Detailed information for compound 370861

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 581.933 | Formula: C25H25ClF7N4O2-
  • H donors: 2 H acceptors: 3 LogP: 5.93 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN([C@H]1CC[C@H]([C@H]1c1ccc(cc1)F)O[C@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)Cc1n[nH]c(n1)O.[Cl-]
  • InChi: 1S/C25H25F7N4O2.ClH/c1-13(15-9-16(24(27,28)29)11-17(10-15)25(30,31)32)38-20-8-7-19(22(20)14-3-5-18(26)6-4-14)36(2)12-21-33-23(37)35-34-21;/h3-6,9-11,13,19-20,22H,7-8,12H2,1-2H3,(H2,33,34,35,37);1H/p-1/t13-,19-,20+,22+;/m1./s1
  • InChiKey: FUCSKBZQBHJLCL-WICBNPBRSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0218 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0151 0.1071 0.2152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0204 0.0193
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0017 0.005 0.0101
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0274 0.0534
Loa Loa (eye worm) sirtuin 4 0.0017 0.005 0.0039
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0355 0.2636 0.2628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.1071 0.2152
Entamoeba histolytica cysteine protease, putative 0.0656 0.4933 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0274 0.0263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Brugia malayi beta-lactamase 0.0037 0.0204 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0656 0.4933 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0017 0.005 0.0078
Brugia malayi Importin beta-1 subunit 0.0063 0.0401 0.039
Brugia malayi cathepsin Z-like cysteine proteinase 0.0151 0.1071 0.106
Mycobacterium ulcerans lipase LipD 0.0037 0.0204 0.5576
Schistosoma mansoni DNA helicase recq1 0.002 0.0077 0.0065
Trypanosoma cruzi cruzipain precursor, putative 0.0205 0.1486 0.1466
Echinococcus granulosus cathepsin L cysteine protease 0.0355 0.2636 0.2628
Leishmania major silent information regulator 2, putative 0.0017 0.005 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0065
Trypanosoma cruzi cysteine proteinase, putative 0.0355 0.2636 0.2619
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0218 0.0207
Plasmodium vivax serine-repeat antigen (SERA) 0.0151 0.1071 0.217
Echinococcus multilocularis cathepsin L 0.0355 0.2636 0.2628
Loa Loa (eye worm) RecQ helicase 0.002 0.0077 0.0065
Mycobacterium tuberculosis Conserved protein 0.0037 0.0204 0.0149
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0274 0.0263
Loa Loa (eye worm) hypothetical protein 0.0205 0.1486 0.1477
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0014 0.0024 0.0026
Trypanosoma cruzi cysteine proteinase, putative 0.0355 0.2636 0.2619
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0218 0.0194
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Brugia malayi transcriptional regulator, Sir2 family protein 0.0017 0.005 0.0039
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0077 0.0132
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0017 0.005 0.0039
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0077 0.0065
Loa Loa (eye worm) fibroinase 0.0656 0.4933 0.4927
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0014 0.0024 0.0026
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0077 0.0132
Trypanosoma cruzi cysteine peptidase, putative 0.0656 0.4933 0.4921
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0218 0.0239
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0039
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0401 0.039
Giardia lamblia Hypothetical protein 0.0151 0.1071 0.2748
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0211 0.02
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0017 0.005 0.0078
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0204 0.0193
Loa Loa (eye worm) hypothetical protein 0.1319 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0355 0.2636 0.5334
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Mycobacterium ulcerans NAD-dependent deacetylase 0.0053 0.0326 1
Toxoplasma gondii cathepsin CPC1 0.0151 0.1071 0.217
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Entamoeba histolytica hypothetical protein 0.0051 0.031 0.0629
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0053 0.0326 0.064
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0204 0.0149
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0151 0.1071 0.217
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0204 0.0391
Plasmodium falciparum serine repeat antigen 2 0.0151 0.1071 0.2152
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0017 0.005 0.0068
Loa Loa (eye worm) transcriptional regulator 0.0017 0.005 0.0039
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0017 0.005 0.0039
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Plasmodium falciparum serine repeat antigen 7 0.0151 0.1071 0.2152
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0017 0.005 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.1071 0.2152
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0204 0.0149
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1486 0.1466
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0656 0.4933 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0204 0.0391
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0355 0.2636 0.2628
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0077 0.0132
