Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0024 | 0.0113 | 0.5 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0526 | 0.0397 |
Plasmodium falciparum | amino acid transporter, putative | 0.0031 | 0.0215 | 1 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0044 | 0.0387 | 0.0177 |
Brugia malayi | Carboxylesterase family protein | 0.0202 | 0.2547 | 0.2384 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0202 | 0.2547 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0031 | 0.0215 | 0.0595 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0024 | 0.0113 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0258 | 0.0044 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0031 | 0.0215 | 0.0595 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0526 | 0.1851 |
Onchocerca volvulus | 0.0034 | 0.0258 | 0.0209 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0034 | 0.0258 | 0.011 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0031 | 0.0215 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.228 | 0.2111 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0031 | 0.0215 | 0.0595 |
Loa Loa (eye worm) | carboxylesterase | 0.0202 | 0.2547 | 0.2384 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0031 | 0.0215 | 0.0062 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 1 | 1 |
Plasmodium falciparum | transporter, putative | 0.0031 | 0.0215 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0702 | 0.936 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0034 | 0.0258 | 0.011 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0031 | 0.0215 | 0.0062 |
Schistosoma mansoni | acetylcholinesterase | 0.0034 | 0.0258 | 0.0769 |
Echinococcus granulosus | hypothetical protein | 0.0709 | 0.9459 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0034 | 0.0258 | 1 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0031 | 0.0215 | 0.0595 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0031 | 0.0215 | 0.0063 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 0.228 | 0.2283 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 0.228 | 0.2111 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0031 | 0.0215 | 0.0063 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0034 | 0.0258 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 0.228 | 0.2308 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0046 | 0.0414 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0031 | 0.0215 | 0.0063 |
Echinococcus granulosus | acetylcholinesterase | 0.0202 | 0.2547 | 0.257 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 0.228 | 0.2111 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0031 | 0.0215 | 0.0595 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 0.228 | 0.8924 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0031 | 0.0215 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0034 | 0.0258 | 0.0109 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0031 | 0.0215 | 0.0595 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0.228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0258 | 0.0044 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0031 | 0.0215 | 0.0595 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0258 | 0.0044 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0034 | 0.0258 | 0.0769 |
Echinococcus granulosus | neuroligin | 0.0034 | 0.0258 | 0.0109 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0044 | 0.0387 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0031 | 0.0215 | 0.0595 |
Echinococcus granulosus | acetylcholinesterase | 0.0202 | 0.2547 | 0.257 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2022 | 0.1847 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.228 | 0.2111 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 0.228 | 0.8924 |
Echinococcus granulosus | carboxylesterase 5A | 0.0202 | 0.2547 | 0.257 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0801 | 0.0599 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0031 | 0.0215 | 0.0062 |
Echinococcus multilocularis | acetylcholinesterase | 0.0202 | 0.2547 | 0.2598 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0258 | 0.0044 |
Entamoeba histolytica | DNA polymerase alpha catalytic subunit, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0164 | 0.2022 | 0.1847 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0031 | 0.0215 | 0.0595 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0258 | 0.0044 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0258 | 0.0044 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0258 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0258 | 0.0044 |
Onchocerca volvulus | 0.0034 | 0.0258 | 0.0209 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0202 | 0.2547 | 0.2598 |
Onchocerca volvulus | 0.0034 | 0.0258 | 0.0209 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0202 | 0.2547 | 0.2598 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0258 | 0.0769 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0258 | 0.0769 |
Schistosoma mansoni | gliotactin | 0.0034 | 0.0258 | 0.0769 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0258 | 0.0044 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0034 | 0.0258 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0258 | 0.0044 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 0.228 | 0.2111 |
Brugia malayi | Serotonin receptor | 0.0475 | 0.627 | 0.6188 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0202 | 0.2547 | 0.2384 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0258 | 0.0769 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0024 | 0.0113 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0258 | 0.0209 | |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0054 | 0.0526 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.228 | 0.2111 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0258 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0034 | 0.0258 | 0.0769 |
Onchocerca volvulus | CoRest homolog | 0.0168 | 0.2087 | 0.9064 |
Onchocerca volvulus | 0.0034 | 0.0258 | 0.0209 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0258 | 1 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0074 | 0.0801 | 0.2839 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0034 | 0.0258 | 0.011 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0031 | 0.0215 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.2087 | 0.1914 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2547 | 0.2384 |
Brugia malayi | Carboxylesterase family protein | 0.0202 | 0.2547 | 0.2384 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0258 | 0.0044 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0034 | 0.0258 | 1 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0044 | 0.0387 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0031 | 0.0215 | 0.0595 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0182 | 0.228 | 0.2111 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0258 | 0.0044 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0034 | 0.0258 | 0.0109 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0031 | 0.0215 | 0.0063 |
Onchocerca volvulus | 0.0182 | 0.228 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2547 | 0.2384 |
Echinococcus multilocularis | neuroligin | 0.0034 | 0.0258 | 0.011 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0031 | 0.0215 | 0.0063 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0031 | 0.0215 | 0.0595 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0034 | 0.0258 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0258 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0258 | 0.0044 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0031 | 0.0215 | 0.0062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Inhibition of somatic ACE N domain upto 500 uM | ChEMBL. | 16784843 |
Ki (binding) | = 26.3 uM | Inhibition of testis ACE C domain | ChEMBL. | 16784843 |
Ki (binding) | = 26.3 uM | Inhibition of testis ACE C domain | ChEMBL. | 16784843 |
Ratio Ki (binding) | > 25 | Selectivity for ACE C domain over ACE N domain | ChEMBL. | 16784843 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.