Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2529 | 0.6107 |
Brugia malayi | hypothetical protein | 0.0089 | 0.4142 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.2529 | 0.6107 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.4142 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0089 | 0.4142 | 0.2158 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.007 | 0.2813 | 0.6792 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0608 | 0.7399 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.2813 | 0.038 |
Brugia malayi | Heterochromatin protein 1 | 0.007 | 0.2813 | 0.624 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0821 | 0.0969 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.2813 | 0.038 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0821 | 0.0969 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.2529 | 0.5437 |
Echinococcus multilocularis | geminin | 0.0171 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.2813 | 1 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.2813 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0608 | 0.1467 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.2813 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.4142 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2529 | 0.6107 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0821 | 1 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.2813 | 0.038 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.2813 | 0.038 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.2529 | 0.5437 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.2529 | 0.6107 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.2813 | 0.038 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1373 nM | Enhancement of [35S]GTPgammaS binding to human KOR expressed in CHO cells | ChEMBL. | 16777411 |
EC50 (functional) | = 1373 nM | Enhancement of [35S]GTPgammaS binding to human KOR expressed in CHO cells | ChEMBL. | 16777411 |
Efficacy (functional) | = 84 % | Enhancement of [35S]GTPgammaS binding to human KOR expressed in CHO cells relative to U50,488H | ChEMBL. | 16777411 |
Efficacy (functional) | = 84 % | Enhancement of [35S]GTPgammaS binding to human KOR expressed in CHO cells relative to U50,488H | ChEMBL. | 16777411 |
Ki (binding) | = 223 nM | Inhibition of [3H]diprenorphine binding to human KOR expressed in CHO cells | ChEMBL. | 16777411 |
Ki (binding) | = 223 nM | Inhibition of [3H]diprenorphine binding to human KOR expressed in CHO cells | ChEMBL. | 16777411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.