Detailed information for compound 369290

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 812.954 | Formula: C43H56N8O8
  • H donors: 7 H acceptors: 8 LogP: 3.71 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: Oc1ccc(cc1)C[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2[nH]c3c(c2)cccc3)NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@H](NC1=O)C(C)C)CCC2)CC(C)C
  • InChi: 1S/C43H56N8O8/c1-24(2)19-31-38(54)48-33(22-28-21-27-9-5-6-10-30(27)45-28)42(58)50-17-7-11-34(50)40(56)44-23-36(53)46-32(20-26-13-15-29(52)16-14-26)39(55)49-37(25(3)4)43(59)51-18-8-12-35(51)41(57)47-31/h5-6,9-10,13-16,21,24-25,31-35,37,45,52H,7-8,11-12,17-20,22-23H2,1-4H3,(H,44,56)(H,46,53)(H,47,57)(H,48,54)(H,49,55)/t31-,32-,33-,34-,35-,37+/m0/s1
  • InChiKey: OIMNJPZQLZBNCN-RYCDKEGDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Kinase, AGC PKA 0.0085 0.3161 0.6892
Schistosoma mansoni tyrosine kinase 0.0045 0.1452 0.1992
Plasmodium vivax glycogen synthase kinase 3, putative 0.0116 0.4499 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0224 0.0046
Brugia malayi Protein kinase domain containing protein 0.0021 0.0435 0.0647
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0147 0.583 0.7995
Brugia malayi SRC-1 0.0045 0.1452 0.2157
Onchocerca volvulus 0.0016 0.0224 0.0048
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.1452 0.1992
Echinococcus multilocularis serine:threonine protein kinase N2 0.0084 0.3126 0.4286
Echinococcus granulosus cyclin dependent kinase 5 0.0102 0.3912 0.5365
Brugia malayi cell division control protein 2 homolog 0.0102 0.3912 0.581
Loa Loa (eye worm) hypothetical protein 0.0016 0.0224 0.0223
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0085 0.3161 0.6892
Echinococcus granulosus RNA directed DNA polymerase 0.0046 0.1511 0.2072
Schistosoma mansoni protein kinase C mu 0.0021 0.0435 0.0597
Echinococcus multilocularis raf serine:threonine protein kinase 0.0018 0.0307 0.0421
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0194 0.0289
Echinococcus multilocularis serine threonine protein kinase 0.0132 0.5152 0.7066
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0084 0.3126 0.4286
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0085 0.3161 0.399
Trichomonas vaginalis AGC family protein kinase 0.0084 0.3126 0.1912
Echinococcus granulosus tyrosine protein kinase Blk 0.004 0.1269 0.1741
Entamoeba histolytica protein kinase, putative 0.0164 0.6529 0.9687
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0084 0.3126 0.3125
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.1187 0.1628
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0182 0.7292 1
Brugia malayi diacylglycerol kinase 0.0016 0.0224 0.0333
Echinococcus granulosus unc 13 munc13 0.0017 0.0287 0.0393
Loa Loa (eye worm) hypothetical protein 0.0017 0.0287 0.0286
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0164 0.6529 0.6528
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0084 0.3126 0.3125
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0194 0.0289
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.1452 0.1992
Trichomonas vaginalis AGC family protein kinase 0.0089 0.333 0.237
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0287 0.0393
Brugia malayi Variant SH3 domain containing protein 0.0011 0.0001 0.0002
Loa Loa (eye worm) AGC/NDR protein kinase 0.0084 0.3126 0.3125
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.1452 0.1992
Entamoeba histolytica protein kinase, putative 0.0169 0.6733 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.1187 0.1628
Trypanosoma brucei protein kinase, putative 0.0116 0.4499 0.4991
Brugia malayi protein-tyrosine kinase 0.004 0.1269 0.1885
Loa Loa (eye worm) TK/EPH protein kinase 0.0083 0.3093 0.3092
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0102 0.3912 0.7362
Trichomonas vaginalis AGC family protein kinase 0.0169 0.6733 1
Brugia malayi Pleckstrin Homology Domain 0.0021 0.0429 0.0637
Loa Loa (eye worm) hypothetical protein 0.0161 0.6421 0.6421
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0064 0.2273 0.3281
