Detailed information for compound 37086

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 246.234 | Formula: C14H11FO3
  • H donors: 1 H acceptors: 2 LogP: 3.01 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1ccccc1Oc1ccccc1F
  • InChi: 1S/C14H11FO3/c15-11-6-2-4-8-13(11)18-12-7-3-1-5-10(12)9-14(16)17/h1-8H,9H2,(H,16,17)
  • InChiKey: LAVKHAMQQVBXLL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-X-C motif) ligand 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum LCCL domain-containing protein chemokine (C-X-C motif) ligand 8 99 aa 80 aa 25.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Plasmodium falciparum replication factor C subunit 1, putative 0.0019 0.0097 0.1756
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0188
Schistosoma mansoni hypothetical protein 0.0677 0.8543 1
Brugia malayi hypothetical protein 0.0019 0.01 0.0186
Plasmodium vivax steroid dehydrogenase, putative 0.0019 0.01 0.1822
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0024 0.0427
Plasmodium vivax hypothetical protein, conserved 0.0019 0.01 0.1822
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0325 0.403 1
Onchocerca volvulus Sepiapterin reductase homolog 0.0019 0.01 0.1394
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1354 0.3277
Echinococcus granulosus hypothetical protein 0.0019 0.01 0.0089
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.01 0.0188
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.2182
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0046 0.0438 0.0486
Echinococcus granulosus oxidoreductase 0.0019 0.01 0.0089
Onchocerca volvulus 0.0019 0.01 0.1394
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0442 0.1044
Brugia malayi dehydrogenases, short chain protein 9 0.0019 0.01 0.0186
Toxoplasma gondii oxidoreductase, putative 0.0019 0.01 0.0188
Brugia malayi Synaptic glycoprotein SC2 0.0046 0.0438 0.102
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0019 0.01 0.0089
Schistosoma mansoni survival motor neuron protein 0.0047 0.0454 0.0505
Onchocerca volvulus 0.0056 0.0565 1
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0019 0.01 0.0076
Toxoplasma gondii carbonyl reductase 1, putative 0.0019 0.01 0.0188
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.0226
Leishmania major short chain dehydrogenase, putative 0.0019 0.01 0.0188
Plasmodium falciparum steroid dehydrogenase, putative 0.0019 0.01 0.1822
Leishmania major GTP-binding protein, putative 0.0021 0.0114 0.0226
Brugia malayi hypothetical protein 0.023 0.281 0.6866
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0469 0.0523
Schistosoma mansoni hypothetical protein 0.0298 0.3681 0.4293
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.01 0.0188
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0019 0.01 0.0089
Schistosoma mansoni carbonyl reductase 0.0019 0.01 0.0089
Loa Loa (eye worm) hypothetical protein 0.0082 0.0908 0.2178
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.01 0.0188
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0097 0.0181
Onchocerca volvulus 0.0019 0.01 0.1394
Brugia malayi hypothetical protein 0.0019 0.01 0.0186
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0325 0.403 1
Plasmodium vivax polyprenol reductase, putative 0.0046 0.0438 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0019 0.01 0.0076
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.01 0.0188
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0097 0.0181
Onchocerca volvulus 0.0019 0.01 0.1394
Entamoeba histolytica Ran family GTPase 0.0021 0.0114 0.0226
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0442 0.1044
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0181
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.01 0.0188
Plasmodium falciparum polyprenol reductase, putative 0.0046 0.0438 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0019 0.01 0.0186
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0019 0.01 0.1762
Brugia malayi MH2 domain containing protein 0.0117 0.1354 0.3277
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0019 0.01 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0442 1
Schistosoma mansoni carbonyl reductase 0.0019 0.01 0.0089
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0019 0.01 0.0089
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.01 0.1762
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0019 0.01 0.1762
Echinococcus granulosus sterol regulatory element binding protein 0.0082 0.0908 0.1038
Loa Loa (eye worm) carboxylesterase 0.0329 0.4082 1
Schistosoma mansoni ran 0.0021 0.0114 0.0106
Schistosoma mansoni topbp1 0.0019 0.0097 0.0085
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.0438 1
Toxoplasma gondii ATPase, AAA family protein 0.0019 0.0097 0.0181
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.01 0.0188
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Schistosoma mansoni hypothetical protein 0.0079 0.087 0.0993
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0114 0.2182
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0019 0.01 0.0089
Leishmania major hypothetical protein, conserved 0.0019 0.01 0.0188
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0442 0.1044
