TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.47 | Formula: C22H20N2O5S
H donors: 0 H acceptors: 4 LogP: 3.37 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1N(C(=O)c2ccc(cc2)C)c2ccccc2S(=O)(=O)n2c1ccc2
InChi: 1S/C22H20N2O5S/c1-3-29-22(26)20-18-8-6-14-23(18)30(27,28)19-9-5-4-7-17(19)24(20)21(25)16-12-10-15(2)11-13-16/h4-14,20H,3H2,1-2H3
InChiKey: BTBIXHNANZJJGR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0468	0.0713
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.002	0.0204	0.0311
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.002	0.0182	0.0182
Schistosoma mansoni	neuropeptide receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus multilocularis	cysteine protease	0.0026	0.0468	0.0713
Onchocerca volvulus		0.002	0.0204	0.0535
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0204	0.0311
Echinococcus granulosus	serotonin receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	beta-lactamase family protein	0.0035	0.0862	0.0862
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0862	0.0814
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0468	0.086
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0862	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0204	0.0311
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0468	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0049	0.1462	1
Loa Loa (eye worm)	LGC-31 protein	0.0042	0.1183	0.1069
Schistosoma mansoni	nAChR subunit	0.0042	0.1183	0.1803
Giardia lamblia	Cathepsin B precursor	0.0049	0.1462	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0042	0.1183	0.1183
Loa Loa (eye worm)	TYRA-2 protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0042	0.1183	0.1069
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0128	0.0873
Schistosoma mansoni	biogenic amine receptor	0.002	0.0204	0.0311
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1278	0.1948
Schistosoma mansoni	neuropeptide receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.0201
Loa Loa (eye worm)	acetylcholine receptor protein	0.002	0.0182	0.0055
Onchocerca volvulus		0.0026	0.0468	0.3086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0468	0.3201
Leishmania major	cathepsin L-like protease	0.0026	0.0468	0.2551
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0042	0.1183	0.1803
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.002	0.0204	0.0311
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0326	0.0326
Echinococcus multilocularis	dro:myosuppressin receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0204	0.0311
Echinococcus granulosus	glycine receptor subunit beta	0.0042	0.1183	0.1803
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.002	0.0204	0.0311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0149	0.1018
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0128	0.0873
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0022
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0204	0.0311
Brugia malayi	MH2 domain containing protein	0.0116	0.4422	0.4422
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0989	0.6452
Echinococcus granulosus	neuropeptide receptor A26	0.002	0.0204	0.0311
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0204	0.0311
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Onchocerca volvulus		0.0035	0.0862	0.6895
Echinococcus granulosus	peptide allatostatin:somatostatin	0.002	0.0204	0.0311
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.002	0.0204	0.0311
Onchocerca volvulus		0.002	0.0182	0.0318
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0042	0.1183	0.1183
Onchocerca volvulus		0.002	0.0204	0.0535
Loa Loa (eye worm)	ACC-1 protein	0.0042	0.1183	0.1069
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0862	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Echinococcus multilocularis	neuropeptide FF receptor 2	0.002	0.0204	0.0311
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0468	0.3086
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0862	0.0744
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Schistosoma mansoni	neurotransmitter gated ion channel	0.002	0.0182	0.0277
Onchocerca volvulus		0.002	0.0204	0.0535
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Toxoplasma gondii	ABC1 family protein	0.0035	0.0862	0.5502
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0862	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0862	0.1314
Schistosoma mansoni	nAChR subunit	0.002	0.0182	0.0277
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.4422	0.4349
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0204	0.0078
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0128	0.1291
Onchocerca volvulus		0.0023	0.0326	0.171
Echinococcus granulosus	g protein coupled receptor	0.002	0.0204	0.0311
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0468	0.0713
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0468	0.0345
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0042	0.1183	0.1183
Schistosoma mansoni	histamine h1 receptor	0.002	0.0204	0.0311
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.002	0.0204	0.0311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0204	0.0311
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0468	0.4734
