Detailed information for compound 371083

Basic information

Technical information
  • TDR Targets ID: 371083
  • Name: rhizoxin
  • MW: 625.749 | Formula: C35H47NO9
  • H donors: 1 H acceptors: 4 LogP: 5.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO[C@H]([C@H]([C@H]1OC(=O)[C@@H]2O[C@H]2C[C@H]2CC(=O)O[C@H](C2)[C@@H](/C=C/[C@@H]2[C@]([C@H](C1)O)(C)O2)C)C)/C(=C/C=C/C(=C/c1coc(n1)C)/C)/C
  • InChi: 1S/C35H47NO9/c1-19(13-25-18-41-23(5)36-25)9-8-10-21(3)32(40-7)22(4)27-17-29(37)35(6)30(45-35)12-11-20(2)26-14-24(16-31(38)42-26)15-28-33(43-28)34(39)44-27/h8-13,18,20,22,24,26-30,32-33,37H,14-17H2,1-7H3/b9-8+,12-11+,19-13+,21-10+/t20-,22+,24+,26-,27+,28+,29+,30-,32+,33-,35-/m1/s1
  • InChiKey: OWPCHSCAPHNHAV-QIPOKPRISA-N  

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Synonyms

  • AIDS031100
  • E-87/010
  • NSC-332598
  • FR-900216
  • Antibiotic WF-1360
  • BRN 5692896
  • NSC 332598
  • WF-1360
  • CRC-87/01
  • 4,7,12,18-Tetraoxatetracyclo[15.3.1.03,5.011,13]heneicos-14-ene-6,19-dione, 10-hydroxy-8-[(1S,2R,3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyl-4-oxazolyl)-3,5,7-octatrienyl]-11,16-dimethyl-, (1S,3S,5R,8S,10S,11R,13R,16S,17R)-
  • AIDS-031100

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major zeta tubulin, putative Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major gamma-tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major delta tubulin, putative Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major epsilon tubulin, putative Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus multilocularis tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Plasmodium falciparum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania infantum gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K10391 tubulin epsilon, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania donovani tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei gambiense delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Loa Loa (eye worm) tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin delta chain, putative Get druggable targets OG5_143817 All targets in OG5_143817
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_127652 All targets in OG5_127652
Cryptosporidium parvum gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma congolense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus granulosus tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma congolense tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K10389 tubulin gamma, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum Beta-tubulin, related Get druggable targets OG5_127652 All targets in OG5_127652
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania donovani tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Schistosoma mansoni tubulin subunit gamma Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania braziliensis zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit epsilon Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma brucei zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania major zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma cruzi tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_143817 All targets in OG5_143817
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin epsilon chain, putative gamma-tubulin 447 aa 479 aa 28.2 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Trypanosoma brucei epsilon tubulin epsilon tubulin, putative 470 aa 488 aa 68.0 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0196 0.0504 0.2917
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0105 0.0814
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0033 0.0191
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0053 0.0303
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0019 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0016 0.0121
Loa Loa (eye worm) hypothetical protein 0.0074 0.0154 0.0883
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0106 0.0106
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0056 0.0105 0.2126
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0061 0.0356
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0144 0.0354 0.2043
Brugia malayi Tubulin alpha chain 0.0471 0.1288 0.7457
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0061 0.0061
Trichomonas vaginalis tubulin beta chain, putative 0.019 0.0487 0.2819
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0006 0.0027
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.0018 0.0018
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0056 0.0105 0.2126
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0091 0.0518
Trypanosoma brucei tubulin delta chain 0.0363 0.0979 0.5668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0091 0.0524
Echinococcus multilocularis histone deacetylase 0.0266 0.0703 0.0703
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0091 0.0524
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0091 0.0518
Trypanosoma brucei histone deacetylase 3 0.0266 0.0703 0.4068
Brugia malayi Tubulin alpha-2 chain 0.0471 0.1288 0.7457
Plasmodium vivax histone deacetylase, putative 0.0266 0.0703 0.4068
Echinococcus multilocularis serine:threonine protein kinase N2 0.002 0.0001 0.0001
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.001 0.0272
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0105 0.2126
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0109 0.0632
Echinococcus multilocularis nAChR subunit 0.0026 0.0018 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0176 0.0176
Echinococcus granulosus cathepsin L cysteine proteinase 0.0051 0.0091 0.0091
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0107 0.0611
Trichomonas vaginalis apoptosis inducing factor, putative 0.0021 0.0003 0.0018
Leishmania major cathepsin L-like protease 0.0051 0.0091 0.0524
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1728 0.1728
Trypanosoma brucei beta tubulin 0.0625 0.1728 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0056 0.0105 0.0606
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.003 0.0176
Giardia lamblia Alpha-tubulin 0.0471 0.1288 0.7457
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0109 0.0632
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0033 0.0033
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0179 0.0179
Entamoeba histolytica acyl-CoA synthetase, putative 0.0192 0.0493 0.2847
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0355 0.2051
Echinococcus multilocularis tubulin alpha 1C chain 0.0471 0.1288 0.1288
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0019 0.0111
Trypanosoma cruzi histone deacetylase, putative 0.0266 0.0703 0.4068
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0061 0.0061
Leishmania major beta tubulin 0.0625 0.1728 1
Trypanosoma brucei epsilon tubulin 0.0351 0.0947 0.5483
Plasmodium falciparum tubulin gamma chain 0.0384 0.1041 0.6022
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0058 0.0109 0.0632
Trypanosoma brucei C-8 sterol isomerase, putative 0.0381 0.1032 0.5974
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0053 0.0306
Loa Loa (eye worm) zinc carboxypeptidase 0.0058 0.0109 0.0626
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0018 0.0103
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0085 0.0492
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0026 0.0018 0.0018
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0019 0.0111
Leishmania major beta tubulin 0.0625 0.1728 1
Echinococcus granulosus cathepsin l1 0.0051 0.0091 0.0091
Onchocerca volvulus 0.0132 0.0321 0.3401
Entamoeba histolytica cysteine protease, putative 0.0051 0.0091 0.0518
Toxoplasma gondii propionate-CoA ligase 0.0056 0.0105 0.0606
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0109 0.0632
Loa Loa (eye worm) zinc carboxypeptidase 0.0058 0.0109 0.0626
Schistosoma mansoni microtubule-associated protein tau 0.352 1 1
Plasmodium vivax tubulin gamma chain, putative 0.0384 0.1041 0.6022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0144 0.0354 0.7182
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0016 0.0315
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Loa Loa (eye worm) hypothetical protein 0.031 0.0828 0.4789
Echinococcus granulosus tubulin alpha chain 0.0471 0.1288 0.1288
Echinococcus granulosus histone deacetylase 6 0.0272 0.0721 0.0721
Trichomonas vaginalis ferritin, putative 0.0026 0.0016 0.0095
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0019 0.0111
Leishmania major beta tubulin 0.0625 0.1728 1
Brugia malayi protein kinase C II. 0.0074 0.0155 0.0898
Trypanosoma cruzi alpha tubulin, putative 0.0471 0.1288 0.7457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Loa Loa (eye worm) alpha-tubulin 0.0471 0.1288 0.7455
Giardia lamblia Epsilon tubulin 0.0193 0.0496 0.2868
Brugia malayi Pre-SET motif family protein 0.0217 0.0564 0.3263
Loa Loa (eye worm) ACC-1 protein 0.0026 0.0018 0.0096
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.1288 0.7457
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0033 0.0033
Brugia malayi ecdysteroid receptor 0.0041 0.0061 0.0356
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Trypanosoma cruzi zeta tubulin, putative 0.0498 0.1366 0.7907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0016 0.009
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0026 0.0018 0.0103
Onchocerca volvulus 0.0192 0.0493 0.5327
Echinococcus granulosus tubulin gamma 1 chain 0.0384 0.1041 0.1041
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0032 0.0188
Onchocerca volvulus 0.0031 0.0032 0.0164
Echinococcus granulosus alpha tubulin 0.0471 0.1288 0.1288
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0192 0.0493 0.383
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0058 0.0109 0.0632
Trichomonas vaginalis esterase, putative 0.0074 0.0154 0.0889
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0033 0.0191
Schistosoma mansoni alpha tubulin 0.0471 0.1288 0.1288
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0316 0.2453
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Onchocerca volvulus 0.0051 0.0091 0.0816
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0085 0.0486
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.003 0.0176
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.1288 0.7457
Giardia lamblia Delta tubulin 0.0161 0.0404 0.2337
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0056 0.0105 0.0814
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0193 0.0496 0.2868
Schistosoma mansoni serine/threonine kinase 0.002 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0056 0.0105 0.0606