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0204 0.0391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.0024 0.0026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0274 0.0251
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Leishmania major sir2-family protein-like protein 0.0017 0.005 0.0078
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0024 0.0049
Brugia malayi cathepsin L-like precursor 0.0451 0.3367 0.336
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.0024 0.0026
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0204 0.0149
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0077 0.0065
Schistosoma mansoni ap endonuclease 0.0039 0.0218 0.0207
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0211 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0656 0.4933 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0169 0.1211 0.1201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.1071 0.106
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Giardia lamblia Cathepsin B precursor 0.0512 0.3832 1
Loa Loa (eye worm) RNA binding protein 0.0138 0.0977 0.0966
Mycobacterium tuberculosis Conserved protein 0.0037 0.0204 0.0149
Loa Loa (eye worm) beta-lactamase 0.0037 0.0204 0.0193
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0151 0.1071 0.106
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0151 0.1071 0.217
Plasmodium vivax vivapain-3 0.0355 0.2636 0.5345
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0204 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.1071 0.2152
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0218 0.0509
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0169 0.1211 0.1201
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0656 0.4933 0.4927
Plasmodium falciparum serine repeat antigen 1 0.0151 0.1071 0.2152
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0218 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0151 0.1071 0.106
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0151 0.1071 0.2152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Echinococcus granulosus geminin 0.0175 0.1255 0.1245
Brugia malayi Papain family cysteine protease containing protein 0.0355 0.2636 0.2628
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0205 0.1486 0.1477
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0204 0.0149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0274 0.0251
Echinococcus multilocularis cathepsin L cysteine protease 0.0656 0.4933 0.4927
Loa Loa (eye worm) hypothetical protein 0.0205 0.1486 0.1477
Brugia malayi Cathepsin L-like precursor 0.0451 0.3367 0.336
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0451 0.3367 0.3351
Trypanosoma cruzi cruzipain precursor, putative 0.0656 0.4933 0.4921
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Giardia lamblia Cathepsin B precursor 0.0512 0.3832 1
Plasmodium falciparum importin beta, putative 0.0063 0.0401 0.0792
Onchocerca volvulus 0.0656 0.4933 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0053 0.0326 0.064
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0151 0.1071 0.106
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0151 0.1071 0.106
Plasmodium falciparum serine repeat antigen 3 0.0151 0.1071 0.2152
Echinococcus multilocularis cathepsin L cysteine protease 0.0656 0.4933 0.4927
Schistosoma mansoni chromatin regulatory protein sir2 0.0053 0.0326 0.0315
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0451 0.3367 0.336
Brugia malayi Cathepsin L-like cysteine proteinase 0.0451 0.3367 0.336
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0053 0.0326 0.064
Loa Loa (eye worm) transcriptional regulator 0.0017 0.005 0.0039
Echinococcus multilocularis cysteine protease 0.0656 0.4933 0.4927
Loa Loa (eye worm) TAR-binding protein 0.0138 0.0977 0.0966
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Entamoeba histolytica cysteine proteinase, putative 0.0355 0.2636 0.5345
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Echinococcus multilocularis bloom syndrome protein 0.002 0.0077 0.0065
Schistosoma mansoni cathepsin C 0.0151 0.1071 0.106
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Loa Loa (eye worm) hypothetical protein 0.0205 0.1486 0.1477
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0355 0.2636 0.5334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Onchocerca volvulus 0.0656 0.4933 1
Schistosoma mansoni ran 0.0046 0.0274 0.0263
Loa Loa (eye worm) hypothetical protein 0.0656 0.4933 0.4927
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0151 0.1071 0.217
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0151 0.1071 0.217
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0151 0.1071 0.217
Brugia malayi cathepsin L-like cysteine proteinase 0.0151 0.1071 0.106
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0656 0.4933 0.4927
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Brugia malayi transcriptional regulator, Sir2 family protein 0.0017 0.005 0.0039
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0065
Brugia malayi beta-lactamase family protein 0.0037 0.0204 0.0193
Echinococcus granulosus cathepsin L cysteine proteinase 0.0656 0.4933 0.4927
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0218 0.042
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.0024 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0355 0.2636 0.5334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0204 0.0193
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Leishmania major importin beta-1 subunit, putative 0.0051 0.031 0.0607
