Detailed information for compound 370408

Basic information

Technical information
  • TDR Targets ID: 370408
  • Name: N-(2-fluoro-4-sulfamoylphenyl)-3-sulfanylprop anamide
  • MW: 278.324 | Formula: C9H11FN2O3S2
  • H donors: 2 H acceptors: 3 LogP: -0.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: SCCC(=O)Nc1ccc(cc1F)S(=O)(=O)N
  • InChi: 1S/C9H11FN2O3S2/c10-7-5-6(17(11,14)15)1-2-8(7)12-9(13)3-4-16/h1-2,5,16H,3-4H2,(H,12,13)(H2,11,14,15)
  • InChiKey: BSTAVPKWEITVDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-fluoro-4-sulfamoyl-phenyl)-3-sulfanyl-propanamide
  • N-(2-fluoro-4-sulfamoylphenyl)-3-mercaptopropanamide
  • N-(2-fluoro-4-sulfamoyl-phenyl)-3-mercapto-propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0339 0.133 0.1329
Echinococcus granulosus histone deacetylase 6 0.0737 0.2967 0.7376
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0423 0.3044
Schistosoma mansoni histone deacetylase 0.0784 0.3161 0.7858
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0066 0.0204 0.0204
Brugia malayi POT family protein 0.004 0.0099 0.0099
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0046 0.0123 0.0389
Echinococcus multilocularis allatostatin A receptor 0.0339 0.133 0.3917
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0347 0.0347
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Trypanosoma cruzi histone deacetylase, putative 0.0342 0.1339 0.4235
Echinococcus granulosus high voltage activated calcium channel beta 0.002 0.0013 0.0033
Trichomonas vaginalis histone deacetylase, putative 0.0784 0.3161 1
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0255 0.0983 0.311
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0339 0.133 0.3917
Toxoplasma gondii cathepsin B 0.0056 0.0162 0.0513
Toxoplasma gondii subtilisin SUB2 0.0046 0.0123 0.0389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0183 0.058
Schistosoma mansoni hypothetical protein 0.0031 0.0062 0.0153
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus multilocularis histone deacetylase 8 0.0342 0.1339 0.3944
Echinococcus granulosus multidrug resistance associated protein 7 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0025 0.0035 0.0104
Trypanosoma cruzi cruzipain precursor, putative 0.0019 0.001 0.0032
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0126 0.0909
Loa Loa (eye worm) histone deacetylase 0.0725 0.2917 0.2917
Echinococcus multilocularis Furin 1 0.0255 0.0983 0.2896
Brugia malayi GnHR receptor homolog 0.1257 0.5108 0.5108
Trypanosoma brucei histone deacetylase, putative 0.0725 0.2917 0.923
Loa Loa (eye worm) hypothetical protein 0.0054 0.0155 0.0155
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0347 0.0863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Onchocerca volvulus 0.0339 0.133 0.993
Trypanosoma brucei guanylate kinase, putative 0.002 0.0013 0.0042
Brugia malayi ORL1-like opioid receptor 0.0339 0.133 0.133
Schistosoma mansoni biogenic amine (5HT) receptor 0.0339 0.133 0.3306
Echinococcus granulosus serotonin receptor 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0784 0.3161 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0339 0.133 0.133
Trypanosoma cruzi cysteine peptidase, putative 0.0158 0.0581 0.1839
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0339 0.133 0.3917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0046 0.0123 0.0306
Leishmania major cathepsin L-like protease 0.0158 0.0581 0.1839
Echinococcus granulosus multidrug resistance associated protein 1 0.0016 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Toxoplasma gondii subtilisin SUB9 0.0046 0.0123 0.0389
Echinococcus multilocularis multidrug resistance associated protein 1 0.0016 0.0001 0.0002
Brugia malayi Hemopexin family protein 0.0033 0.0068 0.0068
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0074 0.0183
Leishmania major histone deacetylase, putative 0.0784 0.3161 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus multilocularis histone deacetylase 6 0.0737 0.2967 0.874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Schistosoma mansoni cell polarity protein 0.0023 0.0029 0.0071
Schistosoma mansoni opsin-like receptor 0.0339 0.133 0.3306
Brugia malayi Matrixin family protein 0.0054 0.0155 0.0155
Schistosoma mansoni dishevelled 0.01 0.0346 0.0861
Trypanosoma brucei RNA helicase, putative 0.01 0.0346 0.1094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0339 0.133 0.3306
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.0035 0.0104
Schistosoma mansoni furin-1 (S08 family) 0.0425 0.1684 0.4186
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0074 0.0183
Brugia malayi AKH receptor 0.0339 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0384 0.1512 0.1511
Trypanosoma cruzi histone deacetylase, putative 0.0725 0.2917 0.923
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Entamoeba histolytica cysteine proteinase 1, putative 0.0033 0.007 0.022
Entamoeba histolytica phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative 0.0059 0.0175 0.0553
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0059 0.0176 0.104
Brugia malayi Guanylate kinase family protein 0.002 0.0013 0.0013
Leishmania major cathepsin L-like protease 0.0061 0.0183 0.058
Brugia malayi abnormal cell lineage protein 2 0.002 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.007 0.0222
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Trypanosoma brucei carbonic anhydrase-like protein 0.0214 0.0815 0.2579
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0001 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0037 0.0117
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0051 0.0143 0.0355
Echinococcus multilocularis cysteine protease 0.0061 0.0183 0.054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0061 0.0183 0.054
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0339 0.133 0.3306
Schistosoma mansoni hypothetical protein 0.0033 0.0068 0.0169
Schistosoma mansoni intermediate filament proteins 0.0026 0.0041 0.0103
Onchocerca volvulus 0.0339 0.133 0.993
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0041
Trypanosoma cruzi guanylate kinase, putative 0.002 0.0013 0.0042
Schistosoma mansoni neuropeptide f receptor 76f 0.0339 0.133 0.3306
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0061 0.0183 0.0183
Leishmania major cathepsin L-like protease 0.0061 0.0183 0.058
Echinococcus granulosus guanylate kinase 0.002 0.0013 0.0033
Toxoplasma gondii subtilisin SUB1 0.0046 0.0123 0.0389
Echinococcus granulosus disks large 3 0.0025 0.0035 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0117 0.029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0117 0.029
Mycobacterium leprae PROBABLE HYDROLASE 0.0066 0.0204 0.464
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0339 0.133 0.993
Onchocerca volvulus 0.0339 0.133 0.993
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0209 0.0793 0.2509
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Brugia malayi putative neuropeptide receptor 0.0339 0.133 0.133
Brugia malayi SRC-1 0.0038 0.0089 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Onchocerca volvulus 0.0061 0.0183 0.1094
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0037 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.007 0.0174
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0035
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.0815 0.2026
Onchocerca volvulus 0.0339 0.133 0.993
Schistosoma mansoni site-1 peptidase (S08 family) 0.0046 0.0123 0.0306