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0021 0.0435 0.0597
Trichomonas vaginalis AGC family protein kinase 0.0169 0.6733 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0147 0.583 0.7995
Trypanosoma brucei cdc2-related kinase 1 0.0102 0.3912 0.3674
Echinococcus multilocularis tyrosine protein kinase Srms 0.004 0.1269 0.1741
Echinococcus granulosus mitogen activated protein kinase 3 0.0064 0.2273 0.3117
Loa Loa (eye worm) hypothetical protein 0.0016 0.0224 0.0223
Echinococcus granulosus nervana 2 0.008 0.295 0.4046
Echinococcus granulosus mitogen activated protein kinase 0.0064 0.2273 0.3117
Entamoeba histolytica protein kinase 2, putative 0.0085 0.3161 0.4537
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0101 0.3866 0.3865
Echinococcus multilocularis protein kinase c iota type 0.01 0.3803 0.5215
Loa Loa (eye worm) hypothetical protein 0.0015 0.0194 0.0193
Giardia lamblia Kinase, CMGC CDK 0.0102 0.3912 0.8636
Giardia lamblia Kinase, CMGC CDK 0.0102 0.3912 0.8636
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0102 0.3912 0.3911
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0224 0.0046
Loa Loa (eye worm) raf kinase 0.0016 0.0224 0.0223
Brugia malayi Protein kinase domain containing protein 0.0084 0.3126 0.4642
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0084 0.3126 0.4286
Brugia malayi Protein kinase domain containing protein 0.0084 0.3126 0.4642
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.583 0.7995
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0307 0.0421
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0085 0.3161 0.6892
Echinococcus granulosus myotubularin protein 13 0.0021 0.0429 0.0588
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0116 0.4499 0.617
Schistosoma mansoni serine/threonine kinase 0.0084 0.3126 0.4286
Giardia lamblia Kinase, CMGC GSK 0.0116 0.4499 1
Schistosoma mansoni rac gtpase activating protein 0.0016 0.0224 0.0308
Echinococcus multilocularis cyclin dependent kinase 1 0.0102 0.3912 0.5365
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.3866 0.5301
Echinococcus granulosus serine:threonine protein kinase N2 0.0084 0.3126 0.4286
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.1452 0.1992
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.7292 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1511 0.151
Trypanosoma cruzi cdc2-related kinase 3 0.0102 0.3912 0.7362
Loa Loa (eye worm) SRC-1 0.0045 0.1452 0.1451
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.1452 0.1992
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.1452 0.1992
Loa Loa (eye worm) hypothetical protein 0.0015 0.0194 0.0193
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1452 0.1992
Onchocerca volvulus 0.0064 0.2265 0.3325
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0102 0.3912 0.7362
Brugia malayi Variant SH3 domain containing protein 0.002 0.0412 0.0612
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0182 0.7292 0.7292
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0435 0.0597
Plasmodium vivax protein kinase Crk2 0.0102 0.3912 0.8636
Toxoplasma gondii diacylglycerol kinase, putative 0.0016 0.0224 0.0047
Trypanosoma cruzi cdc2-related kinase 3 0.0102 0.3912 0.7362
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0116 0.4499 0.4498
Loa Loa (eye worm) RasGEF domain-containing protein 0.0016 0.0224 0.0223
Echinococcus granulosus protein kinase c iota type 0.01 0.3803 0.5215
Echinococcus multilocularis Diacylglycerol kinase theta 0.0016 0.0224 0.0308
Echinococcus granulosus protein kinase C gamma type 0.0132 0.5152 0.7066
Echinococcus multilocularis serine:threonine protein kinase 38 0.0084 0.3126 0.4286
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.4499 0.4991
Echinococcus multilocularis endonuclease reverse transcriptase 0.0015 0.0194 0.0267
Brugia malayi RhoGAP domain containing protein 0.0016 0.0224 0.0333
Loa Loa (eye worm) hypothetical protein 0.0016 0.0224 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.2273 0.3117
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0046 0.1511 0.2072
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.3912 0.3674