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0211 0.0406
Giardia lamblia Cathepsin L-like protease 0.0151 0.1071 0.2748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0355 0.2636 0.5334
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0155
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0024 0.0013
Schistosoma mansoni hypothetical protein 0.0175 0.1255 0.1245
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.1071 0.2748
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0151 0.1071 0.106
Entamoeba histolytica recQ family helicase, putative 0.002 0.0077 0.0155
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0274 0.0657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Entamoeba histolytica HEAT repeat domain containing protein 0.0012 0.0011 0.0023
Plasmodium falciparum serine repeat antigen 5 0.0151 0.1071 0.2152
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0014 0.0024 0.0013
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0077 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0204 0.0391
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0204 0.0193
Schistosoma mansoni hypothetical protein 0.0672 0.5053 0.5048
Toxoplasma gondii cathepsin CPL 0.0656 0.4933 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0077 0.0053
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.0977 0.0966
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0151 0.1071 0.217
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0218 0.6079
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0401 0.0813
Entamoeba histolytica hypothetical protein 0.0151 0.1071 0.217
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0017 0.005 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0401 0.0792
Brugia malayi cathepsin F-like cysteine proteinase 0.0151 0.1071 0.106
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0355 0.2636 0.2619
Brugia malayi cathepsin Z-like cysteine proteinase 0.0151 0.1071 0.106
Onchocerca volvulus Cathepsin L homolog 0.0151 0.1071 0.1833
Brugia malayi TAR-binding protein 0.0138 0.0977 0.0966
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0218 0.042
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.031 0.0607
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0204 1
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0355 0.2636 0.5334
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0151 0.1071 0.2152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Schistosoma mansoni cathepsin F (C01 family) 0.0656 0.4933 0.4927
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0401 0.0792
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Brugia malayi Papain family cysteine protease containing protein 0.0656 0.4933 0.4927
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0211 0.0406
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0512 0.3832 0.3825
Loa Loa (eye worm) hypothetical protein 0.0451 0.3367 0.336
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.0977 0.0966
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Brugia malayi transcriptional regulator, Sir2 family protein 0.0017 0.005 0.0039
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0151 0.1071 0.217
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0053 0.0326 0.0303
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0065
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Plasmodium vivax serine-repeat antigen (SERA) 0.0151 0.1071 0.217
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0169 0.1211 0.1201
Loa Loa (eye worm) pip kinase 2 0.0169 0.1211 0.1201
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0204 0.5576
Brugia malayi Pip kinase protein 2 0.0169 0.1211 0.1201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0656 0.4933 0.4927
Brugia malayi Pip kinase protein 1 0.0014 0.0024 0.0013
Toxoplasma gondii histone deacetylase SIR2 0.0053 0.0326 0.0662
Entamoeba histolytica cysteine proteinase, putative 0.0355 0.2636 0.5345
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0053 0.0326 0.0662
Trypanosoma cruzi cysteine peptidase, putative 0.0656 0.4933 0.4921
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0024 0.0013
Toxoplasma gondii histone deacetylase SIR2-like 0.0017 0.005 0.0101
Giardia lamblia Encystation-specific protease 0.0151 0.1071 0.2748
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0024 0.0026
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Brugia malayi NAD-dependent deacetylase SIRT1 0.0017 0.005 0.0039
Toxoplasma gondii cathepsin CPC2 0.0151 0.1071 0.217
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0024 0.0013
Echinococcus granulosus cathepsin l cysteine peptidase 0.0656 0.4933 0.4927
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.031 0.0607
Schistosoma mansoni cathepsin S (C01 family) 0.0151 0.1071 0.106
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0355 0.2636 0.2628
Loa Loa (eye worm) hypothetical protein 0.0169 0.1211 0.1201
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1319 1 1
Echinococcus granulosus chromatin regulatory protein sir2 0.0017 0.005 0.0039
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.0024 0.0013
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0151 0.1071 0.106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0218 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Brugia malayi fibroinase precursor 0.0151 0.1071 0.106