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0019 0.01 0.1805
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.0293 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.01 0.0188
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0488 0.1158
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.01 0.0188
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0325 0.403 0.9872
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0046 0.0438 0.0415
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.01 0.0188
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Mycobacterium leprae Probable oxidoreductase 0.0019 0.01 0.1805
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Brugia malayi dehydrogenases, short chain protein 2 0.0019 0.01 0.0186
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.01 0.1822
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0223
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.01 0.0188
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0019 0.01 0.007
Echinococcus granulosus acetylcholinesterase 0.0329 0.4082 0.4763
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0188
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0488 0.1144
Loa Loa (eye worm) hypothetical protein 0.0056 0.0565 0.1334
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0019 0.0097 0.0181
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Mycobacterium ulcerans dehydrogenase/reductase 0.0019 0.01 0.0188
Trypanosoma cruzi FHA domain containing protein, putative 0.0019 0.0097 0.0181
Giardia lamblia Reductase, putative 0.0019 0.01 0.007
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.01 0.0188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0418 0.0462
Loa Loa (eye worm) hypothetical protein 0.0048 0.0469 0.1097
Loa Loa (eye worm) hypothetical protein 0.0028 0.0209 0.0456
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0019 0.01 0.0076
Schistosoma mansoni importin beta-1 0.0028 0.0209 0.0217
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0019 0.01 0.0188
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0325 0.403 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0442 0.7822
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.01 0.0188
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0046 0.0438 0.1034
Leishmania major hypothetical protein, conserved 0.0019 0.01 0.0188
Echinococcus granulosus BC026374 protein S09 family 0.0056 0.0565 0.0635
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0056 0.0565 1
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0019 0.01 0.0188
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0019 0.01 0.0188
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0019 0.01 0.0089
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0488 0.0545
Loa Loa (eye worm) oxidoreductase 0.0019 0.01 0.0186
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0488 0.0465
Mycobacterium ulcerans hypothetical protein 0.0325 0.403 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.01 0.0188
Loa Loa (eye worm) oxidoreductase 0.0019 0.01 0.0186
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0141 0.0293
Echinococcus multilocularis para nitrobenzyl esterase 0.0056 0.0565 0.0542
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0488 0.0545
Echinococcus granulosus snurportin 1 0.0298 0.3681 0.4293
Echinococcus multilocularis Niemann Pick C1 protein 0.0274 0.3373 0.3357
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.01 0.1762
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Loa Loa (eye worm) hypothetical protein 0.0056 0.0565 0.1334
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.01 0.0188
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0019 0.0097 0.1739
Echinococcus granulosus WW domain containing oxidoreductase 0.0019 0.01 0.0089
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0488 0.1158
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.01 0.1394
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.0438 0.1034
Schistosoma mansoni hypothetical protein 0.0079 0.087 0.0993
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0442 0.1044
Onchocerca volvulus 0.0046 0.0442 0.7724
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0046 0.0438 0.0486
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0019 0.01 0.0188
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Echinococcus granulosus Niemann Pick C1 protein 0.0192 0.2315 0.2689
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.01 0.1762
Plasmodium falciparum importin beta, putative 0.0028 0.0209 0.447
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0192 0.2315 0.5719
Entamoeba histolytica hypothetical protein 0.007 0.0751 0.1815
Schistosoma mansoni neuroligin 3 (S09 family) 0.0056 0.0565 0.0635
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0209 0.0462
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0114 0.0106
Echinococcus multilocularis oxidoreductase 0.0019 0.01 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0438 0.1034
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.01 0.0188
Onchocerca volvulus 0.0047 0.0454 0.7944