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Schistosoma mansoni hypothetical protein 0.0085 0.0186 0.0186
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.001 0.0056
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0349
Trypanosoma brucei RNA helicase, putative 0.0085 0.0186 0.1074
Leishmania major cysteine peptidase A (CPA) 0.0051 0.0091 0.0524
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0018 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0154 0.0889
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0016 0.0121
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0154 0.0889
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.001 0.0075
Leishmania major zeta tubulin, putative 0.0498 0.1366 0.7907
Schistosoma mansoni tubulin subunit beta 0.0625 0.1728 0.1728
Echinococcus multilocularis tubulin alpha chain 0.0471 0.1288 0.1288
Echinococcus granulosus tubulin epsilon chain 0.0384 0.1039 0.1039
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0056 0.0105 0.1969
Echinococcus granulosus Tubulin alpha 1 chain 0.0471 0.1288 0.1288
Plasmodium vivax tubulin alpha chain, putative 0.0471 0.1288 0.7457
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0212 0.1219
Loa Loa (eye worm) alpha-tubulin isotype 2 0.031 0.0828 0.4789
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0016 0.0315
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0061 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0192 0.0493 1
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0042 0.0236
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0058 0.0109 0.0109
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.003 0.0176
Brugia malayi Cytochrome P450 family protein 0.0025 0.0016 0.009
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1728 0.1728
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0032 0.0032
Mycobacterium tuberculosis Probable reductase 0.013 0.0316 0.2453
Loa Loa (eye worm) hypothetical protein 0.0144 0.0354 0.2043
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0061 0.0356
Mycobacterium ulcerans acetyl-CoA synthetase 0.0056 0.0105 0.2126
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0018 0.0103
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Schistosoma mansoni tubulin subunit beta 0.0625 0.1728 0.1728
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0179 0.0179
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0058 0.0109 0.0632
Onchocerca volvulus 0.0338 0.0909 1
Loa Loa (eye worm) oxidoreductase 0.0056 0.0105 0.06
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0349
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0212 0.2174
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Leishmania major beta tubulin 0.0625 0.1728 1
Trypanosoma brucei epsilon tubulin 0.0384 0.1039 0.6014
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0019 0.0111
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0179 0.0179
Brugia malayi hypothetical protein 0.0511 0.1402 0.8113
Brugia malayi hypothetical protein 0.003 0.003 0.0176
Leishmania major cathepsin L-like protease 0.0051 0.0091 0.0524
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0061 0.0061
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0016 0.0139
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0058 0.0109 0.0109
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0166 0.0417 0.2408
Trypanosoma cruzi tubulin gamma chain 0.0384 0.1041 0.6022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0106 0.0106
Echinococcus granulosus expressed protein 0.0026 0.0016 0.0016
Onchocerca volvulus 0.0051 0.0091 0.0816
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0006 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0033 0.0033
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Leishmania major cathepsin L-like protease 0.0051 0.0091 0.0524
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.0018 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0192 0.0493 0.2851
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0056 0.0105 0.2126
Onchocerca volvulus 0.019 0.0487 0.5264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Echinococcus multilocularis microtubule associated protein 2 0.352 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0061 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0061 0.0061
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.001 0.0238
Brugia malayi nuclear hormone receptor 0.0041 0.0061 0.0356
Onchocerca volvulus 0.0338 0.0909 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0082 0.064
Trichomonas vaginalis tubulin gamma chain, putative 0.0384 0.1041 0.6022
Mycobacterium tuberculosis Conserved protein 0.0074 0.0154 0.1195
Loa Loa (eye worm) hypothetical protein 0.0076 0.0159 0.0916
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.004 0.0228
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0061 0.0489
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0016 0.009
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0316 0.2453
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0032 0.0032
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0357 0.2776
Toxoplasma gondii histone deacetylase HDAC3 0.0248 0.0651 0.377
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0058 0.0109 0.0632
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0016 0.0127
Toxoplasma gondii ABC1 family protein 0.0074 0.0154 0.0889
Onchocerca volvulus 0.0104 0.0241 0.2503
Loa Loa (eye worm) tubulin gamma chain 0.0384 0.1041 0.602
Schistosoma mansoni ferritin 0.0026 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0032 0.0032
Echinococcus multilocularis beta tubulin 0.0625 0.1728 0.1728
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Leishmania major delta tubulin, putative 0.0363 0.0979 0.5668
Loa Loa (eye worm) BEN-1 protein 0.0625 0.1728 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0161 0.0404 1
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.004 0.0234
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0016 0.0315
Loa Loa (eye worm) hypothetical protein 0.0051 0.0091 0.0518
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0061 0.0061
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Plasmodium falciparum cysteine proteinase falcipain 3 0.0051 0.0091 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0061 0.0356
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0018 0.0018
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0026 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0061 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0019 0.0111
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0056 0.0105 0.0814
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0016 0.0332
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0056 0.0105 0.0606
Onchocerca volvulus 0.0051 0.0091 0.0816
Schistosoma mansoni nAChR subunit 0.0026 0.0018 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0016 0.0121
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.1288 0.7457
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.004 0.0228
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0154 0.2982
Leishmania major C-8 sterol isomerase-like protein 0.0381 0.1032 0.5974
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0053 0.0306
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0016 0.0315
Leishmania major hypothetical protein, conserved 0.0074 0.0154 0.0889
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.0337 0.1953
Loa Loa (eye worm) tubulin beta chain 0.0161 0.0404 0.2332
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0001 0.0001
Schistosoma mansoni alpha tubulin 0.0471 0.1288 0.1288
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0192 0.0493 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0154 0.0384 0.2222
Schistosoma mansoni hypothetical protein 0.0068 0.0139 0.0139
Treponema pallidum cell division protein FtsZ 0.0161 0.0404 1
Leishmania major cytochrome p450-like protein 0.0025 0.0016 0.009
Brugia malayi Cytochrome P450 family protein 0.0064 0.0125 0.0723
Entamoeba histolytica hypothetical protein 0.0023 0.001 0.0049
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0018 0.0103
Loa Loa (eye worm) hypothetical protein 0.0144 0.0354 0.2043
Loa Loa (eye worm) histone deacetylase 1 0.0248 0.0651 0.3766
Mycobacterium ulcerans hypothetical protein 0.0074 0.0154 0.3119
Schistosoma mansoni hypothetical protein 0.1368 0.385 0.385
Loa Loa (eye worm) histone deacetylase 11 0.0107 0.0248 0.1428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Toxoplasma gondii AGC kinase 0.002 0.0001 0.0007
Onchocerca volvulus 0.0247 0.0649 0.7086
Echinococcus granulosus Tubulin alpha 1 chain 0.0471 0.1288 0.1288
Echinococcus multilocularis tubulin epsilon chain 0.0384 0.1039 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Mycobacterium leprae Probable lipase LipE 0.0074 0.0154 0.2982
Echinococcus granulosus single minded 2 0.0045 0.0073 0.0073
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0056 0.0105 0.0606
Schistosoma mansoni tubulin subunit gamma 0.0384 0.1041 0.1041
Echinococcus granulosus tubulin alpha chain 0.0471 0.1288 0.1288
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0026 0.0018 0.0103
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0026 0.0018 0.0103
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0026 0.0018 0.0018
Brugia malayi Cation transporter family protein 0.0026 0.0018 0.0103
Trypanosoma brucei alpha tubulin 0.0471 0.1288 0.7457
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0136 0.0331 0.2576
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0349
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0053 0.1308
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0061 0.0061
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0016 0.0315
Brugia malayi Tubulin beta-1 chain 0.0625 0.1728 1
Brugia malayi PAS domain containing protein 0.0061 0.0119 0.0689
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.003 0.0176
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0105 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0042 0.0243
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0056 0.0105 0.06
Brugia malayi MH2 domain containing protein 0.0144 0.0355 0.2056
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0034
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0625 0.1728 0.1728
Leishmania major cytochrome p450-like protein 0.0034 0.004 0.0234
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Loa Loa (eye worm) hypothetical protein 0.0107 0.0248 0.1428
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0154 0.3119
Loa Loa (eye worm) hypothetical protein 0.0381 0.1032 0.5972
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0016 0.009
