Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Brugia malayi | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0066 | 0.0032 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.015 | 0.0125 | 0.0092 |
Echinococcus granulosus | dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.294 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Schistosoma mansoni | serine/threonine protein kinase | 0.294 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.294 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Mycobacterium ulcerans | thymidylate synthase | 0.0442 | 0.1157 | 0.1649 |
Schistosoma mansoni | egf-like domain protein | 0.015 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | Kringle domain containing protein | 0.0198 | 0.0295 | 0.0262 |
Brugia malayi | Dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.205 | 0.6848 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.015 | 0.0125 | 0.0092 |
Echinococcus granulosus | laminin | 0.015 | 0.0125 | 0.0092 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.015 | 0.0125 | 0.0092 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0442 | 0.1157 | 0.1259 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0315 | 0.0709 | 0.0678 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0198 | 0.0295 | 0.0262 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.294 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.1116 | 0.3544 | 0.3522 |
Onchocerca volvulus | 0.0992 | 0.3103 | 0.308 | |
Echinococcus multilocularis | laminin | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.021 | 0.0337 | 0.0101 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0198 | 0.0295 | 0.0262 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.294 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0124 | 0.0033 | 0.0033 |
Onchocerca volvulus | Arrow homolog | 0.015 | 0.0125 | 0.0092 |
Onchocerca volvulus | 0.0198 | 0.0295 | 0.0262 | |
Leishmania major | hypothetical protein, conserved | 0.0198 | 0.0295 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.294 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.1157 | 0.1157 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Brugia malayi | Trypsin family protein | 0.1116 | 0.3544 | 0.3522 |
Chlamydia trachomatis | dihydrofolate reductase | 0.205 | 0.6848 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.205 | 0.6848 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.205 | 0.6848 | 0.6838 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0198 | 0.0295 | 0.0262 |
Echinococcus granulosus | Tolloid protein 1 | 0.015 | 0.0125 | 0.0092 |
Echinococcus multilocularis | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Brugia malayi | hypothetical protein | 0.021 | 0.0337 | 0.0305 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1116 | 0.3544 | 0.3544 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.294 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.205 | 0.6848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1116 | 0.3544 | 0.3522 |
Echinococcus multilocularis | Tolloid protein 1 | 0.015 | 0.0125 | 0.0092 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.0295 | 0.0262 |
Echinococcus multilocularis | fibrillin 1 | 0.015 | 0.0125 | 0.0092 |
Onchocerca volvulus | 0.0442 | 0.1157 | 0.1127 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1381 | 0.4481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Toxoplasma gondii | kringle domain-containing protein | 0.0198 | 0.0295 | 0.039 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1116 | 0.3544 | 0.3544 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0125 | 0.0092 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.015 | 0.0125 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.0473 | 0.0441 |
Onchocerca volvulus | 0.1116 | 0.3544 | 0.3522 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Brugia malayi | dihydrofolate reductase family protein | 0.205 | 0.6848 | 0.6838 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.015 | 0.0125 | 0.0125 |
Schistosoma mansoni | dihydrofolate reductase | 0.205 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Echinococcus granulosus | thymidylate synthase | 0.0442 | 0.1157 | 0.1127 |
Brugia malayi | Protein kinase domain containing protein | 0.0198 | 0.0295 | 0.0262 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.0337 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0124 | 0.0033 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.0295 | 0.0295 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1381 | 0.4481 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.