Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0322 | 1 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | protein jagged 2 | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | protein jagged 1 | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Brugia malayi | Muscle positioning protein 4 | 0.0214 | 0.0421 | 0.2452 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0322 | 1 | 0.5 |
Echinococcus granulosus | protein jagged 1 | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | thymidylate synthase | 0.0229 | 0.1716 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0229 | 0.1716 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0322 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0229 | 0.1716 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | Slit protein homolog | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | Notch2 | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | protein jagged 1 | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Delta serrate ligand family protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | fibropellin Ia | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | neural cadherin | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | Putative cubilin | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | slit 2 protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | protein jagged 1 | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0229 | 0.1716 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Cadherin domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Giardia lamblia | High cysteine protein | 0.0214 | 0.0421 | 0.5 |
Echinococcus granulosus | fibropellin Ia | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0229 | 0.1716 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0229 | 0.1716 | 1 |
Brugia malayi | thymidylate synthase | 0.0229 | 0.1716 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0229 | 0.1716 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0322 | 1 | 0.5 |
Echinococcus multilocularis | neural cadherin | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | delta-like protein 1 | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | notch-like transmembrane receptor | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | slit 2 protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | notch | 0.0214 | 0.0421 | 0.2452 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | thymidylate synthase | 0.0229 | 0.1716 | 1 |
Loa Loa (eye worm) | notch protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0214 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | septate junction protein | 0.0214 | 0.0421 | 0.2452 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0322 | 1 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | EGF-like domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Onchocerca volvulus | 0.0214 | 0.0421 | 0.2452 | |
Schistosoma mansoni | notch | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Brugia malayi | Cadherin domain containing protein | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | slit | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | protein jagged 2 | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | notch | 0.0214 | 0.0421 | 0.2452 |
Echinococcus granulosus | protein jagged 2 | 0.0214 | 0.0421 | 0.2452 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0421 | 0.2452 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Counts (functional) | = 25.8 min-1 | Ability to cause loss of righting reflex in mice represented as no. of counts for each animal for a total of 90 min when 100 mg/kg dose was administered intraperitoneally | ChEMBL. | 4032437 |
Counts (functional) | = 25.8 min-1 | Ability to cause loss of righting reflex in mice represented as no. of counts for each animal for a total of 90 min when 100 mg/kg dose was administered intraperitoneally | ChEMBL. | 4032437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.