Plasmodium vivax histone deacetylase, putative 0.0107 0.0248 0.1434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Echinococcus granulosus histone deacetylase 1 0.0248 0.0651 0.0651
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0061 0.0061
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0161 0.0404 0.2337
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0061 0.0356
Loa Loa (eye worm) tubulin alpha-3 chain 0.0281 0.0745 0.4307
Onchocerca volvulus 0.0058 0.0109 0.1026
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0032 0.0032
Brugia malayi Cathepsin L-like precursor 0.0034 0.0042 0.0243
Toxoplasma gondii alpha tubulin TUBA1 0.0471 0.1288 0.7457
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0079 0.0171 0.0171
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0016 0.0121
Trichomonas vaginalis histone deacetylase, putative 0.0248 0.0651 0.377
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0154 0.0154
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0016 0.0121
Brugia malayi nuclear receptor NHR-88 0.0041 0.0061 0.0356
Toxoplasma gondii histone deacetylase HDAC5 0.0107 0.0248 0.1434
Onchocerca volvulus 0.0056 0.0105 0.0975
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0085 0.0085
Trypanosoma brucei histone deacetylase 2 0.0107 0.0248 0.1434
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0058 0.0109 0.0632
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.002 0.0001 0.0001
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0056 0.0105 0.0606
Onchocerca volvulus 0.009 0.0199 0.2038
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.001 0.0056
Echinococcus multilocularis RNA directed DNA polymerase 0.0045 0.0072 0.0072
Echinococcus granulosus tubulin alpha chain 0.0471 0.1288 0.1288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.009 0.0199 0.1148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0016 0.009
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Brugia malayi Tubulin gamma chain 0.0384 0.1041 0.6022
Schistosoma mansoni nAChR subunit 0.0026 0.0018 0.0018
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0026 0.0018 0.0018
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0016 0.0315
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0034 0.019
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0091 0.0524
Loa Loa (eye worm) tubulin beta-2A chain 0.0625 0.1728 1
Trichomonas vaginalis tubulin alpha chain, putative 0.019 0.0487 0.2819
Brugia malayi Protein kinase domain containing protein 0.002 0.0001 0.0007
Trichomonas vaginalis histone deacetylase, putative 0.0248 0.0651 0.377
Echinococcus multilocularis aryl hydrocarbon receptor 0.0133 0.0323 0.0323
Loa Loa (eye worm) ctsf protein 0.0051 0.0091 0.0518
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0016 0.0121
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0179 0.0455 0.2635
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0316 0.2453
Brugia malayi Tubulin alpha chain 0.0161 0.0404 0.2337
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0001 0.0001
Echinococcus multilocularis tubulin alpha 1C chain 0.0471 0.1288 0.1288
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0149 0.0149
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1728 0.1728
Leishmania major beta tubulin 0.0625 0.1728 1
Giardia lamblia Beta tubulin 0.0625 0.1728 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0056 0.0105 0.2126
Leishmania major beta tubulin 0.0625 0.1728 1
Leishmania major histone deacetylase, putative 0.0248 0.0651 0.377
Mycobacterium ulcerans cell division protein FtsZ 0.0161 0.0404 0.8195
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0091 0.0524
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.019
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0016 0.0315
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0016 0.0121
Loa Loa (eye worm) cytochrome P450 0.0025 0.0016 0.0083
Schistosoma mansoni tubulin subunit beta 0.0625 0.1728 0.1728
Echinococcus multilocularis tubulin subunit beta 0.0625 0.1728 0.1728
Echinococcus multilocularis tubulin alpha 3 chain 0.0471 0.1288 0.1288
Trichomonas vaginalis tubulin epsilon chain, putative 0.0471 0.1288 0.7457
Echinococcus granulosus tubulin alpha 3 chain 0.0471 0.1288 0.1288
Schistosoma mansoni peptidase 0.0058 0.0109 0.0109
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0058 0.0109 0.0632
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0056 0.0105 0.2126
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0337 0.0337
Onchocerca volvulus 0.0056 0.0105 0.0975
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.009 0.0199 0.1148
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0154 0.0889
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0058 0.0109 0.0632
Brugia malayi histone deacetylase 1 (HD1) 0.0248 0.0651 0.377
Loa Loa (eye worm) hypothetical protein 0.0195 0.05 0.2889
Plasmodium vivax tubulin beta chain, putative 0.0625 0.1728 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0212 0.1225
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0471 0.1288 0.7457
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0077 0.0445
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0034 0.0034
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.0018 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0136 0.0331 0.2576
Trichomonas vaginalis tubulin epsilon chain, putative 0.0161 0.0404 0.2337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0019 0.0111
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0016 0.009
Schistosoma mansoni histone deacetylase 0.0248 0.0651 0.0651
Echinococcus granulosus tubulin subunit beta 0.0625 0.1728 0.1728
Trypanosoma cruzi zeta tubulin, putative 0.0498 0.1366 0.7907
Entamoeba histolytica tubulin family protein 0.0625 0.1728 1
Leishmania major acetyl-CoA synthetase, putative 0.0056 0.0105 0.0606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0154 0.0889
Onchocerca volvulus 0.0338 0.0909 1
Brugia malayi Cathepsin L-like precursor 0.0051 0.0091 0.0524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0019 0.0111
Trypanosoma brucei zeta tubulin 0.0498 0.1366 0.7907
Toxoplasma gondii histone deacetylase HDAC1 0.0266 0.0703 0.4068
Trypanosoma brucei polo-like protein kinase 0.0094 0.0212 0.1225
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0091 0.0524
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0058 0.0109 0.0109
Brugia malayi beta-lactamase 0.0074 0.0154 0.0889
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0229 0.1326
Trypanosoma cruzi histone deacetylase, putative 0.0107 0.0248 0.1434
Loa Loa (eye worm) beta-lactamase 0.0074 0.0154 0.0883
Brugia malayi TAR-binding protein 0.0138 0.0337 0.1953
Echinococcus granulosus RNA directed DNA polymerase 0.0045 0.0072 0.0072
Trichomonas vaginalis histone deacetylase, putative 0.0248 0.0651 0.377
Echinococcus multilocularis Tubulin alpha 1 chain 0.0471 0.1288 0.1288
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0212 0.1225
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0061 0.0061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0032 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0337 0.0337
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0316 0.6333
Echinococcus multilocularis histone deacetylase 6 0.0266 0.0703 0.0703
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Leishmania major cathepsin L-like protease 0.0196 0.0504 0.2917
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0026 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0019 0.0111
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0058 0.0109 0.0632
Echinococcus granulosus cysteine protease 0.0027 0.0019 0.0019
Leishmania major beta tubulin 0.0625 0.1728 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1728 0.1728
Loa Loa (eye worm) glutathione reductase 0.0057 0.0107 0.0611
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0061 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0061 0.0349
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0053 0.1308
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0171 0.0171
Schistosoma mansoni peptidase 0.0058 0.0109 0.0109
Echinococcus multilocularis histone deacetylase 7 0.0266 0.0703 0.0703
Schistosoma mansoni hypothetical protein 0.0058 0.0109 0.0109
Brugia malayi jmjC domain containing protein 0.0057 0.0106 0.0615
Brugia malayi hypothetical protein 0.0022 0.0006 0.0034
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0349
Loa Loa (eye worm) hypothetical protein 0.0056 0.0105 0.06
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0061 0.0061
Onchocerca volvulus 0.0051 0.0091 0.0816
Toxoplasma gondii zinc carboxypeptidase, putative 0.0058 0.0109 0.0632
Schistosoma mansoni nAChR subunit 0.0026 0.0018 0.0018
Echinococcus multilocularis expressed protein 0.0026 0.0016 0.0016
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0056 0.0105 0.2126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0091 0.0524
Brugia malayi histone deacetylase 11 0.0107 0.0248 0.1434
Loa Loa (eye worm) alpha-tubulin 0.0471 0.1288 0.7455
Brugia malayi alpha-tubulin 0.0471 0.1288 0.7457
Plasmodium falciparum acyl-CoA synthetase 0.0144 0.0354 0.2048
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0026 0.0018 0.0103
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.1286 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0061 0.0356
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0016 0.0121
Loa Loa (eye worm) hypothetical protein 0.0034 0.0042 0.0236
Trichomonas vaginalis tubulin, putative 0.0194 0.0497 0.2876
Onchocerca volvulus 0.0074 0.0154 0.1524
Echinococcus granulosus tubulin beta 1 chain 0.0625 0.1728 0.1728
Trypanosoma cruzi histone deacetylase, putative 0.0107 0.0248 0.1434
Brugia malayi Cathepsin L-like precursor 0.0051 0.0091 0.0524
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0061 0.0061
Giardia lamblia Gamma tubulin 0.0384 0.1041 0.6022
Echinococcus multilocularis serine threonine protein kinase 0.0065 0.013 0.013
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0019 0.0111
Echinococcus multilocularis cysteine protease 0.0051 0.0091 0.0091
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0016 0.0405
Plasmodium vivax vivapain-1 0.0027 0.0019 0.0111
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.001 0.0195
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0033 0.0191
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0026 0.0018 0.0103
Brugia malayi Hr1 repeat family protein 0.002 0.0001 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0149 0.0149
Plasmodium falciparum glutathione reductase 0.0057 0.0107 0.0617
Brugia malayi Tubulin beta chain 0.0161 0.0404 0.2337
