Detailed information for compound 370533

Basic information

Technical information
  • TDR Targets ID: 370533
  • Name: tricyclodecane-9-yl-xanthogenate
  • MW: 229.382 | Formula: C11H17OS2-
  • H donors: 0 H acceptors: 0 LogP: 4.05 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [SH2-]C(=S)OC1CC2CC1C1C2CCC1
  • InChi: 1S/C11H16OS2/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8/h6-10H,1-5H2,(H,13,14)/p-1
  • InChiKey: PWLXJBSAUKKGCM-UHFFFAOYSA-M  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0471 0.4066 1
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.0619 0.0605
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0471 0.4066 1
Echinococcus granulosus dro:myosuppressin receptor 0.0085 0.0619 0.0605
Brugia malayi Tachykinin-like peptides receptor 99D 0.0085 0.0619 0.0617
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0085 0.0619 0.0605
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0084 0.0617 0.1021
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.0619 0.0605
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0079 0.0572 0.0947
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Mycobacterium ulcerans polyketide synthase 0.0079 0.0572 0.0943
Brugia malayi ORL1-like opioid receptor 0.0085 0.0619 0.0617
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0471 0.4066 1
Echinococcus multilocularis g-protein coupled receptor 0.0085 0.0619 0.0605
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus multilocularis neuropeptide receptor 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.007 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.019 0.0175
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0085 0.0619 0.0605
Onchocerca volvulus Fatty acid synthase homolog 0.0117 0.0911 0.0638
Brugia malayi Rhodanese-like domain containing protein 0.0068 0.0473 0.0472
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0085 0.0619 0.0617
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0051 0.0317 0.0781
Loa Loa (eye worm) MBCTL1 0.0058 0.0383 0.0369
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0471 0.4066 0.6745
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.0619 0.0617
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.0619 0.0617
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0383 0.0369
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0085 0.0619 0.0617
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.0619 0.0605
Echinococcus granulosus alpha 1A adrenergic receptor 0.0085 0.0619 0.0605
Echinococcus multilocularis g protein coupled receptor 0.0085 0.0619 0.0605
Schistosoma mansoni neuropeptide receptor 0.0085 0.0619 0.0617
Schistosoma mansoni axis inhibition protein axin 0.0023 0.007 0.0069
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.0619 0.0605
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0043 0.0243 0.0402
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0056
Echinococcus granulosus neuropeptide FF receptor 2 0.0085 0.0619 0.0605
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0383 0.0369
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0028 0.0116 0.0101
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.007 0.0056
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.032 0.0306
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0691 0.6027 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.0619 0.0617
Echinococcus granulosus 7tm_1 domain containing protein 0.0085 0.0619 0.0605
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.0619 0.0605
Brugia malayi PXA domain containing protein 0.0023 0.007 0.0069
Echinococcus granulosus somatostatin receptor 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0056
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0074 0.006
Brugia malayi follicle stimulating hormone receptor 0.0085 0.0619 0.0617
Entamoeba histolytica rodhanase-like domain containing protein 0.0068 0.0473 0.6784
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0691 0.6027 1
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.007 0.0056
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0085 0.0619 0.0617
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.007 0.0069
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.0619 0.0605
Onchocerca volvulus 0.0085 0.0619 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0116 0.0114
Echinococcus granulosus beta-adrenergic receptor kinase 0.0028 0.0116 0.0101
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.0619 0.0617
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.007 0.0069
Echinococcus multilocularis sex peptide receptor 0.0085 0.0619 0.0605
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0197 0.1621 0.2688
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0016 0.0004 0.0005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0085 0.0619 0.0605
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0544 0.0896
Trichomonas vaginalis conserved hypothetical protein 0.0224 0.1863 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0075 0.053 0.0877
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0079 0.0572 0.0892
Brugia malayi AKH receptor 0.0085 0.0619 0.0617