Brugia malayi	Serotonin receptor	0.002	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0204	0.0311
Echinococcus granulosus	cathepsin b	0.0139	0.544	0.8294
Toxoplasma gondii	cathepsin CPL	0.0026	0.0468	0.2551
Echinococcus granulosus	g protein coupled receptor	0.002	0.0204	0.0311
Echinococcus granulosus	nAChR subunit	0.0023	0.0326	0.0497
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0204	0.0078
Loa Loa (eye worm)	cathepsin B	0.0049	0.1462	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.0201
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.002	0.0204	0.0311
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0128	0.0195
Plasmodium vivax	vivapain-2	0.0026	0.0468	0.4106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0989	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0862	0.0744
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0182	0.0182
Echinococcus multilocularis	sex peptide receptor	0.002	0.0204	0.0311
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0468	0.4734
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.002	0.0204	0.0311
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0156	0.6196	0.6147
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0042	0.1183	0.1803
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Schistosoma mansoni	neuropeptide f receptor 76f	0.002	0.0204	0.0311
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.002	0.0182	0.0277
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0468	0.0713
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.114	0.7796
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0128	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.1183	0.1183
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.114	1
Onchocerca volvulus		0.0026	0.0468	0.3086
Brugia malayi	Dopamine receptor	0.002	0.0204	0.0204
Brugia malayi	Cation transporter family protein	0.0042	0.1183	0.1183
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0204	0.0311
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1278	0.1948
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0326	0.0497
Schistosoma mansoni	biogenic amine receptor	0.002	0.0204	0.0311
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0042	0.1183	0.1183
Echinococcus granulosus	orexin receptor type 2	0.002	0.0204	0.0311
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0468	0.086
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0019	0.0149	0.0274
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0468	0.0468
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0468	0.3201
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0042	0.1183	0.1803
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0989	1
Leishmania major	cathepsin L-like protease	0.0026	0.0468	0.2551
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0042	0.1183	0.1183
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0128	0.0235
Schistosoma mansoni	biogenic amine receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0042	0.1183	0.1803
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0204	0.0311
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0042	0.1183	0.1803
Brugia malayi	cathepsin B-like cysteine proteinase	0.0139	0.544	0.544
Leishmania major	cathepsin L-like protease	0.0026	0.0468	0.2551
Leishmania major	cathepsin L-like protease	0.0026	0.0468	0.2551
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0042	0.1183	0.1183
Echinococcus granulosus	dro:myosuppressin receptor	0.002	0.0204	0.0311
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Echinococcus granulosus	allatostatin A receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0042	0.1183	0.1069
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0862	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.002	0.0204	0.0078
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0042	0.1183	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0862	0.0744
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Brugia malayi	G protein-coupled receptor F59B2.13	0.002	0.0204	0.0204
Onchocerca volvulus		0.0042	0.1183	1
Brugia malayi	neuropeptide F receptor	0.002	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0862	0.0814
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0862	0.0814
Echinococcus granulosus	somatostatin receptor	0.002	0.0204	0.0311
Brugia malayi	G-protein coupled receptor	0.002	0.0204	0.0204
Onchocerca volvulus		0.0026	0.0468	0.3086
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0042	0.1183	0.1803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0204	0.0311
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0204	0.0311
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Onchocerca volvulus		0.0026	0.0468	0.3086
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0862	0.0744
Onchocerca volvulus		0.002	0.0204	0.0535
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Schistosoma mansoni	calcium-activated potassium channel	0.0156	0.6196	0.9446
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Onchocerca volvulus		0.002	0.0204	0.0535
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus granulosus	hypothetical protein	0.002	0.0204	0.0311
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0042	0.1183	0.1069