Loa Loa (eye worm) zinc carboxypeptidase 0.0058 0.0109 0.0626
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0154 0.1195
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0033 0.0191
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0027
Mycobacterium leprae cell division protein FtsZ 0.0161 0.0404 0.8159
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0033 0.0191
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0033 0.0191
Loa Loa (eye worm) hypothetical protein 0.0074 0.0154 0.0883
Plasmodium vivax vivapain-2 0.0051 0.0091 0.0524
Loa Loa (eye worm) tubulin alpha chain 0.0471 0.1288 0.7455
Loa Loa (eye worm) hypothetical protein 0.0074 0.0154 0.0883
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0033 0.0185
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0061 0.0349
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0248 0.0651 0.377
Leishmania major cytochrome p450-like protein 0.0025 0.0016 0.009
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0018 0.0103
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0042 0.0243
Mycobacterium ulcerans lipase LipD 0.0074 0.0154 0.3119
Leishmania major histone deacetylase, putative 0.0266 0.0703 0.4068
Trichomonas vaginalis tubulin gamma chain, putative 0.0161 0.0404 0.2337
Loa Loa (eye worm) hypothetical protein 0.0076 0.0159 0.0916
Onchocerca volvulus 0.0034 0.0042 0.0271
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0026 0.0018 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0116 0.0669
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0192 0.0493 0.383
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0338 0.0909 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0016 0.0121
Loa Loa (eye worm) hypothetical protein 0.0034 0.0042 0.0236
Mycobacterium ulcerans putative regulatory protein 0.0045 0.0073 0.1489
Brugia malayi AMP-binding enzyme family protein 0.0056 0.0105 0.0606
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0056 0.0105 0.0606
Brugia malayi tubulin alpha-2 chain 0.0471 0.1288 0.7457
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1728 0.1728
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0061 0.0349
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0053 0.0306
Echinococcus granulosus serine:threonine protein kinase N2 0.002 0.0001 0.0001
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0144 0.0354 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0039 0.0053 0.0053
Trichomonas vaginalis tubulin beta chain, putative 0.0625 0.1728 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1728 0.1728
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0337 0.0337
Brugia malayi isocitrate dehydrogenase 0.0031 0.0033 0.0191
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0116 0.0669
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0018 0.0018
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0109 0.0632
Plasmodium vivax tubulin alpha chain, putative 0.0471 0.1288 0.7457
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0154 0.1195
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0091 0.0518
Entamoeba histolytica tubulin family protein 0.0625 0.1728 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0033 0.0191
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0056 0.0105 0.0105
Trypanosoma cruzi tubulin delta chain 0.0363 0.0979 0.5668
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0016 0.0315
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0033 0.0033
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0051 0.0091 0.0518
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0136 0.0331 0.2576
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.009 0.0199 0.1148
Loa Loa (eye worm) hypothetical protein 0.028 0.0743 0.4299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0091 0.0524
Loa Loa (eye worm) tubulin alpha 2 0.0119 0.0285 0.1641
Onchocerca volvulus 0.0046 0.0075 0.064
Leishmania major beta tubulin 0.0625 0.1728 1
Echinococcus multilocularis cysteine protease 0.0051 0.0091 0.0091
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0019 0.0105
Echinococcus multilocularis cathepsin L 0.0027 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0016 0.0315
Echinococcus granulosus histone deacetylase 6 0.0266 0.0703 0.0703
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0116 0.0116
Echinococcus granulosus cathepsin l1 0.0034 0.0042 0.0042
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0021 0.0003 0.0018
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0016 0.0315
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0154 0.0889
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0053 0.0299
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0154 0.0154
Leishmania major beta tubulin 0.0625 0.1728 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0056 0.0105 0.0814
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.004 0.0234
Brugia malayi jmjC domain containing protein 0.0057 0.0106 0.0615
Brugia malayi Tubulin beta chain 0.019 0.0487 0.2819
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0192 0.0493 0.2847
Mycobacterium tuberculosis Cell division protein FtsZ 0.0161 0.0404 0.3139
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0091 0.0524
Brugia malayi Protein kinase domain containing protein 0.002 0.0001 0.0007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0061 0.0061
Leishmania major cathepsin L-like protease 0.0196 0.0504 0.2917
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0212 0.1225
Loa Loa (eye worm) hypothetical protein 0.0076 0.0159 0.0916
Brugia malayi AMP-binding enzyme family protein 0.0056 0.0105 0.0606
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0053 0.0306
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0056 0.0105 0.1969
Brugia malayi Sodium:neurotransmitter symporter family protein 0.009 0.0199 0.1154
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0056 0.0105 0.06
Loa Loa (eye worm) hypothetical protein 0.0068 0.0139 0.0797
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0019 0.0019
Echinococcus granulosus geminin 0.1368 0.385 0.385
Echinococcus granulosus histone deacetylase 8 0.0107 0.0248 0.0248
Brugia malayi Cation transporter family protein 0.0026 0.0018 0.0103
Plasmodium vivax tubulin epsilon chain, putative 0.0384 0.1039 0.6014
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0026 0.0018 0.0096
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0026 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0074 0.0154 0.0883
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0091 0.0524
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0056 0.0105 0.0606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0061 0.0349
Entamoeba histolytica tubulin alpha-1 chain 0.0471 0.1288 0.7455
Trypanosoma cruzi cruzipain precursor, putative 0.0196 0.0504 0.2917
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0016 0.0315
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0212 0.1225
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0061 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0061 0.0061
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0105 0.0814
Trichomonas vaginalis tubulin alpha chain, putative 0.0351 0.0947 0.5483
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0056 0.0105 0.0606
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0016 0.0127
Onchocerca volvulus 0.0293 0.078 0.8553
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0026 0.0018 0.0096
Toxoplasma gondii cathepsin CPL 0.0051 0.0091 0.0524
Loa Loa (eye worm) serotonin transporter b 0.009 0.0199 0.1148
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.0337 0.1948
Leishmania major gamma-tubulin 0.0384 0.1041 0.6022
Loa Loa (eye worm) hypothetical protein 0.0192 0.0493 0.2847
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0053 0.0306
Leishmania major 4-coumarate:coa ligase-like protein 0.0192 0.0493 0.2851
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0061 0.0061
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Brugia malayi Thioredoxin reductase 0.0057 0.0107 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Brugia malayi cathepsin L-like precursor 0.0034 0.0042 0.0243
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0105 0.2126
Schistosoma mansoni tubulin subunit alpha 0.0161 0.0404 0.0404
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0026 0.0018 0.0018
Schistosoma mansoni tubulin subunit epsilon 0.0384 0.1039 0.1039
Brugia malayi Cell division protein ftsZ 0.0161 0.0404 0.2337
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0026 0.0018 0.0103
Echinococcus multilocularis tubulin beta 1 chain 0.0625 0.1728 0.1728
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0085 0.0085
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0212 0.0212
Loa Loa (eye worm) solute carrier family 6 member 4 0.009 0.0199 0.1148
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0027
Echinococcus multilocularis histone deacetylase 6 0.0266 0.0703 0.0703
Echinococcus granulosus nAChR subunit 0.0026 0.0018 0.0018
Trichomonas vaginalis histone deacetylase, putative 0.0248 0.0651 0.377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0016 0.0315
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0349
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.1288 0.7457
Loa Loa (eye worm) histone deacetylase 3 0.0248 0.0651 0.3766
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.0564 0.3258
Leishmania major trypanothione reductase 0.0057 0.0107 0.0617
Toxoplasma gondii beta-1 tubulin, putative 0.0625 0.1728 1
Toxoplasma gondii beta tubulin 0.0625 0.1728 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0053 0.0411
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0192 0.0493 1
Leishmania major beta tubulin 0.0625 0.1728 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0019 0.0019
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Schistosoma mansoni ferritin light chain 0.0026 0.0016 0.0016
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0058 0.0109 0.0632
Schistosoma mansoni tubulin subunit alpha 0.0471 0.1288 0.1288
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0016 0.0121
Loa Loa (eye worm) hypothetical protein 0.0056 0.0105 0.06
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0019 0.0105
Schistosoma mansoni cytochrome P450 0.0025 0.0016 0.0016
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0033 0.0191
Trypanosoma cruzi histone deacetylase, putative 0.0266 0.0703 0.4068
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Echinococcus multilocularis serine:threonine protein kinase 38 0.002 0.0001 0.0001
Echinococcus granulosus ferritin 0.0026 0.0016 0.0016
