Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0853 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0853 | 0.5 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0853 | 0.5 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0853 | 0.5 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0853 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Inhibition of beta amyloid-ABAD interaction by ELISA at 1 mM | ChEMBL. | 16781151 |
Activity (binding) | = 95.6 % | Inhibition of recombinant ABAD (unknown origin) assessed as remaining activity at 25 uM using acetoacetyl-CoA as substrate in presence of NADH by spectrophotometry | ChEMBL. | 27287370 |
IC50 (binding) | = 6.46 uM | Inhibition of beta amyloid-ABAD interaction by ELISA | ChEMBL. | 16781151 |
LogP | = 1.34 | Partition coefficient, log P of the compound | ChEMBL. | 16781151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.