Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0328 | 0.0797 | 0.0174 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2941 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1124 | 0.3602 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2941 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.2941 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2941 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2941 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2941 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.2941 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0328 | 0.0797 | 0.0174 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0328 | 0.0797 | 0.0174 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2941 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0328 | 0.0797 | 0.0174 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0328 | 0.0797 | 0.0174 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0328 | 0.0797 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1124 | 0.3602 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0328 | 0.0797 | 0.0174 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1124 | 0.3602 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2941 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1124 | 0.3602 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1124 | 0.3602 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0328 | 0.0797 | 0.0174 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1124 | 0.3602 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0328 | 0.0797 | 0.0174 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 68 nM | Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells | ChEMBL. | 16806922 |
Ki (binding) | = 68 nM | Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells | ChEMBL. | 16806922 |
Ki (binding) | > 2000 nM | Displacement of [3H]methylspiperone from dopamine D2 receptor expressed in CHO cells | ChEMBL. | 16806922 |
Ki (binding) | > 2000 nM | Displacement of [3H]methylspiperone from dopamine D2 receptor expressed in CHO cells | ChEMBL. | 16806922 |
Ratio Ki (binding) | > 29 | Selectivity for D1 receptor over D2 receptor | ChEMBL. | 16806922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.