Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | amidase | 0.0317 | 0.2192 | 0.2809 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0996 | 0.7805 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0067 | 0.0128 | 0.0164 |
Brugia malayi | Papain family cysteine protease containing protein | 0.01 | 0.0402 | 0.0514 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0996 | 0.7805 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0996 | 0.7805 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.0402 | 0.0514 |
Onchocerca volvulus | Cathepsin F homolog | 0.01 | 0.0402 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0177 | 0.1034 | 0.1034 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.01 | 0.0402 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Leishmania major | carbonic anhydrase-like protein | 0.0177 | 0.1034 | 0.0854 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Entamoeba histolytica | cysteine proteinase, putative | 0.01 | 0.0402 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Echinococcus granulosus | carbonic anhydrase | 0.0083 | 0.0259 | 0.0259 |
Entamoeba histolytica | cysteine protease, putative | 0.01 | 0.0402 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0349 | 0.2455 | 0.3145 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0996 | 0.7805 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0177 | 0.1034 | 0.1325 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.0402 | 0.0514 |
Echinococcus multilocularis | cysteine protease | 0.01 | 0.0402 | 0.0402 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0067 | 0.0128 | 0.0164 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0996 | 0.7805 | 0.7805 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.01 | 0.0402 | 0.0402 |
Onchocerca volvulus | 0.01 | 0.0402 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0382 | 0.2729 | 0.3496 |
Brugia malayi | cathepsin L-like precursor | 0.0067 | 0.0128 | 0.0164 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0382 | 0.2729 | 0.3496 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0067 | 0.0128 | 0.0164 |
Echinococcus granulosus | cathepsin l1 | 0.01 | 0.0402 | 0.0402 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0996 | 0.7805 | 1 |
Leishmania major | cathepsin L-like protease | 0.0382 | 0.2729 | 0.3143 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0996 | 0.7805 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0259 | 0.0172 |
Echinococcus multilocularis | carbonic anhydrase | 0.0083 | 0.0259 | 0.0259 |
Onchocerca volvulus | Cathepsin L homolog | 0.01 | 0.0402 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Brugia malayi | MAP kinase sur-1 | 0.0996 | 0.7805 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0177 | 0.1034 | 0.1325 |
Echinococcus granulosus | carbonic anhydrase II | 0.0177 | 0.1034 | 0.1034 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.01 | 0.0402 | 0.0357 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.01 | 0.0402 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0067 | 0.0128 | 0.0164 |
Schistosoma mansoni | carbonic anhydrase | 0.0083 | 0.0259 | 0.0332 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.0402 | 0.0514 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.01 | 0.0402 | 0.0514 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Brugia malayi | Cathepsin L-like precursor | 0.0067 | 0.0128 | 0.0164 |
Entamoeba histolytica | cysteine proteinase, putative | 0.01 | 0.0402 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0996 | 0.7805 | 0.7805 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.01 | 0.0402 | 0.0514 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0317 | 0.2192 | 0.2192 |
Echinococcus multilocularis | carbonic anhydrase | 0.0083 | 0.0259 | 0.0259 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.01 | 0.0402 | 0.0402 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0083 | 0.0259 | 0.0332 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.0402 | 0.0514 |
Toxoplasma gondii | cathepsin CPL | 0.01 | 0.0402 | 0.0188 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1261 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0996 | 0.7805 | 0.7805 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Loa Loa (eye worm) | ctsf protein | 0.01 | 0.0402 | 0.0357 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.01 | 0.0402 | 0.0357 |
Leishmania major | cathepsin L-like protease | 0.0382 | 0.2729 | 0.3143 |
Plasmodium vivax | vivapain-2 | 0.01 | 0.0402 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.01 | 0.0402 | 0.0514 |
Echinococcus granulosus | carbonic anhydrase | 0.0083 | 0.0259 | 0.0259 |
Plasmodium vivax | vivapain-2 | 0.01 | 0.0402 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0083 | 0.0259 | 0.0259 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0083 | 0.0259 | 0.0332 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0083 | 0.0259 | 0.0332 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0177 | 0.1034 | 0.1325 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0382 | 0.2729 | 0.3496 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0382 | 0.2729 | 0.3496 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0177 | 0.1034 | 0.118 |