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.01 0.0188
Loa Loa (eye worm) hypothetical protein 0.0046 0.0442 0.103
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0442 0.1044
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.01 0.0188
Echinococcus granulosus tumor protein p63 0.0329 0.408 0.4761
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0056 0.0565 0.0635
Treponema pallidum DNA ligase (lig) 0.0019 0.0097 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.01 0.0188
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0019 0.01 0.1762
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0114 0.0226
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.01 0.0076
Entamoeba histolytica short chain dehydrogenase family protein 0.0019 0.01 0.0188
Onchocerca volvulus 0.0019 0.01 0.1394
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Onchocerca volvulus 0.0056 0.0565 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0488 0.1158
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0024 0.0427
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0097 0.0181
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.01 0.1762
Echinococcus granulosus Protein patched homolog 1 0.0082 0.0908 0.1038
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.01 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0908 0.2207
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0268 0.4748
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0019 0.01 0.0186
Mycobacterium tuberculosis Probable dehydrogenase 0.0019 0.01 0.1762
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Leishmania major importin beta-1 subunit, putative 0.0023 0.0141 0.0293
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.01 0.0188
Schistosoma mansoni hypothetical protein 0.0047 0.0454 0.0505
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0418 0.0971
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0046 0.0438 0.1034
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0019 0.01 0.0188
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0179
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Loa Loa (eye worm) hypothetical protein 0.0046 0.0442 0.103
Loa Loa (eye worm) hypothetical protein 0.0034 0.0293 0.0662
Onchocerca volvulus 0.0019 0.01 0.1394
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0019 0.01 0.0188
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0325 0.403 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0209 0.0462
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0019 0.01 0.0186
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.281 0.2793
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Brugia malayi Carboxylesterase family protein 0.0056 0.0565 0.1334
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0019 0.01 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.01 0.0188
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0188
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.01 0.1762
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0488 0.0465
Echinococcus multilocularis acetylcholinesterase 0.0329 0.4082 0.4067
Loa Loa (eye worm) oxidoreductase 0.0019 0.01 0.0186
Leishmania major oxidoreductase-like protein 0.0019 0.01 0.0188
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0141 0.0293
Onchocerca volvulus 0.0056 0.0565 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0488 0.1158
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.01 0.1762
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0488 0.1158
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0019 0.01 0.1822
Plasmodium vivax importin-beta 2, putative 0.0028 0.0209 0.447
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0019 0.01 0.1762
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.01 0.0188
Entamoeba histolytica short chain dehydrogenase family protein 0.0019 0.01 0.0188
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.01 0.0188
Mycobacterium ulcerans dehydrogenase 0.0019 0.01 0.0188
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.01 0.0188
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0442 0.1044
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Brugia malayi topoisomerase 0.0019 0.0097 0.0179
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0019 0.01 0.0188
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0488 0.1158
Echinococcus granulosus importin subunit beta 1 0.0028 0.0209 0.0217
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0019 0.0097 0.0181
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0209 0.0186
Echinococcus multilocularis expressed conserved protein 0.018 0.2165 0.2147
Echinococcus granulosus neuroligin 0.0056 0.0565 0.0635
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.0438 0.1034
Echinococcus multilocularis protein dispatched 1 0.0094 0.1057 0.1036
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.01 0.0188
Loa Loa (eye worm) hypothetical protein 0.0034 0.0293 0.0662
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0179
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.01 0.1762
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0019 0.01 0.0188
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0442 0.1044
