Detailed information for compound 370671

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 852.053 | Formula: C39H65N9O10S
  • H donors: 7 H acceptors: 10 LogP: 0.42 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 3
  • SMILES: CSCC[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)CN(C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@H]3N(C(=O)[C@H](NC1=O)CCC(=O)N)CCC3)CCC2)[C@H](CC)C)[C@H](O)C
  • InChi: 1S/C39H65N9O10S/c1-8-22(4)31-36(55)45-32(23(5)49)39(58)46(6)20-30(51)41-26(19-21(2)3)34(53)42-24(15-18-59-7)33(52)43-25(13-14-29(40)50)37(56)48-17-10-12-28(48)38(57)47-16-9-11-27(47)35(54)44-31/h21-28,31-32,49H,8-20H2,1-7H3,(H2,40,50)(H,41,51)(H,42,53)(H,43,52)(H,44,54)(H,45,55)/t22?,23?,24-,25-,26-,27-,28-,31-,32-/m0/s1
  • InChiKey: KWUHGHLCSWZXRH-UXUUSHKSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0048 0.0197 0.0861
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0054 0.024 0.1941
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.011 0.0083
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.011 0.011
Echinococcus granulosus Glycosyl transferase family 35 0.0328 0.2285 0.2285
Entamoeba histolytica hypothetical protein 0.0137 0.0858 0.215
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0783 0.0783
Entamoeba histolytica hypothetical protein 0.0137 0.0858 0.215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0167 0.0167
Trichomonas vaginalis cytidine deaminase, putative 0.0054 0.024 0.0392
Trypanosoma cruzi thymidine kinase, putative 0.0504 0.3592 1
Schistosoma mansoni phosphoglucomutase 0.0043 0.0158 0.0158
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0023 0.0253
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.045
Leishmania major thymidylate kinase-like protein 0.0142 0.0899 0.2455
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0859 0.0859
Echinococcus granulosus thymidine kinase 0.1363 1 1
Onchocerca volvulus 0.0054 0.024 0.1049
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0243
Mycobacterium tuberculosis Conserved protein 0.0036 0.0103 0.0151
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0142 0.0895 0.9954
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0243
Treponema pallidum thymidylate kinase (tmk) 0.0142 0.0899 1
Trypanosoma brucei ingi protein (ORF1) 0.005 0.0208 0.0518
Trichomonas vaginalis glycogen phosphorylase, putative 0.0328 0.2285 0.6256
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.045
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.011 0.0019
Echinococcus multilocularis glycogen phosphorylase 0.0328 0.2285 0.2285
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0197 0.0861
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.045
Entamoeba histolytica hypothetical protein 0.0137 0.0858 0.215
Brugia malayi Inositol-1 0.0037 0.011 0.0479
Echinococcus multilocularis thymidylate kinase 0.0142 0.0899 0.0899
Brugia malayi carbohydrate phosphorylase 0.0328 0.2285 1
Trichomonas vaginalis thymidine kinase, putative 0.0504 0.3592 1
Entamoeba histolytica hypothetical protein 0.0137 0.0858 0.215
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0137 0.0858 0.215
Echinococcus granulosus thymidylate kinase 0.0142 0.0899 0.0899
Trypanosoma brucei thymidylate kinase, putative 0.0142 0.0899 0.2455
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0208 0.0518
Leishmania major ribonuclease H1, putative 0.0043 0.0158 0.0378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0167 0.0167
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0083 0.0362
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0142 0.0899 1
Echinococcus multilocularis thymidine kinase 0.1363 1 1
Leishmania major cathepsin L-like protease 0.0056 0.0255 0.065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0167 0.0167
Trichomonas vaginalis ribonuclease H1, putative 0.0043 0.0158 0.0157
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.154 1
Trypanosoma brucei ribonuclease H1 0.0043 0.0158 0.0378
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0167 0.0167
Entamoeba histolytica thymidine kinase, putative 0.0504 0.3592 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0044 0.0165 0.0399
Brugia malayi RNase H family protein 0.0043 0.0158 0.069
Schistosoma mansoni thymidylate kinase 0.0142 0.0899 0.0899
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Schistosoma mansoni glycogen phosphorylase 0.0142 0.0895 0.0895
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0858 0.2165
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0858 0.2165
Echinococcus multilocularis glycogen phosphorylase 0.0328 0.2285 0.2285
Leishmania major cathepsin L-like protease 0.0056 0.0255 0.065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Leishmania major cathepsin L-like protease 0.0056 0.0255 0.065
Leishmania major cytidine deaminase-like protein 0.0054 0.024 0.0608
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1363 1 1
Echinococcus granulosus solute carrier family 28 0.0346 0.242 0.242
Trichomonas vaginalis glycogen phosphorylase, putative 0.0328 0.2285 0.6256
Giardia lamblia Thymidine kinase 0.0504 0.3592 0.3819
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0197 0.0861
Echinococcus granulosus glycogen phosphorylase 0.0328 0.2285 0.2285
Loa Loa (eye worm) inositol-1 0.0037 0.011 0.0479
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0255 0.065
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0226 0.1521 0.1521
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0103 0.0151
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0131 0.0816 0.0816
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0103 0.0269