Echinococcus granulosus | cathepsin l1 | 0.0067 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.2192 | 0.2689 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Onchocerca volvulus | 0.01 | 0.0402 | 1 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0996 | 0.7805 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.0402 | 0.0514 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0083 | 0.0259 | 0.0332 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0996 | 0.7805 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0067 | 0.0128 | 0.0164 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0177 | 0.1034 | 0.1325 |
Leishmania major | cathepsin L-like protease | 0.0382 | 0.2729 | 0.3143 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0996 | 0.7805 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0177 | 0.1034 | 0.118 |
Trypanosoma brucei | protein kinase, putative | 0.0996 | 0.7805 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0996 | 0.7805 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0177 | 0.1034 | 0.1325 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0996 | 0.7805 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0083 | 0.0259 | 0.0332 |
Schistosoma mansoni | amidase | 0.0317 | 0.2192 | 0.2809 |
Echinococcus multilocularis | cysteine protease | 0.01 | 0.0402 | 0.0402 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0083 | 0.0259 | 0.0332 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0317 | 0.2192 | 0.2192 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0259 | 0.0172 |
Onchocerca volvulus | 0.01 | 0.0402 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0996 | 0.7805 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0083 | 0.0259 | 0.0332 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0996 | 0.7805 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0402 | 0.0357 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Plasmodium falciparum | carbonic anhydrase | 0.0083 | 0.0259 | 0.6462 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0259 | 0.0172 |
Loa Loa (eye worm) | cysteine protease | 0.01 | 0.0402 | 0.0357 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Brugia malayi | Cathepsin L-like precursor | 0.01 | 0.0402 | 0.0514 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.01 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | fibroinase | 0.01 | 0.0402 | 0.0357 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.01 | 0.0402 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0083 | 0.0259 | 0.0332 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Onchocerca volvulus | Cathepsin L homolog | 0.01 | 0.0402 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0259 | 0.0332 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.01 | 0.0402 | 0.0402 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.01 | 0.0402 | 0.0402 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0177 | 0.1034 | 0.1325 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0177 | 0.1034 | 0.1325 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.01 | 0.0402 | 0.0402 |
Onchocerca volvulus | 0.01 | 0.0402 | 1 | |
Onchocerca volvulus | 0.01 | 0.0402 | 1 | |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0317 | 0.2192 | 0.2192 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Onchocerca volvulus | 0.01 | 0.0402 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0317 | 0.2192 | 0.2809 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0996 | 0.7805 | 0.7805 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0317 | 0.2192 | 0.2192 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0996 | 0.7805 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0996 | 0.7805 | 1 |
Onchocerca volvulus | 0.01 | 0.0402 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0382 | 0.2729 | 0.3496 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0067 | 0.0128 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.01 | 0.0402 | 0.0514 |
Echinococcus granulosus | carbonic anhydrase | 0.0083 | 0.0259 | 0.0259 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.03 | 0.2053 | 0.2631 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0083 | 0.0259 | 0.0172 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 375 nM | Agonist activity at mu opioid receptor assessed as inhibition of electrically-evoked contraction of guinea pig ileum | ChEMBL. | 16942034 |
IC50 (functional) | = 9049 nM | Agonist activity at delta opioid receptor assessed as inhibition of electrically-evoked contraction of mouse vas deferens | ChEMBL. | 16942034 |
Ki (binding) | = 0.37 nM | Displacement of [3H]DAMGO from mu opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membrane | ChEMBL. | 16942034 |
Ki (binding) | = 0.64 nM | Displacement of [3H]deltorphin2 from delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membrane | ChEMBL. | 16942034 |
pA2 (functional) | < 5 | Antagonist activity at delta opioid receptor assessed as inhibition of deltorphin2-induced contraction of mouse vas deferens | ChEMBL. | 16942034 |
Ratio Ki (binding) | = 1.7 | Selectivity for mu opioid receptor over delta opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membrane | ChEMBL. | 16942034 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.