Detailed information for compound 369929

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.355 | Formula: C19H15N5O
  • H donors: 0 H acceptors: 3 LogP: 2.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCn1nc(C)c2c(c1=O)nc(n1c2cc(n1)c1ccccc1)C
  • InChi: 1S/C19H15N5O/c1-4-10-23-19(25)18-17(12(2)21-23)16-11-15(14-8-6-5-7-9-14)22-24(16)13(3)20-18/h1,5-9,11H,10H2,2-3H3
  • InChiKey: NHJWBSMROQXKRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0042 0.0044 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus family S9 non peptidase ue S09 family 0.1265 0.168 0.168
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0029 0.0027 0.0027
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0005 0.0005
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Brugia malayi hypothetical protein 0.002 0.0016 0.0016
Onchocerca volvulus 0.0029 0.0027 0.016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0246 0.0317 0.0317
Loa Loa (eye worm) acetylcholinesterase 1 0.7486 1 1
Schistosoma mansoni myosin xvIII 0.0012 0.0005 0.0005
Schistosoma mansoni memapsin-2 (A01 family) 0.051 0.0671 0.0671
Loa Loa (eye worm) aspartic protease BmAsp-2 0.002 0.0016 0.0016
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.1265 0.168 0.168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0703 0.0928 0.5373
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0005 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0029 0.0027 0.0027
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0005 0.0005
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0029 0.0027 0.0027
Echinococcus multilocularis acetylcholinesterase 0.7486 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0005 0.0005
Onchocerca volvulus 0.1265 0.168 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0043 0.0163
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1208 0.1603 0.1603
Echinococcus granulosus g protein coupled receptor 0.0012 0.0005 0.0005
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.1265 0.168 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0005 0.0005
Brugia malayi hypothetical protein 0.0049 0.0054 0.0054
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0044 0.0044
Echinococcus granulosus sex peptide receptor 0.0012 0.0005 0.0005
Echinococcus granulosus lysine specific histone demethylase 1A 0.0049 0.0054 0.0054
Echinococcus granulosus para nitrobenzyl esterase 0.1265 0.168 0.168
Onchocerca volvulus 0.1265 0.168 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0044 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0005 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Echinococcus multilocularis serotonin receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.0035
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0005 0.0005
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0005 0.0005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0005 0.0005
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0049 0.0054 0.0323
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0005 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0005 0.0005
Trypanosoma cruzi UDP-galactopyranose mutase 0.0049 0.0054 0.0264
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1265 0.168 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0016 0.0016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0005 0.0005
Schistosoma mansoni cathepsin D (A01 family) 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0054 1
Schistosoma mansoni opsin-like receptor 0.0012 0.0005 0.0005
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0005 0.0005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0043 0.0163
Loa Loa (eye worm) hypothetical protein 0.0049 0.0054 0.0054
Plasmodium vivax SET domain protein, putative 0.0035 0.0035 0.5113
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0016 0.0016
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0052 0.0052
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis choline O acetyltransferase 0.0194 0.0247 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0035 0.0035
Brugia malayi amine oxidase, flavin-containing family protein 0.0049 0.0054 0.0054
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1265 0.168 0.168
Loa Loa (eye worm) carboxylesterase 0.1265 0.168 0.168
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0005 0.0005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0005 0.0005
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1265 0.168 0.168
Schistosoma mansoni hypothetical protein 0.0042 0.0044 0.0044
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1265 0.168 1
Loa Loa (eye worm) hypothetical protein 0.1265 0.168 0.168
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0044 0.0044
Trichomonas vaginalis set domain proteins, putative 0.028 0.0363 0.2087
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0016
Echinococcus granulosus lysine specific histone demethylase 1A 0.0049 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0049 0.0054 0.0054
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus allatostatin A receptor 0.0012 0.0005 0.0005
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0029 0.0027 0.0027
