Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | SET domain containing protein | 0.0013 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0002 | 0.0002 |
Echinococcus granulosus | dihydrofolate reductase | 1.7305 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 1.7305 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.0002 | 0.0413 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3745 | 0.216 | 0.216 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0013 | 0.0013 |
Onchocerca volvulus | Netrin receptor homolog | 0.0015 | 0.0004 | 0.0017 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Mycobacterium ulcerans | endonuclease IV | 0.0082 | 0.0042 | 0.0042 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0019 | 0.0185 |
Mycobacterium ulcerans | sugar phosphate isomerases/epimerases | 0.0022 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0012 | 0.0002 | 0.0002 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0015 | 0.0004 | 0.0004 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.2509 | 0.7227 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Mycobacterium leprae | PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) | 0.0082 | 0.0042 | 0.0042 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0023 | 0.0023 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0079 | 0.004 | 0.004 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0066 | 0.0033 | 0.0033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0237 | 0.0132 | 0.0132 |
Echinococcus granulosus | thymidylate synthase | 0.3745 | 0.216 | 0.216 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0012 | 0.0002 | 0.0002 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Brugia malayi | Hypothetical 29.7 kDa protein C05D11.5 in chromosome III | 0.0022 | 0.0007 | 0.0007 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Onchocerca volvulus | 0.0044 | 0.002 | 0.0094 | |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 0.0038 | 0.0038 |
Brugia malayi | Type III restriction enzyme, res subunit family protein | 0.0012 | 0.0002 | 0.0002 |
Leishmania major | oxidoreductase-like protein | 0.0016 | 0.0004 | 0.0005 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0013 | 0.0018 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3745 | 0.216 | 0.216 |
Schistosoma mansoni | hypothetical protein | 0.0351 | 0.0198 | 0.0198 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.0088 | 0.0046 | 0.0063 |
Echinococcus granulosus | Chromo domain | 0.0012 | 0.0002 | 0.0002 |
Trichomonas vaginalis | Heterochromatin protein, putative | 0.0012 | 0.0002 | 0.0018 |
Brugia malayi | Pre-SET motif family protein | 0.0222 | 0.0123 | 0.0123 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0197 | 0.0109 | 0.0109 |
Echinococcus granulosus | GMP synthase glutamine hydrolyzing | 0.0035 | 0.0015 | 0.0015 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.7305 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0074 | 0.0038 | 0.0038 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0012 | 0.0002 | 0.0002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1782 | 0.1025 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.0038 | 0.0369 |
Brugia malayi | Dihydrofolate reductase | 1.7305 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.2509 | 0.7227 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0009 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.2509 | 0.7227 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 1.2509 | 0.7227 | 1 |
Brugia malayi | thymidylate synthase | 0.3745 | 0.216 | 0.216 |
Plasmodium falciparum | glutamine-dependent NAD(+) synthetase, putative | 0.0088 | 0.0046 | 0.0063 |
Leishmania major | GMP synthase, putative,glutamine amidotransferase, putative | 0.0035 | 0.0015 | 0.0021 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0237 | 0.0132 | 0.0132 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.0002 | 0.0003 |
Mycobacterium ulcerans | NAD synthetase | 0.0088 | 0.0046 | 0.0046 |
Toxoplasma gondii | endonuclease IV APN | 0.0082 | 0.0042 | 0.0058 |
Schistosoma mansoni | chromobox protein | 0.0074 | 0.0038 | 0.0038 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.0002 | 0.0413 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0197 | 0.0109 | 0.0109 |
Plasmodium falciparum | GMP synthase [glutamine-hydrolyzing] | 0.0035 | 0.0015 | 0.0021 |
Echinococcus multilocularis | geminin | 0.0351 | 0.0198 | 0.0198 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0002 | 0.0003 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.2509 | 0.7227 | 1 |
Brugia malayi | Valyl-tRNA synthetase | 0.0012 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0012 | 0.0002 | 0.0009 | |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0012 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0016 | 0.0004 | 0.0018 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0222 | 0.0123 | 0.0123 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0016 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0042 | 0.0042 |
Trichomonas vaginalis | chromobox protein, putative | 0.0012 | 0.0002 | 0.0018 |
Mycobacterium tuberculosis | Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) | 0.0088 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0004 | 0.0004 |