Loa Loa (eye worm)	fibroinase	0.0026	0.0468	0.0345
Brugia malayi	Cation transporter family protein	0.0042	0.1183	0.1183
Onchocerca volvulus		0.002	0.0182	0.0318
Echinococcus multilocularis	g-protein coupled receptor	0.002	0.0204	0.0311
Schistosoma mansoni	hypothetical protein	0.0156	0.6196	0.9446
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.002	0.0204	0.0204
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.114	0.1738
Echinococcus granulosus	sex peptide receptor	0.002	0.0204	0.0311
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.002	0.0204	0.0204
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.002	0.0204	0.0535
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0204	0.0311
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.002	0.0204	0.0311
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0204	0.0311
Schistosoma mansoni	amine GPCR	0.002	0.0204	0.0311
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0204	0.0311
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0204	0.0311
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0862	0.0814
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0042	0.1183	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.0201
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0468	0.3201
Echinococcus granulosus	glycine receptor subunit beta	0.0042	0.1183	0.1803
Echinococcus multilocularis	neuropeptide receptor A26	0.002	0.0204	0.0311
Echinococcus granulosus	neuropeptide s receptor	0.002	0.0204	0.0311
Schistosoma mansoni	amine GPCR	0.002	0.0204	0.0311
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0042	0.1183	0.1803
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	melatonin receptor type 1A	0.002	0.0204	0.0078
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0204	0.0311
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0204	0.0311
Brugia malayi	ORL1-like opioid receptor	0.002	0.0204	0.0204
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.007	0.2416	0.2318
Schistosoma mansoni	hypothetical protein	0.0165	0.6559	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0862	0.5895
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0042	0.1183	0.1803
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1278	0.1948
Giardia lamblia	Cathepsin B precursor	0.0049	0.1462	1
Onchocerca volvulus		0.0026	0.0468	0.3086
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0468	0.0468
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0023	0.0326	0.0326
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0468	0.0713
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0468	0.4734
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0042	0.1183	0.1803
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0862	0.7561
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0022
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0128	0.0235
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	hypothetical protein	0.002	0.0182	0.0182
Echinococcus granulosus	g-protein coupled receptor	0.002	0.0204	0.0311
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.002	0.0204	0.0204
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0468	0.0468
Brugia malayi	Cation transporter family protein	0.0042	0.1183	0.1183
Leishmania major	cathepsin L-like protease	0.0026	0.0468	0.2551
Schistosoma mansoni	hypothetical protein	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.002	0.0204	0.0078
Schistosoma mansoni	ap endonuclease	0.0018	0.0128	0.0195
Echinococcus multilocularis	nAChR subunit	0.0042	0.1183	0.1803
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0049	0.1462	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0204	0.0311
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0468	0.0345
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Brugia malayi	cathepsin L-like precursor	0.0019	0.0149	0.0149
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0862	0.5
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0042	0.1183	0.1803
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0204	0.0311
Onchocerca volvulus		0.0042	0.1183	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0862	0.0744
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0204	0.0311
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1278	0.1948
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0862	0.0814
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0204	0.0311
Brugia malayi	RE15519p	0.002	0.0204	0.0204
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0128	0.0195
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0042	0.1183	0.1803
Onchocerca volvulus		0.0026	0.0468	0.3086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0468	0.3201
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Onchocerca volvulus		0.0042	0.1183	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0468	0.086
Brugia malayi	excitatory GABA receptor EXP-1A	0.0042	0.1183	0.1183
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0128	0.1291
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0862	0.0814
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0204	0.0311
Brugia malayi	hypothetical protein	0.002	0.0182	0.0182
Onchocerca volvulus		0.0035	0.0862	0.6895