Schistosoma mansoni tyrosine kinase 0.0045 0.1452 0.1992
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.3912 0.3674
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.008 0.295 0.4046
Trypanosoma cruzi rac serine-threonine kinase, putative 0.009 0.3365 0.4908
Echinococcus multilocularis cyclin dependent kinase 1 0.0102 0.3912 0.5365
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0079 0.2915 0.1439
Brugia malayi Ras association domain family 1 isoform A 0.0016 0.0224 0.0333
Echinococcus multilocularis tyrosine protein kinase Blk 0.004 0.1269 0.1741
Echinococcus granulosus ephrin type A receptor 4 A 0.0081 0.2995 0.4108
Echinococcus granulosus protein kinase shaggy 0.0116 0.4499 0.617
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0287 0.0393
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0427
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0116 0.4499 0.4498
Schistosoma mansoni atypical protein kinase C 0.01 0.3803 0.5215
Brugia malayi ephrin receptor 1 precursor 0.0032 0.0911 0.1352
Loa Loa (eye worm) hypothetical protein 0.0015 0.0194 0.0193
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0064 0.2273 0.2272
Echinococcus granulosus nervana 2 0.008 0.295 0.4046
Plasmodium falciparum glycogen synthase kinase 3 0.0116 0.4499 1
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0103 0.3924 0.5828
Echinococcus granulosus Diacylglycerol kinase theta 0.0016 0.0224 0.0308
Loa Loa (eye worm) AGC/AKT protein kinase 0.0169 0.6733 0.6733
Toxoplasma gondii AGC kinase 0.0164 0.6529 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0052 0.1785 0.1783
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0021 0.0435 0.0434
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0224 0.0308
Brugia malayi protein kinase C II. 0.0101 0.3866 0.5741
Onchocerca volvulus 0.0017 0.0287 0.0148
Echinococcus multilocularis Glutaredoxin protein 5 0.008 0.295 0.4046
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.3126 0.4286
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1452 0.1992
Echinococcus granulosus serine/threonine protein kinase 0.009 0.3365 0.4615
Trichomonas vaginalis AGC family protein kinase 0.0169 0.6733 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0435 0.0597
Onchocerca volvulus 0.0116 0.4499 0.6913
Loa Loa (eye worm) hypothetical protein 0.0032 0.093 0.0929
Trichomonas vaginalis AGC family protein kinase 0.0084 0.3126 0.1912
Brugia malayi intracellular kinase 0.0116 0.4499 0.6682
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.0224 0.0223
Loa Loa (eye worm) hypothetical protein 0.0062 0.2188 0.2187
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.583 0.7995
Entamoeba histolytica hypothetical protein 0.0016 0.0224 0.0046
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0021 0.0435 0.0434
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0102 0.3912 0.3911
Brugia malayi Protein kinase domain containing protein 0.0169 0.6733 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0102 0.3912 0.5685
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.1452 0.1992
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0287 0.0393
Echinococcus multilocularis cyclin dependent kinase 5 0.0102 0.3912 0.5365
Echinococcus multilocularis mitogen activated protein kinase 3 0.0064 0.2273 0.3117
Plasmodium falciparum protein kinase 5 0.0102 0.3912 0.8636
Echinococcus granulosus cyclin dependent kinase 0.0102 0.3912 0.5365
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0194 0.0289
Loa Loa (eye worm) RhoGAP domain-containing protein 0.002 0.0412 0.0411
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.3365 0.485
Loa Loa (eye worm) AGC/PKN protein kinase 0.0084 0.3126 0.3125
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0287 0.0393
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.3126 0.4286
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.3912 0.5365
Schistosoma mansoni vav2 0.0025 0.0616 0.0845
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.002 0.0412 0.0565
Echinococcus multilocularis nervana 2 0.008 0.295 0.4046