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0325 0.403 1
Echinococcus granulosus steroid dehydrogenase 0.0019 0.01 0.0089
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.01 0.1762
Onchocerca volvulus 0.0056 0.0565 1
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0046 0.0438 0.1034
Loa Loa (eye worm) hypothetical protein 0.0046 0.0442 0.103
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0427
Echinococcus multilocularis snurportin 1 0.0298 0.3681 0.3666
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Leishmania major short chain dehydrogenase-like protein 0.0019 0.01 0.0188
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Echinococcus granulosus carbonyl reductase 1 0.0019 0.01 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0442 0.1044
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0082 0.0908 0.2178
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0488 0.1158
Schistosoma mansoni carbonyl reductase 0.0019 0.01 0.0089
Giardia lamblia Hypothetical protein 0.0019 0.01 0.007
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0442 0.1044
Brugia malayi hypothetical protein 0.0019 0.0097 0.0179
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0442 0.7822
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0195 0.2353 0.2734
Echinococcus multilocularis tumor protein p63 0.0329 0.408 0.4065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0293 0.0662
Onchocerca volvulus 0.0019 0.01 0.1394
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Loa Loa (eye worm) oxidoreductase 0.0019 0.01 0.0186
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0019 0.01 0.1762
Brugia malayi CHE-14 protein 0.0082 0.0908 0.2178
Mycobacterium ulcerans short-chain type oxidoreductase 0.0019 0.01 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.01 0.0188
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0181
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0019 0.01 0.0188
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0179
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0097 0.0181
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0019 0.01 0.1762
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.01 0.0188
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0056 0.0565 0.0635
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0141 0.0293
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.0293 0.067
Loa Loa (eye worm) carboxylesterase 0.0056 0.0565 0.1334
Mycobacterium ulcerans carveol-like dehydrogenase 0.0019 0.01 0.0188
Brugia malayi RNA, U transporter 1 0.0079 0.0871 0.2087
Onchocerca volvulus 0.0019 0.01 0.1394
Echinococcus multilocularis Niemann Pick C1 protein 0.0192 0.2315 0.2296
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.01 0.0188
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0056 0.0565 0.0635
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0019 0.0097 0.0181
Entamoeba histolytica hypothetical protein 0.0019 0.01 0.0188
Echinococcus granulosus replication factor c subunit 1 0.0019 0.0097 0.0085
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0488 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0097 0.0181
Trichomonas vaginalis steroid dehydrogenase, putative 0.0019 0.01 0.0188
Leishmania major pteridine reductase 1 0.0019 0.01 0.0188
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.01 0.1762
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.01 0.0188
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.01 0.0188
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Schistosoma mansoni patched 1 0.0082 0.0908 0.1038
Leishmania major 3-keto-dihydrosphingosine reductase 0.0019 0.01 0.0188
Brugia malayi hypothetical protein 0.007 0.0751 0.1791
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0097 0.0181
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0019 0.01 0.1762
Brugia malayi Carboxylesterase family protein 0.0056 0.0565 0.1334
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.0438 1
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0046 0.0438 0.1034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0268 0.4748
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Mycobacterium tuberculosis Carboxylesterase LipT 0.0056 0.0565 1
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0418 0.0971
Mycobacterium ulcerans oxidoreductase 0.0019 0.01 0.0188
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0442 1
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0442 0.103
Echinococcus granulosus expressed conserved protein 0.018 0.2165 0.2514
Brugia malayi oxidoreductase 0.0019 0.01 0.0186
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0188
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Echinococcus multilocularis conserved hypothetical protein 0.0019 0.01 0.0076
Echinococcus granulosus carboxylesterase 5A 0.0329 0.4082 0.4763
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.0293 0.6483
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Echinococcus granulosus carbonyl reductase 1 0.0019 0.01 0.0089
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0056 0.0565 1
Onchocerca volvulus 0.0019 0.01 0.1394