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0339 0.133 0.3917
Schistosoma mansoni guanylate kinase 0.002 0.0013 0.0033
Loa Loa (eye worm) guanylate kinase 0.002 0.0013 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0339 0.0339
Echinococcus granulosus G protein coupled receptor 139 0.0339 0.133 0.3306
Echinococcus granulosus cysteine protease 0.0033 0.007 0.0174
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0374 0.269
Schistosoma mansoni ATP-dependent RNA Helicase 0.0025 0.0035 0.0088
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0046 0.0123 0.0884
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Onchocerca volvulus 0.0061 0.0183 0.1094
Schistosoma mansoni neuropeptide receptor 0.0339 0.133 0.3306
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0126 0.04
Toxoplasma gondii histone deacetylase HDAC3 0.0784 0.3161 1
Loa Loa (eye worm) glutathione reductase 0.0047 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.007 0.007
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0226 0.0562
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0841 0.3394 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.0339 0.133 0.3306
Brugia malayi multidrug resistance related protein 1 0.0016 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0038 0.0089 0.0221
Echinococcus multilocularis G-protein coupled receptor, putative 0.0339 0.133 0.3917
Toxoplasma gondii subtilisin SUB11 0.0046 0.0123 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0061 0.0183 0.058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0255 0.0983 0.311
Leishmania major histone deacetylase, putative 0.0725 0.2917 0.923
Trypanosoma brucei guanylate kinase, putative 0.002 0.0013 0.0042
Onchocerca volvulus 0.0029 0.0051 0.0072
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0061 0.0183 0.058
Loa Loa (eye worm) matrix metalloproteinase 0.0054 0.0155 0.0155
Brugia malayi Cathepsin L-like precursor 0.0042 0.0106 0.0106
Echinococcus multilocularis multidrug resistance associated protein 7 0.0016 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Brugia malayi Cathepsin L-like precursor 0.0061 0.0183 0.0183
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.2446 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0074 0.0217
Brugia malayi neuroendocrine convertase 1 precursor 0.0634 0.2544 0.2544
Plasmodium falciparum carbonic anhydrase 0.0101 0.0347 0.1099
Echinococcus granulosus g-protein coupled receptor 0.0339 0.133 0.3306
Leishmania major cathepsin L-like protease 0.0158 0.0581 0.1839
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.0815 0.2579
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0339 0.133 0.3306
Giardia lamblia MRP-like ABC transporter 0.0016 0.0001 0.0002
Echinococcus granulosus carbonic anhydrase II 0.0214 0.0815 0.2026
Brugia malayi ABC transporter transmembrane region family protein 0.0016 0.0001 0.0001
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0339 0.133 0.3306
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0117 0.0117
Echinococcus granulosus high voltage activated calcium channel beta 0.002 0.0013 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.007 0.022
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0001 0.0001
Schistosoma mansoni maguk P55 subfamily member 26 0.0025 0.0035 0.0088
Onchocerca volvulus 0.0339 0.133 0.993
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Onchocerca volvulus 0.0061 0.0183 0.1094
Loa Loa (eye worm) hypothetical protein 0.01 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0784 0.3161 0.316
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.2462 0.7788
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.0183 0.0183
Echinococcus multilocularis musashi 0.0026 0.0041 0.0122
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0339 0.133 0.3306
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.0391 0.1237
Leishmania major hypothetical protein, conserved 0.0025 0.0037 0.0117
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0046 0.0123 0.2672
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0001 0.0004
Giardia lamblia High cysteine membrane protein Group 2 0.0359 0.1412 0.4466
Schistosoma mansoni histone deacetylase 0.0784 0.3161 0.7858
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0041 0.0041
Echinococcus granulosus tm gpcr rhodopsin 0.0841 0.3394 0.8439
Echinococcus granulosus neuropeptide receptor 0.0491 0.1953 0.4855
Schistosoma mansoni histone deacetylase hda2 0.0342 0.1339 0.3328
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0784 0.3161 1
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Giardia lamblia Furin precursor putative serine protease 0.0209 0.0793 0.2509
Loa Loa (eye worm) G-protein coupled receptor 0.0339 0.133 0.1329
Brugia malayi Melatonin receptor type 1A 0.0339 0.133 0.133
Plasmodium falciparum subtilisin-like protease 3 0.0046 0.0123 0.0389
Loa Loa (eye worm) ctsf protein 0.0061 0.0183 0.0183
Loa Loa (eye worm) histone deacetylase 1 0.0784 0.3161 0.316
Echinococcus multilocularis dro:myosuppressin receptor 0.0339 0.133 0.3917
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0339 0.133 0.3306
Echinococcus multilocularis rhodopsin orphan GPCR 0.0339 0.133 0.3917
Echinococcus multilocularis serotonin receptor 0.0339 0.133 0.3917
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0339 0.0339
Echinococcus granulosus tachykinin peptides receptor 99D 0.0339 0.133 0.3306
Trypanosoma cruzi cysteine protease, putative 0.0033 0.007 0.0222
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus granulosus sex peptide receptor 0.0339 0.133 0.3306
Leishmania major cathepsin L-like protease 0.0061 0.0183 0.058
Echinococcus granulosus disks large 1 0.002 0.0013 0.0033
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0339 0.133 0.3306
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0339 0.133 0.3917
Echinococcus granulosus intermediate filament protein 0.0026 0.0041 0.0103
Loa Loa (eye worm) DIX domain-containing protein 0.0023 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0255 0.0983 0.311
Toxoplasma gondii hypothetical protein 0.0101 0.0347 0.1099
Brugia malayi neuropeptide F receptor 0.0339 0.133 0.133
Echinococcus granulosus biogenic amine 5HT receptor 0.0339 0.133 0.3306
Leishmania major histone deacetylase, putative 0.0725 0.2917 0.923
Trypanosoma cruzi multidrug resistance protein E, putative 0.0016 0.0001 0.0002
Schistosoma mansoni tyrosine kinase 0.0038 0.0089 0.0221
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0339 0.133 0.3917
Echinococcus granulosus tyrosine kinase 0.0034 0.0074 0.0183
Echinococcus granulosus g protein coupled receptor 0.0339 0.133 0.3306
Toxoplasma gondii subtilisin SUB10 0.0046 0.0123 0.0389
Plasmodium vivax histone deacetylase 1, putative 0.0784 0.3161 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Echinococcus granulosus histone deacetylase 6 0.0725 0.2917 0.7253
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0339 0.133 0.3917
Echinococcus multilocularis fmrfamide receptor 0.0339 0.133 0.3917
Leishmania major trypanothione reductase 0.0047 0.0126 0.04
Brugia malayi guanylate kinase 0.002 0.0013 0.0013
Giardia lamblia Multidrug resistance-associated protein 1 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0117 0.029
Echinococcus granulosus neuropeptides capa receptor 0.0339 0.133 0.3306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0183 0.058
Schistosoma mansoni amine GPCR 0.0339 0.133 0.3306