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0058 0.0383 0.0942
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.007 0.0056
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0197 0.1621 0.2688
Loa Loa (eye worm) fatty acid synthase 0.0051 0.0315 0.0301
Echinococcus multilocularis serotonin receptor 0.0844 0.7391 0.7387
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0068 0.0053
Brugia malayi hypothetical protein 0.0224 0.1863 0.1862
Echinococcus granulosus axis inhibition protein axin 0.0023 0.007 0.0056
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.007 0.0069
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0691 0.6027 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0368
Loa Loa (eye worm) hypothetical protein 0.0063 0.0425 0.0411
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0084 0.0617 0.0615
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0068 0.0473 0.2534
Brugia malayi Serotonin receptor 0.0085 0.0619 0.0617
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0059 0.0389 0.0638
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0085 0.0619 0.0605
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0025 0.0023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0085 0.0619 0.0605
Echinococcus multilocularis g protein coupled receptor 0.0085 0.0619 0.0605
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.007 0.0056
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0067 0.046 0.0762
Echinococcus multilocularis dro:myosuppressin receptor 0.0085 0.0619 0.0605
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.007 0.0056
Schistosoma mansoni opsin-like receptor 0.0085 0.0619 0.0617
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.007 0.0069
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.007 0.0069
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Echinococcus granulosus biogenic amine 5HT receptor 0.0461 0.3975 0.3966
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.0619 0.0605
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0068 0.0473 0.0459
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0471 0.4066 1
Brugia malayi mbt repeat family protein 0.0051 0.032 0.0319
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0084 0.0617 0.1017
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.007 0.0056
Echinococcus granulosus neuropeptide receptor 0.0085 0.0619 0.0605
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) 0.0047 0.0279 0.0461
Onchocerca volvulus 0.0085 0.0619 0.0337
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0056
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.007 0.0069
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1137 1 1
Onchocerca volvulus 0.0068 0.0473 0.0187
Mycobacterium ulcerans polyketide synthase Pks9 0.0059 0.0389 0.0638
Echinococcus granulosus thymidylate synthase 0.0471 0.4066 0.4057
Echinococcus granulosus sex peptide receptor 0.0085 0.0619 0.0605
Brugia malayi hypothetical protein 0.0023 0.007 0.0069
Echinococcus multilocularis muscleblind protein 0.0306 0.259 0.258
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0004 0.0003
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1137 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0461 0.3975 0.3974
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.007 0.0056
Schistosoma mansoni biogenic amine receptor 0.0085 0.0619 0.0617
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0066 0.0454 0.0747
Schistosoma mansoni growth hormone secretagogue receptor 0.0085 0.0619 0.0617
Brugia malayi neuropeptide F receptor 0.0085 0.0619 0.0617
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0197 0.1621 0.3627
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.007 0.0056
Echinococcus granulosus neuropeptide receptor 0.0085 0.0619 0.0605
Schistosoma mansoni opsin-like receptor 0.0085 0.0619 0.0617
Schistosoma mansoni opsin-like receptor 0.0085 0.0619 0.0617
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.1662 0.165
Trichomonas vaginalis cdc25b, putative 0.0068 0.0473 0.2534
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0085 0.0619 0.0617
Onchocerca volvulus 0.0471 0.4066 0.3888
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0043 0.0245 0.0039
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0085 0.0619 0.0605
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0544 0.09
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0076 0.0544 0.0818
Onchocerca volvulus 0.0085 0.0619 0.0337
Mycobacterium tuberculosis Hypothetical protein 0.0224 0.1863 0.3089
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0079 0.0572 0.0943
Schistosoma mansoni regulator of G protein signaling 0.0023 0.007 0.0069
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Schistosoma mansoni biogenic amine receptor 0.0085 0.0619 0.0617
Loa Loa (eye worm) TYRA-2 protein 0.0085 0.0619 0.0605
Loa Loa (eye worm) melatonin receptor type 1A 0.0085 0.0619 0.0605
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0471 0.4066 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.0619 0.0617
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0085 0.0619 0.0617
Echinococcus multilocularis muscleblind protein 1 0.0306 0.259 0.258