Brugia malayi Pax transcription activation domain interacting protein 0.0019 0.0097 0.0179
Trypanosoma brucei protein kinase, putative 0.005 0.0488 0.1158
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0427
Giardia lamblia Short-chain dehydrogenase, putative 0.0019 0.01 0.007
Onchocerca volvulus 0.0056 0.0565 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0019 0.01 0.1805
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0329 0.4082 0.4763
Loa Loa (eye worm) dehydrogenase 0.0019 0.01 0.0186
Loa Loa (eye worm) hypothetical protein 0.0034 0.0293 0.0662
Brugia malayi Dehydrogenases, short chain protein 30 0.0019 0.01 0.0186
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0418 0.0395
Brugia malayi Niemann-Pick C1 protein precursor 0.0192 0.2315 0.5646
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0056 0.0565 0.0542
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.01 0.0188
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0179
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0325 0.403 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.0293 0.6483
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0019 0.01 0.1762
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.01 0.0188
Entamoeba histolytica hypothetical protein 0.007 0.0751 0.1815
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0046 0.0438 0.1034
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0024 0.0427
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0056 0.0565 0.1351
Echinococcus granulosus synaptic glycoprotein sc2 0.0046 0.0438 0.0486
Loa Loa (eye worm) oxidoreductase 0.0019 0.01 0.0186
Trichomonas vaginalis replication factor C large subunit, putative 0.0019 0.0097 0.0181
Echinococcus granulosus para nitrobenzyl esterase 0.0056 0.0565 0.0635
Loa Loa (eye worm) hypothetical protein 0.0046 0.0438 0.102
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.3681 0.9013
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.01 0.0089
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Onchocerca volvulus 0.0033 0.0273 0.4605
Loa Loa (eye worm) hypothetical protein 0.0325 0.403 0.9872
Leishmania major hypothetical protein, conserved 0.0019 0.01 0.0188
Onchocerca volvulus 0.0019 0.0097 0.1343
Brugia malayi hypothetical protein 0.0019 0.0097 0.0179
Brugia malayi DKFZp564C0469 protein 0.0019 0.0097 0.0179
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0046 0.0438 0.0486
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0488 0.1158
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0751 0.0853
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0019 0.01 0.1394
Onchocerca volvulus 0.0019 0.01 0.1394
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Mycobacterium ulcerans carboxylesterase, LipT 0.0056 0.0565 0.1351
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0019 0.01 0.1805
Entamoeba histolytica hypothetical protein 0.0023 0.0141 0.0293
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0024 0.0427
Leishmania major hypothetical protein, conserved 0.0019 0.01 0.0188
Brugia malayi Dehydrogenases, short chain protein 2 0.0019 0.01 0.0186
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.01 0.0076
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0325 0.403 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0565 0.1334
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0427
Brugia malayi MAP kinase sur-1 0.005 0.0488 0.1144
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0024 0.0427
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0418 0.0395
Echinococcus multilocularis BC026374 protein (S09 family) 0.0056 0.0565 0.0542
Schistosoma mansoni hypothetical protein 0.0677 0.8543 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.01 0.0188
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0179
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0451
Schistosoma mansoni ran 0.0021 0.0114 0.0106
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.01 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.01 0.0188
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0019 0.01 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0438 0.1034
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0114 0.0091
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.01 0.0188
Onchocerca volvulus 0.0048 0.0469 0.8228
Onchocerca volvulus 0.0046 0.0438 0.7651
Loa Loa (eye worm) hypothetical protein 0.0329 0.4082 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1354 0.3277
Entamoeba histolytica hypothetical protein 0.0046 0.0438 0.1034
Loa Loa (eye worm) acetylcholinesterase 1 0.0329 0.4082 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0751 0.0729
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0442 0.1044
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0325 0.403 1
Echinococcus multilocularis carboxylesterase 5A 0.0329 0.4082 0.4067
Echinococcus granulosus carbonyl reductase 1 0.0019 0.01 0.0089
Schistosoma mansoni hypothetical protein 0.007 0.0751 0.0853
Mycobacterium ulcerans hypothetical protein 0.0046 0.0442 0.1044
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0442 0.1044
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0019 0.01 0.1805