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0212 0.1225
Onchocerca volvulus 0.0074 0.0154 0.1524
Echinococcus multilocularis histone deacetylase 3 0.0248 0.0651 0.0651
Echinococcus multilocularis histone deacetylase 1 0.0248 0.0651 0.0651
Trichomonas vaginalis set domain proteins, putative 0.0247 0.0649 0.3759
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0355 0.2051
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0058 0.0109 0.0632
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1728 0.1728
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.0018 0.0018
Brugia malayi histone deacetylase 3 (HD3) 0.0248 0.0651 0.377
Brugia malayi Cathepsin L-like precursor 0.0051 0.0091 0.0524
Plasmodium falciparum tubulin delta chain, putative 0.0161 0.0404 0.2337
Schistosoma mansoni survival motor neuron protein 0.0104 0.0241 0.0241
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0053 0.0053
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0192 0.0493 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0018 0.0018
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0106 0.0106
Echinococcus multilocularis Tubulin alpha 1 chain 0.0471 0.1288 0.1288
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0061 0.0356
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1728 0.1728
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0016 0.0315
Brugia malayi beta-lactamase family protein 0.0074 0.0154 0.0889
Schistosoma mansoni peptidase 0.0058 0.0109 0.0109
Leishmania major 4-coumarate:coa ligase-like protein 0.0192 0.0493 0.2851
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0034 0.0196
Loa Loa (eye worm) hypothetical protein 0.0144 0.0354 0.2043
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0338 0.0909 0.0909
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0363 0.0979 0.5668
Schistosoma mansoni histone deacetylase 4 5 0.0266 0.0703 0.0703
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0109 0.0632
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0107 0.0617
Schistosoma mansoni histone deacetylase 4 5 0.0266 0.0703 0.0703
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0357 0.7193
Schistosoma mansoni hypothetical protein 0.0104 0.0241 0.0241
Onchocerca volvulus 0.0041 0.0061 0.0489
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0091 0.0524
Schistosoma mansoni protease m14 carboxypeptidase 0.0058 0.0109 0.0109
Entamoeba histolytica acyl-coA synthetase, putative 0.0192 0.0493 0.2847
Leishmania major epsilon tubulin, putative 0.0384 0.1039 0.6014
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0074 0.0155 0.0892
Loa Loa (eye worm) hypothetical protein 0.0471 0.1288 0.7455
Trichomonas vaginalis tubulin epsilon chain, putative 0.0471 0.1288 0.7457
Schistosoma mansoni nAChR subunit 0.0026 0.0018 0.0018
Trypanosoma cruzi histone deacetylase, putative 0.0266 0.0703 0.4068
Trichomonas vaginalis histone deacetylase, putative 0.0248 0.0651 0.377
Schistosoma mansoni tubulin subunit delta 0.0161 0.0404 0.0404
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0116 0.2347
Schistosoma mansoni histone deacetylase hda2 0.0107 0.0248 0.0248
Mycobacterium tuberculosis Conserved protein 0.0074 0.0154 0.1195
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0026 0.0018 0.0103
Echinococcus multilocularis hypothetical protein 0.0471 0.1288 0.1288
Plasmodium vivax vivapain-3 0.0027 0.0019 0.0111
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0109 0.0632
Onchocerca volvulus 0.0338 0.0909 1
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.003 0.0176
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0154 0.0883
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0144 0.0354 0.2751
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0091 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0105 0.2126
Loa Loa (eye worm) ACC-1 protein 0.0026 0.0018 0.0096
Plasmodium falciparum tubulin epsilon chain, putative 0.0384 0.1039 0.6014
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0019 0.0105
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0018 0.0103
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0061 0.0489
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0061 0.0061
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0033 0.0191
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0016 0.0315
Echinococcus multilocularis 0.0058 0.0109 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Schistosoma mansoni histone deacetylase hda2 0.0272 0.0721 0.0721
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0105 0.2126
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0056 0.0105 0.0814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0061 0.0061
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0091 0.0091
Echinococcus multilocularis beta tubulin 0.0625 0.1728 0.1728
Trypanosoma brucei beta tubulin 0.0351 0.0947 0.5483
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1728 0.1728
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0091 0.0091
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0107 0.0617
Schistosoma mansoni nAChR subunit 0.0026 0.0018 0.0018
Schistosoma mansoni tubulin subunit beta 0.0625 0.1728 0.1728
Brugia malayi steroid hormone receptor 0.0041 0.0061 0.0356
Echinococcus granulosus GPCR family 2 0.0032 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0091 0.0524
Echinococcus granulosus NDR protein kinase 0.002 0.0001 0.0001
Brugia malayi excitatory GABA receptor EXP-1A 0.0026 0.0018 0.0103
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0034 0.0196
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0381 0.1032 0.5974
Trypanosoma brucei histone deacetylase 4 0.0266 0.0703 0.4068
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0026 0.0018 0.0018
Schistosoma mansoni nAChR subunit 0.0026 0.0018 0.0018
Echinococcus multilocularis peroxisome assembly protein 26 0.0471 0.1288 0.1288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Echinococcus granulosus histone deacetylase 0.0266 0.0703 0.0703
Echinococcus granulosus histone deacetylase 6 0.0266 0.0703 0.0703
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0139 0.0803
Leishmania major beta tubulin 0.0625 0.1728 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0016 0.0121
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0033 0.0257
Trypanosoma brucei trypanothione reductase 0.0057 0.0107 0.0617
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0155 0.0155
Trypanosoma brucei alpha tubulin 0.0471 0.1288 0.7457
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.003 0.0176
Trichomonas vaginalis histone deacetylase, putative 0.0248 0.0651 0.377
Loa Loa (eye worm) hypothetical protein 0.0034 0.0042 0.0236
Loa Loa (eye worm) hypothetical protein 0.0082 0.0179 0.1028
Trichomonas vaginalis tubulin alpha chain, putative 0.019 0.0487 0.2819
Echinococcus multilocularis serine:threonine protein kinase N2 0.0058 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0006 0.0006
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0019 0.0019
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0229 0.1326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Trichomonas vaginalis tubulin epsilon chain, putative 0.0625 0.1728 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0026 0.0018 0.0096
Trypanosoma brucei epsilon tubulin 0.0384 0.1039 0.6014
Onchocerca volvulus 0.0069 0.014 0.1373
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0034
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0033 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0085 0.0085
Onchocerca volvulus 0.0056 0.0105 0.0975
Echinococcus granulosus tubulin delta chain 0.0161 0.0404 0.0404
Leishmania major histone deacetylase, putative 0.0266 0.0703 0.4068
Schistosoma mansoni alpha tubulin 0.0471 0.1288 0.1288
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0105 0.2126
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0018 0.0103
Loa Loa (eye worm) tubulin alpha 2 0.031 0.0828 0.4789
Plasmodium falciparum thioredoxin reductase 0.0057 0.0107 0.0617
Brugia malayi Cathepsin L-like precursor 0.0051 0.0091 0.0524
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0018 0.0103
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0091 0.0091
Echinococcus granulosus aryl hydrocarbon receptor 0.0133 0.0323 0.0323
Echinococcus granulosus tubulin alpha 0.0351 0.0947 0.0947
Echinococcus granulosus Protein kinase C brain isozyme 0.0079 0.0171 0.0171
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0116 0.0899
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0056 0.0105 0.0606
Echinococcus granulosus tubulin beta 4A class IVa 0.0625 0.1728 0.1728
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0212 0.1225
Loa Loa (eye worm) hypothetical protein 0.0043 0.0067 0.038
Brugia malayi nuclear receptor RXR 0.0022 0.0006 0.0034
Toxoplasma gondii tubulin, putative 0.0032 0.0035 0.0204
Plasmodium falciparum histone deacetylase 1 0.0248 0.0651 0.377
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0061 0.0356
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0154 0.1195
Brugia malayi cytochrome P450 0.0025 0.0016 0.009
Echinococcus granulosus Tubulin alpha 1 chain 0.0471 0.1288 0.1288
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0033 0.0033
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0016 0.0315
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0105 0.2126
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0105 0.2126
Schistosoma mansoni single-minded 0.0061 0.0119 0.0119
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1728 0.1728
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.1288 0.7457
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0091 0.0816
Echinococcus granulosus protein kinase C gamma type 0.0065 0.013 0.013
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0091 0.0524
Trypanosoma brucei tubulin gamma chain 0.0384 0.1041 0.6022
Loa Loa (eye worm) hypothetical protein 0.009 0.0199 0.1148
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0061 0.0061
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0056 0.0105 0.2126
Trypanosoma brucei Carboxypeptidase-like protein 0.0058 0.0109 0.0632
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0029 0.0029
Plasmodium vivax histone deacetylase 2, putative 0.0266 0.0703 0.4068
Brugia malayi Protein kinase domain containing protein 0.002 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Schistosoma mansoni tubulin subunit alpha 0.0471 0.1288 0.1288
Schistosoma mansoni tubulin subunit alpha 0.0471 0.1288 0.1288
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0248 0.0651 0.3766
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0116 0.0116
Trypanosoma brucei alpha tubulin, putative 0.019 0.0487 0.2819