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Loa Loa (eye worm) hypothetical protein 0.0051 0.032 0.0306
Echinococcus granulosus orexin receptor type 2 0.0085 0.0619 0.0605
Echinococcus granulosus g protein coupled receptor 0.0085 0.0619 0.0605
Brugia malayi neuropeptide F receptor 0.0085 0.0619 0.0617
Schistosoma mansoni neuropeptide receptor 0.0085 0.0619 0.0617
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.0619 0.0617
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.0619 0.0617
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0079 0.0572 0.0943
Schistosoma mansoni amine GPCR 0.0085 0.0619 0.0617
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0076 0.0544 0.0818
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0085 0.0619 0.0617
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0068 0.0473 0.2534
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0041 0.023 0.0379
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0079 0.0572 0.0892
Trichomonas vaginalis cdc25b, putative 0.0068 0.0473 0.2534
Brugia malayi putative neuropeptide receptor 0.0085 0.0619 0.0617
Loa Loa (eye worm) hypothetical protein 0.0497 0.4297 0.4289
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.007 0.0056
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.0619 0.0605
Schistosoma mansoni amine GPCR 0.0085 0.0619 0.0617
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.0619 0.0617
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0084 0.0617 0.0615
Schistosoma mansoni neuropeptide receptor 0.0085 0.0619 0.0617
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.007 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0116 0.0114
Schistosoma mansoni hypothetical protein 0.0085 0.0619 0.0617
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0844 0.7391 0.7387
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.032 0.0319
Echinococcus multilocularis somatostatin receptor 0.0085 0.0619 0.0605
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0471 0.4066 0.6745
Brugia malayi PXA domain containing protein 0.0023 0.007 0.0069
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.0619 0.0617
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0068 0.0066
Onchocerca volvulus 0.0068 0.0473 0.0187
Schistosoma mansoni alpha-1 adrenergic receptor 0.0085 0.0619 0.0617
Trichomonas vaginalis hypothetical protein 0.0197 0.1621 0.8703
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0341 0.0339
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Loa Loa (eye worm) RGS-3 protein 0.0023 0.007 0.0056
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Onchocerca volvulus 0.0085 0.0619 0.0337
Brugia malayi G-protein coupled receptor 0.0085 0.0619 0.0617
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0068 0.0473 0.2534
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0085 0.0619 0.0617
Echinococcus granulosus 7TM GPCR rhodopsin 0.0085 0.0619 0.0605
Brugia malayi Dopamine receptor protein 2 0.0085 0.0619 0.0617
Mycobacterium leprae 3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I) 0.0047 0.0279 0.0129
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0075 0.053 0.0877
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0048 0.0291 0.0481
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0056
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.007 0.0056
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.1662 0.165
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0291 0.029
Echinococcus granulosus g protein coupled receptor 0.0085 0.0619 0.0605
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0664 1
Echinococcus granulosus expressed protein 0.0451 0.3882 0.3873
Onchocerca volvulus 0.0085 0.0619 0.0337
Entamoeba histolytica rodhanase-like domain containing protein 0.0068 0.0473 0.6784
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Onchocerca volvulus 0.0085 0.0619 0.0337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.0619 0.0617
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.0619 0.0617
Schistosoma mansoni hypothetical protein 0.0311 0.2638 0.2637
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.0619 0.0605
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0079 0.0572 0.0947
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.8593 0.8591
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0084 0.0617 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0368
Echinococcus multilocularis neuropeptide receptor A26 0.0085 0.0619 0.0605
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.007 0.0069
Echinococcus multilocularis G protein coupled receptor 139 0.0085 0.0619 0.0605
Schistosoma mansoni neuropeptide f receptor 76f 0.0085 0.0619 0.0617
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.032 0.0306
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Onchocerca volvulus 0.0085 0.0619 0.0337
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.032 0.0306
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.0619 0.0605
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0197 0.1621 0.3988
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.0619 0.0617
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0383 0.0369