Echinococcus multilocularis neuropeptide Y receptor 0.0339 0.133 0.3917
Echinococcus granulosus tm gpcr rhodopsin 0.0339 0.133 0.3306
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0016 0.0001 0.0002
Echinococcus multilocularis cathepsin L cysteine protease 0.0061 0.0183 0.054
Loa Loa (eye worm) histone deacetylase 11 0.0342 0.1339 0.1338
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0339 0.133 0.3917
Brugia malayi PDZ domain containing protein 0.0052 0.0148 0.0148
Brugia malayi cathepsin L-like precursor 0.0042 0.0106 0.0106
Echinococcus granulosus g protein coupled receptor 0.0339 0.133 0.3306
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0614 0.2462 0.7252
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Brugia malayi Serotonin receptor 0.0339 0.133 0.133
Loa Loa (eye worm) TYRA-2 protein 0.0339 0.133 0.1329
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0016 0.0001 0.0002
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0046 0.0123 0.0306
Schistosoma mansoni multidrug resistance protein 0.0016 0.0001 0.0001
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.007 0.022
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0089 0.0221
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0051 0.0143 0.0421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Echinococcus multilocularis GPCR, family 2 0.0031 0.0062 0.0181
Brugia malayi hypothetical protein 0.0552 0.2205 0.2205
Trypanosoma cruzi histone deacetylase 1, putative 0.0784 0.3161 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0037 0.0117
Echinococcus granulosus neuroendocrine convertase 2 0.0634 0.2544 0.6324
Onchocerca volvulus Neuropeptide F receptor homolog 0.0339 0.133 0.993
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Entamoeba histolytica protein kinase, putative 0.003 0.0058 0.0182
Echinococcus multilocularis neuroendocrine convertase 2 0.0634 0.2544 0.7494
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0089 0.0221
Trypanosoma brucei histone deacetylase 1 0.0784 0.3161 1
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Onchocerca volvulus 0.0339 0.133 0.993
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0046 0.0123 0.0884
Schistosoma mansoni opsin-like receptor 0.0339 0.133 0.3306
Echinococcus multilocularis G protein coupled receptor 139 0.0491 0.1953 0.5753
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0339 0.133 0.3306
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0147 0.054 0.1342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0339 0.133 0.3306
Mycobacterium tuberculosis Probable guanylate kinase Gmk 0.002 0.0013 0.0096
Brugia malayi G-protein coupled receptor 0.0339 0.133 0.133
Loa Loa (eye worm) TK protein kinase 0.0034 0.0074 0.0073
Echinococcus multilocularis neuropeptide receptor 0.0339 0.133 0.3917
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0255 0.0983 0.311
Schistosoma mansoni neuropeptide receptor 0.0339 0.133 0.3306
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0339 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0042 0.0106 0.0106
Leishmania major histone deacetylase, putative 0.0784 0.3161 1
Loa Loa (eye worm) hypothetical protein 0.0552 0.2205 0.2205
Onchocerca volvulus 0.0042 0.0106 0.0499
Loa Loa (eye worm) TK protein kinase 0.003 0.0058 0.0057
Plasmodium falciparum histone deacetylase 2 0.0725 0.2917 0.923
Brugia malayi Serotonin receptor 0.0339 0.133 0.133
Echinococcus multilocularis histone deacetylase 6 0.0725 0.2917 0.8594
Onchocerca volvulus Matrilysin homolog 0.012 0.0426 0.2964
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Echinococcus granulosus peptide allatostatin:somatostatin 0.0339 0.133 0.3306
Onchocerca volvulus Cathepsin F homolog 0.0061 0.0183 0.1094
Loa Loa (eye worm) hypothetical protein 0.0025 0.0037 0.0037
Schistosoma mansoni maguk P55 subfamily member 26 0.002 0.0013 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0183 0.058
Mycobacterium ulcerans hydrolase 0.0066 0.0204 0.1464
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0209 0.0793 0.2509
Echinococcus granulosus rhodopsin orphan GPCR 0.0339 0.133 0.3306
Plasmodium vivax vivapain-3 0.0033 0.007 0.0222
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0255 0.0983 0.311
Leishmania major cathepsin L-like protease 0.0158 0.0581 0.1839
Mycobacterium leprae Possible secreted protease 0.0046 0.0123 0.2672
Brugia malayi Dopamine receptor protein 2 0.0339 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0068 0.0211 0.021
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0016 0.0001 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0062 0.0181
Echinococcus granulosus biogenic amine 5HT receptor 0.0339 0.133 0.3306
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0347 0.1023
Loa Loa (eye worm) hypothetical protein 0.0066 0.0204 0.0203
Schistosoma mansoni multidrug resistance protein 0.0016 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Brugia malayi cathepsin B-like cysteine proteinase 0.0147 0.054 0.054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.2462 0.7788
Loa Loa (eye worm) endoprotease bli-4 0.0994 0.4022 0.4022
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0339 0.133 0.133
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0025 0.0035 0.0088
Loa Loa (eye worm) carbonic anhydrase 3 0.0214 0.0815 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0139 0.0504 0.1595
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) 0.0205 0.0775 0.5569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0106 0.0336
Echinococcus multilocularis membrane bound transcription factor site 1 0.0046 0.0123 0.0362
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0339 0.133 0.3917
Echinococcus granulosus GPCR family 2 0.0031 0.0062 0.0153
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0025 0.0035 0.0104
Schistosoma mansoni neuropeptide F-like receptor 0.0339 0.133 0.3306
Trypanosoma brucei trypanothione reductase 0.0047 0.0126 0.04
Trichomonas vaginalis histone deacetylase, putative 0.0784 0.3161 1
Brugia malayi hypothetical protein 0.0071 0.0226 0.0226
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.007 0.022
Plasmodium vivax vivapain-2 0.0061 0.0183 0.058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0117 0.0344
Brugia malayi DIX domain containing protein 0.0023 0.0027 0.0027
Plasmodium falciparum subtilisin-like protease 1 0.0046 0.0123 0.0389
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0089 0.0221
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0016 0.0001 0.0002
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Echinococcus granulosus lamin 0.0026 0.0041 0.0103
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0061 0.0183 0.054
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0423 1
Toxoplasma gondii histone deacetylase HDAC1 0.0725 0.2917 0.923
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.002 0.0013 0.0033
Echinococcus granulosus histone deacetylase 3 0.0784 0.3161 0.7858
Onchocerca volvulus 0.0339 0.133 0.993
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0046 0.0123 0.0884
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0183 0.0578
Echinococcus granulosus rhodopsin orphan GPCR 0.0339 0.133 0.3306
Brugia malayi histone deacetylase 1 (HD1) 0.0784 0.3161 0.3161
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Brugia malayi neuropeptide F receptor 0.0339 0.133 0.133
Loa Loa (eye worm) matrixin family protein 0.0087 0.029 0.029