Echinococcus granulosus g protein coupled receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0005 0.0005
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0029 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0807 0.1067 0.1067
Loa Loa (eye worm) hypothetical protein 0.1265 0.168 0.168
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0005 0.0005
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0412 0.054 0.054
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus g protein coupled receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Schistosoma mansoni opsin-like receptor 0.0012 0.0005 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.7486 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0005 0.0005
Brugia malayi hypothetical protein 0.0042 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis sex peptide receptor 0.0012 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0012 0.0005 0.0005
Echinococcus multilocularis BC026374 protein (S09 family) 0.1265 0.168 0.168
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0005 0.0005
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0049 0.0054 0.0054
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0005 0.0005
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0005 0.0005
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0054 0.0054
Brugia malayi Eukaryotic aspartyl protease family protein 0.002 0.0016 0.0016
Echinococcus granulosus carboxylesterase 5A 0.7486 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0029 0.0027 0.016
Brugia malayi Dopamine receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.1265 0.168 0.168
Trypanosoma cruzi UDP-galactopyranose mutase 0.0049 0.0054 0.0264
Onchocerca volvulus 0.0012 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0005 0.0005
Onchocerca volvulus 0.002 0.0016 0.0092
Brugia malayi ORL1-like opioid receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0005 0.0005
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0029 0.0027 0.0027
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0046 0.0046
Brugia malayi Carboxylesterase family protein 0.7486 1 1
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0049 0.0054 0.0054
Entamoeba histolytica hypothetical protein 0.0042 0.0044 0.5
Schistosoma mansoni histamine h1 receptor 0.0012 0.0005 0.0005
Brugia malayi Pepsin A precursor 0.002 0.0016 0.0016
Schistosoma mansoni neuropeptide receptor 0.0012 0.0005 0.0005
Brugia malayi SWIRM domain containing protein 0.0049 0.0054 0.0054
Schistosoma mansoni neuropeptide receptor 0.0012 0.0005 0.0005
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0049 0.0054 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0807 0.1067 1
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0042 0.0044 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0005 0.0005
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0807 0.1067 0.1067
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Schistosoma mansoni amine oxidase 0.0049 0.0054 0.0054
Echinococcus granulosus orexin receptor type 2 0.0012 0.0005 0.0005
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0005 0.0005
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus acetylcholinesterase 0.7486 1 1
Echinococcus multilocularis para nitrobenzyl esterase 0.1265 0.168 0.168
Loa Loa (eye worm) hypothetical protein 0.1265 0.168 0.168
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis acetylcholinesterase 0.7486 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0005 0.0005
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0005 0.0005
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0005 0.0005
Brugia malayi Dopamine receptor protein 2 0.0012 0.0005 0.0005
Schistosoma mansoni choline o-acyltransferase 0.0029 0.0027 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0005 0.0005
Schistosoma mansoni amine oxidase 0.0049 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0035 0.0035
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0035 0.0035
Brugia malayi larval opioid receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0005 0.0005
Brugia malayi aspartic protease BmAsp-1, identical 0.002 0.0016 0.0016
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.1265 0.168 0.168
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0049 0.0054 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0049 0.0054 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.7486 1 1
Schistosoma mansoni biogenic amine receptor 0.0012 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0005 0.0005
Brugia malayi Serotonin receptor 0.0012 0.0005 0.0005
Trichomonas vaginalis spcc417.12 protein, putative 0.1265 0.168 1
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0005
Brugia malayi Carboxylesterase family protein 0.1265 0.168 0.168
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0016 0.0016
Brugia malayi Pre-SET motif family protein 0.0246 0.0317 0.0317
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0016 0.0016
Onchocerca volvulus 0.028 0.0363 0.216
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0005 0.0005
Echinococcus granulosus neuropeptide receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0029 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.7486 1 1