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0383 0.0382
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.0619 0.0605
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.007 0.0056
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0085 0.0619 0.0605
Loa Loa (eye worm) RecQ helicase 0.0023 0.0068 0.0053
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.007 0.0056
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0084 0.0617 0.0959
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1137 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.007 0.0056
Brugia malayi Dopamine receptor protein 1 0.0497 0.4297 0.4296
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0368
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0664 1
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0116 0.0114
Echinococcus granulosus biogenic amine 5HT receptor 0.0844 0.7391 0.7387
Loa Loa (eye worm) hypothetical protein 0.0844 0.7391 0.7387
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1137 1 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0102 0.077 0.1275
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0306 0.259 0.258
Echinococcus multilocularis G-protein coupled receptor, putative 0.0085 0.0619 0.0605
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0046 0.0271 0.0448
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.0619 0.0605
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0028 0.0116 0.0114
Echinococcus granulosus serotonin receptor 0.0085 0.0619 0.0605
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0471 0.4066 0.4065
Brugia malayi hypothetical protein 0.0023 0.007 0.0069
Mycobacterium ulcerans thioesterase 0.0043 0.0245 0.0399
Schistosoma mansoni hypothetical protein 0.0085 0.0619 0.0617
Brugia malayi Dopamine receptor 0.0085 0.0619 0.0617
Mycobacterium leprae Probable polyketide synthase Pks1 0.0079 0.0572 0.0892
Brugia malayi G-protein coupled receptor 0.0085 0.0619 0.0617
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0085 0.0619 0.0605
Onchocerca volvulus 0.0085 0.0619 0.0337
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.0619 0.0605
Schistosoma mansoni histamine h1 receptor 0.0085 0.0619 0.0617
Brugia malayi Melatonin receptor type 1A 0.0085 0.0619 0.0617
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0084 0.0617 0.1514
Brugia malayi Serotonin receptor 0.0085 0.0619 0.0617
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1137 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus granulosus peptide allatostatin:somatostatin 0.0085 0.0619 0.0605
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0341 0.0339
Brugia malayi putative neuropeptide receptor NPR1 0.0085 0.0619 0.0617
Onchocerca volvulus 0.0085 0.0619 0.0337
Schistosoma mansoni amine GPCR 0.0085 0.0619 0.0617
Brugia malayi G protein-coupled receptor 0.0085 0.0619 0.0617
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0368
Loa Loa (eye worm) hypothetical protein 0.0063 0.0425 0.0411
Echinococcus multilocularis thymidylate synthase 0.0471 0.4066 0.4057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.0619 0.0617
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.0619 0.0605
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.007 0.0069
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0471 0.4066 0.6722
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus granulosus tachykinin peptides receptor 99D 0.0085 0.0619 0.0605
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0037 0.0192 0.0317
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0068 0.0473 0.0459
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0059 0.0389 0.0414
Mycobacterium leprae Polyketide synthase Pks13 0.0102 0.077 0.1408
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0079 0.0572 0.0947
Mycobacterium ulcerans thymidylate synthase 0.0471 0.4066 0.6743
Brugia malayi RE15519p 0.0085 0.0619 0.0617
Onchocerca volvulus 0.0085 0.0619 0.0337
Loa Loa (eye worm) hypothetical protein 0.0306 0.259 0.258
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0085 0.0619 0.0605
Brugia malayi G protein-coupled receptor F59B2.13 0.0085 0.0619 0.0617
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.007 0.0069
Echinococcus granulosus G protein coupled receptor 139 0.0085 0.0619 0.0605
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0084 0.0617 0.0603
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Toxoplasma gondii type I fatty acid synthase, putative 0.0062 0.0412 0.1013
Brugia malayi sulfakinin receptor protein 0.0085 0.0619 0.0617
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Mycobacterium ulcerans polyketide synthase Pks13 0.0102 0.077 0.1271
Schistosoma mansoni adenoreceptor 0.0085 0.0619 0.0617
Schistosoma mansoni serine/threonine protein kinase 0.1137 1 1
Mycobacterium ulcerans thioesterase TesA 0.0043 0.0245 0.0399
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.0619 0.0617
Brugia malayi Muscleblind-like protein 0.0306 0.259 0.2589
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.0619 0.0605
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0068 0.0473 0.0459
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0068 0.0356