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0017 0.005 0.0039
Brugia malayi Cathepsin L-like precursor 0.0451 0.3367 0.336
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0274 0.0556
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Loa Loa (eye worm) hypothetical protein 0.0451 0.3367 0.336
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0211 0.0428
Echinococcus multilocularis tar DNA binding protein 0.0138 0.0977 0.0966
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0151 0.1071 0.2152
Toxoplasma gondii ABC1 family protein 0.0037 0.0204 0.0414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0151 0.1071 0.217
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0151 0.1071 0.217
Leishmania major cysteine peptidase A (CPA) 0.0656 0.4933 1
Onchocerca volvulus 0.0656 0.4933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0274 0.0263
Mycobacterium leprae Probable lipase LipE 0.0037 0.0204 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0211 0.0406
Plasmodium falciparum serine repeat antigen 8 0.0151 0.1071 0.2152
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0151 0.1071 0.106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Giardia lamblia Cysteine protease 0.0151 0.1071 0.2748
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0017 0.005 0.0026
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0151 0.1071 0.2152
Loa Loa (eye worm) inositol-1 0.0038 0.0211 0.02
Giardia lamblia Hypothetical protein 0.0151 0.1071 0.2748
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Schistosoma mansoni cathepsin F (C01 family) 0.0656 0.4933 0.4927
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1071 0.2152
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0218 0.0207
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0014 0.0024 0.0026
Onchocerca volvulus Cathepsin L homolog 0.0656 0.4933 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0151 0.1071 0.106
Plasmodium vivax vivapain-2 0.0656 0.4933 1
Echinococcus granulosus tar DNA binding protein 0.0138 0.0977 0.0966
Trypanosoma brucei SIR2-like protein 4, putative 0.0017 0.005 0.0078
Leishmania major GTP-binding protein, putative 0.0046 0.0274 0.0534
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0077 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Echinococcus granulosus cathepsin l1 0.0656 0.4933 0.4927
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0204 0.0391
Echinococcus granulosus cysteine protease 0.0355 0.2636 0.2628
Giardia lamblia Cysteine protease 0.0151 0.1071 0.2748
Brugia malayi beta-lactamase family protein 0.0037 0.0204 0.0193
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0211 0.0406
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0656 0.4933 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1319 1 1
Giardia lamblia Cysteine protease 0.0151 0.1071 0.2748
Plasmodium vivax vivapain-1 0.0355 0.2636 0.5345
Loa Loa (eye worm) cysteine protease 0.0656 0.4933 0.4927
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0151 0.1071 0.2152
Trypanosoma cruzi cysteine peptidase, putative 0.0355 0.2636 0.2619
Onchocerca volvulus 0.0656 0.4933 1
Plasmodium vivax importin-beta 2, putative 0.0063 0.0401 0.0813
Entamoeba histolytica cysteine proteinase, putative 0.0355 0.2636 0.5345
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0024 0.0049
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0218 0.0207
Giardia lamblia Cathepsin L-like protease 0.0151 0.1071 0.2748
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0014 0.0024 0.0013
Schistosoma mansoni cathepsin s 0.0205 0.1486 0.1477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Giardia lamblia Transcriptional regulator, Sir2 family 0.0053 0.0326 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Plasmodium vivax transportin, putative 0.0012 0.0011 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1071 0.2152
Loa Loa (eye worm) cathepsin B 0.0512 0.3832 0.3825
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0151 0.1071 0.217
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0036 0.0197 0.6915
Toxoplasma gondii preprocathepsin c precursor, putative 0.0151 0.1071 0.217
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0512 0.3832 0.7764
Mycobacterium tuberculosis Conserved protein 0.0037 0.0204 0.0149
Echinococcus granulosus cathepsin L 0.0355 0.2636 0.2628
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0274 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Toxoplasma gondii exonuclease III APE 0.0039 0.0218 0.0442
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.1071 0.106
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.1071 0.2748
Brugia malayi cathepsin F-like cysteine proteinase 0.0205 0.1486 0.1477
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0218 0.042
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0077 0.0065
Echinococcus granulosus bloom syndrome protein 0.002 0.0077 0.0065
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0512 0.3832 0.3817
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.0024 0.0026
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0205 0.1486 0.1477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0077 0.0138
Brugia malayi RNA, U transporter 1 0.0179 0.1288 0.1278
Plasmodium falciparum serine repeat antigen 9 0.0151 0.1071 0.2152
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1071 0.2152
Plasmodium vivax unspecified product 0.0355 0.2636 0.5345
