TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 603.171 | Formula: C34H35ClN2O4S
H donors: 0 H acceptors: 3 LogP: 7.35 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)S(=O)(=O)N(c1ccccc1C(=O)c1ccccc1)C(c1ccccc1OCCCN1CCCC1)C
InChi: 1S/C34H35ClN2O4S/c1-26(30-14-6-8-17-33(30)41-25-11-24-36-22-9-10-23-36)37(42(39,40)29-20-18-28(35)19-21-29)32-16-7-5-15-31(32)34(38)27-12-3-2-4-13-27/h2-8,12-21,26H,9-11,22-25H2,1H3
InChiKey: MHGZBVHCBAKBRE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APH1B gamma secretase subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831
Loa Loa (eye worm)	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma mansoni	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Brugia malayi	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Echinococcus granulosus	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma japonicum	ko:K06172 anterior pharynx defective 1, putative	Get druggable targets OG5_130831	All targets in OG5_130831

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0142	0.3728	1
Schistosoma mansoni	tyrosine kinase	0.0005	0.0006	0.0006
Loa Loa (eye worm)	SRC-1	0.001	0.0136	0.0171
Entamoeba histolytica	SH2 domain containing protein	0.0005	0.0006	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0004
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0005	0.0006	0.0084
Echinococcus multilocularis	endophilin A3	0.0005	0.0003	0.0003
Plasmodium vivax	replication protein A1, large subunit, putative	0.0017	0.033	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0292	0.0292
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0006	0.0008
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0371	0.9972	1
Echinococcus granulosus	GPCR family 2	0.0015	0.0292	0.0293
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0005	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.001	0.0136	0.0136
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0005	0.0003	0.0003
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0035	0.0826	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Echinococcus granulosus	c src tyrosine kinase	0.001	0.0136	0.0136
Schistosoma mansoni	growth factor receptor-bound protein	0.0122	0.3202	0.3202
Loa Loa (eye worm)	SH2 domain-containing protein	0.0005	0.0006	0.0008
Echinococcus granulosus	nostrin	0.0005	0.0003	0.0003
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0005	0.0003	0.0003
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0142	0.3728	0.3739
Loa Loa (eye worm)	protein-tyrosine kinase	0.0005	0.0003	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0006	0.0008
Echinococcus multilocularis		0.0005	0.0006	0.0006
Brugia malayi	SH2 domain containing protein	0.0005	0.0006	0.0008
Echinococcus granulosus	Spectrin alpha actinin	0.0005	0.0003	0.0003
Schistosoma mansoni	vav2	0.0005	0.0006	0.0006
Entamoeba histolytica	protein kinase, putative	0.0005	0.0006	0.0009
Schistosoma mansoni	sorbin	0.0005	0.0003	0.0003
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0005	0.0003	0.0003
Schistosoma mansoni	growth factor receptor-bound protein	0.0122	0.3202	0.3202
Schistosoma mansoni	dreadlocks/dock	0.0005	0.0003	0.0003
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0005	0.0006	0.0006
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0005	0.0006	0.0006
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0005	0.0003	0.0003
Onchocerca volvulus		0.0005	0.0006	0.0084
Loa Loa (eye worm)	thyroid receptor interactor	0.0005	0.0003	0.0004
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0005	0.0006	0.0006
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0005	0.0003	0.0003
Echinococcus multilocularis	tensin	0.0005	0.0006	0.0006
Echinococcus granulosus	signal transduction protein lnk realted	0.0005	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.001	0.0136	0.0136
Echinococcus granulosus	gamma secretase subunit aph 1	0.0296	0.7921	0.7944
Schistosoma mansoni	shc transforming protein	0.0005	0.0006	0.0006
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0005	0.0003	0.0003
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0003	0.0004
Brugia malayi	SH2 domain containing protein	0.0005	0.0006	0.0008
Brugia malayi	gamma-secretase subunit aph-1	0.0296	0.7921	1
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.0031	0.0726	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0292	0.0292
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0033	0.0779	0.9429
Schistosoma mansoni	tyrosine kinase	0.0005	0.0006	0.0006
