TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 342.386 | Formula: C20H22O5
H donors: 3 H acceptors: 5 LogP: 2.57 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)C1CCC2C(C1)CC1C(=C(O)c3c(C1)c(O)ccc3O)C2=O
InChi: 1S/C20H22O5/c1-9(21)10-2-3-13-11(6-10)7-12-8-14-15(22)4-5-16(23)18(14)20(25)17(12)19(13)24/h4-5,10-13,22-23,25H,2-3,6-8H2,1H3
InChiKey: CWLAYYXVQIWWAE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0057	0.0785	0.2448
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0108	0.1716	0.5351
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0108	0.1716	0.5351
Brugia malayi	nuclear hormone receptor	0.0051	0.0674	0.0638
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0038	0.0089
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.0915	0.0915
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.105	0.2482
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0675	0.0675
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0108	0.1716	0.1685
Toxoplasma gondii	hypothetical protein	0.0028	0.0246	0.118
Brugia malayi	hypothetical protein	0.0057	0.0785	0.0751
Brugia malayi	hypothetical protein	0.0064	0.0914	0.0879
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.105	0.3275
Schistosoma mansoni	coup transcription factor	0.0108	0.1716	0.4003
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0038	0.0089
Echinococcus granulosus	nuclear receptor nhr 48	0.0051	0.0674	0.21
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.0915	0.0881
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0053	0.0701	1
Loa Loa (eye worm)	hypothetical protein	0.0562	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0057	0.0785	0.1856
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0043	0.0531	0.0495
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.0915	0.2162
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0108	0.1716	0.4003
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0038	0.0038
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0108	0.1716	0.5351
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0108	0.1716	0.1685
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0118	0.5
Echinococcus multilocularis	jun protein	0.0082	0.1234	0.2916
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0051	0.0674	0.21
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0108	0.1716	0.4056
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.008	0.1205	1
Brugia malayi	nuclear receptor RXR	0.0051	0.0674	0.0638
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0915	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0108	0.1716	0.4056
Brugia malayi	nuclear hormone receptor family member odr-7	0.0051	0.0674	0.0638
Schistosoma mansoni	hypothetical protein	0.0066	0.0954	0.2186
Schistosoma mansoni	zinc finger protein	0.0051	0.0674	0.1517
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0915	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0051	0.0674	0.0674
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0675	0.0675
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0057	0.0785	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0785	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0785	0.0785
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0108	0.1716	0.1716
Brugia malayi	Nuclear hormone receptor-like 1	0.0108	0.1716	0.1685
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0421	0.1313
Loa Loa (eye worm)	steroid hormone receptor	0.0108	0.1716	0.1716
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0118	0.0081
Schistosoma mansoni	jun-related protein	0.0066	0.0954	0.2186
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0043	0.0531	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1716	0.1716
Schistosoma mansoni	transcription factor LCR-F1	0.019	0.3207	0.7558
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1716	0.1716
Schistosoma mansoni	retinoic acid receptor RXR	0.0108	0.1716	0.4003
Entamoeba histolytica	hypothetical protein	0.019	0.3207	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0057	0.0785	0.1783
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0051	0.0674	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1716	0.1716
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0246	0.118
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0108	0.1716	0.1685
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0108	0.1716	0.1685
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0108	0.1716	0.1716
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0108	0.1716	0.1716
Onchocerca volvulus		0.0108	0.1716	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0785	0.0785
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0057	0.0785	0.1783
Loa Loa (eye worm)	DR-78	0.0051	0.0674	0.0674
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.0915	0.2852
Brugia malayi	hypothetical protein	0.0057	0.0785	0.0751
Schistosoma mansoni	nuclear hormone receptor	0.0108	0.1716	0.4003
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0108	0.1716	0.4056
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0051	0.0674	0.21
Schistosoma mansoni	hypothetical protein	0.0138	0.2258	0.5294
Brugia malayi	ecdysone receptor	0.0051	0.0674	0.0638
Schistosoma mansoni	nuclear hormone receptor	0.0051	0.0674	0.1517
Schistosoma mansoni	nuclear receptor nhr-48	0.0051	0.0674	0.1517
Brugia malayi	conserved hypotetical protein	0.0051	0.0674	0.0638
Loa Loa (eye worm)	hypothetical protein	0.008	0.1205	0.1205
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.008	0.1205	1
Brugia malayi	nuclear hormone receptor	0.0108	0.1716	0.1685
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0108	0.1716	0.1685
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0246	0.4232	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0057	0.0785	0.0751
Brugia malayi	orphan nuclear receptor NR2E1	0.0051	0.0674	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Brugia malayi	nuclear receptor NHR-67	0.0051	0.0674	0.0638
Onchocerca volvulus	Protein ultraspiracle homolog	0.0108	0.1716	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0051	0.0674	0.1517
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0051	0.0674	0.21
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0108	0.1716	0.1716
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0038	0.0089
Brugia malayi	Steroid receptor seven-up type 2	0.0108	0.1716	0.1685
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0051	0.0674	0.1592
Echinococcus granulosus	ecdysone induced protein 78C	0.0108	0.1716	0.5351
Entamoeba histolytica	hypothetical protein	0.019	0.3207	1
Brugia malayi	Nuclear hormone receptor E75	0.0051	0.0674	0.0638
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.008	0.1205	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0108	0.1716	0.4056
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0051	0.0674	0.0638
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0138	0.2258	0.7039
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0246	0.118
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0108	0.1716	0.1716
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0108	0.1716	0.1716
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.0603	0.1349
Schistosoma mansoni	ap endonuclease	0.0021	0.0118	0.0192
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0108	0.1716	0.5351
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0082	0.1234	0.2916
Brugia malayi	hypothetical protein	0.019	0.3207	0.3182
Echinococcus granulosus	peptidase Clp S14 family	0.0053	0.0701	0.2187
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.008	0.1205	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0915	1
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.008	0.1205	0.3758
