Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0674 | 0.309 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0529 | 0.1638 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0674 | 0.309 | 0.309 |
Toxoplasma gondii | cathepsin CPL | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0464 | 0.0983 | 0.0983 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0529 | 0.1638 | 0.53 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.309 | 0.309 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0674 | 0.309 | 0.2336 |
Onchocerca volvulus | 0.0674 | 0.309 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.309 | 1 |
Onchocerca volvulus | 0.0674 | 0.309 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0674 | 0.309 | 0.309 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0674 | 0.309 | 1 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.309 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1364 | 1 | 1 |
Onchocerca volvulus | 0.0674 | 0.309 | 1 | |
Loa Loa (eye worm) | cathepsin B | 0.0529 | 0.1638 | 0.0726 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0674 | 0.309 | 0.309 |
Echinococcus multilocularis | cysteine protease | 0.0674 | 0.309 | 0.309 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.309 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0674 | 0.309 | 0.309 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.309 | 0.309 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Onchocerca volvulus | 0.0674 | 0.309 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0674 | 0.309 | 0.309 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0674 | 0.309 | 0.309 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0674 | 0.309 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0674 | 0.309 | 0.309 |
Loa Loa (eye worm) | ctsf protein | 0.0674 | 0.309 | 0.2336 |
Leishmania major | cysteine peptidase A (CPA) | 0.0674 | 0.309 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0674 | 0.309 | 0.309 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.309 | 0.309 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1364 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0529 | 0.1638 | 0.1638 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1364 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.309 | 0.309 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0529 | 0.1638 | 0.53 |
Loa Loa (eye worm) | cysteine protease | 0.0674 | 0.309 | 0.2336 |
Giardia lamblia | Cathepsin B precursor | 0.0529 | 0.1638 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0674 | 0.309 | 0.2336 |
Echinococcus granulosus | cathepsin l1 | 0.0464 | 0.0983 | 0.0983 |
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.309 | 0.2336 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.309 | 0.309 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0674 | 0.309 | 0.309 |
Echinococcus multilocularis | cysteine protease | 0.0674 | 0.309 | 0.309 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.309 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1364 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0674 | 0.309 | 0.2336 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0464 | 0.0983 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0674 | 0.309 | 0.309 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.309 | 1 |
Onchocerca volvulus | 0.0674 | 0.309 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0464 | 0.0983 | 0.0983 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0464 | 0.0983 | 0.0983 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0674 | 0.309 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0674 | 0.309 | 0.309 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0529 | 0.1638 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0529 | 0.1638 | 0.1638 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1364 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1364 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0674 | 0.309 | 0.309 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1364 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0674 | 0.309 | 1 |
Plasmodium vivax | vivapain-2 | 0.0674 | 0.309 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0674 | 0.309 | 0.309 |
Onchocerca volvulus | 0.0674 | 0.309 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1364 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0464 | 0.0983 | 0.0983 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1364 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Echinococcus granulosus | cathepsin b | 0.1364 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0674 | 0.309 | 0.309 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0464 | 0.0983 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Leishmania major | cathepsin L-like protease | 0.0674 | 0.309 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0674 | 0.309 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0674 | 0.309 | 0.309 |
Onchocerca volvulus | 0.0674 | 0.309 | 1 | |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0464 | 0.0983 | 0.0983 |
Plasmodium vivax | vivapain-2 | 0.0674 | 0.309 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0674 | 0.309 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0674 | 0.309 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0674 | 0.309 | 0.309 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0674 | 0.309 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0464 | 0.0983 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0464 | 0.0983 | 0.0983 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 40 mg kg-1 | Anti-inflammatory activity in orally dosed Wistar rat assessed as reduction of carrageenan-induced paw edema at 30 mg/kg, po | ChEMBL. | 16730986 |
Inhibition (binding) | = 0 % | Inhibition of microsomal COX1 at 10 uM | ChEMBL. | 16730986 |
Inhibition (binding) | = 0 % | Inhibition of microsomal COX1 at 10 uM | ChEMBL. | 16730986 |
Inhibition (binding) | = 25 % | Inhibition of human recombinant COX2 expressed in sf9 cells infected with baculovirus at 10 uM | ChEMBL. | 16730986 |
Inhibition (binding) | = 25 % | Inhibition of human recombinant COX2 expressed in sf9 cells infected with baculovirus at 10 uM | ChEMBL. | 16730986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.