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.0136	0.0136
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.001	0.0136	0.0136
Schistosoma mansoni	hypothetical protein	0.0005	0.0006	0.0006
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0006	0.0008
Schistosoma mansoni	hypothetical protein	0.0015	0.0292	0.0292
Echinococcus multilocularis	N chimaerin	0.0005	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0015	0.0292	0.0292
Schistosoma mansoni	adapter molecule crk	0.001	0.0136	0.0136
Echinococcus granulosus	endophilin A3	0.0005	0.0003	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Brugia malayi	Tensin	0.0005	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0004
Brugia malayi	Variant SH3 domain containing protein	0.001	0.0136	0.0171
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0005	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0005	0.0003	0.0003
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.001	0.0136	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Schistosoma mansoni	hypothetical protein	0.0005	0.0003	0.0003
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.001	0.0136	0.0136
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Echinococcus multilocularis	SH2 motif	0.0005	0.0006	0.0006
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0005	0.0006	0.0006
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1197	0.1512
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0005	0.0006	0.0006
Brugia malayi	protein-tyrosine kinase	0.0005	0.0006	0.0008
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0003	0.0004
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0006	0.0008
Onchocerca volvulus		0.0005	0.0006	0.0084
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0005	0.0006	0.0009
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0005	0.0006	0.0006
Schistosoma mansoni	SH2A	0.0005	0.0006	0.0006
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0292	0.0369
Echinococcus granulosus	NCK adaptor protein	0.001	0.0136	0.0136
Brugia malayi	Guanylate kinase family protein	0.0005	0.0003	0.0004
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0005	0.0006	0.0006
Echinococcus granulosus	growth factor receptor bound protein 2	0.0122	0.3202	0.3211
Echinococcus multilocularis	NCK adaptor protein	0.001	0.0136	0.0136
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0005	0.0003	0.0003
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0005	0.0006	0.0006
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.001	0.0136	0.0136
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0292	0.0292
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0136	0.0136
Onchocerca volvulus		0.0005	0.0003	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Brugia malayi	Spectrin alpha chain	0.0005	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0778	0.0983
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0142	0.3728	0.3728
Onchocerca volvulus		0.0005	0.0006	0.0084
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0005	0.0003	0.0003
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0005	0.0006	0.0006
Brugia malayi	SH2 domain containing protein	0.0005	0.0006	0.0008
Schistosoma mansoni	hypothetical protein	0.0015	0.0292	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Echinococcus multilocularis	nostrin	0.0005	0.0003	0.0003
Echinococcus multilocularis	expressed protein	0.0005	0.0003	0.0003
Entamoeba histolytica	hypothetical protein	0.0142	0.3728	1
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0371	0.9972	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0005	0.0006	0.0006
Onchocerca volvulus		0.0005	0.0006	0.0084
Schistosoma mansoni	hypothetical protein	0.0033	0.0778	0.0778
Schistosoma mansoni	hypothetical protein	0.0142	0.3728	0.3728
Schistosoma mansoni	dynamin-associated protein	0.0005	0.0003	0.0003
Giardia lamblia	Hypothetical protein	0.0005	0.0013	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Brugia malayi	SH2 domain containing protein	0.0005	0.0006	0.0008
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0005	0.0003	0.0004
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0292	0.0293
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0005	0.0006	0.0006
Schistosoma mansoni	tensin-related	0.0005	0.0006	0.0006
Schistosoma mansoni	formin binding protein and related proteins	0.0005	0.0003	0.0003
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0005	0.0003	0.0004