Schistosoma mansoni | dihydrofolate reductase | 1.7305 | 1 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0013 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0007 | 0.0007 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.0002 | 0.0002 |
Brugia malayi | hypothetical protein | 0.0237 | 0.0132 | 0.0132 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Onchocerca volvulus | 0.0012 | 0.0002 | 0.0009 | |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.0008 | 0.0078 |
Schistosoma mansoni | chromobox protein | 0.0012 | 0.0002 | 0.0002 |
Toxoplasma gondii | chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 | 0.0012 | 0.0002 | 0.0003 |
Schistosoma mansoni | P2X receptor subunit | 0.0197 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 0.0038 | 0.0038 |
Echinococcus granulosus | Chromobox protein 3 | 0.0012 | 0.0002 | 0.0002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0012 | 0.0116 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0045 | 0.0021 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0004 | 0.0004 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0013 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Brugia malayi | Associated with TFs and helicases family protein | 0.0012 | 0.0002 | 0.0002 |
Schistosoma mansoni | chromobox protein | 0.0074 | 0.0038 | 0.0038 |
Echinococcus multilocularis | thymidylate synthase | 0.3745 | 0.216 | 0.216 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0016 | 0.0004 | 0.0004 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Mycobacterium ulcerans | thymidylate synthase | 0.3745 | 0.216 | 0.216 |
Entamoeba histolytica | chromodomain-helicase-DNA-binding protein, putative | 0.0012 | 0.0002 | 0.0413 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 0.0038 | 0.0038 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.0032 | 0.0032 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0019 | 0.0185 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0023 | 0.0023 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0064 | 0.0032 | 0.0032 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0014 | 0.0014 |
Echinococcus multilocularis | Chromobox protein 3 | 0.0012 | 0.0002 | 0.0002 |
Schistosoma mansoni | P2X receptor subunit | 0.0197 | 0.0109 | 0.0109 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0015 | 0.0004 | 0.0005 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.7305 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0004 | 0.0004 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0015 | 0.0004 | 0.0004 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.0021 | 0.0203 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 0.0038 | 0.0038 |
Giardia lamblia | NH3-dependent NAD+ synthetase | 0.0088 | 0.0046 | 1 |
Leishmania major | pteridine reductase 1 | 0.0214 | 0.0119 | 0.0164 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.0053 | 0.0025 | 0.0025 |
Plasmodium falciparum | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0082 | 0.0042 | 0.0058 |
Brugia malayi | Uncoordinated protein 44 | 0.0015 | 0.0004 | 0.0004 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0079 | 0.004 | 0.004 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0005 | 0.0005 |
Trichomonas vaginalis | chromobox protein, putative | 0.0012 | 0.0002 | 0.0018 |
Plasmodium vivax | GMP synthetase, putative | 0.0035 | 0.0015 | 0.0021 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0252 | 0.0141 | 0.0141 |
Schistosoma mansoni | GMP synthetase | 0.0035 | 0.0015 | 0.0015 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0016 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0002 | 0.0002 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 0.0008 | 0.0008 |
Echinococcus granulosus | geminin | 0.0351 | 0.0198 | 0.0198 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.7305 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.7305 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.0002 | 0.0003 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0044 | 0.002 | 0.002 |
Onchocerca volvulus | 0.0033 | 0.0014 | 0.0064 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.0032 | 0.0032 |
Trypanosoma brucei | NAD+ synthase, putative | 0.0088 | 0.0046 | 0.0063 |
Entamoeba histolytica | recQ family helicase, putative | 0.0012 | 0.0002 | 0.0413 |
Brugia malayi | CHD4 protein | 0.0012 | 0.0002 | 0.0002 |
Chlamydia trachomatis | endonuclease IV | 0.0082 | 0.0042 | 0.0042 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.0002 | 0.0413 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0016 | 0.0004 | 0.0004 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0002 | 0.0003 |
Brugia malayi | GMP synthase | 0.0035 | 0.0015 | 0.0015 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Toxoplasma gondii | bifunctional GMP synthase/glutamine amidotransferase protein | 0.0035 | 0.0015 | 0.0021 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0012 | 0.0002 | 0.0003 |
Brugia malayi | chromobox protein homolog 3 | 0.0042 | 0.0019 | 0.0019 |
Plasmodium vivax | glutamine-dependent NAD(+) synthetase, putative | 0.0088 | 0.0046 | 0.0063 |
Mycobacterium ulcerans | epimerase | 0.0022 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0012 | 0.0116 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Onchocerca volvulus | 0.3745 | 0.216 | 1 | |
