Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0383 | 0.0804 | 0.0189 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3283 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0383 | 0.0804 | 0.0189 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1255 | 0.3571 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0383 | 0.0804 | 0.0189 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0383 | 0.0804 | 0.0189 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1255 | 0.3571 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0383 | 0.0804 | 0.0189 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3283 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1255 | 0.3571 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3283 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1255 | 0.3571 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.3283 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.3283 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0383 | 0.0804 | 0.0189 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3283 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0383 | 0.0804 | 0.0189 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1255 | 0.3571 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1255 | 0.3571 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0383 | 0.0804 | 0.0189 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3283 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3283 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.3283 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0383 | 0.0804 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.0006 uM | Antiviral activity against wild type HIV1 in HeLa-JC53 cells | ChEMBL. | 16806925 |
EC50 (functional) | = 0.0006 uM | Antiviral activity against wild type HIV1 in HeLa-JC53 cells | ChEMBL. | 16806925 |
EC50 (functional) | = 0.015 uM | Antiviral activity against HIV1 Y188L mutant in HeLa-JC53 cells | ChEMBL. | 16806925 |
EC50 (functional) | = 0.015 uM | Antiviral activity against HIV1 Y188L mutant in HeLa-JC53 cells | ChEMBL. | 16806925 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 16806925 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.