raf kinase	0.0023	0.0223	0.0223
Echinococcus multilocularis	cyclin dependent kinase 1	0.0114	0.2875	0.3777
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0031	0.0442	0.0442
Echinococcus multilocularis	N chimaerin	0.003	0.041	0.0306
Schistosoma mansoni	serine/threonine kinase	0.0123	0.313	0.4137
Echinococcus multilocularis	aurora kinase A	0.0057	0.1196	0.1413
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0023	0.0223	0.0223
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0065	0.145	0.177
Onchocerca volvulus		0.0236	0.6415	1
Brugia malayi	diacylglycerol kinase	0.0023	0.0223	0.0331
Brugia malayi	diacylglycerol kinase	0.0023	0.0223	0.0331
Entamoeba histolytica	protein kinase domain containing protein	0.0057	0.1196	0.1533
Echinococcus granulosus	protein kinase shaggy	0.017	0.4503	0.6069
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0114	0.2875	0.2875
Entamoeba histolytica	cyclin, putative	0.0031	0.0454	0.0399
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.003	0.041	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0193	0.0193
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0117	0.2947	0.3878
Trypanosoma cruzi	aurora B kinase, putative	0.0057	0.1196	0.0315
Trichomonas vaginalis	CMGC family protein kinase	0.017	0.4503	0.6476
Trichomonas vaginalis	CMGC family protein kinase	0.0114	0.2875	0.3906
Echinococcus granulosus	cyclin B3 1	0.0031	0.0454	0.0367
Brugia malayi	ephrin receptor 1 precursor	0.0047	0.0909	0.1349
Loa Loa (eye worm)	hypothetical protein	0.003	0.0427	0.0427
Entamoeba histolytica	protein kinase , putative	0.0057	0.1196	0.1533
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.017	0.4503	0.68
Echinococcus multilocularis	RNA directed DNA polymerase	0.0067	0.1509	0.1853
Brugia malayi	MAP kinase sur-1	0.0094	0.2278	0.3383
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0059	0.1267	0.1513
Brugia malayi	protein kinase C II.	0.0148	0.387	0.5746
Entamoeba histolytica	protein kinase, putative	0.0057	0.1196	0.1533
Toxoplasma gondii	diacylglycerol kinase, putative	0.0023	0.0223	0.0047
Trypanosoma cruzi	cdc2-related kinase 3	0.0114	0.2875	0.5232
Trypanosoma cruzi	cdc2-related kinase 1	0.0114	0.2875	0.5232
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0065	0.145	0.177
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0114	0.2875	0.4231
Echinococcus multilocularis	nervana 2	0.0117	0.2947	0.3878
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.003	0.041	0.0306
Brugia malayi	serine/threonine protein kinase 6	0.0057	0.1196	0.1776
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0181	0.0181
Brugia malayi	Ras association domain family 1 isoform A	0.0023	0.0223	0.0331
Echinococcus multilocularis	cyclin b3	0.0031	0.0454	0.0367
Echinococcus granulosus	Rac GTPase activating protein 1	0.0023	0.0223	0.0042
Echinococcus granulosus	unc 13 munc13	0.0025	0.0285	0.013
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0057	0.1196	0.2328
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0123	0.313	0.4137
Echinococcus multilocularis	cyclins	0.0031	0.0454	0.0367
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0025	0.0285	0.013
Echinococcus granulosus	NDR protein kinase	0.0123	0.313	0.4137
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0131	0.337	0.6682
Trichomonas vaginalis	cyclin B, putative	0.0031	0.0454	0.0085
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0031	0.0442	0.0351
Echinococcus multilocularis	cyclins	0.0031	0.0454	0.0367
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.017	0.4503	0.6069
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.003	0.041	0.041
Echinococcus granulosus	serine/threonine protein kinase	0.0131	0.337	0.4474
Entamoeba histolytica	cell division protein kinase 2, putative	0.0114	0.2875	0.4099
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0065	0.145	0.177
Trichomonas vaginalis	AGC family protein kinase	0.0247	0.6735	1
Echinococcus multilocularis	cyclins	0.0031	0.0454	0.0367
Plasmodium falciparum	protein kinase 5	0.0114	0.2875	0.6223
Loa Loa (eye worm)	hypothetical protein	0.0236	0.6415	0.6415
Loa Loa (eye worm)	TK/EPH protein kinase	0.0122	0.3089	0.3089
Brugia malayi	protein-tyrosine kinase	0.0059	0.1267	0.1881
Entamoeba histolytica	cyclin family protein	0.0031	0.0454	0.0399
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0057	0.1196	0.1533
Echinococcus granulosus	myotubularin protein 13	0.003	0.0427	0.033
Entamoeba histolytica	cyclin, putative	0.0053	0.1089	0.1369
Schistosoma mansoni	ephrin receptor	0.0096	0.2345	0.303
Echinococcus granulosus	cyclins	0.0031	0.0454	0.0367
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0057	0.1196	0.1413
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0023	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0236	0.6415	0.6415
Brugia malayi	GCC2 and GCC3 family protein	0.0022	0.0193	0.0286