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Plasmodium falciparum serine repeat antigen 6 0.0151 0.1071 0.2152
Trypanosoma brucei cysteine peptidase C (CPC) 0.0512 0.3832 0.7764
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Echinococcus multilocularis cathepsin b 0.1319 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Entamoeba histolytica phosphoinositide kinase, putative 0.0014 0.0024 0.0049
Schistosoma mansoni inositol monophosphatase 0.0038 0.0211 0.02
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Brugia malayi RNA binding protein 0.0138 0.0977 0.0966
Toxoplasma gondii cathepsin B 0.0512 0.3832 0.7769
Entamoeba histolytica cysteine proteinase, putative 0.0451 0.3367 0.6826
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0077 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.1071 0.2152
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Loa Loa (eye worm) hypothetical protein 0.0063 0.0401 0.039
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0204 0.018
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0204 0.0149
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Echinococcus multilocularis cysteine protease 0.0656 0.4933 0.4927
Entamoeba histolytica cysteine proteinase 1, putative 0.0355 0.2636 0.5345
Schistosoma mansoni DNA helicase recq5 0.002 0.0077 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0204 0.0149
Echinococcus granulosus snurportin 1 0.0672 0.5053 0.5048
Echinococcus multilocularis snurportin 1 0.0672 0.5053 0.5048
Schistosoma mansoni hypothetical protein 0.0175 0.1255 0.1245
Onchocerca volvulus 0.0169 0.1211 0.213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Echinococcus multilocularis cathepsin b 0.1319 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Loa Loa (eye worm) transcriptional regulator 0.0017 0.005 0.0039
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Plasmodium vivax unspecified product 0.0205 0.1486 0.3013
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0218 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0218 0.0442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Trypanosoma cruzi cysteine protease, putative 0.0355 0.2636 0.2619
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0077 0.0132
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0077 0.0132
Echinococcus granulosus cathepsin b 0.1319 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0355 0.2636 0.2628
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0017 0.005 0.0039
Loa Loa (eye worm) FYVE zinc finger family protein 0.0014 0.0024 0.0013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0211 0.0428
Giardia lamblia Cysteine protease 0.0151 0.1071 0.2748
Onchocerca volvulus 0.0451 0.3367 0.6689
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Brugia malayi cathepsin L precursor 0.0151 0.1071 0.106
Onchocerca volvulus 0.0656 0.4933 1
Entamoeba histolytica cysteine proteinase, putative 0.0656 0.4933 1
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0204 0.0391
Mycobacterium ulcerans hypothetical protein 0.0037 0.0204 0.5576
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1071 0.106
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.1071 0.106
Echinococcus multilocularis geminin 0.0175 0.1255 0.1245
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.0024 0.0013
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0274 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0218 0.0442
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0211 0.0188
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0014 0.0024 0.0013
Echinococcus granulosus cathepsin b 0.1319 1 1
Giardia lamblia Sirtuin type 2 0.0017 0.005 0.0068
Schistosoma mansoni cathepsin F (C01 family) 0.0451 0.3367 0.336
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0204 0.018
Plasmodium falciparum serine repeat antigen 4 0.0151 0.1071 0.2152
Onchocerca volvulus 0.0656 0.4933 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Loa Loa (eye worm) ctsf protein 0.0656 0.4933 0.4927
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.1732 1
Echinococcus granulosus cathepsin l1 0.0451 0.3367 0.336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.0024 0.0026
Plasmodium vivax unspecified product 0.0151 0.1071 0.217
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0151 0.1071 0.2748
Giardia lamblia Cathepsin B precursor 0.0512 0.3832 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1071 0.106
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0204 0.5576
Onchocerca volvulus 0.0656 0.4933 1
Trichomonas vaginalis ran, putative 0.0046 0.0274 0.0534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0011 0.0023
Entamoeba histolytica Ran family GTPase 0.0046 0.0274 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Onchocerca volvulus Cathepsin L homolog 0.0656 0.4933 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0053 0.0326 0.064
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0274 0.0556
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0204 0.0149
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0218 0.042
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0017 0.005 0.0101
Trichomonas vaginalis esterase, putative 0.0037 0.0204 0.0391
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0204 0.0193
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0077 0.0132
Giardia lamblia Cathepsin L precursor 0.0151 0.1071 0.2748