Brugia malayi Histone deacetylase family protein 0.0266 0.0703 0.4068
Leishmania major cathepsin L-like protease 0.0051 0.0091 0.0524
Schistosoma mansoni sodium/chloride dependent transporter 0.009 0.0199 0.0199
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0154 0.0889
Trypanosoma brucei cytochrome P450, putative 0.0034 0.004 0.0234
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0016 0.0315
Leishmania major beta tubulin 0.0625 0.1728 1
Treponema pallidum sodium- and chloride- dependent transporter 0.009 0.0199 0.4939
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Loa Loa (eye worm) tubulin alpha-2 chain 0.0471 0.1288 0.7455
Trypanosoma brucei alpha tubulin 0.0471 0.1288 0.7457
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0061 0.0061
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0016 0.009
Brugia malayi Carboxypeptidase A2 precursor 0.0058 0.0109 0.0632
Trypanosoma brucei histone deacetylase 1 0.0248 0.0651 0.377
Giardia lamblia Alpha-tubulin 0.0471 0.1288 0.7457
Echinococcus multilocularis protein kinase c iota type 0.0034 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0144 0.0354 0.2043
Loa Loa (eye worm) BEN-1 protein 0.0625 0.1728 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0349
Echinococcus multilocularis tubulin alpha chain 0.0471 0.1288 0.1288
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.0018 0.0018
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Trypanosoma brucei beta tubulin 0.0625 0.1728 1
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Mycobacterium leprae Conserved hypothetical protein 0.0025 0.0016 0.0122
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.001 0.0195
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0056 0.0105 0.0606
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0016 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0212 0.1225
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0381 0.1032 0.5974
Schistosoma mansoni apoferritin-2 0.0026 0.0016 0.0016
Echinococcus granulosus tubulin alpha chain 0.0471 0.1288 0.1288
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0248 0.0651 0.377
Entamoeba histolytica hypothetical protein 0.0072 0.0149 0.0854
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0053 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Schistosoma mansoni tar DNA-binding protein 0.0138 0.0337 0.0337
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0116 0.0275 0.1594
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0061 0.0356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0091 0.0524
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0016 0.0121
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.001 0.0238
Brugia malayi hypothetical protein 0.0022 0.0006 0.0034
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0016 0.0121
Leishmania major cathepsin L-like protease 0.0051 0.0091 0.0524
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0056 0.0105 0.1969
Leishmania major histone deacetylase, putative 0.0248 0.0651 0.377
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.002 0.0001 0.0001
Trypanosoma cruzi histone deacetylase 1, putative 0.0248 0.0651 0.377
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0053 0.1072
Trypanosoma cruzi beta tubulin, putative 0.0625 0.1728 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0154 0.0154
Trypanosoma brucei alpha tubulin 0.0471 0.1288 0.7457
Plasmodium vivax acetyl-CoA synthetase, putative 0.0056 0.0105 0.0606
Trichomonas vaginalis tubulin epsilon chain, putative 0.0625 0.1728 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0051 0.0091 0.0524
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0001 0.0001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0091 0.0091
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0109 0.0632
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.001 0.0056
Trichomonas vaginalis tubulin alpha chain, putative 0.0625 0.1728 1
Leishmania major beta tubulin 0.0625 0.1728 1
Toxoplasma gondii histone deacetylase HDAC2 0.0248 0.0651 0.377
Brugia malayi glutathione reductase 0.0057 0.0107 0.0617
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.0504 0.2917
Loa Loa (eye worm) hypothetical protein 0.0293 0.078 0.4512
Plasmodium vivax vivapain-2 0.0051 0.0091 0.0524
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Schistosoma mansoni ap endonuclease 0.0038 0.0053 0.0053
Trichomonas vaginalis antibiotic synthetase, putative 0.0056 0.0105 0.0606
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0107 0.0107
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0019 0.0111
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.002 0.0001 0.0001
Echinococcus granulosus tubulin alpha 1C chain 0.0471 0.1288 0.1288
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Echinococcus multilocularis tubulin alpha chain 0.0471 0.1288 0.1288
Loa Loa (eye worm) cysteine protease 0.0051 0.0091 0.0518
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0116 0.2347
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0016 0.0121
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0018 0.0018
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Echinococcus granulosus histone deacetylase 7 0.0266 0.0703 0.0703
Entamoeba histolytica hypothetical protein 0.0072 0.0149 0.0854
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0192 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Plasmodium vivax acyl-CoA synthetase, putative 0.0144 0.0354 0.2048
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0056 0.0105 0.06
Trypanosoma cruzi tubulin delta chain 0.0363 0.0979 0.5668
Brugia malayi beta-lactamase family protein 0.0074 0.0154 0.0889
Loa Loa (eye worm) CYP4Cod1 0.0034 0.004 0.0228
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0006 0.0034
Trypanosoma brucei rac serine-threonine kinase, putative 0.002 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0281 0.0745 0.4307
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0154 0.0889
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Brugia malayi bHLH-PAS transcription factor 0.0045 0.0073 0.0425
Schistosoma mansoni tubulin subunit beta 0.0625 0.1728 0.1728
Giardia lamblia Beta tubulin 0.0625 0.1728 1
Loa Loa (eye worm) hypothetical protein 0.0192 0.0493 0.2847
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0033 0.0191
Schistosoma mansoni coup transcription factor 0.0041 0.0061 0.0061
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Mycobacterium ulcerans hypothetical protein 0.0192 0.0493 1
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0058 0.0109 0.0109
Brugia malayi beta-tubulin, identical 0.0625 0.1728 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0061 0.0349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0042 0.0243
Leishmania major 4-coumarate:coa ligase-like protein 0.0192 0.0493 0.2851
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0056 0.0105 0.0606
Schistosoma mansoni apoferritin-2 0.0026 0.0016 0.0016
Trichomonas vaginalis tubulin alpha chain, putative 0.019 0.0487 0.2819
Loa Loa (eye worm) hypothetical protein 0.0057 0.0107 0.0613
Loa Loa (eye worm) hypothetical protein 0.01 0.0229 0.1321
Loa Loa (eye worm) hypothetical protein 0.0159 0.0399 0.2302
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0016 0.0121
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0106 0.0609
Echinococcus multilocularis survival motor neuron protein 1 0.0511 0.1402 0.1402
Onchocerca volvulus 0.0074 0.0154 0.1524
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0016 0.0315
Echinococcus multilocularis ferritin 0.0026 0.0016 0.0016
Toxoplasma gondii flagellar/basal body protein 0.0058 0.0109 0.0632
Loa Loa (eye worm) RNA binding protein 0.0138 0.0337 0.1948
Plasmodium falciparum alpha tubulin 1 0.0471 0.1288 0.7457
Mycobacterium ulcerans acyl-CoA synthetase 0.0192 0.0493 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0026 0.0018 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0154 0.1195
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0053 0.0306
Trypanosoma brucei histone deacetylase, putative 0.0266 0.0703 0.4068
Brugia malayi Tubulin alpha-2 chain 0.0471 0.1288 0.7457
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0046 0.0075 0.0426
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0016 0.0315
Trypanosoma cruzi Carboxypeptidase-like protein 0.0058 0.0109 0.0632
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.002 0.0001 0.0001
Brugia malayi Protein kinase c protein 2 0.006 0.0115 0.0665
Brugia malayi Histone deacetylase 1 0.0248 0.0651 0.377
Echinococcus granulosus beta tubulin 0.0625 0.1728 0.1728
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0058 0.0109 0.0109
Brugia malayi AMP-binding enzyme family protein 0.0192 0.0493 0.2851
Echinococcus granulosus survival motor neuron protein 1 0.0511 0.1402 0.1402
Loa Loa (eye worm) LGC-31 protein 0.0026 0.0018 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0085 0.0085
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0212 0.1225
Toxoplasma gondii histone deacetylase HDAC4 0.0107 0.0248 0.1434
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0106 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0212 0.1225
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0019 0.0111
Leishmania major beta tubulin 0.0625 0.1728 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0016 0.0121
Onchocerca volvulus 0.0051 0.0091 0.0816
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0053 0.0306
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0109 0.0632
Leishmania major beta tubulin 0.0625 0.1728 1
Echinococcus multilocularis serotonin transporter 0.009 0.0199 0.0199
Plasmodium falciparum tubulin beta chain 0.0625 0.1728 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0471 0.1288 0.1288
Loa Loa (eye worm) tubulin beta-1 chain 0.0625 0.1728 1
Loa Loa (eye worm) beta-tubulin 0.0625 0.1728 1
Toxoplasma gondii thioredoxin reductase 0.0057 0.0107 0.0617
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0058 0.0109 0.0632
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0349
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0229 0.1321
Echinococcus granulosus tubulin subunit TubB 0.0471 0.1288 0.1288
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0058 0.0109 0.0632
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0085 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0056 0.0105 0.0606
Echinococcus multilocularis tubulin alpha chain 0.0471 0.1288 0.1288
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.003 0.0176
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0056 0.0105 0.0606
Brugia malayi Cathepsin L-like precursor 0.0051 0.0091 0.0524