Echinococcus multilocularis histone deacetylase 7 0.0725 0.2917 0.8594
Toxoplasma gondii histone deacetylase HDAC5 0.0342 0.1339 0.4235
Echinococcus multilocularis sex peptide receptor 0.0339 0.133 0.3917
Leishmania major cysteine peptidase A (CPA) 0.0061 0.0183 0.058
Echinococcus multilocularis cathepsin b 0.0147 0.054 0.159
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus granulosus lamin dm0 0.0026 0.0041 0.0103
Brugia malayi Cathepsin L-like precursor 0.0061 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0074 0.0217
Trypanosoma cruzi guanylate kinase, putative 0.002 0.0013 0.0042
Mycobacterium ulcerans guanylate kinase 0.002 0.0013 0.0096
Trypanosoma brucei cysteine peptidase C (CPC) 0.0056 0.0162 0.0513
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Brugia malayi hypothetical protein 0.0339 0.133 0.133
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.0183 0.0183
Brugia malayi endoprotease bli-4 precursor 0.0994 0.4022 0.4022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.007 0.0222
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0039
Echinococcus granulosus furin 0.0994 0.4022 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0339 0.133 0.3306
Loa Loa (eye worm) matrixin family protein 0.012 0.0426 0.0425
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0347 0.0347
Leishmania major ABC-thiol transporter 0.0016 0.0001 0.0002
Treponema pallidum NADH oxidase 0.0016 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0123 0.0389
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus multilocularis histone deacetylase 6 0.0725 0.2917 0.8594
Brugia malayi hypothetical protein 0.0339 0.133 0.133
Brugia malayi hypothetical protein 0.0339 0.133 0.133
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0255 0.0983 0.311
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0089 0.0261
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0153 0.0561 0.1653
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0056 0.0162 0.0513
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0051 0.0143 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0123 0.0389
Trichomonas vaginalis histone deacetylase, putative 0.0784 0.3161 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.054 0.0539
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Loa Loa (eye worm) hypothetical protein 0.0099 0.0339 0.0339
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0046 0.0045
Loa Loa (eye worm) guanylate kinase 0.0025 0.0035 0.0035
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0046 0.0123 0.0389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0051 0.0143 0.0355
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0089 0.0261
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0101 0.0347 0.0347
Plasmodium vivax subtilisin-like protease 1 0.0046 0.0123 0.0389
Onchocerca volvulus 0.0061 0.0183 0.1094
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0147 0.054 0.1708
Brugia malayi G-protein coupled receptor 0.0339 0.133 0.133
Leishmania major guanylate kinase, putative 0.002 0.0013 0.0042
Plasmodium falciparum histone deacetylase 1 0.0784 0.3161 1
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.0183 0.0578
Brugia malayi Cathepsin L-like cysteine proteinase 0.0042 0.0106 0.0106
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0089 0.0221
Brugia malayi Histone deacetylase family protein 0.0725 0.2917 0.2917
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0089 0.0261
Leishmania major carbonic anhydrase-like protein 0.0214 0.0815 0.2579
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0347 0.0863
Trypanosoma cruzi cruzipain precursor, putative 0.0158 0.0581 0.1839
Schistosoma mansoni neuropeptide receptor 0.0491 0.1953 0.4855
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0339 0.133 0.3306
Echinococcus granulosus somatostatin receptor 0.0339 0.133 0.3306
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0214 0.0815 0.0815
Brugia malayi Cytochrome P450 family protein 0.0017 0.0001 0.0001
Echinococcus multilocularis segment polarity protein dishevelled 0.01 0.0346 0.102
Schistosoma mansoni biogenic amine receptor 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0056 0.0162 0.0513
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Schistosoma mansoni amine GPCR 0.0339 0.133 0.3306
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0062 0.0153
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0089 0.0261
Brugia malayi Matrixin family protein 0.0087 0.029 0.029
Echinococcus granulosus alpha 1A adrenergic receptor 0.0339 0.133 0.3306
Schistosoma mansoni hypothetical protein 0.0068 0.0211 0.0524
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.0035 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0123 0.0389
Loa Loa (eye worm) histone deacetylase 3 0.0784 0.3161 0.316
Toxoplasma gondii subtilisin SUB8 0.0046 0.0123 0.0389
Toxoplasma gondii subtilisin SUB7 0.0046 0.0123 0.0389
Onchocerca volvulus 0.0033 0.0068 0.0206
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0051 0.0143 0.0142
Loa Loa (eye worm) hypothetical protein 0.0054 0.0155 0.0155
Echinococcus granulosus neuropeptide Y receptor 0.0339 0.133 0.3306
Echinococcus multilocularis cathepsin L cysteine protease 0.0061 0.0183 0.054
Brugia malayi Peripheral plasma membrane protein CASK 0.0029 0.0051 0.0051
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0071 0.0223 0.0555
Echinococcus granulosus chromobox protein 2 0.0197 0.0746 0.1854
Echinococcus granulosus histone deacetylase 7 0.0725 0.2917 0.7253
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0062 0.0062
Plasmodium vivax subtilisin-like serine protease, putative 0.0046 0.0123 0.0389
Echinococcus multilocularis high voltage activated calcium channel beta 0.002 0.0013 0.0039
Echinococcus multilocularis histone deacetylase 3 0.0784 0.3161 0.9311
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0051 0.0143 0.0421
Onchocerca volvulus 0.0339 0.133 0.993
Onchocerca volvulus 0.0339 0.133 0.993
Trypanosoma brucei histone deacetylase 2 0.0342 0.1339 0.4235
Toxoplasma gondii subtilisin SUB4 0.0046 0.0123 0.0389
Echinococcus granulosus segment polarity protein dishevelled 0.01 0.0346 0.0861
Schistosoma mansoni MAGUK homolog 0.0025 0.0035 0.0088
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.007 0.022
Brugia malayi hypothetical protein 0.0339 0.133 0.133
Brugia malayi Matrixin family protein 0.0054 0.0155 0.0155
Brugia malayi putative neuropeptide receptor NPR1 0.0339 0.133 0.133
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0089 0.0261
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0214 0.0815 0.0815
Schistosoma mansoni hypothetical protein 0.0339 0.133 0.3306
Trypanosoma brucei subtilisin peptidase 0.0046 0.0123 0.0389
Trypanosoma cruzi histone deacetylase, putative 0.0725 0.2917 0.923
Brugia malayi Histone deacetylase family protein 0.0725 0.2917 0.2917
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0339 0.133 0.1329
Entamoeba histolytica guanylate kinase, putative 0.002 0.0013 0.0041
Plasmodium vivax subtilisin-like protease 2, putative 0.0046 0.0123 0.0389
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0054 0.0155 0.0386
Plasmodium falciparum subtilisin-like protease 2 0.0046 0.0123 0.0389
Schistosoma mansoni site-1 peptidase (S08 family) 0.0046 0.0123 0.0306
Echinococcus multilocularis segment polarity protein dishevelled 0.01 0.0346 0.102
Brugia malayi Cathepsin L-like precursor 0.0061 0.0183 0.0183