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Onchocerca volvulus		0.002	0.0204	0.0535
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.002	0.0204	0.0204
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.544	0.8294
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.002	0.0204	0.0311
Onchocerca volvulus		0.002	0.0204	0.0535
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0862	0.0814
Brugia malayi	beta-lactamase family protein	0.0035	0.0862	0.0862
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0204	0.0311
Schistosoma mansoni	adenoreceptor	0.002	0.0204	0.0311
Onchocerca volvulus		0.002	0.0204	0.0535
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0204	0.0311
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0862	0.1584
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Brugia malayi	Serotonin receptor	0.002	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0862	0.0744
Schistosoma mansoni	alpha-1 adrenergic receptor	0.002	0.0204	0.0311
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0862	0.5895
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.544	0.8294
Echinococcus multilocularis	G protein coupled receptor 139	0.002	0.0204	0.0311
Schistosoma mansoni	hypothetical protein	0.002	0.0204	0.0311
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0042	0.1183	0.1803
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0468	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Leishmania major	cysteine peptidase A (CPA)	0.0026	0.0468	0.2551
Onchocerca volvulus		0.002	0.0204	0.0535
Echinococcus granulosus	neuropeptide receptor	0.002	0.0204	0.0311
Plasmodium vivax	vivapain-2	0.0026	0.0468	0.4106
Schistosoma mansoni	nAChR subunit	0.002	0.0182	0.0277
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0042	0.1183	0.1803
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0042	0.1183	0.1183
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0468	0.3201
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0128	0.0873
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0468	0.3201
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0468	0.0468
Onchocerca volvulus		0.0035	0.0862	0.6895
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0862	0.5895
Echinococcus granulosus	G protein coupled receptor 139	0.002	0.0204	0.0311
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0862	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0862	0.5895
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0042	0.1183	0.1803
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0468	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0149	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0042	0.1183	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.0201
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0149	0.0149
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0042	0.1183	0.1803
Entamoeba histolytica	hypothetical protein	0.0023	0.0326	0.3295
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.0201
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0042	0.1183	0.1803
Echinococcus granulosus	nAChR subunit	0.0042	0.1183	0.1803
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0139	0.544	0.8294
Schistosoma mansoni	calcium-activated potassium channel	0.0149	0.5861	0.8936
Onchocerca volvulus		0.002	0.0204	0.0535
Leishmania major	cathepsin L-like protease	0.0026	0.0468	0.2551
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0042	0.1183	0.1069
Onchocerca volvulus		0.002	0.0204	0.0535
Onchocerca volvulus		0.0023	0.0326	0.171
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0468	0.3086
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0862	0.1584
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.002	0.0204	0.0078
Onchocerca volvulus		0.0042	0.1183	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.114	0.7796
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0049	0.1462	1
Schistosoma mansoni	nAChR subunit	0.0042	0.1183	0.1803
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0862	0.0814
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Schistosoma mansoni	neurotransmitter gated ion channel	0.0023	0.0326	0.0497
Schistosoma mansoni	nAChR subunit	0.0042	0.1183	0.1803
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0042	0.1183	0.1803
Schistosoma mansoni	nAChR subunit	0.0042	0.1183	0.1803
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0042	0.1183	0.1803
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.002	0.0204	0.0311
Brugia malayi	Tachykinin-like peptides receptor 99D	0.002	0.0204	0.0204
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0862	0.1314
Onchocerca volvulus		0.002	0.0204	0.0535
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	AKH receptor	0.002	0.0204	0.0204
Echinococcus multilocularis	allatostatin A receptor	0.002	0.0204	0.0311
Leishmania major	hypothetical protein, conserved	0.0035	0.0862	0.5502
Brugia malayi	Dopamine receptor protein 2	0.002	0.0204	0.0204
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0862	1
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0326	0.0201
Leishmania major	cathepsin L-like protease	0.0026	0.0468	0.2551
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.1183	0.1183
