Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0522 | 0.0892 | 0.0208 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.4083 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0522 | 0.0892 | 0.0208 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0522 | 0.0892 | 0.0208 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1561 | 0.3549 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0522 | 0.0892 | 0.0208 |
Echinococcus granulosus | dihydrofolate reductase | 0.4083 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1561 | 0.3549 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.4083 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.4083 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0522 | 0.0892 | 0.0208 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.4083 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0522 | 0.0892 | 0.0208 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.4083 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1561 | 0.3549 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0522 | 0.0892 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1561 | 0.3549 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.4083 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.4083 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1561 | 0.3549 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0522 | 0.0892 | 0.0208 |
Brugia malayi | Dihydrofolate reductase | 0.4083 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1561 | 0.3549 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0522 | 0.0892 | 0.0208 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.