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0005 0.0005
Loa Loa (eye worm) aspartyl protease 6 0.002 0.0016 0.0016
Echinococcus granulosus choline O acetyltransferase 0.0194 0.0247 0.0247
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0005 0.0005
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0005 0.0005
Brugia malayi putative neuropeptide receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus neuroligin 0.1265 0.168 0.168
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Brugia malayi Stress-activated protein kinase jnk-1 0.1208 0.1603 0.1603
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis 0.0049 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus hypothetical protein 0.0708 0.0935 0.0935
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0049 0.0054 0.0054
Loa Loa (eye worm) aspartic protease BmAsp-1 0.002 0.0016 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0016 0.0016
Brugia malayi GnHR receptor homolog 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0054 0.0054
Onchocerca volvulus 0.0012 0.0005 0.0028
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0029 0.0027 0.0027
Brugia malayi Choline O-acetyltransferase 0.0194 0.0247 0.0247
Echinococcus multilocularis conserved hypothetical protein 0.0696 0.0919 0.0919
Brugia malayi Carboxylesterase family protein 0.1265 0.168 0.168
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0005 0.0005
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0049 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0039 0.0039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0005 0.0005
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Mycobacterium ulcerans carboxylesterase, LipT 0.1265 0.168 1
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0005 0.0005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0034 0.0034
Schistosoma mansoni acetylcholinesterase 0.1265 0.168 0.168
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0005 0.0005
Brugia malayi G-protein coupled receptor 0.0012 0.0005 0.0005
Brugia malayi Melatonin receptor type 1A 0.0012 0.0005 0.0005
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0049 0.0054 0.5
Schistosoma mansoni biogenic amine receptor 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0029 0.0027 0.016
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0005 0.0005
Brugia malayi RE15519p 0.0012 0.0005 0.0005
Brugia malayi G-protein coupled receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0005 0.0005
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Echinococcus granulosus acetylcholinesterase 0.7486 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0046 0.0046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0005 0.0005
Onchocerca volvulus 0.1265 0.168 1
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Mycobacterium tuberculosis Carboxylesterase LipT 0.1265 0.168 1
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0005 0.0005
Leishmania major UDP-galactopyranose mutase 0.0049 0.0054 0.0264
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0035 0.5113
Onchocerca volvulus 0.1265 0.168 1
Brugia malayi Carboxylesterase family protein 0.1265 0.168 0.168
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0005 0.0005
Schistosoma mansoni adenoreceptor 0.0012 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Schistosoma mansoni neuropeptide receptor 0.0012 0.0005 0.0005
Onchocerca volvulus 0.002 0.0016 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.1208 0.1603 0.1603
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0061 0.007 0.007
Brugia malayi aspartic protease BmAsp-2, identical 0.002 0.0016 0.0016
Echinococcus granulosus fmrfamide receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0005 0.0005
Brugia malayi neuropeptide F receptor 0.0012 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0054 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0703 0.0928 0.5373
Onchocerca volvulus 0.0012 0.0005 0.0028
Loa Loa (eye worm) carboxylesterase 0.7486 1 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0049 0.0054 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.1265 0.168 0.168
Loa Loa (eye worm) hypothetical protein 0.0194 0.0247 0.0247
Brugia malayi Dopamine receptor protein 1 0.0012 0.0005 0.0005
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0005 0.0005
Brugia malayi Choline O-acetyltransferase 0.0194 0.0247 0.0247
Onchocerca volvulus 0.0012 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0005 0.0005
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0035 0.0035
Echinococcus granulosus somatostatin receptor 0.0012 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0005 0.0005
Echinococcus granulosus BC026374 protein S09 family 0.1265 0.168 0.168
Schistosoma mansoni cathepsin D (A01 family) 0.002 0.0016 0.0016
Schistosoma mansoni choline o-acyltransferase 0.0194 0.0247 0.0247
Echinococcus multilocularis serotonin receptor 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0005 0.0005
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0005 0.0005
Onchocerca volvulus 0.1265 0.168 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0653 0.0862 0.4966