Echinococcus granulosus serine threonine protein kinase nrc 0.0085 0.3161 0.4335
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.004 0.1269 0.1741
Echinococcus granulosus Rac GTPase activating protein 1 0.0016 0.0224 0.0308
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.4499 0.4991
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.1452 0.1992
Brugia malayi MAP kinase sur-1 0.0064 0.2273 0.3376
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.002 0.0412 0.0565
Entamoeba histolytica protein kinase, putative 0.0084 0.3126 0.4483
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.4499 0.6583
Echinococcus multilocularis N chimaerin 0.002 0.0412 0.0565
Brugia malayi Hr1 repeat family protein 0.0084 0.3126 0.4642
Echinococcus granulosus N chimaerin 0.002 0.0412 0.0565
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0116 0.4499 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0085 0.3161 0.4335
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.008 0.295 0.4046
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0107 0.4129 0.8337
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0021 0.0435 0.0647
Trypanosoma cruzi cdc2-related kinase 1 0.0102 0.3912 0.7362
Brugia malayi diacylglycerol kinase 0.0016 0.0224 0.0333
Loa Loa (eye worm) hypothetical protein 0.0161 0.6421 0.6421
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.1269 0.1741
Entamoeba histolytica protein kinase, putative 0.002 0.0405 0.0323
Schistosoma mansoni serine/threonine-protein kinase 0.009 0.3365 0.4615
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.1452 0.1992
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1452 0.1992
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0116 0.4499 0.6795
Loa Loa (eye worm) hypothetical protein 0.0016 0.0224 0.0223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0224 0.0223
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0016 0.0224 0.0223
Echinococcus granulosus tyrosine protein kinase Lyn 0.005 0.1663 0.2281
Echinococcus multilocularis cyclin dependent kinase 0.0102 0.3912 0.5365
Loa Loa (eye worm) hypothetical protein 0.0016 0.0224 0.0223
Echinococcus multilocularis nervana 2 0.008 0.295 0.4046
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0084 0.3126 0.4286
Entamoeba histolytica protein kinase, putative 0.0036 0.1082 0.1357
Loa Loa (eye worm) hypothetical protein 0.0064 0.2265 0.2264
Echinococcus granulosus tyrosine kinase 0.004 0.1269 0.1741
Trichomonas vaginalis AGC family protein kinase 0.0169 0.6733 1
Entamoeba histolytica protein kinase, putative 0.0116 0.4499 0.6583
Loa Loa (eye worm) hypothetical protein 0.0177 0.7099 0.7098
Brugia malayi p70 ribosomal S6 kinase beta 0.0164 0.6529 0.9696
Echinococcus multilocularis myotubularin protein 13 0.0021 0.0429 0.0588
Giardia lamblia Kinase, AGC AKT 0.0103 0.3924 0.8665
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.3365 0.485
Trypanosoma cruzi cdc2-related kinase 1 0.0102 0.3912 0.7362
Schistosoma mansoni protein kinase C 0.0017 0.0287 0.0393
Giardia lamblia Kinase, CMGC MAPK 0.0064 0.2273 0.4829
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0116 0.4499 0.617
Echinococcus multilocularis RNA directed DNA polymerase 0.0046 0.1511 0.2072
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0224 0.0308
Trypanosoma brucei rac serine-threonine kinase, putative 0.0169 0.6733 1
Schistosoma mansoni hypothetical protein 0.0016 0.0224 0.0308
Schistosoma mansoni protein kinase C mu 0.0016 0.0224 0.0308
Echinococcus granulosus protein kinase c eta type 0.0016 0.0224 0.0308
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0116 0.4499 1
Trichomonas vaginalis AGC family protein kinase 0.0169 0.6733 1
Giardia lamblia Kinase, CMGC GSK 0.0116 0.4499 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0021 0.0435 0.0597
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.3912 0.5365
Brugia malayi Protein kinase domain containing protein 0.0102 0.3912 0.581
Loa Loa (eye worm) hypothetical protein 0.0097 0.3701 0.37
Brugia malayi RhoGAP domain containing protein 0.002 0.0412 0.0612
Echinococcus multilocularis unc 13 (munc13) 0.0017 0.0287 0.0393