Echinococcus multilocularis	geminin	0.0165	0.6559	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.002	0.0204	0.0311
Brugia malayi	putative neuropeptide receptor NPR1	0.002	0.0204	0.0204
Echinococcus multilocularis	orexin receptor type 2	0.002	0.0204	0.0311
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0468	0.3201
Schistosoma mansoni	myosin xvIII	0.002	0.0204	0.0311
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.002	0.0204	0.0311
Echinococcus granulosus	tachykinin peptides receptor 99D	0.002	0.0204	0.0311
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.5497	0.8381
Onchocerca volvulus	Putative nachr subunit	0.0042	0.1183	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0128	0.0128
Brugia malayi	GnHR receptor homolog	0.002	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0862	0.0744
Echinococcus multilocularis	cathepsin b	0.0139	0.544	0.8294
Echinococcus granulosus	g protein coupled receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0042	0.1183	0.1069
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0139	0.544	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0468	0.0468
Schistosoma mansoni	opsin-like receptor	0.002	0.0204	0.0311
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0042	0.1183	0.1183
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0042	0.1183	0.1803
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.002	0.0182	0.0277
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Loa Loa (eye worm)	GABA receptor subunit	0.0023	0.0326	0.0201
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Schistosoma mansoni	hypothetical protein	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus granulosus	7TM GPCR rhodopsin	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Schistosoma mansoni	amine GPCR	0.002	0.0204	0.0311
Schistosoma mansoni	hypothetical protein	0.0165	0.6559	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Schistosoma mansoni	amine GPCR	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus granulosus	geminin	0.0165	0.6559	1
Onchocerca volvulus		0.0042	0.1183	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0019	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0204	0.0311
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0204	0.0078
Loa Loa (eye worm)	ACC-1 protein	0.0042	0.1183	0.1069
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.002	0.0182	0.0055
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.002	0.0204	0.0204
Giardia lamblia	Cathepsin B precursor	0.0049	0.1462	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Onchocerca volvulus		0.002	0.0204	0.0535
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0204	0.0311
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0149	0.0227
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.002	0.0182	0.0277
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1278	0.1948
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.4422	0.4349
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0468	0.0468
Loa Loa (eye worm)	cysteine protease	0.0026	0.0468	0.0345
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0862	0.1314
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.002	0.0204	0.0311
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0042	0.1183	0.1803
Schistosoma mansoni	neuropeptide receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.002	0.0204	0.0311
Echinococcus granulosus	7tm_1 domain containing protein	0.002	0.0204	0.0311
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0468	0.4734
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.1183	0.1183
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0862	0.0862
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.002	0.0182	0.0182
Onchocerca volvulus		0.002	0.0204	0.0535
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.5497	0.8381
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.002	0.0204	0.0078
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.002	0.0182	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Brugia malayi	G protein-coupled receptor	0.002	0.0204	0.0204
Brugia malayi	G-protein coupled receptor	0.002	0.0204	0.0204
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.114	0.7585
Echinococcus granulosus	neuropeptide FF receptor 2	0.002	0.0204	0.0311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0149	0.1018
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0182	0.0182
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0468	0.4734
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0149	0.0149
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0468	0.0713
Echinococcus multilocularis	cathepsin b	0.0139	0.544	0.8294
Schistosoma mansoni	nAChR subunit	0.0042	0.1183	0.1803
Loa Loa (eye worm)	acetyltransferase	0.014	0.5497	0.5439
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	Melatonin receptor type 1A	0.002	0.0204	0.0204
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.1278	0.1278
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0139	0.544	0.5381
Schistosoma mansoni	acetylcholine receptor subunit beta	0.002	0.0182	0.0277
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0468	0.086
Onchocerca volvulus		0.002	0.0204	0.0535