Brugia malayi | Protein cec-1. | 0.0012 | 0.0002 | 0.0002 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0015 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0012 | 0.0002 | 0.0002 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0016 | 0.0004 | 0.0005 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0016 | 0.0004 | 0.0005 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0197 | 0.0109 | 0.0109 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 1 | 0.0012 | 0.0002 | 0.0002 |
Trypanosoma cruzi | NAD+ synthase, putative | 0.0088 | 0.0046 | 0.0063 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0132 | 0.0132 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0012 | 0.0002 | 0.0018 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Schistosoma mansoni | glutamine-dependent NAD(+) synthetase | 0.0088 | 0.0046 | 0.0046 |
Onchocerca volvulus | 0.0253 | 0.0141 | 0.0653 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0022 | 0.0007 | 0.0007 |
Trypanosoma brucei | GMP synthase [glutamine-hydrolysing] | 0.0035 | 0.0015 | 0.0021 |
Mycobacterium ulcerans | GMP synthase | 0.0035 | 0.0015 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0.0007 | 0.0007 |
Plasmodium vivax | heterochromatin protein 1, putative | 0.0012 | 0.0002 | 0.0003 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1782 | 0.1025 | 0.1418 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.0004 | 0.0004 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.0006 | 0.0009 |
Trichomonas vaginalis | hypothetical protein | 0.0012 | 0.0002 | 0.0018 |
Echinococcus granulosus | Ankyrin | 0.0015 | 0.0004 | 0.0004 |
Mycobacterium tuberculosis | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) | 0.0082 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | thymidylate synthase | 0.3745 | 0.216 | 0.216 |
Plasmodium vivax | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0082 | 0.0042 | 0.0058 |
Echinococcus multilocularis | Ankyrin | 0.0015 | 0.0004 | 0.0004 |
Entamoeba histolytica | NAD synthetase, putative | 0.0088 | 0.0046 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0197 | 0.0109 | 0.0109 |
Trypanosoma brucei | cytochrome P450, putative | 0.0013 | 0.0002 | 0.0003 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0016 | 0.0004 | 0.0004 |
Trichomonas vaginalis | chromobox protein, putative | 0.0012 | 0.0002 | 0.0018 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Plasmodium vivax | hypothetical protein, conserved | 0.0012 | 0.0002 | 0.0003 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0018 | 0.0005 | 0.0005 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.0032 | 0.0032 |
Onchocerca volvulus | Putative hydroxypyruvate isomerase | 0.0022 | 0.0007 | 0.0034 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0013 | 0.0013 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0016 | 0.0004 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0015 | 0.0015 |
Plasmodium falciparum | heterochromatin protein 1 | 0.0012 | 0.0002 | 0.0003 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0015 | 0.0004 | 0.0004 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0015 | 0.0004 | 0.0005 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0012 | 0.0002 | 0.0002 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0015 | 0.0004 | 0.0004 |
Schistosoma mansoni | P2X receptor subunit | 0.0197 | 0.0109 | 0.0109 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.0032 | 0.0032 |
Echinococcus multilocularis | chromobox protein 2 | 0.0012 | 0.0002 | 0.0002 |
Entamoeba histolytica | chromodomain-helicase-DNA-binding protein, putative | 0.0012 | 0.0002 | 0.0413 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0019 | 0.0019 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.0038 | 0.0369 |
Schistosoma mansoni | hypothetical protein | 0.0351 | 0.0198 | 0.0198 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 0.0008 | 0.0008 |
Brugia malayi | follicle stimulating hormone receptor | 0.0252 | 0.0141 | 0.0141 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0197 | 0.0109 | 0.0109 |
Echinococcus granulosus | chromobox protein 2 | 0.0012 | 0.0002 | 0.0002 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0013 | 0.0013 |
Echinococcus multilocularis | dihydrofolate reductase | 1.7305 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 0.0002 | 0.0003 |
Brugia malayi | DNA-(Apurinic or apyrimidinic site) lyase | 0.0082 | 0.0042 | 0.0042 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0013 | 0.0013 |
Schistosoma mansoni | netrin receptor unc5 | 0.0015 | 0.0004 | 0.0004 |
Leishmania major | NAD synthase, putative | 0.0088 | 0.0046 | 0.0063 |
Trichomonas vaginalis | nh(3)-dependent NAD(+) synthetase, putative | 0.0088 | 0.0046 | 0.0444 |
Plasmodium falciparum | chromodomain-helicase-DNA-binding protein 1 homolog, putative | 0.0012 | 0.0002 | 0.0003 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0064 | 0.0032 | 0.0032 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0012 | 0.0002 | 0.0002 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0019 | 0.0088 |
