Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Enterococcus durans | Aminoglycoside acetyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | oxidoreductase | Aminoglycoside acetyltransferase | 183 aa | 167 aa | 23.4 % |
Trichomonas vaginalis | conserved hypothetical protein | Aminoglycoside acetyltransferase | 183 aa | 158 aa | 22.2 % |
Leishmania infantum | acyl-CoA dehydrogenase, putative | Aminoglycoside acetyltransferase | 183 aa | 171 aa | 19.9 % |
Brugia malayi | acetyltransferase, GNAT family protein | Aminoglycoside acetyltransferase | 183 aa | 169 aa | 21.3 % |
Leishmania donovani | acyl-CoA dehydrogenase, putative | Aminoglycoside acetyltransferase | 183 aa | 171 aa | 19.9 % |
Mycobacterium tuberculosis | Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase) | Aminoglycoside acetyltransferase | 183 aa | 149 aa | 23.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidylate synthase | 0.2055 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.2055 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2055 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0977 | 0.4721 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2055 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2055 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2055 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2055 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.002 | 0.0026 | 0.0026 |
Giardia lamblia | ABC transporter | 0.0019 | 0.0025 | 0.5 |
Schistosoma mansoni | ABC transporter | 0.0017 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | thymidylate synthase | 0.2055 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0977 | 0.4721 | 0.4707 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.002 | 0.0026 | 0.0026 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.002 | 0.0026 | 0.0026 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.002 | 0.0026 | 0.0026 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0977 | 0.4721 | 0.4715 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.002 | 0.0026 | 0.0026 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2055 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.2055 | 1 | 1 |
Brugia malayi | ABC transporter family protein | 0.0017 | 0.0012 | 0.0012 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2055 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.002 | 0.0026 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0977 | 0.4721 | 0.4721 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2055 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0017 | 0.0012 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0011 | 0.0011 |
Onchocerca volvulus | 0.2055 | 1 | 1 | |
Entamoeba histolytica | ABC transporter, putative | 0.002 | 0.0026 | 0.5 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.002 | 0.0026 | 0.0026 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2055 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Inhibition of Enterococcus faecium C238 growth in presence of kanamycin A | ChEMBL. | 16913716 |
Ki (binding) | = 11 nM | Inhibition of Enterococcus faecium AAC(6')Ii | ChEMBL. | 16913716 |
Ki (binding) | = 11 nM | Inhibition of Enterococcus faecium AAC(6')Ii | ChEMBL. | 16913716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.