Schistosoma mansoni multidrug resistance protein 0.0016 0.0001 0.0001
Echinococcus granulosus allatostatin A receptor 0.0339 0.133 0.3306
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0062 0.0181
Plasmodium vivax histone deacetylase, putative 0.0725 0.2917 0.923
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0147 0.054 0.1342
Leishmania major cathepsin L-like protease 0.0061 0.0183 0.058
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0016 0.0001 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Loa Loa (eye worm) hypothetical protein 0.0054 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Echinococcus multilocularis lamin dm0 0.0026 0.0041 0.0122
Brugia malayi Subtilase family protein 0.0046 0.0123 0.0123
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0046 0.0123 0.0306
Leishmania major pentamidine resistance protein 1 0.0016 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0339 0.133 0.3306
Echinococcus granulosus rhodopsin orphan GPCR 0.0339 0.133 0.3306
Trypanosoma brucei histone deacetylase 4 0.0725 0.2917 0.923
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Entamoeba histolytica hypothetical protein 0.0071 0.0226 0.0713
Echinococcus multilocularis neuropeptides capa receptor 0.0339 0.133 0.3917
Echinococcus granulosus 7TM GPCR rhodopsin 0.0339 0.133 0.3306
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0339 0.133 0.3917
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0046 0.0123 0.0389
Onchocerca volvulus Matrilysin homolog 0.0054 0.0155 0.0878
Onchocerca volvulus 0.0054 0.0155 0.0878
Echinococcus multilocularis cysteine protease 0.0061 0.0183 0.054
Echinococcus multilocularis lamin 0.0026 0.0041 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Echinococcus granulosus neuropeptide FF receptor 2 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0379 0.1494 0.1493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0089 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Schistosoma mansoni multidrug resistance protein 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0046 0.0123 0.0629
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0994 0.4022 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0339 0.133 0.1329
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Plasmodium vivax vivapain-2 0.0061 0.0183 0.058
Echinococcus granulosus cathepsin L cysteine protease 0.0033 0.007 0.0174
Echinococcus multilocularis 0.0785 0.3162 0.9316
Brugia malayi larval opioid receptor 0.0339 0.133 0.133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Plasmodium falciparum histone deacetylase, putative 0.0725 0.2917 0.923
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0056 0.0162 0.0403
Entamoeba histolytica hypothetical protein 0.0071 0.0226 0.0713
Brugia malayi Cathepsin L-like precursor 0.0042 0.0106 0.0106
Schistosoma mansoni amine GPCR 0.0339 0.133 0.3306
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0339 0.0339
Echinococcus granulosus cathepsin l1 0.0042 0.0106 0.0264
Schistosoma mansoni carbonic anhydrase 0.0101 0.0347 0.0863
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.007 0.0222
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0339 0.133 0.133
Schistosoma mansoni hypothetical protein 0.0165 0.0614 0.1526
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0347 0.0347
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0374 0.269
Schistosoma mansoni myosin xvIII 0.0339 0.133 0.3306
Brugia malayi histone deacetylase 11 0.0342 0.1339 0.1339
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Echinococcus granulosus carbonic anhydrase 0.0101 0.0347 0.0863
Trichomonas vaginalis hypothetical protein 0.0209 0.0793 0.2509
Brugia malayi hypothetical protein 0.0025 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0165 0.0614 0.1526
Schistosoma mansoni cell polarity protein 0.0025 0.0035 0.0088
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0056 0.0162 0.0513
Loa Loa (eye worm) hypothetical protein 0.0396 0.1561 0.1561
Brugia malayi Tachykinin-like peptides receptor 99D 0.0339 0.133 0.133
Echinococcus granulosus hypothetical protein 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Brugia malayi protein-tyrosine kinase 0.0034 0.0074 0.0074
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0347 0.0347
Echinococcus granulosus cathepsin l1 0.0061 0.0183 0.0455
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0071 0.0223 0.0555
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0347 0.1023
Giardia lamblia Multidrug resistance-associated protein 1 0.0016 0.0001 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Mycobacterium ulcerans epoxide hydrolase EphA 0.0354 0.1391 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0153 0.0561 0.1395
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0061 0.0183 0.058
Giardia lamblia ABC transporter, putative 0.0016 0.0001 0.0002
Trypanosoma cruzi histone deacetylase, putative 0.0725 0.2917 0.923
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0106 0.0106
Onchocerca volvulus 0.0339 0.133 0.993
Brugia malayi Matrixin family protein 0.0054 0.0155 0.0155
Entamoeba histolytica histone deacetylase, putative 0.0784 0.3161 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0994 0.4022 0.4022
Echinococcus granulosus neuropeptide receptor A26 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Onchocerca volvulus 0.0339 0.133 0.993
Schistosoma mansoni cathepsin s 0.0019 0.001 0.0025
Schistosoma mansoni histone deacetylase 4 5 0.0725 0.2917 0.7253
Giardia lamblia Histone deacetylase 0.0784 0.3161 1
Onchocerca volvulus 0.0339 0.133 0.993
Plasmodium vivax glutathione reductase, putative 0.0047 0.0126 0.04
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0339 0.133 0.3306
Brugia malayi Thioredoxin reductase 0.0047 0.0126 0.0126
Brugia malayi hypothetical protein 0.0339 0.133 0.133
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0062 0.0153
Echinococcus multilocularis cathepsin L 0.0033 0.007 0.0206
Plasmodium vivax histone deacetylase, putative 0.0342 0.1339 0.4235
Onchocerca volvulus 0.0339 0.133 0.993
Schistosoma mansoni MAGUK homolog 0.0025 0.0035 0.0088
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0037 0.0117
Trypanosoma cruzi tyrosine phosphatase, putative 0.0059 0.0175 0.0554
Schistosoma mansoni hypothetical protein 0.0071 0.0226 0.0562
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus granulosus segment polarity protein dishevelled 0.01 0.0346 0.0861
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0339 0.133 0.3306
Echinococcus multilocularis orexin receptor type 2 0.0339 0.133 0.3917
Trypanosoma brucei multidrug resistance protein E 0.0016 0.0001 0.0002
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.002 0.0013 0.0013
Echinococcus multilocularis high voltage activated calcium channel beta 0.002 0.0013 0.0039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0226 0.0562
Echinococcus granulosus histone deacetylase 1 0.0784 0.3161 0.7858
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.007 0.0174
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0117 0.0344
Brugia malayi Dopamine receptor protein 1 0.0339 0.133 0.133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0183 0.058
Echinococcus multilocularis neuropeptide receptor 0.0491 0.1953 0.5753
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Onchocerca volvulus Matrix metalloproteinase homolog 0.012 0.0426 0.2964
Loa Loa (eye worm) hypothetical protein 0.0046 0.0123 0.0122