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0005	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0005	0.0006	0.0006
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0005	0.0006	0.0006
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0005	0.0006	0.0008
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0136	0.0136
Echinococcus granulosus	SH2 motif	0.0005	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0136	0.0136
Echinococcus granulosus	N chimaerin	0.0005	0.0006	0.0006
Echinococcus granulosus	intersectin 2	0.0005	0.0003	0.0003
Schistosoma mansoni	tyrosine kinase	0.001	0.0136	0.0136
Schistosoma mansoni	eps8-related protein	0.0005	0.0003	0.0003
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0005	0.0006	0.0009
Loa Loa (eye worm)	TK protein kinase	0.0005	0.0006	0.0008
Schistosoma mansoni	replication factor A 1 rfa1	0.0035	0.0826	0.0826
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0005	0.0003	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Plasmodium falciparum	replication protein A1, large subunit	0.0017	0.033	0.5
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0005	0.0003	0.0003
Loa Loa (eye worm)	TK/ABL protein kinase	0.0005	0.0006	0.0008
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0005	0.0006	0.0006
Brugia malayi	SH2 domain containing protein	0.0005	0.0006	0.0008
Schistosoma mansoni	Dab2-interacting protein-like	0.0005	0.0003	0.0003
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0005	0.0003	0.0039
Echinococcus granulosus	replication protein A 70 kDa DNA binding	0.0035	0.0826	0.0829
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0005	0.0006	0.0006
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0005	0.0003	0.0003
Schistosoma mansoni	sorting nexin	0.0005	0.0003	0.0003
Onchocerca volvulus		0.0005	0.0003	0.0039
Schistosoma mansoni	run and tbc1 domain containing	0.0005	0.0003	0.0003
Echinococcus granulosus	tyrosine protein kinase Lyn	0.001	0.0136	0.0136
Brugia malayi	protein-tyrosine kinase	0.0005	0.0003	0.0004
Schistosoma mansoni	tensin	0.0005	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0005	0.0006	0.0006
Loa Loa (eye worm)	p53BP2	0.0005	0.0003	0.0004
Schistosoma mansoni	transcription factor LCR-F1	0.0142	0.3728	0.3728
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0005	0.0003	0.0003
Brugia malayi	Variant SH3 domain containing protein	0.001	0.0136	0.0171
Echinococcus multilocularis	transfer RNA-Ala	0.0005	0.0003	0.0003
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0005	0.0006	0.0006
Onchocerca volvulus		0.0005	0.0006	0.0084
Echinococcus granulosus	expressed protein	0.0005	0.0003	0.0003
Toxoplasma gondii	replication factor-a protein 1 (rpa1) subfamily protein	0.0017	0.033	1
Onchocerca volvulus		0.0005	0.0003	0.0039
Schistosoma mansoni	hypothetical protein	0.0015	0.0292	0.0292
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0003	0.0004
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0122	0.3202	0.4042
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0296	0.7921	1
Schistosoma mansoni	tensin	0.0005	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0292	0.0369
Schistosoma mansoni	nck2/grb4	0.001	0.0136	0.0136
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0296	0.7921	0.7921
Echinococcus multilocularis	SH2 motif	0.0005	0.0006	0.0006
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0005	0.0003	0.0003
Brugia malayi	SH3 domain containing protein	0.0005	0.0003	0.0004
Echinococcus granulosus	tyrosine protein kinase Src64B	0.001	0.0136	0.0136
Echinococcus multilocularis	tensin	0.0005	0.0006	0.0006
Schistosoma mansoni	apoptosis stimulating of P53	0.0005	0.0003	0.0003
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0017	0.033	0.3975
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0005	0.0006	0.0008
Trypanosoma brucei	Replication factor A protein 1	0.0017	0.033	0.1089
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0005	0.0006	0.0008
Onchocerca volvulus		0.0005	0.0006	0.0084
Echinococcus granulosus	SH2 domain containing protein 7	0.0005	0.0006	0.0006
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0122	0.3202	0.3202
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0003	0.0004
Brugia malayi	SH2 domain containing protein	0.0005	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0004
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1197	0.1512
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0005	0.0006	0.0006
Schistosoma mansoni	tensin-related	0.0005	0.0006	0.0006