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0051	0.0674	0.1517
Echinococcus granulosus	thyroid hormone receptor alpha	0.0051	0.0674	0.21
Brugia malayi	tailless protein	0.0051	0.0674	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0051	0.0674	0.21
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0108	0.1716	0.4003
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.038	0.0344
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.008	0.1205	1
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.0915	0.2092
Brugia malayi	nuclear receptor NHR-88	0.0051	0.0674	0.0638
Echinococcus multilocularis	FTZ F1 alpha	0.0108	0.1716	0.4056
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0118	0.0369
Schistosoma mansoni	peptidase Clp (S14 family)	0.008	0.1205	0.2784
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0053	0.0701	0.4744
Echinococcus multilocularis	nuclear receptor nhr 48	0.0051	0.0674	0.1592
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.0915	1
Schistosoma mansoni	nuclear hormone receptor	0.0051	0.0674	0.1517
Echinococcus granulosus	jun protein	0.0082	0.1234	0.3847
Brugia malayi	hypothetical protein	0.0051	0.0674	0.0638
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0108	0.1716	0.1716
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0108	0.1716	0.1685
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0053	0.0701	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0108	0.1716	0.4003
Brugia malayi	nuclear receptor RXR	0.0057	0.0785	0.0751
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0108	0.1716	0.4003
Schistosoma mansoni	ap endonuclease	0.0021	0.0118	0.0192
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.008	0.1205	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0082	0.1234	0.3847
Brugia malayi	Probable ClpP-like protease	0.008	0.1205	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Brugia malayi	nuclear receptor NHR-88	0.0108	0.1716	0.1685
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0675	0.064
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0108	0.1716	0.1685
Schistosoma mansoni	RAR-like nuclear receptor	0.0108	0.1716	0.4003
Brugia malayi	ecdysteroid receptor	0.0108	0.1716	0.1685
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0038	0.0038
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.008	0.1205	1
Brugia malayi	steroid hormone receptor	0.0108	0.1716	0.1685
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0108	0.1716	0.5351
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0108	0.1716	0.5351
Echinococcus granulosus	GPCR family 2	0.0016	0.0038	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1716	0.1716
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.008	0.1205	1
Brugia malayi	bZIP transcription factor family protein	0.0082	0.1234	0.1201
Entamoeba histolytica	hypothetical protein	0.019	0.3207	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0028	0.0246	0.118
Schistosoma mansoni	thyroid hormone receptor	0.0246	0.4232	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0108	0.1716	0.4003
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0051	0.0674	0.1592
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0051	0.0674	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0785	0.0785
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0108	0.1716	0.5351
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.008	0.1205	0.5
Entamoeba histolytica	hypothetical protein	0.019	0.3207	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1716	0.1716
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0043	0.0531	0.1656
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0051	0.0674	0.0638
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0051	0.0674	0.1592
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Schistosoma mansoni	nuclear receptor	0.0051	0.0674	0.1517
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0108	0.1716	0.1685
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0108	0.1716	0.1685
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0038	0.0117
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0051	0.0674	0.1592
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0108	0.1716	0.1685
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0038	0.0117
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0118	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0427	0.0427
Schistosoma mansoni	hypothetical protein	0.0035	0.038	0.0816
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.0915	0.2579
Echinococcus multilocularis	ecdysone induced protein 78C	0.0108	0.1716	0.4056
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1193	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1716	0.1716
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1716	0.1716
Onchocerca volvulus		0.0064	0.0914	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.019	0.3207	1
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.0603	0.1349
Brugia malayi	Nuclear hormone receptor-like 1	0.0057	0.0785	0.0751
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0108	0.1716	0.1685
Loa Loa (eye worm)	hypothetical protein	0.0035	0.038	0.038
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0108	0.1716	0.4003
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0108	0.1716	1
Onchocerca volvulus	Bile acid receptor homolog	0.0108	0.1716	1
Schistosoma mansoni	hypothetical protein	0.019	0.3207	0.7558
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0675	0.064
Brugia malayi	photoreceptor-specific nuclear receptor	0.0108	0.1716	0.1685
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0108	0.1716	0.4056
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.019	0.3207	0.758
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0479	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0108	0.1716	0.1685
Schistosoma mansoni	thyroid hormone receptor	0.0246	0.4232	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0118	0.0118
Brugia malayi	hypothetical protein	0.0051	0.0674	0.0638
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.008	0.1205	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0479	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0108	0.1716	0.1685
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0051	0.0674	0.1592
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0043	0.0531	0.1255
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0053	0.0701	0.1657
Echinococcus granulosus	FTZ F1 alpha	0.0108	0.1716	0.5351
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0674	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1716	0.1716
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0785	0.0785
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0138	0.2258	0.5335
Brugia malayi	Nuclear hormone receptor E75	0.0051	0.0674	0.0638
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.008	0.1205	0.2848
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0108	0.1716	0.4003
Schistosoma mansoni	nuclear receptor	0.0051	0.0674	0.1517
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0421	0.0995
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0108	0.1716	0.4056
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.008	0.1205	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 75 uM	Inhibitory activity against tetracycline uptake in everted membrane vesicles derived from Tc-resistant Escherichia coli bearing class B tetracycline resistance efflux protein (Tet)	ChEMBL.	8176712
IC50 (functional)	> 75 uM	Inhibitory activity against tetracycline uptake in everted membrane vesicles derived from Tc-resistant Escherichia coli bearing class B tetracycline resistance efflux protein (Tet)	ChEMBL.	8176712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 37059