Loa Loa (eye worm) hypothetical protein 0.0096 0.0217 0.125
Echinococcus multilocularis protein kinase c epsilon type 0.0074 0.0155 0.0155
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.031 0.0828 0.4793
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.0018 0.0018
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0058 0.0109 0.0632
Schistosoma mansoni hypothetical protein 0.1368 0.385 0.385
Echinococcus granulosus protein kinase c epsilon type 0.0074 0.0155 0.0155
Trichomonas vaginalis tubulin, putative 0.019 0.0487 0.2819
Mycobacterium ulcerans beta-lactamase 0.0074 0.0154 0.3119
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0033 0.0033
Brugia malayi Cathepsin L-like precursor 0.0034 0.0042 0.0243
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0053 0.0306
Loa Loa (eye worm) zinc carboxypeptidase 0.0058 0.0109 0.0626
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.0504 0.2917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0061 0.0349
Brugia malayi Cathepsin L-like precursor 0.0051 0.0091 0.0524
Loa Loa (eye worm) hypothetical protein 0.0074 0.0154 0.0883
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0027
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0016 0.0405
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0212 0.1225
Entamoeba histolytica hypothetical protein 0.0072 0.0149 0.0854
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0026 0.0018 0.0018
Echinococcus granulosus histone deacetylase 3 0.0248 0.0651 0.0651
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0026 0.0018 0.0018
Trichomonas vaginalis antibiotic synthetase, putative 0.0056 0.0105 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0404 0.2337
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0061 0.0356
Schistosoma mansoni ferritin 0.0026 0.0016 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0105 0.0814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.0504 0.2917
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.0018 0.0018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0154 0.1195
Trypanosoma cruzi epsilon tubulin, putative 0.0384 0.1039 0.6014
Echinococcus multilocularis tubulin alpha chain 0.0471 0.1288 0.1288
Echinococcus multilocularis GPCR, family 2 0.0032 0.0034 0.0034
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0006 0.0034
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0107 0.0829
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0061 0.0356
Plasmodium vivax delta tubulin, putative 0.0161 0.0404 0.2337
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.001 0.0056
Plasmodium vivax histone deacetylase 1, putative 0.0248 0.0651 0.377
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0212 0.1219
Trichomonas vaginalis tubulin, putative 0.019 0.0487 0.2819
Loa Loa (eye worm) hypothetical protein 0.0511 0.1402 0.8112
Schistosoma mansoni hypothetical protein 0.0072 0.0149 0.0149
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0061 0.0356
Echinococcus granulosus cathepsin L 0.0027 0.0019 0.0019
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0026 0.0018 0.0096
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0154 0.1195
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.019 0.0487 0.2819
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0061 0.0356
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0016 0.0121
Loa Loa (eye worm) tubulin alpha chain 0.0471 0.1288 0.7455
Echinococcus granulosus tubulin alpha chain 0.0471 0.1288 0.1288
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0106 0.0106
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0061 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0136 0.0331 0.2576
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0116 0.2347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0091 0.0524
Schistosoma mansoni ferritin 0.0026 0.0016 0.0016
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.009 0.0199 0.0199
Schistosoma mansoni ap endonuclease 0.0038 0.0053 0.0053
Trypanosoma cruzi epsilon tubulin, putative 0.0384 0.1039 0.6014
Echinococcus granulosus beta tubulin 0.0625 0.1728 0.1728
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0212 0.1225
Trypanosoma cruzi histone deacetylase 1, putative 0.0248 0.0651 0.377
Loa Loa (eye worm) hypothetical protein 0.0031 0.0032 0.0181
Schistosoma mansoni kinase 0.0048 0.008 0.008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0061 0.0061
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0058 0.0109 0.1026
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0056 0.0105 0.0814
Onchocerca volvulus 0.0058 0.0109 0.1026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Brugia malayi Cytochrome P450 family protein 0.0034 0.004 0.0234
Echinococcus multilocularis 0.0025 0.0016 0.0016
Onchocerca volvulus Carboxypeptidase D homolog 0.0058 0.0109 0.1026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0154 0.3119
Schistosoma mansoni tubulin subunit beta 0.0161 0.0404 0.0404
Giardia lamblia Histone deacetylase 0.0248 0.0651 0.377
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0016 0.0016
Loa Loa (eye worm) tubulin beta chain 0.0625 0.1728 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0277 0.1597
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0018 0.0103
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.0504 0.2917
Echinococcus multilocularis tubulin delta chain 0.0161 0.0404 0.0404
Mycobacterium ulcerans acyl-CoA synthetase 0.0056 0.0105 0.2126
Brugia malayi tubulin alpha chain - mouse 0.0471 0.1288 0.7457
Trichomonas vaginalis tubulin gamma chain, putative 0.0384 0.1039 0.6014
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0061 0.0356
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0179 0.1034
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0116 0.0116
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0056 0.0105 0.0105
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0061 0.0061
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0058 0.0109 0.0109
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0154 0.0889
Brugia malayi hypothetical protein 0.0072 0.0149 0.086
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0018 0.0018
Onchocerca volvulus 0.0076 0.0159 0.1587
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0058 0.0109 0.0632
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0357 0.2776
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.0626
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0019 0.0019
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0056 0.0105 0.0606
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0045 0.0072 0.0072
Mycobacterium ulcerans acyl-CoA synthetase 0.0192 0.0493 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0178 0.0452 0.0452
Plasmodium vivax unspecified product 0.0027 0.0019 0.0111
Loa Loa (eye worm) fibroinase 0.0051 0.0091 0.0518
Schistosoma mansoni acetyl-CoA synthetase 0.0056 0.0105 0.0105
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0056 0.0105 0.0814
Brugia malayi Histone deacetylase family protein 0.0266 0.0703 0.4068
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0058 0.0109 0.0109
Entamoeba histolytica tubulin alpha chain, putative 0.0471 0.1288 0.7455
Echinococcus multilocularis transfer RNA-Lys 0.0045 0.0073 0.0073
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0149 0.0149
Loa Loa (eye worm) tubulin beta-4 chain 0.0625 0.1728 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.0018 0.0018
Plasmodium falciparum histone deacetylase, putative 0.0266 0.0703 0.4068
Leishmania major alpha tubulin 0.0471 0.1288 0.7457
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0016 0.0121
Plasmodium falciparum histone deacetylase 2 0.0266 0.0703 0.4068
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0019 0.0105
Entamoeba histolytica hypothetical protein 0.0072 0.0149 0.0854
Brugia malayi RNA binding protein 0.0138 0.0337 0.1953
Schistosoma mansoni tubulin subunit beta 0.0625 0.1728 0.1728
Leishmania major acetyl-CoA synthetase, putative 0.0056 0.0105 0.0606
Entamoeba histolytica histone deacetylase, putative 0.0248 0.0651 0.3766
Leishmania major beta tubulin 0.0625 0.1728 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.001 0.0056
Leishmania major beta tubulin 0.0625 0.1728 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0471 0.1288 0.1288
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0026 0.0018 0.0018
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0051 0.0091 0.0524
Echinococcus multilocularis tubulin alpha 0.0351 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0096
Echinococcus granulosus cathepsin l cysteine peptidase 0.0051 0.0091 0.0091
Entamoeba histolytica acyl-CoA synthetase, putative 0.0192 0.0493 0.2847
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0061 0.0061
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0056 0.0105 0.0814
Giardia lamblia Kinase, PLK 0.0094 0.0212 0.1225
Onchocerca volvulus 0.0051 0.0091 0.0816
Schistosoma mansoni atypical protein kinase C 0.0034 0.0041 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0016 0.0121
Schistosoma mansoni ferritin 0.0026 0.0016 0.0016
Echinococcus granulosus tubulin alpha 3 chain 0.0471 0.1288 0.1288
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0019 0.0105
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0192 0.0493 1
Onchocerca volvulus Cathepsin F homolog 0.0051 0.0091 0.0816
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0026 0.0018 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0154 0.1195
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0061 0.0061
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0053 0.0053
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.004 0.0821
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0241 0.1394
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0019 0.0111
Echinococcus multilocularis tar DNA binding protein 0.0138 0.0337 0.0337
Echinococcus granulosus serotonin transporter 0.009 0.0199 0.0199
Schistosoma mansoni histone deacetylase 0.0248 0.0651 0.0651
Brugia malayi Cation transporter family protein 0.0026 0.0018 0.0103
Brugia malayi hypothetical protein 0.0293 0.078 0.4516
Leishmania major beta tubulin 0.0625 0.1728 1
Trypanosoma brucei beta tubulin 0.0625 0.1728 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0316 0.2453
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0154 0.0889
Mycobacterium leprae putative cytochrome p450 0.0025 0.0016 0.0122
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0116 0.0116
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0058 0.0109 0.0109
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0281 0.0745 0.4311