Leishmania major	replication factor A, 51kDa subunit, putative	0.0017	0.033	1
Echinococcus granulosus	src region	0.0005	0.0003	0.0003
Schistosoma mansoni	suppressor of cytokine signaling	0.0005	0.0006	0.0006
Echinococcus granulosus	hypothetical protein	0.0005	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.001	0.0136	0.0136
Schistosoma mansoni	suppressor of cytokine signaling	0.0005	0.0006	0.0006
Echinococcus granulosus	kelch ECH associated protein 1	0.0371	0.9972	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0005	0.0006	0.0008
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.001	0.0136	0.0136
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0778	0.0983
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0292	0.0369
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.0136	0.0171
Brugia malayi	Myosin tail family protein	0.0005	0.0003	0.0004
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0005	0.0006	0.0006
Schistosoma mansoni	tyrosine kinase	0.001	0.0136	0.0136
Schistosoma mansoni	tyrosine kinase	0.001	0.0136	0.0136
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0005	0.0003	0.0003
Echinococcus multilocularis	tyrosine kinase	0.0005	0.0006	0.0006
Brugia malayi	SH2 domain containing protein	0.0005	0.0006	0.0008
Brugia malayi	RhoGAP domain containing protein	0.0005	0.0006	0.0008
Echinococcus multilocularis	replication protein A 70 kDa DNA binding	0.0035	0.0826	0.0826
Onchocerca volvulus		0.0005	0.0003	0.0039
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0035	0.0826	1
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0006	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.0136	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0006	0.0008
Echinococcus granulosus	tyrosine kinase	0.0005	0.0006	0.0006
Onchocerca volvulus		0.0005	0.0006	0.0084
Onchocerca volvulus		0.0005	0.0006	0.0084
Schistosoma mansoni	signal transduction protein lnk-related	0.0005	0.0006	0.0006
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0292	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0004
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.001	0.0136	0.0136
Echinococcus multilocularis	tyrosine protein kinase shark	0.0005	0.0006	0.0006
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0005	0.0003	0.0003
Onchocerca volvulus		0.0005	0.0003	0.0039
Brugia malayi	Variant SH3 domain containing protein	0.0005	0.0003	0.0004
Schistosoma mansoni	C-fyn	0.0005	0.0003	0.0003
Brugia malayi	SRC-1	0.001	0.0136	0.0171
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0136	0.0136
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0005	0.0003	0.0003
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0005	0.0006	0.0008
Echinococcus granulosus	tyrosine protein kinase Srms	0.0005	0.0006	0.0006
Entamoeba histolytica	hypothetical protein	0.0142	0.3728	1
Schistosoma mansoni	GTPase activating protein	0.0005	0.0006	0.0006
Trypanosoma cruzi	Replication factor A protein 1	0.0017	0.033	0.1089
Echinococcus multilocularis	intersectin 2	0.0005	0.0003	0.0003
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0005	0.0006	0.0006
Echinococcus multilocularis	kelch ECH associated protein 1	0.0371	0.9972	0.9972
Echinococcus granulosus	tyrosine protein kinase Src42A	0.001	0.0136	0.0136
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0005	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Onchocerca volvulus	Putative cortactin	0.0005	0.0003	0.0039
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0005	0.0006	0.0006
Brugia malayi	Sex muscle abnormal protein 5	0.0122	0.3202	0.4042
Trypanosoma cruzi	Aph-1 protein, putative	0.0115	0.3009	1
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0296	0.7921	0.7921
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0005	0.0006	0.0084
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.001	0.0136	0.0136
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0005	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.001	0.0136	0.0136
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0005	0.0003	0.0003
Onchocerca volvulus		0.0005	0.0006	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0004
Echinococcus multilocularis	kelch ECH associated protein 1	0.0371	0.9972	0.9972
Echinococcus multilocularis	Spectrin alpha actinin	0.0005	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0136	0.0171
Onchocerca volvulus		0.0005	0.0006	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Echinococcus multilocularis	SHC transforming protein 3	0.0005	0.0006	0.0006