Onchocerca volvulus 0.0036 0.0103 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0858 0.2165
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0103 0.0225
Onchocerca volvulus 0.0054 0.024 0.1049
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0255 0.065
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Leishmania major hypothetical protein, conserved 0.0036 0.0103 0.0225
Plasmodium vivax thymidylate kinase, putative 0.0142 0.0899 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0142 0.0895 0.2256
Trypanosoma brucei thymidylate kinase, putative 0.0142 0.0899 0.2455
Schistosoma mansoni hypothetical protein 0.0127 0.0783 0.0783
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0103 0.0103
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.011 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0167 0.0167
Trypanosoma cruzi cytidine deaminase-like protein 0.0054 0.024 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Onchocerca volvulus Glycogen phosphorylase homolog 0.0328 0.2285 1
Schistosoma mansoni phosphoglucomutase 0.0043 0.0158 0.0158
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0142 0.0895 0.5579
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0103 0.0103
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0137 0.0858 0.0858
Entamoeba histolytica hypothetical protein 0.0137 0.0858 0.215
Brugia malayi beta-lactamase family protein 0.0036 0.0103 0.045
Echinococcus multilocularis ribonuclease H1 0.0043 0.0158 0.0158
Echinococcus multilocularis Glycosyl transferase, family 35 0.0328 0.2285 0.2285
Onchocerca volvulus Ribonuclease H1 homolog 0.0043 0.0158 0.069
Brugia malayi beta-lactamase 0.0036 0.0103 0.045
Schistosoma mansoni thymidine kinase 0.1363 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0255 0.065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Schistosoma mansoni inositol monophosphatase 0.0037 0.011 0.011
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0103 0.1145
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0346 0.242 0.242
Giardia lamblia Glycogen phosphorylase 0.0328 0.2285 0.2366
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0362
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0131 0.0816 0.0816
Entamoeba histolytica glycogenphosphorylase, putative 0.0142 0.0895 0.2256
Toxoplasma gondii ABC1 family protein 0.0036 0.0103 0.0915
Echinococcus granulosus ribonuclease H1 0.0043 0.0158 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Trichomonas vaginalis cytidine deaminase, putative 0.0054 0.024 0.0392
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0783 0.0783
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0023 0.0253
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0103 0.045
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0103 0.0151
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Schistosoma mansoni lipoxygenase 0.0131 0.0816 0.0816
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.005 0.0208 0.0518
Entamoeba histolytica glycogen phosphorylase, putative 0.0328 0.2285 0.6249
Trypanosoma cruzi cruzipain precursor, putative 0.0056 0.0255 0.065
Schistosoma mansoni hypothetical protein 0.0296 0.204 0.204
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0158 0.0378
Schistosoma mansoni inositol monophosphatase 0.0037 0.011 0.011
Echinococcus multilocularis solute carrier family 28 0.0346 0.242 0.242
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0103 0.045
Mycobacterium tuberculosis Conserved protein 0.0036 0.0103 0.0151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0167 0.0731
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0346 0.242 0.242
Entamoeba histolytica hypothetical protein 0.0137 0.0858 0.215
Schistosoma mansoni thyroid hormone receptor 0.0137 0.0859 0.0859
Trichomonas vaginalis thymidylate kinase, putative 0.0142 0.0899 0.2281
Plasmodium falciparum thymidylate kinase 0.0142 0.0899 1
Echinococcus granulosus cytidine deaminase 0.0054 0.024 0.024
Schistosoma mansoni phosphoglucomutase 0.0043 0.0158 0.0158
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0243
Brugia malayi cytidine deaminase, identical 0.0054 0.024 0.1049
Brugia malayi beta-lactamase family protein 0.0036 0.0103 0.045
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0137 0.0858 0.0779
Trypanosoma brucei thymidine kinase 0.0504 0.3592 1
Brugia malayi RNase H family protein 0.0043 0.0158 0.069
Mycobacterium ulcerans cytidine deaminase 0.0054 0.024 0.1718
Entamoeba histolytica glycogen phosphorylase, putative 0.0142 0.0895 0.2256
Echinococcus multilocularis transfer RNA-Ile 0.1363 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0103 0.0151
Mycobacterium tuberculosis Conserved protein 0.0036 0.0103 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0103 0.0225
Brugia malayi thymidylate kinase 0.0142 0.0899 0.3933
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0137 0.0858 0.215
Trypanosoma brucei cytidine deaminase 0.0054 0.024 0.0608
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0197 0.0861
Toxoplasma gondii thymidylate kinase 0.0142 0.0899 1
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0346 0.242 0.242
Giardia lamblia Deoxynucleoside kinase 0.1249 0.915 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0328 0.2285 0.6249
Entamoeba histolytica Thymidylate kinase, putative 0.0142 0.0899 0.2267
Trypanosoma cruzi thymidylate kinase, putative 0.0142 0.0899 0.2455
Onchocerca volvulus 0.0036 0.0103 0.045
Brugia malayi RNase H family protein 0.0043 0.0158 0.069
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0142 0.0899 1
Trichomonas vaginalis thymidine kinase, putative 0.0504 0.3592 1