Echinococcus multilocularis g protein coupled receptor 0.0339 0.133 0.3917
Schistosoma mansoni hypothetical protein 0.0031 0.0062 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0117 0.029
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0147
Schistosoma mansoni maguk P55 subfamily member 35 0.0025 0.0035 0.0088
Schistosoma mansoni chromobox protein 0.0197 0.0746 0.1854
Echinococcus granulosus neuropeptides capa receptor 0.0339 0.133 0.3306
Onchocerca volvulus Cathepsin L homolog 0.0061 0.0183 0.1094
Toxoplasma gondii cathepsin CPL 0.0061 0.0183 0.058
Echinococcus granulosus guanylate kinase 0.002 0.0013 0.0033
Plasmodium vivax histone deacetylase 2, putative 0.0725 0.2917 0.923
Echinococcus granulosus neuropeptide receptor 0.0339 0.133 0.3306
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0339 0.133 0.3306
Onchocerca volvulus 0.0061 0.0183 0.1094
Schistosoma mansoni mannosidase endo-alpha 0.002 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.0035 0.0088
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0339 0.133 0.3306
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Loa Loa (eye worm) melatonin receptor type 1A 0.0339 0.133 0.1329
Echinococcus multilocularis g protein coupled receptor 0.0339 0.133 0.3917
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.01 0.0346 0.0346
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Leishmania major subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Schistosoma mansoni growth hormone secretagogue receptor 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Leishmania major hypothetical protein, unknown function 0.0059 0.0175 0.0554
Schistosoma mansoni alpha-1 adrenergic receptor 0.0339 0.133 0.3306
Loa Loa (eye worm) SRC-1 0.0038 0.0089 0.0088
Loa Loa (eye worm) hypothetical protein 0.0342 0.1339 0.1338
Entamoeba histolytica hypothetical protein 0.0071 0.0226 0.0713
Loa Loa (eye worm) neuropeptide F receptor 0.0339 0.133 0.1329
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Loa Loa (eye worm) subtilase 0.0046 0.0123 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0209 0.0793 0.2509
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0046 0.0123 0.2672
Schistosoma mansoni tyrosine kinase 0.0134 0.0486 0.1209
Echinococcus multilocularis 0.0071 0.0223 0.0658
Schistosoma mansoni amine GPCR 0.0339 0.133 0.3306
Echinococcus granulosus fmrfamide receptor 0.0339 0.133 0.3306
Echinococcus granulosus histone deacetylase 8 0.0342 0.1339 0.3328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0183 0.058
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0074 0.0217
Toxoplasma gondii subtilisin SUB6 0.0046 0.0123 0.0389
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.007 0.0222
Trichomonas vaginalis histone deacetylase, putative 0.0784 0.3161 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0226 0.0666
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.007 0.0222
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0374 0.269
Echinococcus multilocularis carbonic anhydrase II 0.0214 0.0815 0.2401
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.0815 0.2579
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0339 0.133 0.3306
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0339 0.133 0.3306
Schistosoma mansoni cathepsin F (C01 family) 0.0061 0.0183 0.0455
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0001 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Schistosoma mansoni lamin 0.0026 0.0041 0.0103
Trichomonas vaginalis sap-102, putative 0.002 0.0013 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0117 0.029
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0089 0.0261
Loa Loa (eye worm) POT family protein 0.004 0.0099 0.0099
Onchocerca volvulus 0.0061 0.0183 0.1094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Schistosoma mansoni hypothetical protein 0.01 0.0346 0.086
Loa Loa (eye worm) hypothetical protein 0.0101 0.0347 0.0347
Echinococcus multilocularis somatostatin receptor 0.0339 0.133 0.3917
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0037 0.0117
Schistosoma mansoni hypothetical protein 0.0101 0.0347 0.0863
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.0035 0.0088
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.002 0.0013 0.0013
Onchocerca volvulus 0.0061 0.0183 0.1094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0183 0.058
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.0035 0.0088
Echinococcus granulosus rhodopsin orphan GPCR 0.0339 0.133 0.3306
Echinococcus multilocularis neuropeptides capa receptor 0.0339 0.133 0.3917
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0046 0.0123 0.0884
Giardia lamblia Cathepsin B precursor 0.0056 0.0162 0.0513
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus multilocularis neuropeptide s receptor 0.0339 0.133 0.3917
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0354 0.1391 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0106 0.0106
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0347 0.0863
Loa Loa (eye worm) proprotein convertase 2 0.0255 0.0983 0.0982
Brugia malayi Histone deacetylase 1 0.0784 0.3161 0.3161
Plasmodium vivax unspecified product 0.0033 0.007 0.0222
Echinococcus granulosus neuropeptide s receptor 0.0339 0.133 0.3306
Echinococcus granulosus cathepsin b 0.0147 0.054 0.1342
Echinococcus granulosus g protein coupled receptor 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0101 0.0347 0.0347
Schistosoma mansoni opsin-like receptor 0.0339 0.133 0.3306
Echinococcus granulosus histone deacetylase 0.0725 0.2917 0.7253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0339 0.133 0.3917
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.0815 0.2026
Trichomonas vaginalis discs large, putative 0.002 0.0013 0.0042
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.002 0.0013 0.0013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0061 0.0183 0.058
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0046 0.0123 0.0389
Loa Loa (eye worm) hypothetical protein 0.0031 0.0062 0.0061
Trichomonas vaginalis calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative 0.002 0.0013 0.0042
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0339 0.133 0.3917
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0089 0.0221
Entamoeba histolytica hypothetical protein 0.0071 0.0226 0.0713
Onchocerca volvulus 0.0028 0.0048 0.0053
Echinococcus granulosus cathepsin L 0.0033 0.007 0.0174
Schistosoma mansoni neuropeptide F-like receptor 0.0339 0.133 0.3306
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0089 0.0221
Brugia malayi hypothetical protein 0.0339 0.133 0.133
Echinococcus granulosus rhodopsin orphan GPCR 0.0339 0.133 0.3306
Echinococcus multilocularis g protein coupled receptor 0.0339 0.133 0.3917
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0147 0.054 0.1342
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Mycobacterium tuberculosis Probable reductase 0.0107 0.0374 0.269
Echinococcus multilocularis serotonin receptor 0.0339 0.133 0.3917
Loa Loa (eye worm) TK/EGFR protein kinase 0.0134 0.0486 0.0486
Loa Loa (eye worm) G-protein coupled receptor 0.0339 0.133 0.1329
Echinococcus granulosus cathepsin b 0.0147 0.054 0.1342
Loa Loa (eye worm) fibroinase 0.0061 0.0183 0.0183
Leishmania major phosphoinositide phosphatase 0.0205 0.0775 0.2452
Echinococcus granulosus carbonic anhydrase 0.0101 0.0347 0.0863
Echinococcus multilocularis fmrfamide receptor 0.0339 0.133 0.3917