Schistosoma mansoni	unc-13 (munc13)	0.0025	0.0285	0.013
Loa Loa (eye worm)	cyclin domain-containing protein	0.0031	0.0454	0.0454
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0124	0.3166	0.6898
Brugia malayi	RhoGEF domain containing protein	0.0023	0.0223	0.0331
Giardia lamblia	Aurora kinase	0.0057	0.1196	0.2328
Schistosoma mansoni	rac gtpase activating protein	0.0023	0.0223	0.0042
Trichomonas vaginalis	AGC family protein kinase	0.0247	0.6735	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0131	0.337	0.4856
Schistosoma mansoni	hypothetical protein	0.0023	0.0223	0.0042
Onchocerca volvulus		0.017	0.4503	0.6926
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.145	0.177
Plasmodium vivax	protein kinase Crk2	0.0114	0.2875	0.6223
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0065	0.145	0.177
Echinococcus granulosus	tyrosine protein kinase Blk	0.0059	0.1267	0.1513
Echinococcus granulosus	serine:threonine protein kinase N2	0.0123	0.313	0.4137
Schistosoma mansoni	serine/threonine protein kinase	0.0148	0.387	0.5178
Loa Loa (eye worm)	AUR protein kinase	0.0057	0.1196	0.1196
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0266	0.7294	1
Schistosoma mansoni	diacylglycerol kinase theta	0.0023	0.0223	0.0042
Entamoeba histolytica	diacylglycerol kinase, putative	0.0023	0.0223	0.0046
Trypanosoma brucei	protein kinase, putative	0.017	0.4503	0.6046
Trichomonas vaginalis	CMGC family protein kinase	0.0094	0.2278	0.2965
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0148	0.387	0.387
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0114	0.2875	0.2875
Brugia malayi	protein kinase C3,putative	0.0031	0.0442	0.0656
Echinococcus granulosus	serine threonine protein kinase nrc	0.0124	0.3166	0.4187
Echinococcus granulosus	cyclins	0.0031	0.0454	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Entamoeba histolytica	protein kinase, putative	0.0123	0.313	0.449
Echinococcus multilocularis	nervana 2	0.0117	0.2947	0.3878
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1089	0.1089
Trypanosoma brucei	cdc2-related kinase 3	0.0114	0.2875	0.3163
Echinococcus granulosus	aurora kinase A	0.0057	0.1196	0.1413
Brugia malayi	Protein kinase domain containing protein	0.0123	0.313	0.4648
Entamoeba histolytica	protein kinase, putative	0.003	0.0412	0.0335
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0114	0.2875	0.5232
Brugia malayi	Hr1 repeat family protein	0.0123	0.313	0.4648
Entamoeba histolytica	diacylglycerol kinase, putative	0.0023	0.0223	0.0046
Toxoplasma gondii	aurora kinase	0.0057	0.1196	0.1583
Echinococcus granulosus	cyclins	0.0031	0.0454	0.0367
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0065	0.145	0.177
Echinococcus multilocularis	cyclin dependent kinase	0.0114	0.2875	0.3777
Giardia lamblia	Hypothetical protein	0.0031	0.0454	0.0605
Echinococcus granulosus	RNA directed DNA polymerase	0.0067	0.1509	0.1853
Echinococcus multilocularis	cyclins	0.0031	0.0454	0.0367
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.145	0.177
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0031	0.0442	0.0442
Onchocerca volvulus		0.0025	0.0285	0.0148
Entamoeba histolytica	protein kinase, putative	0.0247	0.6735	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0123	0.313	0.313
Loa Loa (eye worm)	hypothetical protein	0.003	0.0427	0.0427
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0094	0.2278	0.3485
Brugia malayi	Protein kinase c protein 2	0.01	0.2467	0.3663
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.017	0.4503	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0247	0.6735	0.6735
Trichomonas vaginalis	cyclins, putative	0.0053	0.1089	0.1087
Echinococcus multilocularis	cyclins	0.0031	0.0454	0.0367
Trichomonas vaginalis	cyclin B, putative	0.0053	0.1089	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0193	0.0193
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0057	0.1196	0.1533
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0124	0.3166	0.6898
Brugia malayi	Protein kinase domain containing protein	0.0123	0.313	0.4648
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0223	0.0223
Schistosoma mansoni	protein kinase C mu	0.0023	0.0223	0.0042
Giardia lamblia	Kinase, CMGC GSK	0.017	0.4503	1
Trypanosoma cruzi	Protein kinase B	0.0131	0.337	0.6682
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.1196	0.1257

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 37 nM	Inhibition of IL4-induced IgE synthesis in human peripheral blood lymphocytes	ChEMBL.	16814547
T1/2 (ADMET)	= 45 min	Half life of the compound assessed as CYP1A1 mediated metabolism at 1 uM	ChEMBL.	16814547
T1/2 (ADMET)	= 95 min	Half life of the compound assessed as CYP1A2 mediated metabolism at 1 uM	ChEMBL.	16814547
T1/2 (ADMET)	> 120 min	Stability in human liver microsome at 1uM	ChEMBL.	16814547

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 369280