Schistosoma mansoni glycogen phosphorylase 0.0328 0.2285 0.2285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Echinococcus multilocularis thyroid hormone receptor alpha 0.0137 0.0859 0.0859
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0137 0.0858 0.215
Brugia malayi hypothetical protein 0.0025 0.0023 0.0099
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.011 0.011
Trypanosoma cruzi thymidine kinase, putative 0.0504 0.3592 1
Giardia lamblia Cytidine deaminase 0.0054 0.024 0.0091
Trypanosoma brucei unspecified product 0.005 0.0208 0.0518
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0051 0.0218 0.0549
Loa Loa (eye worm) beta-lactamase 0.0036 0.0103 0.045
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0103 0.0151
Schistosoma mansoni hypothetical protein 0.0142 0.0899 0.0899
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0103 0.0151
Schistosoma mansoni hypothetical protein 0.0171 0.111 0.111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0255 0.065
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0103 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0167 0.0167
Loa Loa (eye worm) glycogen phosphorylase 0.0328 0.2285 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0103 0.0103
Schistosoma mansoni glycogen phosphorylase 0.0328 0.2285 0.2285
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0158 0.0378
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0054 0.024 0.1088
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0243
Loa Loa (eye worm) deoxynucleoside kinase 0.0137 0.0858 0.3754
Leishmania major thymidine kinase, putative 0.0504 0.3592 1
Schistosoma mansoni hypothetical protein 0.0052 0.0225 0.0225
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0056 0.0253 0.0646
Trypanosoma brucei ingi protein (ORF1) 0.005 0.0208 0.0518
Chlamydia trachomatis glycogen phosphorylase 0.0328 0.2285 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.011 0.0991
Mycobacterium ulcerans thymidylate kinase 0.0142 0.0899 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0103 0.0151
Trichomonas vaginalis thymidine kinase, putative 0.0504 0.3592 1
Echinococcus granulosus geminin 0.0171 0.111 0.111
Echinococcus multilocularis thymidine kinase 0.1363 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.045
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0137 0.0858 0.0858
Brugia malayi Deoxynucleoside kinase family protein 0.0137 0.0858 0.3754
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0858 0.2165
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0142 0.0899 0.5604
Trypanosoma cruzi thymidylate kinase, putative 0.0142 0.0899 0.2455
Echinococcus multilocularis geminin 0.0171 0.111 0.111
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.045
Giardia lamblia Hypothetical protein 0.0137 0.0858 0.0779
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0023 0.0253
Schistosoma mansoni hypothetical protein 0.0171 0.111 0.111
Mycobacterium leprae Probable lipase LipE 0.0036 0.0103 0.0269
Loa Loa (eye worm) thymidylate kinase 0.0142 0.0899 0.3933
Echinococcus multilocularis cytidine deaminase 0.0054 0.024 0.024
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0137 0.0858 0.0858
Entamoeba histolytica hypothetical protein 0.0137 0.0858 0.215
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.011 0.0019
Giardia lamblia CDC8 0.0142 0.0899 0.0824
Trichomonas vaginalis thymidylate kinase, putative 0.0142 0.0899 0.2281
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0043 0.0158 0.061
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0056 0.0253 0.0646
Entamoeba histolytica cytidine deaminase, putative 0.0054 0.024 0.0374
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0099
Trypanosoma brucei RNA helicase, putative 0.0296 0.204 0.5653
Entamoeba histolytica hypothetical protein 0.0137 0.0858 0.215
Giardia lamblia Hypothetical protein 0.0137 0.0858 0.0779
Echinococcus granulosus glycogen phosphorylase 0.0328 0.2285 0.2285
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0103 0.0225
Schistosoma mansoni lipoxygenase 0.0092 0.0521 0.0521
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0167 0.0731
Schistosoma mansoni thymidylate kinase 0.0142 0.0899 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0858 0.2165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0167 0.0167
Leishmania major hypothetical protein, conserved 0.0056 0.0253 0.0646
Toxoplasma gondii ribonuclease HI protein 0.0043 0.0158 0.154
Onchocerca volvulus 0.0036 0.0103 0.045
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0137 0.0858 0.215
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0054 0.024 0.2476
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0054 0.024 0.0608
Onchocerca volvulus Putative thymidylate kinase 0.0142 0.0899 0.3933
Entamoeba histolytica hypothetical protein 0.0137 0.0858 0.215
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0103 0.0103

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Vasorelaxant activity against norepinephrine-induced contraction of rat thoracic aortic ring with endothelium ChEMBL. 16784851
Activity (functional) 0 Vasorelaxant activity against norepinephrine-induced contraction of rat thoracic aortic ring without endothelium ChEMBL. 16784851
Activity (functional) 0 Inhibition of potassium ion depolarised calcium-induced contraction of rat aorta mediated by voltage dependent calcium channel at 10 uM ChEMBL. 16784851
Activity (functional) 0 Inhibition of norepinephrine-induced contraction in rat aorta mediated by receptor operated calcium channel in presence of nicardipine at 10 uM ChEMBL. 16784851

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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