Onchocerca volvulus		0.0005	0.0006	0.0084
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0005	0.0006	0.0006
Echinococcus granulosus	tyrosine protein kinase Blk	0.0005	0.0006	0.0006
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.0136	0.0136
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0292	0.0293
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0005	0.0006	0.0008
Echinococcus granulosus	tyrosine protein kinase Fyn	0.001	0.0136	0.0136
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0005	0.0006	0.0006
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0004
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0005	0.0006	0.0008
Trypanosoma cruzi	Aph-1 protein, putative	0.0115	0.3009	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0005	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0004
Schistosoma mansoni	hypothetical protein	0.0005	0.0006	0.0006
Loa Loa (eye worm)	replication factor A 73 kDa subunit	0.0035	0.0826	0.1043
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1197	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0004
Echinococcus granulosus	tyrosine protein kinase shark	0.0005	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.001	0.0136	0.0136
Loa Loa (eye worm)	SH2 domain-containing protein	0.0005	0.0006	0.0008
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Entamoeba histolytica	replication factor A protein 1, putative	0.0015	0.0283	0.0753
Brugia malayi	Src substrate cortactin	0.0005	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Onchocerca volvulus		0.0005	0.0006	0.0084
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Loa Loa (eye worm)	SH2 domain-containing protein	0.0005	0.0006	0.0008
Brugia malayi	replication factor A 73 kDa subunit	0.0035	0.0826	0.1043
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0005	0.0003	0.0003
Brugia malayi	Peripheral plasma membrane protein CASK	0.0005	0.0003	0.0004
Brugia malayi	hypothetical protein	0.0005	0.0006	0.0008
Echinococcus granulosus	expressed conserved protein	0.0005	0.0006	0.0006
Brugia malayi	SH2 domain containing protein	0.0005	0.0006	0.0008
Trypanosoma brucei	Aph-1 protein, putative	0.0115	0.3009	1
Loa Loa (eye worm)	guanylate kinase	0.0005	0.0003	0.0004
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0005	0.0006	0.0006
Echinococcus granulosus	tyrosine kinase	0.0005	0.0006	0.0006
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0006	0.0008
Schistosoma mansoni	hypothetical protein	0.0372	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0005	0.0006	0.0006
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0005	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Schistosoma mansoni	cell polarity protein	0.0005	0.0003	0.0003
Brugia malayi	SH2 domain containing protein	0.0005	0.0006	0.0008
Entamoeba histolytica	hypothetical protein	0.0142	0.3728	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Echinococcus granulosus	tensin	0.0005	0.0006	0.0006
Echinococcus granulosus	SHC transforming protein 3	0.0005	0.0006	0.0006
Brugia malayi	BRCA2 repeat family protein	0.0007	0.0066	0.0083
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Echinococcus multilocularis	SH2 motif	0.0005	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0005	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Schistosoma mansoni	tensin	0.0005	0.0006	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0005	0.0003	0.0003
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0005	0.0006	0.0006
Echinococcus granulosus	SH2 motif	0.0005	0.0006	0.0006
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1197	0.1512
Loa Loa (eye worm)	TK/FER protein kinase	0.0005	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0006	0.0008
Loa Loa (eye worm)	BRCA2 repeat family protein	0.0007	0.0066	0.0083
Brugia malayi	hypothetical protein	0.0142	0.3728	0.4707
Echinococcus multilocularis	SH2 domain containing protein 7	0.0005	0.0006	0.0006
Loa Loa (eye worm)	STAT protein	0.0005	0.0006	0.0008

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.2 uM	Inhibition of beta amyloid protein 40 production	ChEMBL.	16766183
IC50 (binding)	= 1.2 uM	Inhibition of beta amyloid protein 40 production	ChEMBL.	16766183
Ratio IC50 (binding)	= 1.7	Inhibition of beta amyloid protein 40 production relative to 4-chloro-N-(2,5-difluorophenyl)-N-(1-(2-(3-(pyrrolidin-1-yl)propoxy)phenyl)ethyl)benzenesulfonamide	ChEMBL.	16766183

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 369453