Leishmania major cathepsin L-like protease 0.0656 0.4933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0451 0.3367 0.6819
Plasmodium vivax vivapain-2 0.0656 0.4933 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0017 0.005 0.0078
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0151 0.1071 0.2152
Onchocerca volvulus Cathepsin F homolog 0.0656 0.4933 1
Schistosoma mansoni cathepsin B (C01 family) 0.0151 0.1071 0.106
Brugia malayi Inositol-1 0.0038 0.0211 0.02
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.0024 0.0026
Plasmodium vivax NAD-dependent deacetylase, putative 0.0053 0.0326 0.0662
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.005 0.0101
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0014 0.0024 0.0013
Schistosoma mansoni ap endonuclease 0.0039 0.0218 0.0207
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0211 0.5842
Schistosoma mansoni inositol monophosphatase 0.0038 0.0211 0.02
Plasmodium vivax hypothetical protein, conserved 0.0017 0.005 0.0101
Echinococcus multilocularis cathepsin L 0.0151 0.1071 0.106
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0017 0.005 0.0039
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0169 0.1211 0.1201
Entamoeba histolytica cysteine proteinase, putative 0.0355 0.2636 0.5345
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0512 0.3832 0.7764
Schistosoma mansoni ran 0.0046 0.0274 0.0263
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Leishmania major hypothetical protein, conserved 0.0037 0.0204 0.0391
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0151 0.1071 0.2152
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.0024 0.0049
Brugia malayi Cathepsin L-like precursor 0.0656 0.4933 0.4927
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0014 0.0024 0.0013
Schistosoma mansoni importin beta-1 0.0063 0.0401 0.039
Plasmodium falciparum cysteine proteinase falcipain 3 0.0656 0.4933 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0017 0.005 0.0101
Schistosoma mansoni chromatin regulatory protein sir2 0.0017 0.005 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1071 0.2152
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0053 0.0326 0.0303
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0077 0.0155
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0014 0.0024 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0451 0.3367 0.6819
Echinococcus granulosus importin subunit beta 1 0.0063 0.0401 0.039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0218 0.0207
Onchocerca volvulus 0.0151 0.1071 0.1833
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0017 0.005 0.0026
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.031 0.0287
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0053 0.0326 0.064
Trypanosoma cruzi cysteine peptidase, putative 0.0656 0.4933 0.4921
Entamoeba histolytica cysteine protease, putative 0.0151 0.1071 0.217
Brugia malayi Cathepsin L-like precursor 0.0205 0.1486 0.1477
Entamoeba histolytica cysteine proteinase, putative 0.0656 0.4933 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0151 0.1071 0.1049
Echinococcus multilocularis chromatin regulatory protein sir2 0.0017 0.005 0.0039
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0077 0.0065
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0151 0.1071 0.217
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0024 0.0049
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0151 0.1071 0.217
Trichomonas vaginalis importin beta-1, putative 0.0051 0.031 0.0607
Loa Loa (eye worm) pip kinase 1 0.0014 0.0024 0.0013
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0017 0.005 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0977 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.1071 0.2152
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0053 0.0326 0.0937
Trypanosoma cruzi major cysteine proteinase, putative 0.0151 0.1071 0.1049
Giardia lamblia Cathepsin B precursor 0.0151 0.1071 0.2748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0211 0.0188
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0014 0.0024 0.0026
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0211 0.0406
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0656 0.4933 0.4927
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0656 0.4933 1
Giardia lamblia Hypothetical protein 0.0017 0.005 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0656 0.4933 1
Echinococcus granulosus cathepsin L 0.0151 0.1071 0.106
Entamoeba histolytica cysteine protease, putative 0.0355 0.2636 0.5345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0656 0.4933 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0672 0.5053 0.5048
Trypanosoma cruzi cysteine peptidase, putative 0.0656 0.4933 0.4921
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.0024 0.0049
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0151 0.1071 0.2748
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0053 0.0326 0.064
Mycobacterium ulcerans beta-lactamase 0.0037 0.0204 0.5576
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0204 0.0193
Entamoeba histolytica cysteine proteinase 2 0.0355 0.2636 0.5345

Activities

Activity type Activity value Assay description Source Reference
Solubility = 3.5 ug ml-1 Aqueous solubility at pH 2.5 ChEMBL. 16831551

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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