Brugia malayi | Death domain containing protein | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | M-phase phosphoprotein, mpp8 | 0.0012 | 0.0002 | 0.0002 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0023 | 0.0008 | 0.0078 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0023 | 0.0023 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.0021 | 0.0203 |
Toxoplasma gondii | glutamine-dependent NAD(+) synthetase protein, putative | 0.0088 | 0.0046 | 0.0063 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0064 | 0.0032 | 0.0032 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Echinococcus granulosus | death domain containing protein | 0.0015 | 0.0004 | 0.0004 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0012 | 0.0002 | 0.0003 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0012 | 0.0002 | 0.0003 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0015 | 0.0004 | 0.0004 |
Trypanosoma brucei | pteridine reductase 1 | 0.0208 | 0.0115 | 0.0159 |
Onchocerca volvulus | 0.0048 | 0.0023 | 0.0106 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0013 | 0.0013 |
Brugia malayi | hypothetical protein | 0.1782 | 0.1025 | 0.1025 |
Loa Loa (eye worm) | helicase | 0.0012 | 0.0002 | 0.0002 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 1 | 0.0012 | 0.0002 | 0.0002 |
Mycobacterium leprae | PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) | 0.0088 | 0.0046 | 0.0046 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0074 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0002 | 0.0002 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0013 | 0.0013 |
Echinococcus multilocularis | GMP synthase (glutamine hydrolyzing) | 0.0035 | 0.0015 | 0.0015 |
Echinococcus multilocularis | Chromo domain | 0.0012 | 0.0002 | 0.0002 |
Schistosoma mansoni | chromobox protein | 0.0012 | 0.0002 | 0.0002 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.2509 | 0.7227 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1782 | 0.1025 | 0.1025 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0064 | 0.0032 | 0.0044 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.0002 | 0.0002 |
Plasmodium vivax | hypothetical protein, conserved | 0.0012 | 0.0002 | 0.0003 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0197 | 0.0109 | 0.0109 |
Treponema pallidum | NAD synthetase | 0.0088 | 0.0046 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3745 | 0.216 | 0.216 |
Loa Loa (eye worm) | RecQ helicase | 0.0023 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0023 | 0.0008 | 0.0008 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Trichomonas vaginalis | set domain proteins, putative | 0.0253 | 0.0141 | 0.1377 |
Entamoeba histolytica | chromodomain-helicase-DNA-binding protein, putative | 0.0012 | 0.0002 | 0.0413 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0012 | 0.0002 | 0.0018 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0197 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0015 | 0.0004 | 0.0004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 10 uM.min | AUC in Balb/C mouse at 0.5 mg/kg, iv and 2 mg/kg, ip | ChEMBL. | 16870445 |
beta t1/2 (ADMET) | = 17 min | Beta half life in Balb/C mouse at 0.5 mg/kg, iv and 2 mg/kg, ip | ChEMBL. | 16870445 |
CL (ADMET) | = 72 ml/min.kg | Clearance in Balb/C mouse at 0.5 mg/kg, iv and 2 mg/kg, ip | ChEMBL. | 16870445 |
Cmax (ADMET) | = 1.1 uM | Cmax in Balb/C mouse at 0.5 mg/kg, iv and 2 mg/kg, ip | ChEMBL. | 16870445 |
F (ADMET) | = 46 % | Bioavailability in Balb/C mouse at 0.5 mg/kg, iv and 2 mg/kg, ip | ChEMBL. | 16870445 |
GI50 (functional) | = 0.6 nM | Antiproliferative activity against human Nalm6 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 1.1 nM | Antiproliferative activity against human CWR22Rv1 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 1.3 nM | Antiproliferative activity against human A375 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 1.9 nM | Antiproliferative activity against human P12 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 4.5 nM | Antiproliferative activity against human MDA-MB-213 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 5 nM | Antiproliferative activity against human HT1080 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 5.8 nM | Antiproliferative activity against human HCT116 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 5.8 nM | Antiproliferative activity against human BxPC3 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 6.2 nM | Antiproliferative activity against human PC3 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 6.2 nM | Antiproliferative activity against human H1299 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 6.6 nM | Antiproliferative activity against human HeLa-S3 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 6.9 nM | Antiproliferative activity against human DU145 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 7.5 nM | Antiproliferative activity against human HT29 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 8.1 nM | Antiproliferative activity against human DLD1 cells | ChEMBL. | 16870445 |
GI50 (functional) | = 10.7 nM | Antiproliferative activity against human A549 cells | ChEMBL. | 16870445 |
T1/2 (ADMET) | = 3.5 min | Alpha half life in Balb/C mouse at 0.5 mg/kg, iv and 2 mg/kg, ip | ChEMBL. | 16870445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.