Plasmodium vivax glutathione reductase, putative 0.0057 0.0107 0.0617
Entamoeba histolytica tubulin gamma chain 0.0384 0.1041 0.602
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0357 0.2776
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0338 0.0909 0.0909
Mycobacterium tuberculosis Conserved protein 0.0074 0.0154 0.1195
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0349
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0192 0.0493 1
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0109 0.0632
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0106 0.0106
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0026 0.0018 0.0096
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0107 0.0107
Brugia malayi Pre-SET motif family protein 0.0031 0.0032 0.0188
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0016 0.0315
Echinococcus granulosus tubulin alpha 1C chain 0.0471 0.1288 0.1288
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0351 0.0947 0.5483
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0026 0.0018 0.0096
Giardia lamblia Beta tubulin 0.0625 0.1728 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0107 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.017
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.1288 0.7457
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0316 0.2453
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0106 0.0106
Entamoeba histolytica cysteine protease, putative 0.0027 0.0019 0.0105
Loa Loa (eye worm) hypothetical protein 0.0116 0.0275 0.1588
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0077 0.0445
Plasmodium falciparum alpha tubulin 2 0.0471 0.1288 0.7457
Loa Loa (eye worm) norepinephrine transporter 0.009 0.0199 0.1148
Brugia malayi AMP-binding enzyme family protein 0.0192 0.0493 0.2851
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0053 0.0306
Trypanosoma brucei zeta tubulin, putative 0.0498 0.1366 0.7907
Toxoplasma gondii beta-tubulin, putative 0.0625 0.1728 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0154 0.0883
Toxoplasma gondii exonuclease III APE 0.0038 0.0053 0.0306
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0061 0.0061
Trichomonas vaginalis tubulin, putative 0.0625 0.1728 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0056 0.0105 0.2126
Echinococcus granulosus tar DNA binding protein 0.0138 0.0337 0.0337
Onchocerca volvulus Histone deacetylase 10 homolog 0.0107 0.0248 0.258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0061 0.0349
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0154 0.0889
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0109 0.0632
Echinococcus multilocularis histone deacetylase 8 0.0107 0.0248 0.0248
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.001 0.0056
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0016 0.0332
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0248 0.0651 0.377
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0061 0.0356
Onchocerca volvulus 0.0051 0.0091 0.0816
Trypanosoma brucei beta tubulin 0.0625 0.1728 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0018 0.0018
Echinococcus multilocularis histone deacetylase 6 0.0272 0.0721 0.0721
Schistosoma mansoni nAChR subunit 0.0026 0.0018 0.0018
Trichomonas vaginalis tubulin gamma chain, putative 0.0625 0.1728 1
Leishmania major hypothetical protein, conserved 0.003 0.003 0.0176
Echinococcus granulosus peroxisome assembly protein 26 0.0471 0.1288 0.1288
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0018 0.0018
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0016 0.0315
Plasmodium vivax SET domain protein, putative 0.0031 0.0032 0.0188
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0091 0.0816
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0061 0.0489
Loa Loa (eye worm) hypothetical protein 0.0132 0.0321 0.1852
Loa Loa (eye worm) TAR-binding protein 0.0138 0.0337 0.1948
Onchocerca volvulus 0.0082 0.0179 0.1805
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0061 0.0061
Loa Loa (eye worm) histone deacetylase 7A 0.0266 0.0703 0.4064
Echinococcus multilocularis tubulin gamma 1 chain 0.0384 0.1041 0.1041
Echinococcus multilocularis tubulin subunit TubB 0.0471 0.1288 0.1288
Toxoplasma gondii alpha-tubulin I, putative 0.0471 0.1288 0.7457
Brugia malayi p70 ribosomal S6 kinase beta 0.002 0.0001 0.0007
Schistosoma mansoni ferritin light chain 0.0026 0.0016 0.0016
Brugia malayi Cytochrome P450 family protein 0.0034 0.004 0.0234
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.002 0.0001 0.0001
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0338 0.0909 0.0909
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0154 0.0154
Loa Loa (eye worm) histone deacetylase 0.0266 0.0703 0.4064
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0053 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0404 0.2337
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0061 0.0349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0085 0.0085
Echinococcus granulosus protein kinase c iota type 0.0034 0.0041 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0006 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0061 0.0061
Loa Loa (eye worm) tubulin alpha 2 0.031 0.0828 0.4789
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0125 0.0717
Trichomonas vaginalis AGC family protein kinase 0.002 0.0001 0.0007
Echinococcus multilocularis geminin 0.1368 0.385 0.385

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of mouse COX2 ChEMBL. 20129783
IC50 (binding) Inhibition of ovine COX1 ChEMBL. 20129783
IC50 (functional) = 0.15 uM Antitrypanosomal activity against Trypanosoma brucei brucei after 48 hrs by luminescence assay ChEMBL. 20129783
IC50 (functional) = 0.34 uM Cytotoxicity against human Raji cells after 72 hrs by luminescence assay ChEMBL. 20129783
IC50 (functional) = 0.35 uM Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay ChEMBL. 20129783
IC50 (functional) = 0.4 uM Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay ChEMBL. 20129783
IC50 (ADMET) > 50 uM Cytotoxicity against human BJ cells after 72 hrs by luminescence assay ChEMBL. 20129783
Inhibition (functional) Inhibition of Trypanosoma brucei brucei tubulin polymerization assessed as aberrant nuclei at 100 nM after 24 hrs by phase contrast fluorescence microscopy ChEMBL. 20129783
Inhibition (functional) Inhibition of Trypanosoma brucei brucei tubulin polymerization assessed as aberrant nuclei at 1 uM after 24 hrs by phase contrast fluorescence microscopy ChEMBL. 20129783
Inhibition (binding) = 81 % Inhibition of tubulin polymerization in porcine brain at 20 uM ChEMBL. 16870433
Inhibition (binding) = 81 % Inhibition of tubulin polymerization in porcine brain at 20 uM ChEMBL. 16870433
t1/2 (ADMET) Half life in mouse plasma by UPLC-MS analysis ChEMBL. 20129783

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20129783
Trypanosoma brucei gambiense 20129783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26882  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26953  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 25756  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29777  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 25113  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29099  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28601  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 24472  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21739  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28044  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21309  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 24440  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 20919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 22594  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23453  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21545  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29554  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29031  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23905  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21179  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 25450  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 22205  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 27459  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26961  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 22252  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23996  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23078  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 20827  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28024  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28324  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26882  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26953  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25756  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29777  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25113  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29099  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28601  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 24472  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21739  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28044  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21309  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 24440  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 20919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22594  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23453  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21545  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29554  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29031  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23905  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21179  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25450  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22205  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 27459  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26961  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22252  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23996  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23078  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 20827  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28024  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28324  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

7 literature references were collected for this gene.

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