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.007 0.007
Schistosoma mansoni amine GPCR 0.0339 0.133 0.3306
Echinococcus granulosus cathepsin l cysteine peptidase 0.0061 0.0183 0.0455
Brugia malayi histone deacetylase 3 (HD3) 0.0784 0.3161 0.3161
Toxoplasma gondii histone deacetylase HDAC4 0.0342 0.1339 0.4235
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0339 0.133 0.3306
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0016 0.0001 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0339 0.133 0.3306
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0046 0.0123 0.0884
Brugia malayi proprotein convertase 2 0.0634 0.2544 0.2544
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0046 0.0123 0.0884
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0126 0.0314
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0089 0.0261
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0016 0.0001 0.0002
Onchocerca volvulus 0.0339 0.133 0.993
Loa Loa (eye worm) hypothetical protein 0.0101 0.0347 0.0347
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0784 0.3161 1
Loa Loa (eye worm) histone deacetylase 7A 0.0725 0.2917 0.2917
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.0775 0.2452
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0339 0.133 0.3917
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0037 0.0117
Entamoeba histolytica cysteine protease, putative 0.0061 0.0183 0.0578
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0347 0.1023
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Schistosoma mansoni histone deacetylase 4 5 0.0725 0.2917 0.7253
Trypanosoma cruzi subtilisin peptidase 0.0046 0.0123 0.0389
Schistosoma mansoni hypothetical protein 0.0209 0.0793 0.1971
Echinococcus multilocularis chromobox protein 2 0.0197 0.0746 0.2197
Echinococcus granulosus carbonic anhydrase 0.0101 0.0347 0.0863
Brugia malayi sulfakinin receptor protein 0.0552 0.2205 0.2205
Echinococcus multilocularis neuropeptide receptor A26 0.0339 0.133 0.3917
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.001 0.0032
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0062 0.0061
Echinococcus multilocularis g-protein coupled receptor 0.0339 0.133 0.3917
Echinococcus multilocularis neuropeptide Y receptor 0.0339 0.133 0.3917
Echinococcus multilocularis rhodopsin orphan GPCR 0.0339 0.133 0.3917
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0025 0.0035 0.0088
Brugia malayi Guanylate kinase family protein 0.0025 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0051 0.0143 0.0355
Schistosoma mansoni histone deacetylase 1 2 3 0.0342 0.1339 0.3328
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.007 0.0222
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0069 0.0172
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0126 0.0372
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0117 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Brugia malayi hypothetical protein 0.0339 0.133 0.133
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0046 0.0123 0.0884
Brugia malayi glutathione reductase 0.0047 0.0126 0.0126
Echinococcus granulosus Furin 1 0.0255 0.0983 0.2444
Brugia malayi Matrixin family protein 0.0054 0.0155 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0339 0.133 0.3917
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0183 0.058
Echinococcus granulosus tm gpcr rhodopsin 0.0339 0.133 0.3306
Echinococcus multilocularis epidermal growth factor receptor 0.0134 0.0486 0.1432
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0339 0.133 0.3306
Brugia malayi Cathepsin L-like precursor 0.0061 0.0183 0.0183
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Trypanosoma cruzi histone deacetylase 1, putative 0.0784 0.3161 1
Brugia malayi ZU5 domain containing protein 0.002 0.0013 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0037 0.0117
Onchocerca volvulus Histone deacetylase 10 homolog 0.0342 0.1339 1
Schistosoma mansoni neuropeptide receptor 0.0339 0.133 0.3306
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0058 0.0171
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0016 0.0001 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0158 0.0581 0.1839
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.0106 0.0264
Brugia malayi hypothetical protein 0.0339 0.133 0.133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0339 0.133 0.3306
Schistosoma mansoni cathepsin F (C01 family) 0.0061 0.0183 0.0455
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0339 0.133 0.3917
Echinococcus granulosus cathepsin L cysteine proteinase 0.0061 0.0183 0.0455
Echinococcus multilocularis rhodopsin orphan GPCR 0.0339 0.133 0.3917
Echinococcus granulosus geminin 0.0165 0.0614 0.1526
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0339 0.133 0.3306
Echinococcus granulosus 7tm_1 domain containing protein 0.0339 0.133 0.3306
Brugia malayi hypothetical protein 0.0339 0.133 0.133
Loa Loa (eye worm) cysteine protease 0.0061 0.0183 0.0183
Toxoplasma gondii histone deacetylase HDAC2 0.0784 0.3161 1
Brugia malayi hypothetical protein 0.002 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0158 0.0581 0.1839
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0347 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0123 0.0389
Schistosoma mansoni adenoreceptor 0.0339 0.133 0.3306
Toxoplasma gondii subtilisin SUB12 0.0046 0.0123 0.0389
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.0106 0.0334
Schistosoma mansoni biogenic amine (5HT) receptor 0.0339 0.133 0.3306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0183 0.058
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Plasmodium falciparum glutathione reductase 0.0047 0.0126 0.04
Giardia lamblia Guanylate kinase 0.002 0.0013 0.0042
Brugia malayi G protein-coupled receptor F59B2.13 0.0339 0.133 0.133
Chlamydia trachomatis guanylate kinase 0.002 0.0013 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0581 0.1839
Schistosoma mansoni biogenic amine receptor 0.0339 0.133 0.3306
Echinococcus multilocularis guanylate kinase 0.002 0.0013 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0339 0.133 0.3917
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0066 0.0204 0.1464
Brugia malayi Guanylate kinase family protein 0.0029 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0061 0.0183 0.0183
Brugia malayi Cathepsin L-like precursor 0.0019 0.001 0.001
Trypanosoma cruzi histone deacetylase, putative 0.0342 0.1339 0.4235
Giardia lamblia Cathepsin B precursor 0.0056 0.0162 0.0513
Schistosoma mansoni biogenic amine receptor 0.0339 0.133 0.3306
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0374 0.8799
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0339 0.133 0.3306
Schistosoma mansoni hypothetical protein 0.0031 0.0062 0.0153
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0339 0.133 0.1329
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0058 0.0144
Giardia lamblia Cathepsin B precursor 0.0056 0.0162 0.0513
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0339 0.133 0.1329
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.0035 0.0104
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0046 0.0123 0.0362
Leishmania major p-glycoprotein e 0.0016 0.0001 0.0002
Echinococcus multilocularis histone deacetylase 1 0.0784 0.3161 0.9311
Brugia malayi Cathepsin L-like precursor 0.0061 0.0183 0.0183
Leishmania major cytochrome p450-like protein 0.0017 0.0001 0.0004
Trichomonas vaginalis histone deacetylase, putative 0.0784 0.3161 1