Brugia malayi Serotonin receptor 0.0476 0.0625 0.0625
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0005 0.0005
Toxoplasma gondii histone lysine-specific demethylase 0.0049 0.0054 1
Schistosoma mansoni biogenic amine receptor 0.0012 0.0005 0.0005
Schistosoma mansoni BC026374 protein (S09 family) 0.1265 0.168 0.168
Schistosoma mansoni neuropeptide receptor 0.0012 0.0005 0.0005
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0052 0.0052
Schistosoma mansoni amine GPCR 0.0012 0.0005 0.0005
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0005 0.0005
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0046 0.0046
Schistosoma mansoni neuroligin 3 (S09 family) 0.1265 0.168 0.168
Brugia malayi hypothetical protein 0.1265 0.168 0.168
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0005 0.0005
Onchocerca volvulus 0.0012 0.0005 0.0028
Echinococcus granulosus serotonin receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0016 0.0016
Brugia malayi AKH receptor 0.0012 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0005 0.0005
Echinococcus granulosus neuropeptide receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.002 0.0016 0.0016
Loa Loa (eye worm) choline O-acetyltransferase 0.0194 0.0247 0.0247
Onchocerca volvulus 0.0035 0.0035 0.021
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0005 0.0005
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0807 0.1067 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0005 0.0005
Schistosoma mansoni gliotactin 0.1265 0.168 0.168
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1208 0.1603 0.1603
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0005 0.0005
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0005 0.0005
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0005 0.0005
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0035 0.0035
Echinococcus multilocularis carboxylesterase 5A 0.7486 1 1
Onchocerca volvulus 0.0012 0.0005 0.0028
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0046 0.0046
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0005 0.0005
Brugia malayi G protein-coupled receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.1265 0.168 0.168
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0005 0.0005
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0005 0.0005
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Entamoeba histolytica hypothetical protein 0.0042 0.0044 0.5
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0005 0.0005
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0005 0.0005
Brugia malayi Pre-SET motif family protein 0.0035 0.0035 0.0035
Onchocerca volvulus 0.0012 0.0005 0.0028
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0005 0.0005
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0012 0.0005 0.0005
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0049 0.0054 1
Onchocerca volvulus 0.0029 0.0027 0.016
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1265 0.168 0.168
Echinococcus multilocularis somatostatin receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0005 0.0005
Echinococcus multilocularis neuroligin 0.1265 0.168 0.168
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Brugia malayi hypothetical protein 0.0012 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.002 0.0016 0.0016
Brugia malayi Carboxylesterase family protein 0.1265 0.168 0.168
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0029 0.0027 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0005 0.0005
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0049 0.0054 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0005 0.0005
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0005 0.0005
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0012 0.0005 0.0005
Brugia malayi sulfakinin receptor protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Brugia malayi hypothetical protein 0.002 0.0016 0.0016
Echinococcus granulosus c-Jun N-terminal kinases 0.1208 0.1603 0.1603
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0016
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0005 0.0028
Loa Loa (eye worm) carboxylesterase 0.1265 0.168 0.168
Schistosoma mansoni opsin-like receptor 0.0012 0.0005 0.0005
Chlamydia trachomatis protoporphyrinogen oxidase 0.0049 0.0054 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0005 0.0005
Brugia malayi neuropeptide F receptor 0.0012 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0005 0.0005
Echinococcus multilocularis protoporphyrinogen oxidase 0.0049 0.0054 0.0054
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0005 0.0005
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0005 0.0005
Leishmania major C-8 sterol isomerase-like protein 0.0807 0.1067 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0005 0.0005

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0.3 % Inhibition of PDE6 at 0.2 uM ChEMBL. 16913726
Inhibition (binding) = 0.3 % Inhibition of PDE6 at 0.2 uM ChEMBL. 16913726
Inhibition (binding) = 19.7 % Inhibition of PDE5 at 0.2 uM ChEMBL. 16913726
Inhibition (binding) = 19.7 % Inhibition of PDE5 at 0.2 uM ChEMBL. 16913726

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.