Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0481 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0369 | 0.5804 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0481 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0369 | 0.5804 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0369 | 0.5804 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0369 | 0.5804 | 1 |
Brugia malayi | thymidylate synthase | 0.034 | 0.4713 | 0.812 |
Echinococcus multilocularis | thymidylate synthase | 0.034 | 0.4713 | 0.812 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0481 | 1 | 1 |
Trichomonas vaginalis | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0214 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0369 | 0.5804 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.034 | 0.4713 | 0.812 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0214 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.034 | 0.4713 | 0.812 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0369 | 0.5804 | 0.5 |
Onchocerca volvulus | 0.034 | 0.4713 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0481 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.034 | 0.4713 | 0.812 |
Loa Loa (eye worm) | thymidylate synthase | 0.034 | 0.4713 | 0.812 |
Echinococcus granulosus | dihydrofolate reductase | 0.0369 | 0.5804 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0481 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0369 | 0.5804 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.034 | 0.4713 | 0.812 |
Brugia malayi | Dihydrofolate reductase | 0.0369 | 0.5804 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0369 | 0.5804 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.034 | 0.4713 | 0.812 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Maximal non-toxic dose 50 (functional) | = 16 ug ml-1 | Cytotoxicity against Vero cell line | ChEMBL. | 16884306 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis 103471 | ChEMBL. | 16884306 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis 103471 | ChEMBL. | 16884306 |
MIC (functional) | > 16 ug ml-1 | Antibacterial activity against Mycobacterium smegmatis | ChEMBL. | 16884306 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against Mycobacterium marinum | ChEMBL. | 16884306 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against Mycobacterium avium | ChEMBL. | 16884306 |
PI (functional) | = 8 | Protection index, cytotoxicity against Vero cell line/antibacterial activity against Mycobacterium tuberculosis 103471 | ChEMBL. | 16884306 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.