Brugia malayi Dopamine receptor 0.0339 0.133 0.133
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.007 0.0174
Trypanosoma brucei p-glycoprotein 0.0016 0.0001 0.0002
Entamoeba histolytica cysteine protease, putative 0.0033 0.007 0.022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Loa Loa (eye worm) cathepsin B 0.0056 0.0162 0.0162
Loa Loa (eye worm) neuropeptide F receptor 0.0339 0.133 0.1329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.0183 0.058
Schistosoma mansoni histamine h1 receptor 0.0339 0.133 0.3306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0106 0.0336
Schistosoma mansoni hypothetical protein 0.0339 0.133 0.3306
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Brugia malayi G protein-coupled receptor 0.0339 0.133 0.133
Plasmodium falciparum thioredoxin reductase 0.0047 0.0126 0.04
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0793 0.2509
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.007 0.0222
Brugia malayi Cathepsin L-like precursor 0.0061 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus granulosus rhodopsin orphan GPCR 0.0339 0.133 0.3306
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0123 0.0389
Echinococcus multilocularis neuropeptide FF receptor 2 0.0339 0.133 0.3917
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0214 0.0815 0.0815
Echinococcus multilocularis disks large 1 0.002 0.0013 0.0039
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0211 0.0211
Echinococcus multilocularis cathepsin b 0.0147 0.054 0.159
Brugia malayi intermediate filament protein 0.0026 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0183 0.058
Echinococcus multilocularis geminin 0.0165 0.0614 0.1808
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0147 0.054 0.1342
Entamoeba histolytica cysteine proteinase 2 0.0033 0.007 0.022
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0046 0.0123 0.0123
Brugia malayi celfurPC protein 0.0785 0.3162 0.3162
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.0175 0.0553
Brugia malayi RE15519p 0.0339 0.133 0.133
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0339 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus multilocularis disks large 3 0.0025 0.0035 0.0104
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0423 0.3044
Plasmodium falciparum cysteine proteinase falcipain 1 0.0033 0.007 0.0222
Echinococcus granulosus orexin receptor type 2 0.0339 0.133 0.3306
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0126 0.0126
Onchocerca volvulus 0.0339 0.133 0.993
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.002 0.0013 0.0033
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0046 0.0123 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0061 0.0183 0.058
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0019 0.001 0.001
Toxoplasma gondii guanylate kinase family protein 0.002 0.0013 0.0042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0374 0.269
Toxoplasma gondii subtilisin SUB5 0.0046 0.0123 0.0389
Schistosoma mansoni lamin 0.0026 0.0041 0.0103
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpB 0.0205 0.0775 0.5569
Plasmodium vivax unspecified product 0.0019 0.001 0.0032
Schistosoma mansoni histone deacetylase hda2 0.0737 0.2967 0.7376
Brugia malayi follicle stimulating hormone receptor 0.0339 0.133 0.133
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0374 0.269
Plasmodium falciparum guanylate kinase 0.002 0.0013 0.0042
Leishmania major cathepsin L-like protease 0.0061 0.0183 0.058
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Echinococcus granulosus dro:myosuppressin receptor 0.0339 0.133 0.3306
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0339 0.133 0.3917
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0069 0.0204
Plasmodium vivax guanylate kinase, putative 0.002 0.0013 0.0042
Brugia malayi cathepsin F-like cysteine proteinase 0.0019 0.001 0.001
Trypanosoma brucei histone deacetylase 3 0.0725 0.2917 0.923
Plasmodium falciparum cysteine proteinase falcipain 3 0.0061 0.0183 0.058
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0339 0.133 0.3306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.007 0.0222
Plasmodium vivax vivapain-1 0.0033 0.007 0.0222
Echinococcus granulosus epidermal growth factor receptor 0.0134 0.0486 0.1209
Schistosoma mansoni hypothetical protein 0.0339 0.133 0.3306
Echinococcus granulosus histone deacetylase 6 0.0725 0.2917 0.7253
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0255 0.0983 0.2444
Echinococcus granulosus membrane bound transcription factor site 1 0.0046 0.0123 0.0306
Toxoplasma gondii thioredoxin reductase 0.0047 0.0126 0.04
Echinococcus multilocularis guanylate kinase 0.002 0.0013 0.0039
Onchocerca volvulus 0.0339 0.133 0.993
Wolbachia endosymbiont of Brugia malayi guanylate kinase 0.002 0.0013 1
Leishmania major guanylate kinase-like protein 0.002 0.0013 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0339 0.133 0.3917
Brugia malayi Cytochrome P450 family protein 0.0017 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Loa Loa (eye worm) hypothetical protein 0.0339 0.133 0.1329
Schistosoma mansoni dishevelled 0.009 0.0305 0.0757
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0339 0.133 0.3306
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0089 0.0261
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0126 0.04
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Trichomonas vaginalis guanylate kinase, putative 0.002 0.0013 0.0042
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0614 0.2462 0.612
Brugia malayi Cytochrome P450 family protein 0.0027 0.0046 0.0046
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0423 0.3044
Echinococcus multilocularis histone deacetylase 0.0725 0.2917 0.8594
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0025 0.0035 0.0035
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0041 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0339 0.133 0.3306
Brugia malayi Furin-like cysteine rich region family protein 0.0134 0.0486 0.0486
Onchocerca volvulus Cathepsin L homolog 0.0061 0.0183 0.1094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0046 0.0123 0.0389
Onchocerca volvulus 0.0339 0.133 0.993
Echinococcus multilocularis rhodopsin orphan GPCR 0.0339 0.133 0.3917
Schistosoma mansoni hypothetical protein 0.0031 0.0062 0.0153
Trichomonas vaginalis histone deacetylase, putative 0.0784 0.3161 1
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0001 0.0001
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0089 0.0221
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0089 0.0261

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 9.7 nM Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay ChEMBL. 16942027
Ki (binding) = 9.7 nM Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay ChEMBL. 16942027
Ki (binding) = 15 nM Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay ChEMBL. 16942027
Ki (binding) = 15 nM Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay ChEMBL. 16942027
Ki (binding) = 18 nM Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay ChEMBL. 16942027
Ki (binding) = 18 nM Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay ChEMBL. 16942027
Selectivity ratio (binding) = 0.64 Selectivity for human recombinant carbonic anhydrase 9 over carbonic anhydrase 2 ChEMBL. 16942027

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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