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0024 0.0427
Schistosoma mansoni BC026374 protein (S09 family) 0.0056 0.0565 0.0635
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.01 0.0076
Loa Loa (eye worm) hypothetical protein 0.0056 0.0565 0.1334
Loa Loa (eye worm) hypothetical protein 0.0056 0.0565 0.1334
Echinococcus multilocularis protein patched 0.0082 0.0908 0.0886
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0488 0.1158
Echinococcus multilocularis replication factor c subunit 1 0.0019 0.0097 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0268 0.4748
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0097 0.0181
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Schistosoma mansoni acetylcholinesterase 0.0056 0.0565 0.0635
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0019 0.01 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0181
Echinococcus granulosus geminin 0.0677 0.8543 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0442 0.1044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0097 0.0179
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0442 0.103
Schistosoma mansoni retinal dehydrogenase 0.0019 0.01 0.0089
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Schistosoma mansoni DNA ligase IV 0.0019 0.0097 0.0085
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0046 0.0438 0.1034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Echinococcus multilocularis acetylcholinesterase 0.0329 0.4082 0.4067
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.01 0.0188
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0019 0.01 0.0076
Schistosoma mansoni hypothetical protein 0.0079 0.087 0.0993
Loa Loa (eye worm) oxidoreductase 0.0019 0.01 0.0186
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.01 0.1394
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0019 0.01 0.0188
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.01 0.1762
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0442 0.103
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0019 0.01 0.0188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0418 0.0462
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0056 0.0565 0.0635
Brugia malayi Carboxylesterase family protein 0.0056 0.0565 0.1334
Trypanosoma brucei oxidoreductase-like protein 0.0019 0.01 0.0188
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.01 0.1762
Schistosoma mansoni gliotactin 0.0056 0.0565 0.0635
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0186
Loa Loa (eye worm) hypothetical protein 0.0034 0.0293 0.0662
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0488 0.1158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0268 0.4748
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0186
Giardia lamblia Synaptic glycoprotein SC2 0.0046 0.0438 0.8723
Loa Loa (eye worm) hypothetical protein 0.0101 0.1146 0.2765
Echinococcus granulosus carbonyl reductase 1 0.0019 0.01 0.0089
Trichomonas vaginalis spcc417.12 protein, putative 0.0056 0.0565 0.1351
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0488 0.1158
Echinococcus multilocularis geminin 0.0677 0.8543 0.854
Echinococcus granulosus nibrin 0.0019 0.0097 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0418 0.0462
Loa Loa (eye worm) carboxylesterase 0.0056 0.0565 0.1334
Schistosoma mansoni chromosome transmission fidelity factor 0.0019 0.0097 0.0085
Brugia malayi Retinol dehydrogenase 12 0.0019 0.01 0.0186
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0019 0.01 0.0188
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0019 0.01 0.0089
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.01 0.0076
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.01 0.0076
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.01 0.0076
Brugia malayi Carboxylesterase family protein 0.0329 0.4082 1
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.01 0.0076
Brugia malayi Carboxylesterase family protein 0.0056 0.0565 0.1334
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.01 0.1762
Schistosoma mansoni hypothetical protein 0.0079 0.087 0.0993
Onchocerca volvulus 0.0019 0.01 0.1394
Loa Loa (eye worm) hypothetical protein 0.0192 0.2315 0.5646
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.01 0.0188
Echinococcus multilocularis nibrin 0.0019 0.0097 0.0073
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0019 0.01 0.0089
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0209 0.0462
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Leishmania major dehydrogenase-like protein 0.0019 0.01 0.0188
Entamoeba histolytica hypothetical protein 0.0019 0.0097 0.0181
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0019 0.01 0.0188
Toxoplasma gondii oxidoreductase, putative 0.0019 0.01 0.0188
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0019 0.01 0.0188
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.01 0.1762
Entamoeba histolytica hypothetical protein 0.007 0.0751 0.1815
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.01 0.0188
Mycobacterium ulcerans oxidoreductase 0.0019 0.01 0.0188
Plasmodium vivax replication factor C subunit 1, putative 0.0019 0.0097 0.1756