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.002	0.0182	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0042	0.1183	0.1803
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0204	0.0311
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0204	0.0311
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.9145	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1278	0.1948
Echinococcus multilocularis	neuropeptide s receptor	0.002	0.0204	0.0311
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0128	0.5
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0468	0.0468
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Loa Loa (eye worm)	ctsf protein	0.0026	0.0468	0.0345
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.5497	0.5497
Echinococcus granulosus	cathepsin l1	0.0026	0.0468	0.0713
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Trichomonas vaginalis	esterase, putative	0.0035	0.0862	0.5895
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0204	0.0311
Brugia malayi	neuropeptide F receptor	0.002	0.0204	0.0204
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.002	0.0182	0.0277
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0468	0.3201
Brugia malayi	putative neuropeptide receptor	0.002	0.0204	0.0204
Onchocerca volvulus		0.002	0.0182	0.0318
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1278	0.1948
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0078	0.2769	0.2676
Echinococcus multilocularis	serotonin receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Echinococcus multilocularis	glycine receptor subunit beta	0.0042	0.1183	0.1803
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0042	0.1183	0.1803
Schistosoma mansoni	acetylcholine receptor-related	0.002	0.0182	0.0277
Schistosoma mansoni	amine GPCR	0.002	0.0204	0.0311
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0204	0.0078
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0042	0.1183	0.1183
Echinococcus granulosus	cathepsin l1	0.0019	0.0149	0.0227
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Echinococcus multilocularis	G-protein coupled receptor, putative	0.002	0.0204	0.0311
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0862	0.1314
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0468	0.4734
Brugia malayi	Dopamine receptor protein 1	0.002	0.0204	0.0204
Brugia malayi	hypothetical protein	0.002	0.0182	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.002	0.0182	0.0277
Brugia malayi	hypothetical protein	0.002	0.0204	0.0204
Schistosoma mansoni	hypothetical protein	0.002	0.0204	0.0311
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0204	0.0311
Brugia malayi	hypothetical protein	0.002	0.0182	0.0182
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Onchocerca volvulus		0.002	0.0204	0.0535
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.002	0.0204	0.0311
Echinococcus multilocularis	cysteine protease	0.0026	0.0468	0.0713
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0468	0.0713
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0204	0.0311
Echinococcus multilocularis	somatostatin receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0862	0.0814
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0182	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0468	0.3086
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0468	0.3201
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0042	0.1183	0.1183
Schistosoma mansoni	neuropeptide receptor	0.002	0.0204	0.0311
Brugia malayi	hypothetical protein	0.002	0.0182	0.0182
Echinococcus multilocularis	nAChR subunit	0.0023	0.0326	0.0497
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.5324	0.8117
Schistosoma mansoni	ap endonuclease	0.0018	0.0128	0.0195
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0149	0.1506
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0468	0.0713
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0468	0.3201
Echinococcus multilocularis	small conductance calcium activated potassium	0.0156	0.6196	0.9446
Echinococcus granulosus	neuropeptide receptor	0.002	0.0204	0.0311
Echinococcus granulosus	alpha 1A adrenergic receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.1278	0.1165
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0862	0.0744
Onchocerca volvulus		0.002	0.0204	0.0535
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0042	0.1183	0.1803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0243	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0204	0.0078
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0023	0.0326	0.0497
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0204	0.0311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0204	0.0311
Onchocerca volvulus		0.0042	0.1183	1
Schistosoma mansoni	opsin-like receptor	0.002	0.0204	0.0311
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0139	0.544	0.8294
Echinococcus granulosus	fmrfamide receptor	0.002	0.0204	0.0311
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0042	0.1183	0.1803
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Leishmania major	cathepsin L-like protease	0.0026	0.0468	0.2551
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0862	0.5895
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0042	0.1183	0.1803