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0194 0.0289
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.1452 0.1992
Echinococcus granulosus endonuclease reverse transcriptase 0.0015 0.0194 0.0267
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1452 0.1992
Echinococcus granulosus Glutaredoxin protein 5 0.008 0.295 0.4046
Echinococcus multilocularis mitogen activated protein kinase 0.0064 0.2273 0.3117
Brugia malayi Protein kinase c protein 2 0.0068 0.2462 0.3656
Trichomonas vaginalis AGC family protein kinase 0.0169 0.6733 1
Echinococcus granulosus protein kinase c epsilon type 0.0101 0.3866 0.5301
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.1082 0.1484
Brugia malayi RhoGEF domain containing protein 0.0016 0.0224 0.0333
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0085 0.3161 0.4335
Entamoeba histolytica cell division protein kinase 2, putative 0.0102 0.3912 0.5685
Echinococcus multilocularis protein kinase c eta type 0.0016 0.0224 0.0308
Schistosoma mansoni serine/threonine-protein kinase 0.009 0.3365 0.4615
Onchocerca volvulus 0.0021 0.0429 0.0376
Echinococcus multilocularis serine:threonine protein kinase N2 0.0084 0.3126 0.4286
Trypanosoma cruzi Protein kinase B 0.009 0.3365 0.4908
Brugia malayi C1-like domain containing protein 0.0021 0.0435 0.0647
Trichomonas vaginalis AGC family protein kinase 0.0084 0.3126 0.1912
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1452 0.1992
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0102 0.3912 0.3911
Echinococcus multilocularis protein kinase shaggy 0.0116 0.4499 0.617
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0102 0.3912 0.5868
Loa Loa (eye worm) hypothetical protein 0.0015 0.0194 0.0193
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0084 0.3126 0.4286
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0427
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.3912 0.3674
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0182 0.7292 1
Echinococcus multilocularis protein kinase c epsilon type 0.0101 0.3866 0.5301
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.1082 0.1484
Entamoeba histolytica protein kinase, putative 0.0169 0.6733 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0018 0.0307 0.0421
Trypanosoma brucei cdc2-related kinase 3 0.0102 0.3912 0.3674
Loa Loa (eye worm) TK protein kinase 0.0036 0.1082 0.1081
Echinococcus multilocularis ephrin type A receptor 4 A 0.0081 0.2995 0.4108
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1452 0.1992
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0102 0.3912 0.5365
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0116 0.4499 0.617
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.002 0.0412 0.0565
Loa Loa (eye worm) hypothetical protein 0.0016 0.0224 0.0223
Echinococcus multilocularis Rac GTPase activating protein 1 0.0016 0.0224 0.0308
Schistosoma mansoni ephrin receptor 0.0066 0.2348 0.322
Brugia malayi protein kinase C3,putative 0.0021 0.0435 0.0647
Onchocerca volvulus 0.0161 0.6421 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.002 0.0412 0.0565
Echinococcus granulosus cyclin dependent kinase 1 0.0102 0.3912 0.5365
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.4499 0.6583
Echinococcus multilocularis rac serine:threonine kinase 0.009 0.3365 0.4615
Schistosoma mansoni hypothetical protein 0.0015 0.0194 0.0267
Echinococcus granulosus NDR protein kinase 0.0084 0.3126 0.4286
Loa Loa (eye worm) hypothetical protein 0.0161 0.6421 0.6421
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.3126 0.4286
Trichomonas vaginalis AGC family protein kinase 0.0169 0.6733 1
Loa Loa (eye worm) TK protein kinase 0.004 0.1269 0.1268

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Vasorelaxation effect against norepinephrine-induced contraction of rat thoracic aortic ring with endothelium at 100 uM ChEMBL. 16844371
Activity (functional) 0 Vasorelaxation effect against norepinephrine-induced contraction of rat thoracic aortic ring without endothelium at 100 uM ChEMBL. 16844371

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.