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0488 0.0545
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0325 0.403 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0418 0.0462
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0019 0.01 0.1762
Echinococcus granulosus hypothetical protein 0.0019 0.01 0.0089
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0019 0.01 0.0188
Brugia malayi hypothetical protein 0.0056 0.0565 0.1334
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0751 0.0853
Schistosoma mansoni steroid dehydrogenase 0.0019 0.01 0.0089
Loa Loa (eye worm) oxidoreductase 0.0019 0.01 0.0186
Schistosoma mansoni topbp1 0.0019 0.0097 0.0085
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.01 0.0089
Onchocerca volvulus 0.0019 0.01 0.1394
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0223
Echinococcus multilocularis sterol regulatory element binding protein 0.0082 0.0908 0.0886
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0097 0.0181
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.0293 0.5175
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.01 0.0188
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0019 0.01 0.0188
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0442 0.1044
Loa Loa (eye worm) hypothetical protein 0.0056 0.0565 0.1334
Loa Loa (eye worm) hypothetical protein 0.0046 0.0438 0.102
Loa Loa (eye worm) oxidoreductase 0.0019 0.01 0.0186
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0019 0.01 0.0089
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0019 0.0097 0.0179
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.0438 0.1034
Echinococcus granulosus survival motor neuron protein 1 0.023 0.281 0.327
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.01 0.0188
Brugia malayi Importin beta-1 subunit 0.0028 0.0209 0.0456
Leishmania major hypothetical protein, conserved 0.0019 0.01 0.0188
Echinococcus granulosus Niemann Pick C1 protein 0.0274 0.3373 0.3931
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.01 0.0076
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.01 0.1762
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0488 0.1158
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0181
Onchocerca volvulus 0.0019 0.01 0.1394
Leishmania major short chain dehydrogenase, putative 0.0019 0.01 0.0188
Loa Loa (eye worm) oxidoreductase 0.0019 0.01 0.0186
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.01 0.1762
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0427
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0019 0.01 0.0188
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.0226
Loa Loa (eye worm) hypothetical protein 0.0056 0.0565 0.1334
Loa Loa (eye worm) dehydrogenase 0.0019 0.01 0.0186
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0141 0.0293
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.01 0.0188
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0019 0.01 0.0076
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.0226
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.01 0.0188
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.01 0.0188
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0454 0.106
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0019 0.01 0.1805
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0418 0.0462
Loa Loa (eye worm) hypothetical protein 0.0329 0.4082 1
Brugia malayi Carboxylesterase family protein 0.0329 0.4082 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0019 0.01 0.1762
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.01 0.1762
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.01 0.1762
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.01 0.0188
Echinococcus multilocularis neuroligin 0.0056 0.0565 0.0542
Schistosoma mansoni short chain dehydrogenase 0.0019 0.01 0.0089
Entamoeba histolytica hypothetical protein 0.007 0.0751 0.1815
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.01 0.0188
Trichomonas vaginalis ran, putative 0.0021 0.0114 0.0226
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0046 0.0438 0.1034
Loa Loa (eye worm) hypothetical protein 0.023 0.281 0.6866
Echinococcus multilocularis retinol dehydrogenase 13 0.0019 0.01 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0097 0.0181
Echinococcus multilocularis synaptic glycoprotein sc2 0.0046 0.0438 0.0415
Echinococcus granulosus acetylcholinesterase 0.0329 0.4082 0.4763
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0024 0.0427

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) > 95 % Cytotoxicity against mouse L1.2 cells assessed as cell viability by trypan blue dye exclusion assay ChEMBL. 19560921
IC50 (binding) = 13 nM Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay ChEMBL. 19560921
Reduction (functional) NT 0 Reduction in paw swelling at 200 mg/kg po dose in rat using rat paw carrageenin test;NT means not tested. ChEMBL. 6620297
Relative potency (functional) ND 0 Potency relative to [2-(2,4-Dichloro-phenoxy)-phenyl]-acetic acid in rat adjuvant arthritis test;ND means no data. ChEMBL. 6620297

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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