Schistosoma mansoni regulator of G protein signaling 0.0023 0.007 0.0069
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0691 0.6027 1
Echinococcus granulosus neuropeptide s receptor 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Onchocerca volvulus 0.0085 0.0619 0.0337
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.032 0.0306
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.0619 0.0605
Echinococcus multilocularis orexin receptor type 2 0.0085 0.0619 0.0605
Schistosoma mansoni hypothetical protein 0.0037 0.019 0.0188
Trichomonas vaginalis cdc25c, putative 0.0068 0.0473 0.2534
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0664 1
Schistosoma mansoni amine GPCR 0.0085 0.0619 0.0617
Schistosoma mansoni biogenic amine receptor 0.0085 0.0619 0.0617
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0197 0.1621 0.2685
Echinococcus granulosus bloom syndrome protein 0.0023 0.0068 0.0053
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0068 0.0356
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0085 0.0619 0.0605
Echinococcus multilocularis neuropeptide FF receptor 2 0.0085 0.0619 0.0605
Schistosoma mansoni regulator of G protein signaling 0.0023 0.007 0.0069
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.032 0.003
Schistosoma mansoni hypothetical protein 0.0085 0.0619 0.0617
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.0619 0.0605
Echinococcus multilocularis allatostatin A receptor 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Echinococcus granulosus g protein coupled receptor 0.0085 0.0619 0.0605
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0085 0.0619 0.0605
Onchocerca volvulus Neuropeptide F receptor homolog 0.0085 0.0619 0.0337
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0068 0.0473 0.2534
Echinococcus multilocularis expressed protein 0.0451 0.3882 0.3873
Plasmodium falciparum enoyl-acyl carrier reductase 0.0197 0.1621 0.2637
Brugia malayi mbt repeat family protein 0.0051 0.032 0.0319
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.032 0.0319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.0619 0.0617
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0085 0.0619 0.0617
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0085 0.0619 0.0617
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0085 0.0619 0.0605
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0084 0.0617 0.1017
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0068 0.0473 0.0472
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0054 0.0341 0.0327
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0085 0.0619 0.0617
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0013
Mycobacterium ulcerans polyketide synthase MbtC 0.0038 0.0201 0.0327
Schistosoma mansoni amine GPCR 0.0085 0.0619 0.0617
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0691 0.6027 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0844 0.7391 0.739
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0085 0.0619 0.0617
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0544 0.0896
Mycobacterium tuberculosis Probable thioesterase TesA 0.0043 0.0245 0.0404
Echinococcus multilocularis beta adrenergic receptor kinase 0.0028 0.0116 0.0101
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0383 0.0369
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0461 0.3975 0.3966
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0691 0.6027 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.007 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.032 0.0319
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0085 0.0619 0.0337
Onchocerca volvulus 0.0114 0.0883 0.0609
Onchocerca volvulus 0.0085 0.0619 0.0337
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0084 0.0617 0.0603
Mycobacterium ulcerans polyketide synthase 0.0076 0.0544 0.0896
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.0619 0.0617
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0054 0.0346 0.0572
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Onchocerca volvulus 0.0085 0.0619 0.0337
Brugia malayi larval opioid receptor 0.0085 0.0619 0.0617
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0076 0.0544 0.0542
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Loa Loa (eye worm) thymidylate synthase 0.0471 0.4066 0.4057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Echinococcus multilocularis neuropeptide receptor 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0056
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.007 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0084 0.0617 0.1517
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0066 0.0454 0.0747
Onchocerca volvulus 0.0085 0.0619 0.0337
Entamoeba histolytica rodhanase-like domain containing protein 0.0068 0.0473 0.6784
Echinococcus granulosus axis inhibition protein axin 0.0023 0.007 0.0056
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0076 0.0544 0.09
Brugia malayi thymidylate synthase 0.0471 0.4066 0.4065
Toxoplasma gondii type I fatty acid synthase, putative 0.0079 0.0572 0.1407
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0102 0.077 0.1275
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0013
