Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | conserved hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Echinococcus granulosus | hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.127 | 0.3639 | 1 |
Toxoplasma gondii | hypothetical protein | 0.07 | 0.1872 | 0.187 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.07 | 0.1872 | 0.0476 |
Echinococcus multilocularis | carbonic anhydrase II | 0.149 | 0.4322 | 0.3535 |
Echinococcus multilocularis | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Schistosoma mansoni | carbonic anhydrase-related | 0.07 | 0.1872 | 0.0476 |
Echinococcus granulosus | dihydrofolate reductase | 0.3321 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0176 | 0.0248 | 0.0574 |
Leishmania major | carbonic anhydrase-like protein | 0.149 | 0.4322 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.149 | 0.4322 | 0.3535 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Trypanosoma cruzi | hexose transporter, putative | 0.0176 | 0.0248 | 0.0574 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.149 | 0.4322 | 0.3348 |
Schistosoma mansoni | carbonic anhydrase-related | 0.07 | 0.1872 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 0.1872 | 0.0476 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3321 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.3321 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3321 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3321 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3321 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.149 | 0.4322 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 0.8418 |
Schistosoma mansoni | carbonic anhydrase | 0.07 | 0.1872 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 0.1872 | 0.0476 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.149 | 0.4322 | 0.3348 |
Echinococcus granulosus | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.07 | 0.1872 | 0.0476 |
Plasmodium falciparum | carbonic anhydrase | 0.07 | 0.1872 | 0.187 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 0.8322 |
Echinococcus granulosus | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Trypanosoma cruzi | hexose transporter | 0.0176 | 0.0248 | 0.0574 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.149 | 0.4322 | 0.3348 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 0.8322 |
Schistosoma mansoni | carbonic anhydrase-related | 0.07 | 0.1872 | 0.0476 |
Echinococcus granulosus | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 0.1872 | 0.0476 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.149 | 0.4322 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.2285 | 0.1216 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.07 | 0.1872 | 0.0476 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0569 | 0.1465 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.07 | 0.1872 | 0.0476 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.07 | 0.1872 | 0.0476 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3321 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0836 | 0.2294 | 0.1226 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.149 | 0.4322 | 0.3348 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.127 | 0.3639 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.149 | 0.4322 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.149 | 0.4322 | 0.3348 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.149 | 0.4322 | 0.3348 |
Trypanosoma cruzi | hexose transporter, putative | 0.0176 | 0.0248 | 0.0574 |
Schistosoma mansoni | hypothetical protein | 0.07 | 0.1872 | 0.0476 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Schistosoma mansoni | dihydrofolate reductase | 0.3321 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Echinococcus multilocularis | carbonic anhydrase | 0.07 | 0.1872 | 0.0745 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.07 | 0.1872 | 0.0476 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0569 | 0.1465 | 0.0283 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3321 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 95 nM | Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release | ChEMBL. | 16844377 |
IC50 (functional) | = 95 nM | Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release | ChEMBL. | 16844377 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.