Echinococcus granulosus	cathepsin b	0.0139	0.544	0.8294
Echinococcus granulosus	small conductance calcium activated potassium	0.0156	0.6196	0.9446
Schistosoma mansoni	nAChR subunit	0.0042	0.1183	0.1803
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0128	0.112
Schistosoma mansoni	neurotransmitter gated ion channel	0.002	0.0182	0.0277
Onchocerca volvulus	Neuropeptide F receptor homolog	0.002	0.0204	0.0535
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0042	0.1183	0.1183
Echinococcus multilocularis	serotonin receptor	0.002	0.0204	0.0311
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0042	0.1183	0.1803
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0049	0.1462	0.2688
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Brugia malayi	beta-lactamase	0.0035	0.0862	0.0862
Brugia malayi	sulfakinin receptor protein	0.002	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0468	0.0345
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0468	0.3201
Toxoplasma gondii	cathepsin B	0.0049	0.1462	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1183	0.1069
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0862	0.5895
Brugia malayi	larval opioid receptor	0.002	0.0204	0.0204
Schistosoma mansoni	nAChR subunit	0.0042	0.1183	0.1803
Schistosoma mansoni	opsin-like receptor	0.002	0.0204	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0182	0.0055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Mycobacterium ulcerans	lipase LipD	0.0035	0.0862	1
Onchocerca volvulus		0.0026	0.0468	0.3086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0468	0.3201
Echinococcus multilocularis	glycine receptor subunit beta	0.0042	0.1183	0.1803
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0023	0.0326	0.0326
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.114	0.7585
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0042	0.1183	0.1803
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0049	0.1462	0.2229

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Decrease in procaspase 8 expression in human K562 cells by western blot	ChEMBL.	16970408
Activity (functional)	0	Decrease in procaspase 9 expression in human K562 cells by western blot	ChEMBL.	16970408
Activity (functional)	0	BCR-ABL inactivation-independent inhibition of PTDB-induced apoptosis in human K562 cell at 10 uM by western blot	ChEMBL.	16970408
Activity (functional)	= 45.6 %	Apoptotic activity against human K562 cell line at 10 uM after 8 hrs	ChEMBL.	16970408
Activity (functional)	= 45.6 %	Apoptotic activity against human K562 cell line at 10 uM after 8 hrs	ChEMBL.	16970408
Activity (functional)	= 50 %	Apoptotic activity against bone marrow cells of CML affected human (27-83 yrs) at onset phase at 10 uM after 24 hrs	ChEMBL.	16970408
Activity (functional)	= 55 %	Apoptotic activity against peripheral blood cells of CML affected human (27-83 yrs) at onset phase at 10 uM after 24 hrs	ChEMBL.	16970408
Activity (functional)	= 55 %	Apoptotic activity against peripheral blood cells of imatinib-resistant CML affected human (38-70 yrs) at blast crisis phase at 10 uM after 24 hrs	ChEMBL.	16970408
Activity (functional)	= 55 %	Apoptotic activity against peripheral blood cells of CML affected human (27-83 yrs) at onset phase at 10 uM after 24 hrs	ChEMBL.	16970408
Activity (functional)	= 55 %	Apoptotic activity against peripheral blood cells of imatinib-resistant CML affected human (38-70 yrs) at blast crisis phase at 10 uM after 24 hrs	ChEMBL.	16970408
Activity (functional)	= 67.6 %	Apoptotic activity against human K562 cell line at 10 uM after 16 hrs	ChEMBL.	16970408
Activity (functional)	= 67.6 %	Apoptotic activity against human K562 cell line at 10 uM after 16 hrs	ChEMBL.	16970408
Activity (functional)	= 75 %	Apoptotic activity against bone marrow cells of CML affected human (27-83 yrs) at onset phase at 10 uM after 48 hrs	ChEMBL.	16970408
Activity (functional)	= 78 %	Apoptotic activity against peripheral blood cells of CML affected human (27-83 yrs) at onset phase at 10 uM after 48 hrs	ChEMBL.	16970408
Activity (functional)	= 78 %	Apoptotic activity against peripheral blood cells of imatinib-resistant CML affected human (38-70 yrs) at blast crisis phase at 10 uM after 48 hrs	ChEMBL.	16970408
Activity (functional)	= 78 %	Apoptotic activity against peripheral blood cells of CML affected human (27-83 yrs) at onset phase at 10 uM after 48 hrs	ChEMBL.	16970408
Activity (functional)	= 78 %	Apoptotic activity against peripheral blood cells of imatinib-resistant CML affected human (38-70 yrs) at blast crisis phase at 10 uM after 48 hrs	ChEMBL.	16970408
Activity (functional)	= 79.6 %	Apoptotic activity against human K562 cell line at 10 uM after 24 hrs	ChEMBL.	16970408
Activity (functional)	= 79.6 %	Apoptotic activity against human K562 cell line at 10 uM after 24 hrs	ChEMBL.	16970408
Activity (functional)	= 91.7 %	Apoptotic activity against human K562 cell line at 10 uM after 48 hrs	ChEMBL.	16970408
Activity (functional)	= 91.7 %	Apoptotic activity against human K562 cell line at 10 uM after 48 hrs	ChEMBL.	16970408

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL379361
PubChem: 15987069

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 371715