Echinococcus granulosus neuropeptide receptor A26 0.0085 0.0619 0.0605
Schistosoma mansoni regulator of G protein signaling 0.0023 0.007 0.0069
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0085 0.0619 0.0617
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0544 0.0896
Schistosoma mansoni regulator of G protein signaling 0.0023 0.007 0.0069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0012
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0068 0.0473 0.2534
Onchocerca volvulus 0.0085 0.0619 0.0337
Schistosoma mansoni axis inhibition protein axin 0.0023 0.007 0.0069
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0085 0.0619 0.0617
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0197 0.1621 0.1857
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0076 0.0544 0.09
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0383 0.0382
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0342 0.0328
Onchocerca volvulus 0.0085 0.0619 0.0337
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0341 0.0327
Schistosoma mansoni myosin xvIII 0.0085 0.0619 0.0617
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0691 0.6027 1
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.0619 0.0605
Giardia lamblia Methyltransferase like 2 0.0015 0.0001 0.5
Echinococcus multilocularis g protein coupled receptor 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0111 0.0855 0.0841
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.032 0.0306
Schistosoma mansoni hypothetical protein 0.0085 0.0619 0.0617
Brugia malayi Rhodanese-like domain containing protein 0.0068 0.0473 0.0472
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.007 0.0056
Loa Loa (eye worm) hypothetical protein 0.0058 0.0383 0.0369
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0048 0.0291 0.0277
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) 0.0047 0.0279 0.0461
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1137 1 1
Brugia malayi hypothetical protein 0.0085 0.0619 0.0617
Echinococcus granulosus hypothetical protein 0.0085 0.0619 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0368
Echinococcus granulosus muscleblind protein 0.0306 0.259 0.258
Onchocerca volvulus 0.0068 0.0473 0.0187
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0197 0.1621 0.1857
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0691 0.6027 1
Onchocerca volvulus 0.0068 0.0473 0.0187
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0544 0.0896
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0664 1
Echinococcus granulosus allatostatin A receptor 0.0085 0.0619 0.0605
Onchocerca volvulus 0.0085 0.0619 0.0337
Echinococcus multilocularis fmrfamide receptor 0.0085 0.0619 0.0605
Brugia malayi GnHR receptor homolog 0.0085 0.0619 0.0617
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.0619 0.0605
Schistosoma mansoni neuropeptide receptor 0.0085 0.0619 0.0617
Mycobacterium leprae 3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I) 0.0047 0.0279 0.0129
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.0619 0.0605
Echinococcus granulosus fmrfamide receptor 0.0085 0.0619 0.0605
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0013
Echinococcus granulosus g-protein coupled receptor 0.0085 0.0619 0.0605
Entamoeba histolytica fatty acid elongase, putative 0.009 0.0664 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.007 0.0368
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.019 0.0188
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0224 0.1863 0.3612
Echinococcus multilocularis fmrfamide receptor 0.0085 0.0619 0.0605
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0122 0.0953 0.0952
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0068 0.0473 0.0459
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0066 0.0454 0.0585
Onchocerca volvulus 0.0051 0.032 0.003
Echinococcus multilocularis serotonin receptor 0.0844 0.7391 0.7387
Echinococcus multilocularis neuropeptide s receptor 0.0085 0.0619 0.0605
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0028 0.0116 0.0101
Mycobacterium ulcerans fatty acid synthase Fas 0.0041 0.023 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.0619 0.0605
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0085 0.0619 0.0605
Loa Loa (eye worm) hypothetical protein 0.0085 0.0619 0.0605

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Induction of apoptosis in NSC cells by TUNEL assay ChEMBL. 16872828
Activity (functional) 0 Inhibition of reactive oxygen species accumulation in NSC cells relative to control ChEMBL. 16872828
Activity (functional) 0 Induction of necrosis in NSC cells assessed as lactate dehydrogenase release at 56.29 uM within 72 hrs relative to control ChEMBL. 16872828
Activity (functional) 0 Decrease in viability of NSC cells at 56.29 uM for 72 hrs in presence of bFGF ChEMBL. 16872828
Activity (functional) 0 Decrease in viability of NSC cells at 37.53 uM for 48 hrs in presence of bFGF ChEMBL. 16872828
Activity (functional) 0 Decrease in viability of NSC cells at 18.76 uM for 24 hrs in presence of bFGF ChEMBL. 16872828

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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